DECISION ON OPTIMAL COMBINATORIAL THERAPIES IN IMIDS USING SYSTEMS APPROACHES

Project Information

DocTIS

Grant agreement ID: 848028

DOI

10.3030/848028

EC signature date 6 December 2019

Start date 1 January 2020

End date 30 June 2026

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost

€ 6 260 050,00

EU contribution

€ 6 260 050,00

Coordinated by

FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Other (1)

Communication plan

This document will describe in detail the project communication strategy in all of its components: objectives, audiences, actions and tools.

Websites, patent fillings, videos etc. (1)

Creation of the project website

Website set up and launch

Publications

Thesis and dissertations (2)

Towards a large-scale human inflammation atlas at single-cell resolution

Author(s): Laura Jiménez Gracia
Published in: 2024
Publisher: University of Barcelona

Construction and utilization of digital twins for personalized therapeutic predictions

Author(s): Samuel Schäfer
Published in: Linköping University Medical Dissertations, 2024
Publisher: Linköping University Electronic Press
DOI: 10.3384/9789180757089

Peer reviewed articles (23)

A dynamic single cell-based framework for digital twins to prioritize disease genes and drug targets

Author(s): Xinxiu Li; Eun Jung Lee; Sandra Lilja; Joseph Loscalzo; Samuel Schäfer; Martin Smelik; Maria Regina Strobl; Oleg Sysoev; Hui Wang; Huan Zhang; Yelin Zhao; Danuta R. Gawel; Barbara Bohle; Mikael Benson
Published in: Genome Medicine, Issue 1, 2022, ISSN 1756-994X
Publisher: BioMed Central
DOI: 10.1186/s13073-022-01048-4

Biological disease-modifying antirheumatic drugs may mitigate the risk of psoriatic arthritis in patients with chronic plaque psoriasis

Author(s): Paolo Gisondi, Francesco Bellinato, Giovanni Targher, Luca Idolazzi, Giampiero Girolomoni
Published in: Annals of the Rheumatic Diseases, Issue 81, 2025, Page(s) 68-73, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2021-219961

A Transcriptional Map of Human Tonsil Architecture: Beyond the Sum of (Single Cell) Parts

Author(s): Helena L. Crowell, Laura Llaó‐Cid, Gerard Frigola, Samuel Gunz, Irene Ruano, Patricia Lorden, Max Ruiz, Marta Kulis, José Ignacio Martin‐Subero, Holger Heyn, Elias Campo, Anna Pascual‐Reguant
Published in: European Journal of Immunology, Issue 56, 2026, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.70121

STAMP: Single-cell transcriptomics analysis and multimodal profiling through imaging

Author(s): Emanuele Pitino, Anna Pascual-Reguant, Felipe Segato-Dezem, Kellie Wise, Irepan Salvador-Martinez, Helena Lucia Crowell, Maycon Marção, Max Ruiz, Elise Courtois, William F. Flynn, Santhosh Sivajothi, Emily Soja, Ginevra Caratù, German Atzin Mora-Roldan, B. Kate Dredge, Yutian Liu, Hannah Chasteen, Monika Mohenska, Juan C. Nieto, Raymond K.H. Yip, Ruvimbo D. Mishi, José M. Polo, Mohmed Abdalftt
Published in: Cell, Issue 188, 2026, Page(s) 5100-5117.e26, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2025.05.027

Managing the Patient with Psoriasis and Metabolic Comorbidities

Author(s): Francesco Bellinato, Martina Maurelli, Davide Geat, Giampiero Girolomoni, Paolo Gisondi
Published in: American Journal of Clinical Dermatology, Issue 25, 2024, Page(s) 527-540, ISSN 1175-0561
Publisher: Adis International Ltd.
DOI: 10.1007/s40257-024-00857-0

Mechanistic and therapeutic advances in immune-mediated gastrointestinal disorders

Author(s): Nahir Garabatos, Edgar Angelats, Pere Santamaria
Published in: Journal of Allergy and Clinical Immunology, Issue 156, 2025, Page(s) 1133-1159, ISSN 0091-6749
Publisher: Mosby Inc.
DOI: 10.1016/j.jaci.2025.07.024

Targeting of the CD80/86 proinflammatory axis as a therapeutic strategy to prevent severe COVID-19.

