CORDIS provides links to public deliverables and publications of HORIZON projects.
Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .
Deliverables
MRI and clinical data (opens in new window)
Report on MRI and clinical data
Report on the impact of toxin-based loss of DRNDA on the emergence of anxiety-related behaviour (opens in new window)AND-PD Project Management Handbook (opens in new window)
Report on the investigation of alterations in functional and structural connectivity within the serotonergic network in PD-related anxiety/depression (opens in new window)
Report on gene expression profiles of mouse DRNDA neurons (opens in new window)
Report on DRNDA activity manipulation effects on the reciprocal synaptic connectivity between the DRN and the DS in physiological conditions (opens in new window)
Report on the validation of the MPTP model of PD in NHP (opens in new window)
Report illustrating the underlying oxidative stress, mitochondrial status and synaptic contact loss within DRNDA and/or DRN5-HT neurons in post-mortem samples of PD patients with and without anxiety/depression (opens in new window)
Validation of neurotoxin and genetic mouse models of PD (opens in new window)
Report on the validation of neurotoxin and genetic mouse models of PD to examine comorbid anxiety/depression in association with functional impairment of the DRN.
Report on the investigation of changes in cerebral blood flow, neuromelanin density and iron deposition within regions of the serotonergic network (opens in new window)Clinical and behavioural measures in patients with and without anxiety in PD (opens in new window)
Report on clinical and behavioural measures in patients with and without anxiety in PD
Report on gene expression profiles of peripheral blood (opens in new window)Dopaminergic and serotonergic network maps (opens in new window)
Report on dopaminergic and serotonergic network maps
Report on the estimation of phospho-α-syn-positive neurons in the DRN and on the differential vulnerability within DRNDA neuronal subpopulations (opens in new window)Primary care database analysis results (opens in new window)
Report on primary care database analysis results
Report on the impact of DRNDA neuron manipulations on BNST/amyg activity, and the effect of this manipulations in the DS (opens in new window)Progressive NHP model of PD (opens in new window)
A novel, progressive NHP model of PD, based on overexpression of a-synuclein, for the study of comorbid anxiety/depression and the identification of therapeutic interventions
Report on the impact of generating synucleinopathies in the DRN, thereby in DRNDA neurons, on DRNDA physiology and on the emergence of anxiety-related behaviours (opens in new window)Report on selection, assessment and stratification of post-mortem human brain samples used in AND-PD (opens in new window)
Report on gene expression profiles of post-mortem brain (opens in new window)
Report on the efficacy of multiSINEUP-PD approach and of circuits interventions restoring the functional role of DRNDA neurons to prevent co-morbid phenotype (opens in new window)
Report on the functional interplay between DRNDA and DRN5-HT neurons in control subjects (opens in new window)
Report on target engagement in vivo of multiSINEUP-PD models (opens in new window)
Report on the impact of silencing the DRNDA->BNST and DRNDA->amyg projections on the emergence of anxiety-related behaviour, also upon co-silencing of DRN5-HT->DS (opens in new window)
Report on the link between vulnerability of DRNDA cells to degeneration in PD with a stressful pacemaker phenotype (opens in new window)
Roadmap for future clinical research (opens in new window)
Report illustrating the differential pro-inflammatory-associated events in the DRN of PD patients with and without anxiety/depression (opens in new window)
Report on the impact of DRNDA functional decline on DRN output in murine PD models (opens in new window)
Report on correlation with imaging findings (opens in new window)
Report on the functional and molecular alteration DRN dopaminergic and serotonergic network by PET and fMRI studies in preclinical models and its translation to PD patients. (opens in new window)
PPMI analysis (opens in new window)
Report on PPMI analysis results
Data Management Plan according to template defined by the Commission.
Publications
Author(s):
Emma. K. Blundell, Laura. E. Grover, Joshua Stott, and Anette Schrag
Published in:
NPJ Parkinsons Disease, Issue 9: 75, 2023, ISSN 2373-8057
Publisher:
New York NY]: Nature Publishing Group; Parkinson's Disease Foundation, [2015]-
DOI:
10.1038/s41531-023-00512-1
Author(s):
Laura Boi; Yvonne Johansson; Raffaella Tonini; Rosario Moratalla; Gilberto Fisone; Gilad Silberberg
Published in:
eLife, Issue 12 RP90278, 2024, ISSN 2050-084X
Publisher:
eLife Sciences Publications
DOI:
10.7554/elife.90278
Author(s):
Juan Carlos Bazo-Alvarez, Danielle Nimmons, Kate Walters, Irene Petersen, and Anette Schrag
Published in:
British Journal of General Practice, Issue v.74(744), 2024, Page(s) e482-e488, ISSN 0960-1643
Publisher:
Royal College of General Practitioners
DOI:
10.3399/bjgp.2023.0423
Author(s):
Braine, Anaelle; Georges, François
Published in:
Neuroscience and Biobehavioral Reviews, Issue Volume 155, 2023, ISSN 0149-7634
Publisher:
Pergamon Press Ltd.
DOI:
10.1016/j.neubiorev.2023.105475
Author(s):
Hanyuying Wang, Yibo Zhao, Anette Schrag
Published in:
European Journal of Neurology, Issue 30, 2023, Page(s) 2661-2668, ISSN 1351-5101
Publisher:
Blackwell Publishing Inc.
DOI:
10.1111/ene.15890
Author(s):
Sergio Vegas-Suárez, Teresa Morera-Herreras, Catalina Requejo, José Vicente Lafuente, Rosario Moratalla, Cristina Miguélez, and Luisa Ugedo
Published in:
Frontiers in Pharmacology, Issue 13: 953652, 2022, ISSN 1663-9812
Publisher:
Frontiers Media S.A.
DOI:
10.3389/fphar.2022.953652
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