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Drug combinations for rewriting trajectories of renal pathologies in type II diabetes (DC-ren)

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Outreach framework (opens in new window)

Provide evidence for the generalizability of DC-ren framework beyond DKD drug R&D

IP/data management overall report (opens in new window)

IP/data: Setup and maintanance of a database holding information on relevant patent applications in the context of DKDSetup and maintanance of a database holding information on drug development in DKDExploitation of opportunities within DC-ren

Clinical study results (opens in new window)

The observable matrix of the subjects selected for the clinical study is completed. Evidence is provided if decisions made by the DC-ren toolbox assistance are better that ones made according to standard guidelines.

Outreach, applications (opens in new window)

Provide evidence for utility of the DC-ren toolobox approach in the clinical and R&D environment beyond the drugs of primary interest in DC-ren.

Dissemination/public outreach overall report (opens in new window)

Summary report on all dissemination/public outreach activities

Clinical study protocol (opens in new window)

The study protocol for the simulated trial within CANVAS and PRIORITY including sample size specificiations and power calculation, SOPs for sample selection and experimental testing, toolbox decision procedure and statistical analysis is available.

Publications

Candidate composite biomarker to inform drug treatments for diabetic kidney disease (opens in new window)

Author(s): Roger D. Jones, Seyum Abebe, Veronica Distefano, Gert Mayer, Irene Poli, Claudio Silvestri, Debora Slanzi
Published in: Frontiers in Medicine, Issue 10, 2023, ISSN 2296-858X
Publisher: Frontiers Media SA
DOI: 10.3389/fmed.2023.1271407

Precision medicine approaches for diabetic kidney disease: opportunities and challenges (opens in new window)

Author(s): Sok Cin Tye, Petra Denig, Hiddo J L Heerspink
Published in: Nephrology Dialysis Transplantation, Issue 36/Supplement_2, 2021, Page(s) 3-9, ISSN 0931-0509
Publisher: Oxford University Press
DOI: 10.1093/ndt/gfab045

Non adherence to antidiabetic cardiovascular drugs in type 2 diabetes mellitus and its association with renal and cardiovascular outcomes

Author(s): Sara Denicolo, Stefanie Thöni, Paul Perco, Gert Mayer
Published in: J Diabetes Complications, Issue Volume 35, 2021, ISSN 1056-8727
Publisher: Elsevier BV

Biological variation and reference change value of the estimated glomerular filtration rate in humans: A systematic review and meta-analysis (opens in new window)

Author(s): Stefanie Thöni, Felix Keller, Sara Denicolò, Lukas Buchwinkler, Gert Mayer
Published in: Frontiers in Medicine, Issue 9, 2022, ISSN 2296-858X
Publisher: Frontiers Media SA
DOI: 10.3389/fmed.2022.1009358

Combination Therapy of RAS Inhibition and SGLT2 Inhibitors Decreases Levels of Endotrophin in Persons with Type 2 Diabetes (opens in new window)

Author(s): Alexandra Louise Møller, Stefanie Thöni, Felix Keller, Samir Sharifli, Daniel Guldager Kring Rasmussen, Federica Genovese, Morten Asser Karsdal, Gert Mayer
Published in: Biomedicines, Issue 11, 2023, Page(s) 3084, ISSN 2227-9059
Publisher: MDPI
DOI: 10.3390/biomedicines11113084

Prognosis and Personalized In Silico Prediction of Treatment Efficacy in Cardiovascular and Chronic Kidney Disease: A Proof-of-Concept Study (opens in new window)

Author(s): Mayra Alejandra Jaimes Campos, Iván Andújar, Felix Keller, Gert Mayer, Peter Rossing, Jan A. Staessen, Christian Delles, Joachim Beige, Griet Glorieux, Andrew L. Clark, William Mullen, Joost P. Schanstra, Antonia Vlahou, Kasper Rossing, Karlheinz Peter, Alberto Ortiz, Archie Campbell, Frederik Persson, Agnieszka Latosinska, Harald Mischak, Justyna Siwy, Joachim Jankowski
Published in: Pharmaceuticals, Issue 16, 2023, Page(s) 1298, ISSN 1424-8247
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph16091298

