DECISION ON OPTIMAL COMBINATORIAL THERAPIES IN IMIDS USING SYSTEMS APPROACHES

Informacje na temat projektu

DocTIS

Identyfikator umowy o grant: 848028

DOI

10.3030/848028

Data podpisania przez KE 6 Grudnia 2019

Data rozpoczęcia 1 Stycznia 2020

Data zakończenia 30 Czerwca 2026

Finansowanie w ramach

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Koszt całkowity

€ 6 260 050,00

Wkład UE

€ 6 260 050,00

Koordynowany przez

FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA
Spain

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Other (1)

Communication plan

This document will describe in detail the project communication strategy in all of its components: objectives, audiences, actions and tools.

Websites, patent fillings, videos etc. (1)

Creation of the project website

Website set up and launch

Publikacje

Thesis and dissertations (2)

Towards a large-scale human inflammation atlas at single-cell resolution

Autorzy: Laura Jiménez Gracia
Opublikowane w: 2024
Wydawca: University of Barcelona

Construction and utilization of digital twins for personalized therapeutic predictions

Autorzy: Samuel Schäfer
Opublikowane w: Linköping University Medical Dissertations, 2024
Wydawca: Linköping University Electronic Press
DOI: 10.3384/9789180757089

Peer reviewed articles (23)

A dynamic single cell-based framework for digital twins to prioritize disease genes and drug targets

Autorzy: Xinxiu Li; Eun Jung Lee; Sandra Lilja; Joseph Loscalzo; Samuel Schäfer; Martin Smelik; Maria Regina Strobl; Oleg Sysoev; Hui Wang; Huan Zhang; Yelin Zhao; Danuta R. Gawel; Barbara Bohle; Mikael Benson
Opublikowane w: Genome Medicine, Numer 1, 2022, ISSN 1756-994X
Wydawca: BioMed Central
DOI: 10.1186/s13073-022-01048-4

Biological disease-modifying antirheumatic drugs may mitigate the risk of psoriatic arthritis in patients with chronic plaque psoriasis

Autorzy: Paolo Gisondi, Francesco Bellinato, Giovanni Targher, Luca Idolazzi, Giampiero Girolomoni
Opublikowane w: Annals of the Rheumatic Diseases, Numer 81, 2025, Strona(/y) 68-73, ISSN 0003-4967
Wydawca: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2021-219961

A Transcriptional Map of Human Tonsil Architecture: Beyond the Sum of (Single Cell) Parts

Autorzy: Helena L. Crowell, Laura Llaó‐Cid, Gerard Frigola, Samuel Gunz, Irene Ruano, Patricia Lorden, Max Ruiz, Marta Kulis, José Ignacio Martin‐Subero, Holger Heyn, Elias Campo, Anna Pascual‐Reguant
Opublikowane w: European Journal of Immunology, Numer 56, 2026, ISSN 0014-2980
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/eji.70121

STAMP: Single-cell transcriptomics analysis and multimodal profiling through imaging

Autorzy: Emanuele Pitino, Anna Pascual-Reguant, Felipe Segato-Dezem, Kellie Wise, Irepan Salvador-Martinez, Helena Lucia Crowell, Maycon Marção, