Drug combinations for rewriting trajectories of renal pathologies in type II diabetes (DC-ren)

Informations projet

DC-ren

N° de convention de subvention: 848011

DOI

10.3030/848011

Projet clôturé

Date de signature de la CE 13 Decembre 2019

Date de début 1 Janvier 2020

Date de fin 31 Decembre 2024

Financé au titre de

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coût total

€ 5 968 480,00

Contribution de l’UE

€ 5 968 480,00

Coordonné par

MEDIZINISCHE UNIVERSITAT INNSBRUCK
Austria

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (6)

Outreach framework

Provide evidence for the generalizability of DC-ren framework beyond DKD drug R&D

IP/data management overall report

IP/data: Setup and maintanance of a database holding information on relevant patent applications in the context of DKDSetup and maintanance of a database holding information on drug development in DKDExploitation of opportunities within DC-ren

Clinical study results

The observable matrix of the subjects selected for the clinical study is completed. Evidence is provided if decisions made by the DC-ren toolbox assistance are better that ones made according to standard guidelines.

Outreach, applications

Provide evidence for utility of the DC-ren toolobox approach in the clinical and R&D environment beyond the drugs of primary interest in DC-ren.

Dissemination/public outreach overall report

Summary report on all dissemination/public outreach activities

Clinical study protocol

The study protocol for the simulated trial within CANVAS and PRIORITY including sample size specificiations and power calculation, SOPs for sample selection and experimental testing, toolbox decision procedure and statistical analysis is available.

Publications

Peer reviewed articles (22)

Candidate composite biomarker to inform drug treatments for diabetic kidney disease

Auteurs: Roger D. Jones, Seyum Abebe, Veronica Distefano, Gert Mayer, Irene Poli, Claudio Silvestri, Debora Slanzi
Publié dans: Frontiers in Medicine, Numéro 10, 2023, ISSN 2296-858X
Éditeur: Frontiers Media SA
DOI: 10.3389/fmed.2023.1271407

Precision medicine approaches for diabetic kidney disease: opportunities and challenges

Auteurs: Sok Cin Tye, Petra Denig, Hiddo J L Heerspink
Publié dans: Nephrology Dialysis Transplantation, Numéro 36/Supplement_2, 2021, Page(s) 3-9, ISSN 0931-0509
Éditeur: Oxford University Press
DOI: 10.1093/ndt/gfab045

Non adherence to antidiabetic cardiovascular drugs in type 2 diabetes mellitus and its association with renal and cardiovascular outcomes

Auteurs: Sara Denicolo, Stefanie Thöni, Paul Perco, Gert Mayer
Publié dans: J Diabetes Complications, Numéro Volume 35, 2021, ISSN 1056-8727
Éditeur: Elsevier BV

Biological variation and reference change value of the estimated glomerular filtration rate in humans: A systematic review and meta-analysis

Auteurs: Stefanie Thöni, Felix Keller, Sara Denicolò, Lukas Buchwinkler, Gert Mayer
Publié dans: Frontiers in Medicine, Numéro 9, 2022, ISSN 2296-858X
Éditeur: Frontiers Media SA
DOI: 10.3389/fmed.2022.1009358

Combination Therapy of RAS Inhibition and SGLT2 Inhibitors Decreases Levels of Endotrophin in Persons with Type 2 Diabetes

Auteurs: Alexandra Louise Møller, Stefanie Thöni, Felix Keller, Samir Sharifli, Daniel Guldager Kring Rasmussen, Federica Genovese, Morten Asser Karsdal, Gert Mayer
Publié dans: Biomedicines, Numéro 11, 2023, Page(s) 3084, ISSN 2227-9059
Éditeur: MDPI
DOI: 10.3390/biomedicines11113084

Prognosis and Personalized In Silico Prediction of Treatment Efficacy in Cardiovascular and Chronic Kidney Disease: A Proof-of-Concept Study

Auteurs: Mayra Alejandra Jaimes Campos, Iván Andújar, Felix Keller, Gert Mayer, Peter Rossing, Jan A. Staessen, Christian Delles, Joachim Beige, Griet Glorieux, Andrew L. Clark, William Mullen, Joost P. Schanstra, Antonia Vlahou, Kasper Rossing, Karlheinz Peter, Alberto Ortiz, Archie Campbell, Frederik Persson, Agnieszka Latosinska, Harald Mischak, Justyna Siwy, Joachim Jankowski
Publié dans: Pharmaceuticals, Numéro 16, 2023, Page(s) 1298, ISSN 1424-8247
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph16091298

International Variability of Renal and Cardiovascular Outcomes and Mortality in Patients with Type 2 Diabetes Mellitus in Europe

Auteurs: Stefanie Thöni, Felix Keller, Sara Denicolò, Susanne Eder, Lukas Buchwinkler, László Rosivall, Andrzej Wiecek, Patrick Barry Mark, Peter Rossing, Hiddo L. Heerspink, Gert Mayer
Publié dans: Kidney and Blood Pressure Research, Numéro 48, 2024, Page(s) 165-174, ISSN 1420-4096
Éditeur: S. Karger AG
DOI: 10.1159/000528438

Precision medicine in transplantation and hemodialysis

Auteurs: Rainer Oberbauer, Timothy W Meyer
Publié dans: Nephrology Dialysis Transplantation, Numéro 36/Supplement_2, 2021, Page(s) 31-36, ISSN 0931-0509
Éditeur: Oxford University Press
DOI: 10.1093/ndt/gfaa367

Dynamic lipid aptamers: non-polymeric chemical path to early life

Auteurs: Amit Kahana, Svetlana Maslov, Doron Lancet
Publié dans: Chemical Society Reviews, Numéro 50, 2024, Page(s) 11741-11746, ISSN 0306-0012
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d1cs00633a

Non-adherence to antidiabetic and cardiovascular drugs in type 2 diabetes mellitus and its association with renal and cardiovascular outcomes: A narrative review

Auteurs: Sara Denicolò, Paul Perco, Stefanie Thöni, Gert Mayer
Publié dans: Journal of Diabetes and its Complications, Numéro 35, 2021, Page(s) 107931, ISSN 1056-8727
Éditeur: Elsevier BV
DOI: 10.1016/j.jdiacomp.2021.107931

Clonal hematopoiesis of indeterminate potential and diabetic kidney disease: a nested case-control study

Auteurs: Sara Denicolò; Verena Vogi; Felix Keller; Stefanie Thöni; Susanne Eder; Hiddo J.L. Heerspink; László Rosivall; Andrzej Wiecek; Patrick B. Mark; Paul Perco; Johannes Leierer; Andreas Kronbichler; Marion Steger; Simon Schwendinger; Johannes Zschocke; Gert Mayer; Emina Jukic
Publié dans: Kidney International Reports, Numéro 6, 2022, ISSN 2468-0249
Éditeur: Elsevier BV
DOI: 10.1016/j.ekir.2022.01.1064

Exploring Heterogeneity with Category and Cluster Analyses for Mixed Data

Auteurs: Veronica Distefano, Maria Mannone, Irene Poli
Publié dans: Stats, Numéro 6, 2023, Page(s) 747-762, ISSN 2571-905X
Éditeur: MDPI
DOI: 10.3390/stats6030048

Randomized Trial of SGLT2 Inhibitor Identifies Target Proteins in Diabetic Kidney Disease

Auteurs: Tarunveer S. Ahluwalia, Teemu K.E. Rönkkö, Mie K. Eickhoff, Viktor Rotbain Curovic, Justyna Siwy, Susanne Eder, Sara Denicolò, Gert Mayer, Harald Mischak, Peter Rossing, Frederik Persson
Publié dans: Kidney International Reports, Numéro 9, 2024, Page(s) 334-346, ISSN 2468-0249
Éditeur: NPG
DOI: 10.1016/j.ekir.2023.11.020