International Variability of Renal and Cardiovascular Outcomes and Mortality in Patients with Type 2 Diabetes Mellitus in Europe (opens in new window)

Author(s): Stefanie Thöni, Felix Keller, Sara Denicolò, Susanne Eder, Lukas Buchwinkler, László Rosivall, Andrzej Wiecek, Patrick Barry Mark, Peter Rossing, Hiddo L. Heerspink, Gert Mayer
Published in: Kidney and Blood Pressure Research, Issue 48, 2024, Page(s) 165-174, ISSN 1420-4096
Publisher: S. Karger AG
DOI: 10.1159/000528438

Precision medicine in transplantation and hemodialysis (opens in new window)

Author(s): Rainer Oberbauer, Timothy W Meyer
Published in: Nephrology Dialysis Transplantation, Issue 36/Supplement_2, 2021, Page(s) 31-36, ISSN 0931-0509
Publisher: Oxford University Press
DOI: 10.1093/ndt/gfaa367

Dynamic lipid aptamers: non-polymeric chemical path to early life (opens in new window)

Author(s): Amit Kahana, Svetlana Maslov, Doron Lancet
Published in: Chemical Society Reviews, Issue 50, 2024, Page(s) 11741-11746, ISSN 0306-0012
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1cs00633a

Non-adherence to antidiabetic and cardiovascular drugs in type 2 diabetes mellitus and its association with renal and cardiovascular outcomes: A narrative review (opens in new window)

Author(s): Sara Denicolò, Paul Perco, Stefanie Thöni, Gert Mayer
Published in: Journal of Diabetes and its Complications, Issue 35, 2021, Page(s) 107931, ISSN 1056-8727
Publisher: Elsevier BV
DOI: 10.1016/j.jdiacomp.2021.107931

Clonal hematopoiesis of indeterminate potential and diabetic kidney disease: a nested case-control study (opens in new window)

Author(s): Sara Denicolò; Verena Vogi; Felix Keller; Stefanie Thöni; Susanne Eder; Hiddo J.L. Heerspink; László Rosivall; Andrzej Wiecek; Patrick B. Mark; Paul Perco; Johannes Leierer; Andreas Kronbichler; Marion Steger; Simon Schwendinger; Johannes Zschocke; Gert Mayer; Emina Jukic
Published in: Kidney International Reports, Issue 6, 2022, ISSN 2468-0249
Publisher: Elsevier BV
DOI: 10.1016/j.ekir.2022.01.1064

Exploring Heterogeneity with Category and Cluster Analyses for Mixed Data (opens in new window)

Author(s): Veronica Distefano, Maria Mannone, Irene Poli
Published in: Stats, Issue 6, 2023, Page(s) 747-762, ISSN 2571-905X
Publisher: MDPI
DOI: 10.3390/stats6030048

Randomized Trial of SGLT2 Inhibitor Identifies Target Proteins in Diabetic Kidney Disease (opens in new window)

Author(s): Tarunveer S. Ahluwalia, Teemu K.E. Rönkkö, Mie K. Eickhoff, Viktor Rotbain Curovic, Justyna Siwy, Susanne Eder, Sara Denicolò, Gert Mayer, Harald Mischak, Peter Rossing, Frederik Persson
Published in: Kidney International Reports, Issue 9, 2024, Page(s) 334-346, ISSN 2468-0249
Publisher: NPG
DOI: 10.1016/j.ekir.2023.11.020

Assessment of Fibrinogen-like 2 (FGL2) in Human Chronic Kidney Disease through Transcriptomics Data Analysis (opens in new window)

