Drug combinations for rewriting trajectories of renal pathologies in type II diabetes (DC-ren)

Información del proyecto

DC-ren

Identificador del acuerdo de subvención: 848011

DOI

10.3030/848011

Proyecto cerrado

Fecha de la firma de la CE 13 Diciembre 2019

Fecha de inicio 1 Enero 2020

Fecha de finalización 31 Diciembre 2024

Financiado con arreglo a

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coste total

€ 5 968 480,00

Aportación de la UE

€ 5 968 480,00

Coordinado por

MEDIZINISCHE UNIVERSITAT INNSBRUCK
Austria

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (6)

Outreach framework

Provide evidence for the generalizability of DC-ren framework beyond DKD drug R&D

IP/data management overall report

IP/data: Setup and maintanance of a database holding information on relevant patent applications in the context of DKDSetup and maintanance of a database holding information on drug development in DKDExploitation of opportunities within DC-ren

Clinical study results

The observable matrix of the subjects selected for the clinical study is completed. Evidence is provided if decisions made by the DC-ren toolbox assistance are better that ones made according to standard guidelines.

Outreach, applications

Provide evidence for utility of the DC-ren toolobox approach in the clinical and R&D environment beyond the drugs of primary interest in DC-ren.

Dissemination/public outreach overall report

Summary report on all dissemination/public outreach activities

Clinical study protocol

The study protocol for the simulated trial within CANVAS and PRIORITY including sample size specificiations and power calculation, SOPs for sample selection and experimental testing, toolbox decision procedure and statistical analysis is available.

Publicaciones

Peer reviewed articles (22)

Candidate composite biomarker to inform drug treatments for diabetic kidney disease

Autores: Roger D. Jones, Seyum Abebe, Veronica Distefano, Gert Mayer, Irene Poli, Claudio Silvestri, Debora Slanzi
Publicado en: Frontiers in Medicine, Edición 10, 2023, ISSN 2296-858X
Editor: Frontiers Media SA
DOI: 10.3389/fmed.2023.1271407

Precision medicine approaches for diabetic kidney disease: opportunities and challenges

Autores: Sok Cin Tye, Petra Denig, Hiddo J L Heerspink
Publicado en: Nephrology Dialysis Transplantation, Edición 36/Supplement_2, 2021, Página(s) 3-9, ISSN 0931-0509
Editor: Oxford University Press
DOI: 10.1093/ndt/gfab045

Non adherence to antidiabetic cardiovascular drugs in type 2 diabetes mellitus and its association with renal and cardiovascular outcomes

Autores: Sara Denicolo, Stefanie Thöni, Paul Perco, Gert Mayer
Publicado en: J Diabetes Complications, Edición Volume 35, 2021, ISSN 1056-8727
Editor: Elsevier BV

Biological variation and reference change value of the estimated glomerular filtration rate in humans: A systematic review and meta-analysis

Autores: Stefanie Thöni, Felix Keller, Sara Denicolò, Lukas Buchwinkler, Gert Mayer
Publicado en: Frontiers in Medicine, Edición 9, 2022, ISSN 2296-858X
Editor: Frontiers Media SA
DOI: 10.3389/fmed.2022.1009358

Combination Therapy of RAS Inhibition and SGLT2 Inhibitors Decreases Levels of Endotrophin in Persons with Type 2 Diabetes

Autores: Alexandra Louise Møller, Stefanie Thöni, Felix Keller, Samir Sharifli, Daniel Guldager Kring Rasmussen, Federica Genovese, Morten Asser Karsdal, Gert Mayer
Publicado en: Biomedicines, Edición 11, 2023, Página(s) 3084, ISSN 2227-9059
Editor: MDPI
DOI: 10.3390/biomedicines11113084

Prognosis and Personalized In Silico Prediction of Treatment Efficacy in Cardiovascular and Chronic Kidney Disease: A Proof-of-Concept Study