Author(s): Antonio Julià; Irene Bonafonte-Pardàs; Antonio Gomez; María López-Lasanta; Mireia López-Corbeto; Sergio H Martínez-Mateu; Jordi Lladós; Iván Rodríguez-Núñez; Richard M. Myers; S. Marsal
Published in: Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021), Issue 1, 2021, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-90797-0

Characteristics of Patients Experiencing a Flare of Generalized Pustular Psoriasis: A Multicenter Observational Study

Author(s): Francesco Bellinato, Paolo Gisondi, Angelo Marzano, Stefano Piaserico, Clara De Simone, Giovanni Damiani, Giuseppe Argenziano, Marina Venturini, Paolo Dapavo, Antonio Costanzo, Matteo Megna, Francesca Prignano, Martina Burlando, Francesca Satolli, Andrea Carugno, Elena Pezzolo, Marco Romanelli, Aldo Cuccia, Giampiero Girolomoni
Published in: Vaccines, Issue 11, 2023, Page(s) 740, ISSN 2076-393X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines11040740

The transition from mild to moderate‐to‐severe chronic plaque psoriasis

Author(s): Francesco Bellinato, Paolo Gisondi, Guido Mioso, Elena Mason, Danny Straiotto, Stefano Piaserico, Giampiero Girolomoni
Published in: Journal of the European Academy of Dermatology and Venereology, Issue 37, 2024, ISSN 0926-9959
Publisher: Elsevier BV
DOI: 10.1111/jdv.19208

POS0995 SINGLE CELL RNA-SEQ CHARACTERIZATION OF CIRCULATING IMMUNE CELLS IN SJOGREN’S SYNDROME: COMPARISON TO SLE AND RHEUMATOID ARHTRITIS

Author(s): J.L. Andréu Sánchez, A. Gómez-Gómez, Y. Guillen Montalban, P. Vela Casasempere, M.P. Álvarez Hernandez, I. Braña Abascal, M. Fernandez Castro, M.A. López Lasanta, J.M. Pego Reigosa, C. Marras Fernandez Cid, M.J. Garcia-Villanueva, F. Blanco, P. Carreira, C. Perez-Garcia, Í. Rúa-Figueroa, H.F. Avalos Bogado, N. Boix-Martí, E. Kirkegaard-biosca, I. Alvarez Saez, N. Palau Balaña, R. Tortos
Published in: Annals of the Rheumatic Diseases, Issue 83, 2025, Page(s) 861, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2024-eular.4758

Digital Twins for Predictive, Preventive Personalized, and Participatory Treatment of Immune-Mediated Diseases

Author(s): Mikael Benson
Published in: ATVB, Issue 1, 2023, ISSN 0888-7543
Publisher: Academic Press
DOI: 10.1161/atvbaha.122.318331

Macrophage and neutrophil heterogeneity at single-cell spatial resolution in human inflammatory bowel disease

Author(s): Alba Garrido-Trigo, Ana M. Corraliza, Marisol Veny, Isabella Dotti, Elisa Melón-Ardanaz, Aina Rill, Helena L. Crowell, Ángel Corbí, Victoria Gudiño, Miriam Esteller, Iris Álvarez-Teubel, Daniel Aguilar, M. Carme Masamunt, Emily Killingbeck, Youngmi Kim, Michael Leon, Sudha Visvanathan, Domenica Marchese, Ginevra Caratù, Albert Martin-Cardona, Maria Esteve, Ingrid Ordás, Julian Panés, Elena
Published in: Nature Communications, Issue 14, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-40156-6

FixNCut: Single-cell genomics through reversible tissue fixation and dissociation

Author(s): Jiménez-Gracia, Laura; Heyn, Holger
Published in: Genome Biology, Issue 5, 2023, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.5281/zenodo.7837624

Gender perspective in the management of psoriasis

Author(s): Martina MAURELLI, Paolo GISONDI, Giampiero GIROLOMONI
Published in: Italian Journal of Dermatology and Venereology, Issue 160, 2025, ISSN 2784-8671
Publisher: Edizioni Minerva Medica
DOI: 10.23736/s2784-8671.25.08147-2

scDrugPrio: a framework for the analysis of single-cell transcriptomics to address multiple problems in precision medicine in immune-mediated inflammatory diseases. Genome Med 16, 42 (2024).