Author(s): Sara Denicolò, Viji Nair, Johannes Leierer, Michael Rudnicki, Matthias Kretzler, Gert Mayer, Wenjun Ju, Paul Perco
Published in: Biomolecules, Issue 13, 2025, Page(s) 89, ISSN 2218-273X
Publisher: MDPI
DOI: 10.3390/biom13010089

Learning Optimal Dynamic Treatment Regime from Observational Clinical Data through Reinforcement Learning (opens in new window)

Author(s): Seyum Abebe, Irene Poli, Roger D. Jones, Debora Slanzi
Published in: Machine Learning and Knowledge Extraction, Issue 6, 2024, Page(s) 1798-1817, ISSN 2504-4990
Publisher: MAKE
DOI: 10.3390/make6030088

Association of Urinary Epidermal Growth Factor, Fatty Acid-Binding Protein 3, and Vascular Cell Adhesion Molecule 1 Levels with the Progression of Early Diabetic Kidney Disease (opens in new window)

Author(s): Felix Keller, Sara Denicolò, Johannes Leierer, Maren Kruus, Andreas Heinzel, Michael Kammer, Wenjun Ju, Viji Nair, Frederic Burdet, Mark Ibberson, Rajasree Menon, Edgar Otto, Ye Ji Choi, Laura Pyle, Patricia Ladd, Petter M. Bjornstad, Susanne Eder, Laszlo Rosivall, Patrick Barry Mark, Andrzej Wiecek, Hiddo J. Lamber Heerspink, Matthias Kretzler, Rainer Oberbauer, Gert Mayer, Paul Perco
Published in: Kidney and Blood Pressure Research, Issue 49, 2024, Page(s) 1013-1025, ISSN 1420-4096
Publisher: S. Karger AG
DOI: 10.1159/000542267

Micellar Composition Affects Lipid Accretion Kinetics in Molecular Dynamics Simulations: Support for Lipid Network Reproduction (opens in new window)

Author(s): Amit Kahana, Doron Lancet, Zoltan Palmai
Published in: Life, Issue 12, 2024, Page(s) 955, ISSN 2075-1729
Publisher: MDPI
DOI: 10.3390/life12070955

Presence of retinopathy and incident kidney and cardiovascular events in type 2 diabetes with normoalbuminuria – A post-hoc analysis of the PRIORITY randomized clinical trial (opens in new window)

Author(s): Viktor Rotbain Curovic, Nete Tofte, Morten Lindhardt, Katarina Adamova, Stephan J.L. Bakker, Joachim Beige, Joline W.J. Beulens, Andreas L. Birkenfeld, Gemma Currie, Christian Delles, Ingo Dimos, Lidmila Francová, Marie Frimodt-Møller, Peter Girman, Rüdiger Göke, Tine W. Hansen, Tereza Havrdova, Adriaan Kooy, Gozewijnw D. Laverman, Harald Mischak, Gerjan Navis, Giel Nijpels, Marina Noutsou, Al
Published in: Journal of Diabetes and its Complications, Issue 37, 2024, Page(s) 108433, ISSN 1056-8727
Publisher: Elsevier BV
DOI: 10.1016/j.jdiacomp.2023.108433

Non-adherence to cardiometabolic medication as assessed by LC-MS/MS in urine and its association with kidney and cardiovascular outcomes in type 2 diabetes mellitus (opens in new window)

Author(s): Sara Denicolò, Vera Reinstadler, Felix Keller, Stefanie Thöni, Susanne Eder, Hiddo J. L. Heerspink, László Rosivall, Andrzej Wiecek, Patrick B. Mark, Paul Perco, Johannes Leierer, Andreas Kronbichler, Herbert Oberacher, Gert Mayer
Published in: Diabetologia, Issue 67, 2024, Page(s) 1283-1294, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-024-06149-w

Clinical Proteomics, Quo Vadis? (opens in new window)

