Drug combinations for rewriting trajectories of renal pathologies in type II diabetes (DC-ren)

Project description

Dynamical systems theory could support physicians to select optimal therapies

Diseases, co-morbidities, and patients responses to certain therapies are the result of a complicated interplay of numerous factors. The relationships defining how this intricate network of inputs leads to various outputs is extremely difficult to derive using conventional means. Thanks to Big Data, high-level applied mathematics and computers, the EU-funded DC-ren project is developing a tool that will take all this and more into account, and enable optimised personalised drug therapies for significantly enhanced outcomes. The team is focusing on diabetic kidney disease, a common co-morbidity of type 2 diabetes often accompanied by cardiovascular disease. Currently, the drug cocktails targeting it produce highly varied responses. Thanks to its vast patient database, advanced experimental techniques and dynamical systems theory, DC-ren is developing a completely new and widely applicable computational framework for decision support.

Field of science

• /medical and health sciences/basic medicine/pathology
• /medical and health sciences/clinical medicine/endocrinology/diabetes/diabetic nephropathy
• /medical and health sciences/clinical medicine/nephrology/kidney diseases
• /natural sciences/mathematics/applied mathematics/dynamical systems

Programme(s)

• H2020-EU.3.1.1. - Understanding health, wellbeing and disease

Topic(s)

• SC1-BHC-02-2019 - Systems approaches for the discovery of combinatorial therapies for complex disorders

Call for proposal

H2020-SC1-2019-Two-Stage-RTD
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

MEDIZINISCHE UNIVERSITAT INNSBRUCK

Address

Christoph Probst Platz 1
6020 Innsbruck
Austria

Activity type

Higher or Secondary Education Establishments

EU contribution

€ 1 045 300

Participants (7)

EMERGENTEC BIODEVELOPMENT GMBH

Austria

EU contribution

€ 898 775

Address

Gersthofer Strasse 29-31
1180 Vienna

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

MEDIZINISCHE UNIVERSITAET WIEN

Austria

EU contribution

€ 948 800

Address

Spitalgasse 23
1090 Wien

Activity type

Higher or Secondary Education Establishments

MOSAIQUES DIAGNOSTICS GMBH

Germany

EU contribution

€ 701 050

Address

Rotenburger Strasse 20
30659 Hannover

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

ACADEMISCH ZIEKENHUIS GRONINGEN

Netherlands

EU contribution

€ 554 925

Address

Hanzeplein 1
9713 GZ Groningen

Activity type

Higher or Secondary Education Establishments

UNIVERSITA CA' FOSCARI VENEZIA

Italy

EU contribution

€ 781 405

Address

Dorsoduro 3246
30123 Venezia

Activity type

Higher or Secondary Education Establishments

WEIZMANN INSTITUTE OF SCIENCE

Israel

EU contribution

€ 515 237,50

Address

Herzl Street 234
7610001 Rehovot

Activity type

Higher or Secondary Education Establishments

REGION HOVEDSTADEN

Denmark

EU contribution

€ 522 987,50

Address

Kongens Vaenge 2
3400 Hillerod

Activity type

Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)