Autores: Mayra Alejandra Jaimes Campos, Iván Andújar, Felix Keller, Gert Mayer, Peter Rossing, Jan A. Staessen, Christian Delles, Joachim Beige, Griet Glorieux, Andrew L. Clark, William Mullen, Joost P. Schanstra, Antonia Vlahou, Kasper Rossing, Karlheinz Peter, Alberto Ortiz, Archie Campbell, Frederik Persson, Agnieszka Latosinska, Harald Mischak, Justyna Siwy, Joachim Jankowski
Publicado en: Pharmaceuticals, Edición 16, 2023, Página(s) 1298, ISSN 1424-8247
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph16091298

International Variability of Renal and Cardiovascular Outcomes and Mortality in Patients with Type 2 Diabetes Mellitus in Europe

Autores: Stefanie Thöni, Felix Keller, Sara Denicolò, Susanne Eder, Lukas Buchwinkler, László Rosivall, Andrzej Wiecek, Patrick Barry Mark, Peter Rossing, Hiddo L. Heerspink, Gert Mayer
Publicado en: Kidney and Blood Pressure Research, Edición 48, 2024, Página(s) 165-174, ISSN 1420-4096
Editor: S. Karger AG
DOI: 10.1159/000528438

Precision medicine in transplantation and hemodialysis

Autores: Rainer Oberbauer, Timothy W Meyer
Publicado en: Nephrology Dialysis Transplantation, Edición 36/Supplement_2, 2021, Página(s) 31-36, ISSN 0931-0509
Editor: Oxford University Press
DOI: 10.1093/ndt/gfaa367

Dynamic lipid aptamers: non-polymeric chemical path to early life

Autores: Amit Kahana, Svetlana Maslov, Doron Lancet
Publicado en: Chemical Society Reviews, Edición 50, 2024, Página(s) 11741-11746, ISSN 0306-0012
Editor: Royal Society of Chemistry
DOI: 10.1039/d1cs00633a

Non-adherence to antidiabetic and cardiovascular drugs in type 2 diabetes mellitus and its association with renal and cardiovascular outcomes: A narrative review

Autores: Sara Denicolò, Paul Perco, Stefanie Thöni, Gert Mayer
Publicado en: Journal of Diabetes and its Complications, Edición 35, 2021, Página(s) 107931, ISSN 1056-8727
Editor: Elsevier BV
DOI: 10.1016/j.jdiacomp.2021.107931

Clonal hematopoiesis of indeterminate potential and diabetic kidney disease: a nested case-control study

Autores: Sara Denicolò; Verena Vogi; Felix Keller; Stefanie Thöni; Susanne Eder; Hiddo J.L. Heerspink; László Rosivall; Andrzej Wiecek; Patrick B. Mark; Paul Perco; Johannes Leierer; Andreas Kronbichler; Marion Steger; Simon Schwendinger; Johannes Zschocke; Gert Mayer; Emina Jukic
Publicado en: Kidney International Reports, Edición 6, 2022, ISSN 2468-0249
Editor: Elsevier BV
DOI: 10.1016/j.ekir.2022.01.1064

Exploring Heterogeneity with Category and Cluster Analyses for Mixed Data

Autores: Veronica Distefano, Maria Mannone, Irene Poli
Publicado en: Stats, Edición 6, 2023, Página(s) 747-762, ISSN 2571-905X
Editor: MDPI
DOI: 10.3390/stats6030048

Randomized Trial of SGLT2 Inhibitor Identifies Target Proteins in Diabetic Kidney Disease

Autores: Tarunveer S. Ahluwalia, Teemu K.E. Rönkkö, Mie K. Eickhoff, Viktor Rotbain Curovic, Justyna Siwy, Susanne Eder, Sara Denicolò, Gert Mayer, Harald Mischak, Peter Rossing, Frederik Persson
Publicado en: Kidney International Reports, Edición 9, 2024, Página(s) 334-346, ISSN 2468-0249
Editor: NPG
DOI: 10.1016/j.ekir.2023.11.020