Assessment of Fibrinogen-like 2 (FGL2) in Human Chronic Kidney Disease through Transcriptomics Data Analysis

Auteurs: Sara Denicolò, Viji Nair, Johannes Leierer, Michael Rudnicki, Matthias Kretzler, Gert Mayer, Wenjun Ju, Paul Perco
Publié dans: Biomolecules, Numéro 13, 2025, Page(s) 89, ISSN 2218-273X
Éditeur: MDPI
DOI: 10.3390/biom13010089

Learning Optimal Dynamic Treatment Regime from Observational Clinical Data through Reinforcement Learning

Auteurs: Seyum Abebe, Irene Poli, Roger D. Jones, Debora Slanzi
Publié dans: Machine Learning and Knowledge Extraction, Numéro 6, 2024, Page(s) 1798-1817, ISSN 2504-4990
Éditeur: MAKE
DOI: 10.3390/make6030088

Association of Urinary Epidermal Growth Factor, Fatty Acid-Binding Protein 3, and Vascular Cell Adhesion Molecule 1 Levels with the Progression of Early Diabetic Kidney Disease

Auteurs: Felix Keller, Sara Denicolò, Johannes Leierer, Maren Kruus, Andreas Heinzel, Michael Kammer, Wenjun Ju, Viji Nair, Frederic Burdet, Mark Ibberson, Rajasree Menon, Edgar Otto, Ye Ji Choi, Laura Pyle, Patricia Ladd, Petter M. Bjornstad, Susanne Eder, Laszlo Rosivall, Patrick Barry Mark, Andrzej Wiecek, Hiddo J. Lamber Heerspink, Matthias Kretzler, Rainer Oberbauer, Gert Mayer, Paul Perco
Publié dans: Kidney and Blood Pressure Research, Numéro 49, 2024, Page(s) 1013-1025, ISSN 1420-4096
Éditeur: S. Karger AG
DOI: 10.1159/000542267

Micellar Composition Affects Lipid Accretion Kinetics in Molecular Dynamics Simulations: Support for Lipid Network Reproduction

Auteurs: Amit Kahana, Doron Lancet, Zoltan Palmai
Publié dans: Life, Numéro 12, 2024, Page(s) 955, ISSN 2075-1729
Éditeur: MDPI
DOI: 10.3390/life12070955

Presence of retinopathy and incident kidney and cardiovascular events in type 2 diabetes with normoalbuminuria – A post-hoc analysis of the PRIORITY randomized clinical trial

Auteurs: Viktor Rotbain Curovic, Nete Tofte, Morten Lindhardt, Katarina Adamova, Stephan J.L. Bakker, Joachim Beige, Joline W.J. Beulens, Andreas L. Birkenfeld, Gemma Currie, Christian Delles, Ingo Dimos, Lidmila Francová, Marie Frimodt-Møller, Peter Girman, Rüdiger Göke, Tine W. Hansen, Tereza Havrdova, Adriaan Kooy, Gozewijnw D. Laverman, Harald Mischak, Gerjan Navis, Giel Nijpels, Marina Noutsou, Al
Publié dans: Journal of Diabetes and its Complications, Numéro 37, 2024, Page(s) 108433, ISSN 1056-8727
Éditeur: Elsevier BV
DOI: 10.1016/j.jdiacomp.2023.108433

Non-adherence to cardiometabolic medication as assessed by LC-MS/MS in urine and its association with kidney and cardiovascular outcomes in type 2 diabetes mellitus

Auteurs: Sara Denicolò, Vera Reinstadler, Felix Keller, Stefanie Thöni, Susanne Eder, Hiddo J. L. Heerspink, László Rosivall, Andrzej Wiecek, Patrick B. Mark, Paul Perco, Johannes Leierer, Andreas Kronbichler, Herbert Oberacher, Gert Mayer
Publié dans: Diabetologia, Numéro 67, 2024, Page(s) 1283-1294, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-024-06149-w

Clinical Proteomics, Quo Vadis?