Author(s): Samuel Schäfer, Martin Smelik, Oleg Sysoev, Yelin Zhao, Desiré Eklund, Sandra Lilja, Mika Gustafsson, Holger Heyn, Antonio Julia, István A. Kovács, Joseph Loscalzo, Sara Marsal, Huan Zhang, Xinxiu Li, Danuta Gawel, Hui Wang and Mikael Benson
Published in: Genome Medicine, 2024, ISSN 0888-7543
Publisher: Academic Press
DOI: 10.1186/s13073-024-01314-7

Interpretable inflammation landscape of circulating immune cells

Author(s): Laura Jiménez-Gracia, Davide Maspero, Sergio Aguilar-Fernández, Francesco Craighero, Maria Boulougouri, Max Ruiz, Domenica Marchese, Ginevra Caratù, Jose Liñares-Blanco, Miren Berasategi, Ricardo O. Ramirez Flores, Angela Sanzo-Machuca, Ana M. Corraliza, Hoang A. Tran, Rachelly Normand, Jacquelyn Nestor, Yourae Hong, Tessa Kole, Petra van der Velde, Frederique Alleblas, Flaminia Pedretti, Adri
Published in: Nature Medicine, Issue 32, 2026, Page(s) 633-644, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-025-04126-3

Sex Differences in Epidemiology, Mechanisms, and Management of Atopic Dermatitis

Author(s): Martina Maurelli, Paolo Gisondi, Micol Del Giglio, Giampiero Girolomoni
Published in: Dermatologic Therapy, Issue 2025, 2026, ISSN 1396-0296
Publisher: Blackwell Publishing Inc.
DOI: 10.1155/dth/6670747

Sampling time-dependent artifacts in single-cell genomics studies

Author(s): Ramon Massoni-Badosa, Giovanni Iacono, Catia Moutinho, Marta Kulis, Núria Palau, Domenica Marchese, Javier Rodríguez-Ubreva, Esteban Ballestar, Gustavo Rodriguez-Esteban, Sara Marsal, Marta Aymerich, Dolors Colomer, Elias Campo, Antonio Julià, José Ignacio Martín-Subero, Holger Heyn
Published in: Genome Biology, Issue 21/1, 2020, ISSN 1474-760X
Publisher: Genome Biology
DOI: 10.1186/s13059-020-02032-0

Allelic Variants of HLA-C Upstream Region, PSORS1C3, MICA, TNFA and Genes Involved in Epidermal Homeostasis and Barrier Function Influence the Clinical Response to Anti-IL-12/IL-23 Treatment of Patients with Psoriasis

Author(s): Martina Morelli, Marco Galluzzo, Claudia Scarponi, Stefania Madonna, Giovanni Luca Scaglione, Giampiero Girolomoni, Marina Talamonti, Luca Bianchi, Cristina Albanesi
Published in: Vaccines, Issue 10, 2024, Page(s) 1977, ISSN 2076-393X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines10111977

OP0260 DoCTIS: A SINGLE CELL RNA-Seq ATLAS OF DRUG RESPONSE TO TARGETED THERAPIES

Author(s): A. Julià, Y. Guillén, J.A. Patiño Galindo, S.H. Martínez-Mateu, P. Vela Casasempere, A. Fernández Nebro, C. Marras, S. Castañeda, J. Calvo Alén, J. Tornero Molina, J.D.D. Cañete Crespillo, E. Domènech, J.P. Gisbert, J.M. Carrascosa, E. Fonseca, L. Bujanda Fernández de Pierola, V. García Sánchez, B. Siegmund, G. Girolomoni, H. Heyn, L. Jimenez, P. Santamaría, E. Angelats, R. Myers, E.
Published in: Annals of the Rheumatic Diseases, Issue 84, 2025, Page(s) 214, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1016/j.ard.2025.05.270