Assessment of Fibrinogen-like 2 (FGL2) in Human Chronic Kidney Disease through Transcriptomics Data Analysis

Autores: Sara Denicolò, Viji Nair, Johannes Leierer, Michael Rudnicki, Matthias Kretzler, Gert Mayer, Wenjun Ju, Paul Perco
Publicado en: Biomolecules, Edición 13, 2025, Página(s) 89, ISSN 2218-273X
Editor: MDPI
DOI: 10.3390/biom13010089

Learning Optimal Dynamic Treatment Regime from Observational Clinical Data through Reinforcement Learning

Autores: Seyum Abebe, Irene Poli, Roger D. Jones, Debora Slanzi
Publicado en: Machine Learning and Knowledge Extraction, Edición 6, 2024, Página(s) 1798-1817, ISSN 2504-4990
Editor: MAKE
DOI: 10.3390/make6030088

Association of Urinary Epidermal Growth Factor, Fatty Acid-Binding Protein 3, and Vascular Cell Adhesion Molecule 1 Levels with the Progression of Early Diabetic Kidney Disease

Autores: Felix Keller, Sara Denicolò, Johannes Leierer, Maren Kruus, Andreas Heinzel, Michael Kammer, Wenjun Ju, Viji Nair, Frederic Burdet, Mark Ibberson, Rajasree Menon, Edgar Otto, Ye Ji Choi, Laura Pyle, Patricia Ladd, Petter M. Bjornstad, Susanne Eder, Laszlo Rosivall, Patrick Barry Mark, Andrzej Wiecek, Hiddo J. Lamber Heerspink, Matthias Kretzler, Rainer Oberbauer, Gert Mayer, Paul Perco
Publicado en: Kidney and Blood Pressure Research, Edición 49, 2024, Página(s) 1013-1025, ISSN 1420-4096
Editor: S. Karger AG
DOI: 10.1159/000542267

Micellar Composition Affects Lipid Accretion Kinetics in Molecular Dynamics Simulations: Support for Lipid Network Reproduction

Autores: Amit Kahana, Doron Lancet, Zoltan Palmai
Publicado en: Life, Edición 12, 2024, Página(s) 955, ISSN 2075-1729
Editor: MDPI
DOI: 10.3390/life12070955

Presence of retinopathy and incident kidney and cardiovascular events in type 2 diabetes with normoalbuminuria – A post-hoc analysis of the PRIORITY randomized clinical trial

Autores: Viktor Rotbain Curovic, Nete Tofte, Morten Lindhardt, Katarina Adamova, Stephan J.L. Bakker, Joachim Beige, Joline W.J. Beulens, Andreas L. Birkenfeld, Gemma Currie, Christian Delles, Ingo Dimos, Lidmila Francová, Marie Frimodt-Møller, Peter Girman, Rüdiger Göke, Tine W. Hansen, Tereza Havrdova, Adriaan Kooy, Gozewijnw D. Laverman, Harald Mischak, Gerjan Navis, Giel Nijpels, Marina Noutsou, Al
Publicado en: Journal of Diabetes and its Complications, Edición 37, 2024, Página(s) 108433, ISSN 1056-8727
Editor: Elsevier BV
DOI: 10.1016/j.jdiacomp.2023.108433

Non-adherence to cardiometabolic medication as assessed by LC-MS/MS in urine and its association with kidney and cardiovascular outcomes in type 2 diabetes mellitus

Autores: Sara Denicolò, Vera Reinstadler, Felix Keller, Stefanie Thöni, Susanne Eder, Hiddo J. L. Heerspink, László Rosivall, Andrzej Wiecek, Patrick B. Mark, Paul Perco, Johannes Leierer, Andreas Kronbichler, Herbert Oberacher, Gert Mayer
Publicado en: Diabetologia, Edición 67, 2024, Página(s) 1283-1294, ISSN 0012-186X
Editor: Springer Verlag
DOI: 10.1007/s00125-024-06149-w

Clinical Proteomics, Quo Vadis?

