COMORBIDITY MECHANISMS OF ANXIETY AND PARKINSON’S DISEASE

Informations projet

AND-PD

N° de convention de subvention: 848002

DOI

10.3030/848002

Projet clôturé

Date de signature de la CE 6 Decembre 2019

Date de début 1 Janvier 2020

Date de fin 30 Juin 2024

Financé au titre de

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coût total

€ 5 995 848,62

Contribution de l’UE

€ 5 995 848,62

Coordonné par

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (32)

Report on the impact of DRNDA degeneration on DRN5-HT morphology and serotonergic fibre innervation to the DS
MRI and clinical data

Report on MRI and clinical data

Report on the impact of toxin-based loss of DRNDA on the emergence of anxiety-related behaviour
AND-PD Project Management Handbook
Report on the investigation of alterations in functional and structural connectivity within the serotonergic network in PD-related anxiety/depression
Report on gene expression profiles of mouse DRNDA neurons
Report on DRNDA activity manipulation effects on the reciprocal synaptic connectivity between the DRN and the DS in physiological conditions
Report on the validation of the MPTP model of PD in NHP
Report illustrating the underlying oxidative stress, mitochondrial status and synaptic contact loss within DRNDA and/or DRN5-HT neurons in post-mortem samples of PD patients with and without anxiety/depression
Validation of neurotoxin and genetic mouse models of PD

Report on the validation of neurotoxin and genetic mouse models of PD to examine comorbid anxiety/depression in association with functional impairment of the DRN.

Report on the investigation of changes in cerebral blood flow, neuromelanin density and iron deposition within regions of the serotonergic network
Clinical and behavioural measures in patients with and without anxiety in PD

Report on clinical and behavioural measures in patients with and without anxiety in PD

Report on gene expression profiles of peripheral blood
Dopaminergic and serotonergic network maps

Report on dopaminergic and serotonergic network maps

Report on the estimation of phospho-α-syn-positive neurons in the DRN and on the differential vulnerability within DRNDA neuronal subpopulations
Primary care database analysis results

Report on primary care database analysis results

Report on the impact of DRNDA neuron manipulations on BNST/amyg activity, and the effect of this manipulations in the DS
Progressive NHP model of PD

A novel, progressive NHP model of PD, based on overexpression of a-synuclein, for the study of comorbid anxiety/depression and the identification of therapeutic interventions

Report on the impact of generating synucleinopathies in the DRN, thereby in DRNDA neurons, on DRNDA physiology and on the emergence of anxiety-related behaviours
Report on selection, assessment and stratification of post-mortem human brain samples used in AND-PD
Report on gene expression profiles of post-mortem brain
Report on the efficacy of multiSINEUP-PD approach and of circuits interventions restoring the functional role of DRNDA neurons to prevent co-morbid phenotype
Report on the functional interplay between DRNDA and DRN5-HT neurons in control subjects
Report on target engagement in vivo of multiSINEUP-PD models
Report on the impact of silencing the DRNDA->BNST and DRNDA->amyg projections on the emergence of anxiety-related behaviour, also upon co-silencing of DRN5-HT->DS
Report on the link between vulnerability of DRNDA cells to degeneration in PD with a stressful pacemaker phenotype
Roadmap for future clinical research
Report illustrating the differential pro-inflammatory-associated events in the DRN of PD patients with and without anxiety/depression
Report on the impact of DRNDA functional decline on DRN output in murine PD models
Report on correlation with imaging findings
Report on the functional and molecular alteration DRN dopaminergic and serotonergic network by PET and fMRI studies in preclinical models and its translation to PD patients.
PPMI analysis

Report on PPMI analysis results

Open Research Data Pilot (1)

Data Management Plan

Data Management Plan according to template defined by the Commission.

Publications

Peer reviewed articles (6)

The experience of Anxiety for people with Parkinson’s disease

Auteurs: Emma. K. Blundell, Laura. E. Grover, Joshua Stott, and Anette Schrag
Publié dans: NPJ Parkinsons Disease, Numéro 9: 75, 2023, ISSN 2373-8057
Éditeur: New York NY]: Nature Publishing Group; Parkinson's Disease Foundation, [2015]-
DOI: 10.1038/s41531-023-00512-1

Serotonergic and dopaminergic neurons in the dorsal raphe are differentially altered in a mouse model for parkinsonism

Auteurs: Laura Boi; Yvonne Johansson; Raffaella Tonini; Rosario Moratalla; Gilberto Fisone; Gilad Silberberg
Publié dans: eLife, Numéro 12 RP90278, 2024, ISSN 2050-084X
Éditeur: eLife Sciences Publications
DOI: 10.7554/elife.90278

Risk of Parkinson’s disease in people aged ≥50 years with new-onset anxiety: a retrospective cohort study in UK primary care

Auteurs: Juan Carlos Bazo-Alvarez, Danielle Nimmons, Kate Walters, Irene Petersen, and Anette Schrag
Publié dans: British Journal of General Practice, Numéro v.74(744), 2024, Page(s) e482-e488, ISSN 0960-1643
Éditeur: Royal College of General Practitioners
DOI: 10.3399/bjgp.2023.0423

Emotion in action: When emotions meet motor circuits

Auteurs: Braine, Anaelle; Georges, François
Publié dans: Neuroscience and Biobehavioral Reviews, Numéro Volume 155, 2023, ISSN 0149-7634
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2023.105475

Development of anxiety in early Parkinson's disease: A clinical and biomarker study

Auteurs: Hanyuying Wang, Yibo Zhao, Anette Schrag
Publié dans: European Journal of Neurology, Numéro 30, 2023, Page(s) 2661-2668, ISSN 1351-5101
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/ene.15890

Motor cortico-nigral and cortico-entopeduncular information transmission and its modulation by buspirone in control and after dopaminergic denervation

Auteurs: Sergio Vegas-Suárez, Teresa Morera-Herreras, Catalina Requejo, José Vicente Lafuente, Rosario Moratalla, Cristina Miguélez, and Luisa Ugedo
Publié dans: Frontiers in Pharmacology, Numéro 13: 953652, 2022, ISSN 1663-9812
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fphar.2022.953652