DECISION ON OPTIMAL COMBINATORIAL THERAPIES IN IMIDS USING SYSTEMS APPROACHES

Deliverables

This document will describe in detail the project communication strategy in all of its components: objectives, audiences, actions and tools.

Creation of the project website

Website set up and launch

Publications

A dynamic single cell-based framework for digital twins to prioritize disease genes and drug targets

Author(s): Xinxiu Li; Eun Jung Lee; Sandra Lilja; Joseph Loscalzo; Samuel Schäfer; Martin Smelik; Maria Regina Strobl; Oleg Sysoev; Hui Wang; Huan Zhang; Yelin Zhao; Danuta R. Gawel; Barbara Bohle; Mikael Benson
Published in: Genome Medicine, Issue 1, 2022, ISSN 1756-994X
Publisher: BioMed Central
DOI: 10.1186/s13073-022-01048-4

Managing the Patient with Psoriasis and Metabolic Comorbidities

Author(s): Francesco Bellinato, Martina Maurelli, Davide Geat, Giampiero Girolomoni, Paolo Gisondi
Published in: American Journal of Clinical Dermatology, Issue 25, 2024, Page(s) 527-540, ISSN 1175-0561
Publisher: Adis International Ltd.
DOI: 10.1007/s40257-024-00857-0

Targeting of the CD80/86 proinflammatory axis as a therapeutic strategy to prevent severe COVID-19.

Author(s): Antonio Julià; Irene Bonafonte-Pardàs; Antonio Gomez; María López-Lasanta; Mireia López-Corbeto; Sergio H Martínez-Mateu; Jordi Lladós; Iván Rodríguez-Núñez; Richard M. Myers; S. Marsal
Published in: Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021), Issue 1, 2021, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-90797-0

Characteristics of Patients Experiencing a Flare of Generalized Pustular Psoriasis: A Multicenter Observational Study

Author(s): Francesco Bellinato, Paolo Gisondi, Angelo Marzano, Stefano Piaserico, Clara De Simone, Giovanni Damiani, Giuseppe Argenziano, Marina Venturini, Paolo Dapavo, Antonio Costanzo, Matteo Megna, Francesca Prignano, Martina Burlando, Francesca Satolli, Andrea Carugno, Elena Pezzolo, Marco Romanelli, Aldo Cuccia, Giampiero Girolomoni
Published in: Vaccines, Issue 11, 2023, Page(s) 740, ISSN 2076-393X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines11040740

Digital Twins for Predictive, Preventive Personalized, and Participatory Treatment of Immune-Mediated Diseases

Author(s): Mikael Benson
Published in: ATVB, Issue 1, 2023, ISSN 0888-7543
Publisher: Academic Press
DOI: 10.1161/atvbaha.122.318331

Macrophage and neutrophil heterogeneity at single-cell spatial resolution in human inflammatory bowel disease

Author(s): Alba Garrido-Trigo, Ana M. Corraliza, Marisol Veny, Isabella Dotti, Elisa Melón-Ardanaz, Aina Rill, Helena L. Crowell, Ángel Corbí, Victoria Gudiño, Miriam Esteller, Iris Álvarez-Teubel, Daniel Aguilar, M. Carme Masamunt, Emily Killingbeck, Youngmi Kim, Michael Leon, Sudha Visvanathan, Domenica Marchese, Ginevra Caratù, Albert Martin-Cardona, Maria Esteve, Ingrid Ordás, Julian Panés, Elena
Published in: Nature Communications, Issue 14, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-40156-6

FixNCut: Single-cell genomics through reversible tissue fixation and dissociation

Author(s): Jiménez-Gracia, Laura; Heyn, Holger
Published in: Genome Biology, Issue 5, 2023, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.5281/zenodo.7837624

scDrugPrio: a framework for the analysis of single-cell transcriptomics to address multiple problems in precision medicine in immune-mediated inflammatory diseases. Genome Med 16, 42 (2024).

Author(s): Samuel Schäfer, Martin Smelik, Oleg Sysoev, Yelin Zhao, Desiré Eklund, Sandra Lilja, Mika Gustafsson, Holger Heyn, Antonio Julia, István A. Kovács, Joseph Loscalzo, Sara Marsal, Huan Zhang, Xinxiu Li, Danuta Gawel, Hui Wang and Mikael Benson
Published in: Genome Medicine, 2024, ISSN 0888-7543
Publisher: Academic Press
DOI: 10.1186/s13073-024-01314-7

Sampling time-dependent artifacts in single-cell genomics studies

Author(s): Ramon Massoni-Badosa, Giovanni Iacono, Catia Moutinho, Marta Kulis, Núria Palau, Domenica Marchese, Javier Rodríguez-Ubreva, Esteban Ballestar, Gustavo Rodriguez-Esteban, Sara Marsal, Marta Aymerich, Dolors Colomer, Elias Campo, Antonio Julià, José Ignacio Martín-Subero, Holger Heyn
Published in: Genome Biology, Issue 21/1, 2020, ISSN 1474-760X
Publisher: Genome Biology
DOI: 10.1186/s13059-020-02032-0

Allelic Variants of HLA-C Upstream Region, PSORS1C3, MICA, TNFA and Genes Involved in Epidermal Homeostasis and Barrier Function Influence the Clinical Response to Anti-IL-12/IL-23 Treatment of Patients with Psoriasis

Author(s): Martina Morelli, Marco Galluzzo, Claudia Scarponi, Stefania Madonna, Giovanni Luca Scaglione, Giampiero Girolomoni, Marina Talamonti, Luca Bianchi, Cristina Albanesi
Published in: Vaccines, Issue 10, 2024, Page(s) 1977, ISSN 2076-393X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines10111977

HLA-Cw6 and other HLA-C alleles, as well as MICB-DT, DDX58, and TYK2 genetic variants associate with optimal response to anti-IL-17A treatment in patients with psoriasis

Author(s): Martina Morelli, Marco Galluzzo, Stefania Madonna, Claudia Scarponi, Giovanni Luca Scaglione, Tiziana Galluccio, Marco Andreani, Sabatino Pallotta, Giampiero Girolomoni, Luca Bianchi, Marina Talamonti, Cristina Albanesi
Published in: Expert Opinion on Biological Therapy, Issue 21, 2021, Page(s) 259-270, ISSN 1471-2598
Publisher: Ashley Publications Ltd.
DOI: 10.1080/14712598.2021.1862082

An interactive atlas of genomic, proteomic, and metabolomic biomarkers promotes the potential of proteins to predict complex diseases

Author(s): Martin Smelik , Yelin Zhao , Xinxiu Li , Joseph Loscalzo , Oleg Sysoev , Firoj Mahmud , Dina Mansour Aly , Mikael Benson
Published in: Scientific Reports, 2024, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-024-63399-9

Deliverables

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