Autores: Harald Mischak, Joost P. Schanstra, Antonia Vlahou, Joachim Beige
Publicado en: PROTEOMICS, 2025, ISSN 1615-9853
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/pmic.202400346

Urinary peptide analysis to predict the response to blood pressure medication

Autores: Mayra Alejandra Jaimes Campos, Emmanouil Mavrogeorgis, Agnieszka Latosinska, Susanne Eder, Lukas Buchwinkler, Harald Mischak, Justyna Siwy, Peter Rossing, Gert Mayer, Joachim Jankowski
Publicado en: Nephrology Dialysis Transplantation, Edición 39, 2024, Página(s) 873-883, ISSN 0931-0509
Editor: Oxford University Press
DOI: 10.1093/ndt/gfad223

Exploratory Study Analyzing the Urinary Peptidome of T2DM Patients Suggests Changes in ECM but Also Inflammatory and Metabolic Pathways Following GLP-1R Agonist Treatment

Autores: Sonnal Lohia, Justyna Siwy, Emmanouil Mavrogeorgis, Susanne Eder, Stefanie Thöni, Gert Mayer, Harald Mischak, Antonia Vlahou, Vera Jankowski
Publicado en: International Journal of Molecular Sciences, Edición 24, 2023, Página(s) 13540, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms241713540

Conference proceedings (3)

A Proposed Mechanism for in vivo Programming Transmembrane Receptors

Autores: Roger D. Jones, Alan M. Jones
Publicado en: Communications in Computer and Information Science, Artificial Life and Evolutionary Computation, 2024, Página(s) 123-137
Editor: Springer Nature Switzerland
DOI: 10.1007/978-3-031-57430-6_11

Clustering longitudinal data with category theory for diabetic kidney disease

Autores: Mannone, Maria Caterina; Distefano, Veronica; Silvestri, Claudio; Poli, Irene
Publicado en: CLADAG 2021 BOOK OF ABSTRACTS AND SHORT PAPERS, Edición 2021, 2021
Editor: Firenze University Press
DOI: 10.36253/978-88-5518-340-6

Categories and clusters to investigate similarities in Diabetic Kidney Disease patients

Autores: Distefano, Veronica; Mannone, Maria Caterina; Silvestri, Claudio; Poli, Irene
Publicado en: Book of short papers - SIS 2021, Edición 2021, 2021, ISBN 9788891927361
Editor: Pearson

Book chapters (2)

Clustering Trajectories to Study Diabetic Kidney Disease

Autores: Veronica Distefano, Maria Mannone, Irene Poli, Gert Mayer
Publicado en: Communications in Computer and Information Science, Artificial Life and Evolutionary Computation, 2024, Página(s) 271-283
Editor: Springer Nature Switzerland
DOI: 10.1007/978-3-031-57430-6_21

Exploiting the Potential of Bayesian Networks in Deriving New Insight into Diabetic Kidney Disease (DKD)

Autores: Debora Slanzi, Claudio Silvestri, Irene Poli, Gert Mayer
Publicado en: Communications in Computer and Information Science, Artificial Life and Evolutionary Computation, 2024, Página(s) 298-308
Editor: Springer Nature Switzerland
DOI: 10.1007/978-3-031-57430-6_23

Non-peer reviewed articles (1)

Failure of biomarkers to personalize clinical practice in diabetic kidney disease. Are we asking the right questions ?

Autores: Sara Denicolò, Felix Keller, Stefanie Thöni, Gert Mayer und Bernd Mayer* Department of Internal Medicine IV (Nephrology and Hypertension), Medical University Innsbruck *emergentec biodevelopment GmbH, Vienna
Publicado en: Nephro-News, Edición 02/2020, 2020, Página(s) 17-21, ISSN 1682-6817
Editor: Klinik für Innere Medizin III, Abteilung für Nephrologie, Währinger Gürtel 18-20, A-1090 Wien