<i>HLA-Cw6</i> and other HLA-C alleles, as well as <i>MICB-DT, DDX58,</i> and <i>TYK2</i> genetic variants associate with optimal response to anti-IL-17A treatment in patients with psoriasis

Author(s): Martina Morelli, Marco Galluzzo, Stefania Madonna, Claudia Scarponi, Giovanni Luca Scaglione, Tiziana Galluccio, Marco Andreani, Sabatino Pallotta, Giampiero Girolomoni, Luca Bianchi, Marina Talamonti, Cristina Albanesi
Published in: Expert Opinion on Biological Therapy, Issue 21, 2021, Page(s) 259-270, ISSN 1471-2598
Publisher: Ashley Publications Ltd.
DOI: 10.1080/14712598.2021.1862082

ABS0280 UNVEILING SYNERGISTIC DRUG COMBINATIONS FOR IMMUNE-MEDIATED INFLAMMATORY DISEASES: INSIGHTS FROM THE DoCTIS CONSORTIUM USING SYSTEMS BIOLOGY APPROACHES

Author(s): A. Julià, E. Choy, M.A. López Lasanta, P. Vela Casasempere, A. Fernández Nebro, S. Castañeda, C. Marras, J. Calvo Alén, J. Tornero Molina, J.D.D. Cañete Crespillo, E. Domènech, J.P. Gisbert, J.M. Carrascosa, E. Fonseca, L. Bujanda Fernández de Pierola, V. García Sánchez, B. Siegmund, G. Girolomoni, H. Heyn, L. Jimenez, P. Santamaría, E. Angelats, R. Myers, Y. Guillén, S.H. Martínez-Ma
Published in: Annals of the Rheumatic Diseases, Issue 84, 2025, Page(s) 1509-1510, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1016/j.ard.2025.06.869

An interactive atlas of genomic, proteomic, and metabolomic biomarkers promotes the potential of proteins to predict complex diseases

Author(s): Martin Smelik , Yelin Zhao , Xinxiu Li , Joseph Loscalzo , Oleg Sysoev , Firoj Mahmud , Dina Mansour Aly , Mikael Benson
Published in: Scientific Reports, 2024, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-024-63399-9

Conference proceedings (2)

Exploring Query-to-reference Mapping Challenges for Automated Single-Cell Atlas-based Diagnostics

Author(s): Craighero, Francesco - Maspero, Davide - Jiménez-Gracia, Laura - Aguilar-Fernández, Sergio - Boulougouri, Maria - Nieto, Juan - Heyn, Holger
Published in: 2025
Publisher: Learning Meaningful Representations of Life (LMRL) Workshop at ICLR 2025

DoCTIS: a single cell RNA-seq atlas of drug response to targeted therapies in immune-mediated inflammatory diseases

Author(s): B Siegmund, A Julia, Y Guillén, E Domenech Morral, J Gisbert, P Vela Casasempere, A Fernandez Nebro, C Marras, S Castaneda, J Calvo Alen, J Tornero Molino, J Canete Crespillo, J M Carrascosa, E Fonseca, L Bujunda Fernandez de Pierola, V García, G Girolomoni, H Heyn, P SantaMaria, S H Martinez Mateu, R Myers, J A Patino Galindo, E Choy, S Marsal
Published in: Zeitschrift für Gastroenterologie, 79. Jahrestagung der DGVS mit Sektion Endoskopie Jahrestagung der Deutschen Gesellschaft für Allgemein- und Viszeralchirurgie mit den Arbeitsgemeinschaften der DGAV und Jahrestagung der CACP, Issue 63, 2025
Publisher: Georg Thieme Verlag KG
DOI: 10.1055/s-0045-1810718