COMORBIDITY MECHANISMS OF ANXIETY AND PARKINSON’S DISEASE

Informazioni relative al progetto

AND-PD

ID dell’accordo di sovvenzione: 848002

DOI

10.3030/848002

Progetto chiuso

Data della firma CE 6 Dicembre 2019

Data di avvio 1 Gennaio 2020

Data di completamento 30 Giugno 2024

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale

€ 5 995 848,62

Contributo UE

€ 5 995 848,62

Coordinato da

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (32)

Report on the impact of DRNDA degeneration on DRN5-HT morphology and serotonergic fibre innervation to the DS
MRI and clinical data

Report on MRI and clinical data

Report on the impact of toxin-based loss of DRNDA on the emergence of anxiety-related behaviour
AND-PD Project Management Handbook
Report on the investigation of alterations in functional and structural connectivity within the serotonergic network in PD-related anxiety/depression
Report on gene expression profiles of mouse DRNDA neurons
Report on DRNDA activity manipulation effects on the reciprocal synaptic connectivity between the DRN and the DS in physiological conditions
Report on the validation of the MPTP model of PD in NHP
Report illustrating the underlying oxidative stress, mitochondrial status and synaptic contact loss within DRNDA and/or DRN5-HT neurons in post-mortem samples of PD patients with and without anxiety/depression
Validation of neurotoxin and genetic mouse models of PD

Report on the validation of neurotoxin and genetic mouse models of PD to examine comorbid anxiety/depression in association with functional impairment of the DRN.

Report on the investigation of changes in cerebral blood flow, neuromelanin density and iron deposition within regions of the serotonergic network
Clinical and behavioural measures in patients with and without anxiety in PD

Report on clinical and behavioural measures in patients with and without anxiety in PD

Report on gene expression profiles of peripheral blood
Dopaminergic and serotonergic network maps

Report on dopaminergic and serotonergic network maps

Report on the estimation of phospho-α-syn-positive neurons in the DRN and on the differential vulnerability within DRNDA neuronal subpopulations
Primary care database analysis results

Report on primary care database analysis results

Report on the impact of DRNDA neuron manipulations on BNST/amyg activity, and the effect of this manipulations in the DS
Progressive NHP model of PD

A novel, progressive NHP model of PD, based on overexpression of a-synuclein, for the study of comorbid anxiety/depression and the identification of therapeutic interventions

Report on the impact of generating synucleinopathies in the DRN, thereby in DRNDA neurons, on DRNDA physiology and on the emergence of anxiety-related behaviours
Report on selection, assessment and stratification of post-mortem human brain samples used in AND-PD
Report on gene expression profiles of post-mortem brain
Report on the efficacy of multiSINEUP-PD approach and of circuits interventions restoring the functional role of DRNDA neurons to prevent co-morbid phenotype
Report on the functional interplay between DRNDA and DRN5-HT neurons in control subjects
Report on target engagement in vivo of multiSINEUP-PD models
Report on the impact of silencing the DRNDA->BNST and DRNDA->amyg projections on the emergence of anxiety-related behaviour, also upon co-silencing of DRN5-HT->DS
Report on the link between vulnerability of DRNDA cells to degeneration in PD with a stressful pacemaker phenotype
Roadmap for future clinical research
Report illustrating the differential pro-inflammatory-associated events in the DRN of PD patients with and without anxiety/depression
Report on the impact of DRNDA functional decline on DRN output in murine PD models
Report on correlation with imaging findings
Report on the functional and molecular alteration DRN dopaminergic and serotonergic network by PET and fMRI studies in preclinical models and its translation to PD patients.
PPMI analysis

Report on PPMI analysis results

Open Research Data Pilot (1)

Data Management Plan

Data Management Plan according to template defined by the Commission.

Pubblicazioni

Peer reviewed articles (6)

The experience of Anxiety for people with Parkinson’s disease

Autori: Emma. K. Blundell, Laura. E. Grover, Joshua Stott, and Anette Schrag
Pubblicato in: NPJ Parkinsons Disease, Numero 9: 75, 2023, ISSN 2373-8057
Editore: New York NY]: Nature Publishing Group; Parkinson's Disease Foundation, [2015]-
DOI: 10.1038/s41531-023-00512-1

Serotonergic and dopaminergic neurons in the dorsal raphe are differentially altered in a mouse model for parkinsonism

Autori: Laura Boi; Yvonne Johansson; Raffaella Tonini; Rosario Moratalla; Gilberto Fisone; Gilad Silberberg
Pubblicato in: eLife, Numero 12 RP90278, 2024, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.90278

Risk of Parkinson’s disease in people aged ≥50 years with new-onset anxiety: a retrospective cohort study in UK primary care

Autori: Juan Carlos Bazo-Alvarez, Danielle Nimmons, Kate Walters, Irene Petersen, and Anette Schrag
Pubblicato in: British Journal of General Practice, Numero v.74(744), 2024, Pagina/e e482-e488, ISSN 0960-1643
Editore: Royal College of General Practitioners
DOI: 10.3399/bjgp.2023.0423

Emotion in action: When emotions meet motor circuits

Autori: Braine, Anaelle; Georges, François
Pubblicato in: Neuroscience and Biobehavioral Reviews, Numero Volume 155, 2023, ISSN 0149-7634
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2023.105475

Development of anxiety in early Parkinson's disease: A clinical and biomarker study

Autori: Hanyuying Wang, Yibo Zhao, Anette Schrag
Pubblicato in: European Journal of Neurology, Numero 30, 2023, Pagina/e 2661-2668, ISSN 1351-5101
Editore: Blackwell Publishing Inc.
DOI: 10.1111/ene.15890

Motor cortico-nigral and cortico-entopeduncular information transmission and its modulation by buspirone in control and after dopaminergic denervation

Autori: Sergio Vegas-Suárez, Teresa Morera-Herreras, Catalina Requejo, José Vicente Lafuente, Rosario Moratalla, Cristina Miguélez, and Luisa Ugedo
Pubblicato in: Frontiers in Pharmacology, Numero 13: 953652, 2022, ISSN 1663-9812
Editore: Frontiers Media S.A.
DOI: 10.3389/fphar.2022.953652