Auteurs: Harald Mischak, Joost P. Schanstra, Antonia Vlahou, Joachim Beige
Publié dans: PROTEOMICS, 2025, ISSN 1615-9853
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/pmic.202400346

Urinary peptide analysis to predict the response to blood pressure medication

Auteurs: Mayra Alejandra Jaimes Campos, Emmanouil Mavrogeorgis, Agnieszka Latosinska, Susanne Eder, Lukas Buchwinkler, Harald Mischak, Justyna Siwy, Peter Rossing, Gert Mayer, Joachim Jankowski
Publié dans: Nephrology Dialysis Transplantation, Numéro 39, 2024, Page(s) 873-883, ISSN 0931-0509
Éditeur: Oxford University Press
DOI: 10.1093/ndt/gfad223

Exploratory Study Analyzing the Urinary Peptidome of T2DM Patients Suggests Changes in ECM but Also Inflammatory and Metabolic Pathways Following GLP-1R Agonist Treatment

Auteurs: Sonnal Lohia, Justyna Siwy, Emmanouil Mavrogeorgis, Susanne Eder, Stefanie Thöni, Gert Mayer, Harald Mischak, Antonia Vlahou, Vera Jankowski
Publié dans: International Journal of Molecular Sciences, Numéro 24, 2023, Page(s) 13540, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms241713540

Conference proceedings (3)

A Proposed Mechanism for in vivo Programming Transmembrane Receptors

Auteurs: Roger D. Jones, Alan M. Jones
Publié dans: Communications in Computer and Information Science, Artificial Life and Evolutionary Computation, 2024, Page(s) 123-137
Éditeur: Springer Nature Switzerland
DOI: 10.1007/978-3-031-57430-6_11

Clustering longitudinal data with category theory for diabetic kidney disease

Auteurs: Mannone, Maria Caterina; Distefano, Veronica; Silvestri, Claudio; Poli, Irene
Publié dans: CLADAG 2021 BOOK OF ABSTRACTS AND SHORT PAPERS, Numéro 2021, 2021
Éditeur: Firenze University Press
DOI: 10.36253/978-88-5518-340-6

Categories and clusters to investigate similarities in Diabetic Kidney Disease patients

Auteurs: Distefano, Veronica; Mannone, Maria Caterina; Silvestri, Claudio; Poli, Irene
Publié dans: Book of short papers - SIS 2021, Numéro 2021, 2021, ISBN 9788891927361
Éditeur: Pearson

Book chapters (2)

Clustering Trajectories to Study Diabetic Kidney Disease

Auteurs: Veronica Distefano, Maria Mannone, Irene Poli, Gert Mayer
Publié dans: Communications in Computer and Information Science, Artificial Life and Evolutionary Computation, 2024, Page(s) 271-283
Éditeur: Springer Nature Switzerland
DOI: 10.1007/978-3-031-57430-6_21

Exploiting the Potential of Bayesian Networks in Deriving New Insight into Diabetic Kidney Disease (DKD)

Auteurs: Debora Slanzi, Claudio Silvestri, Irene Poli, Gert Mayer
Publié dans: Communications in Computer and Information Science, Artificial Life and Evolutionary Computation, 2024, Page(s) 298-308
Éditeur: Springer Nature Switzerland
DOI: 10.1007/978-3-031-57430-6_23

Non-peer reviewed articles (1)

Failure of biomarkers to personalize clinical practice in diabetic kidney disease. Are we asking the right questions ?

Auteurs: Sara Denicolò, Felix Keller, Stefanie Thöni, Gert Mayer und Bernd Mayer* Department of Internal Medicine IV (Nephrology and Hypertension), Medical University Innsbruck *emergentec biodevelopment GmbH, Vienna
Publié dans: Nephro-News, Numéro 02/2020, 2020, Page(s) 17-21, ISSN 1682-6817
Éditeur: Klinik für Innere Medizin III, Abteilung für Nephrologie, Währinger Gürtel 18-20, A-1090 Wien