Author(s): Harald Mischak, Joost P. Schanstra, Antonia Vlahou, Joachim Beige
Published in: PROTEOMICS, 2025, ISSN 1615-9853
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/pmic.202400346

Urinary peptide analysis to predict the response to blood pressure medication (opens in new window)

Author(s): Mayra Alejandra Jaimes Campos, Emmanouil Mavrogeorgis, Agnieszka Latosinska, Susanne Eder, Lukas Buchwinkler, Harald Mischak, Justyna Siwy, Peter Rossing, Gert Mayer, Joachim Jankowski
Published in: Nephrology Dialysis Transplantation, Issue 39, 2024, Page(s) 873-883, ISSN 0931-0509
Publisher: Oxford University Press
DOI: 10.1093/ndt/gfad223

Exploratory Study Analyzing the Urinary Peptidome of T2DM Patients Suggests Changes in ECM but Also Inflammatory and Metabolic Pathways Following GLP-1R Agonist Treatment (opens in new window)

Author(s): Sonnal Lohia, Justyna Siwy, Emmanouil Mavrogeorgis, Susanne Eder, Stefanie Thöni, Gert Mayer, Harald Mischak, Antonia Vlahou, Vera Jankowski
Published in: International Journal of Molecular Sciences, Issue 24, 2023, Page(s) 13540, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms241713540

A Proposed Mechanism for in vivo Programming Transmembrane Receptors (opens in new window)

Author(s): Roger D. Jones, Alan M. Jones
Published in: Communications in Computer and Information Science, Artificial Life and Evolutionary Computation, 2024, Page(s) 123-137
Publisher: Springer Nature Switzerland
DOI: 10.1007/978-3-031-57430-6_11

Clustering longitudinal data with category theory for diabetic kidney disease (opens in new window)

Author(s): Mannone, Maria Caterina; Distefano, Veronica; Silvestri, Claudio; Poli, Irene
Published in: CLADAG 2021 BOOK OF ABSTRACTS AND SHORT PAPERS, Issue 2021, 2021
Publisher: Firenze University Press
DOI: 10.36253/978-88-5518-340-6

Categories and clusters to investigate similarities in Diabetic Kidney Disease patients

Author(s): Distefano, Veronica; Mannone, Maria Caterina; Silvestri, Claudio; Poli, Irene
Published in: Book of short papers - SIS 2021, Issue 2021, 2021, ISBN 9788891927361
Publisher: Pearson

Clustering Trajectories to Study Diabetic Kidney Disease (opens in new window)

Author(s): Veronica Distefano, Maria Mannone, Irene Poli, Gert Mayer
Published in: Communications in Computer and Information Science, Artificial Life and Evolutionary Computation, 2024, Page(s) 271-283
Publisher: Springer Nature Switzerland
DOI: 10.1007/978-3-031-57430-6_21

Exploiting the Potential of Bayesian Networks in Deriving New Insight into Diabetic Kidney Disease (DKD) (opens in new window)

Author(s): Debora Slanzi, Claudio Silvestri, Irene Poli, Gert Mayer
Published in: Communications in Computer and Information Science, Artificial Life and Evolutionary Computation, 2024, Page(s) 298-308
Publisher: Springer Nature Switzerland
DOI: 10.1007/978-3-031-57430-6_23

Failure of biomarkers to personalize clinical practice in diabetic kidney disease. Are we asking the right questions ?

Author(s): Sara Denicolò, Felix Keller, Stefanie Thöni, Gert Mayer und Bernd Mayer* Department of Internal Medicine IV (Nephrology and Hypertension), Medical University Innsbruck *emergentec biodevelopment GmbH, Vienna
Published in: Nephro-News, Issue 02/2020, 2020, Page(s) 17-21, ISSN 1682-6817
Publisher: Klinik für Innere Medizin III, Abteilung für Nephrologie, Währinger Gürtel 18-20, A-1090 Wien

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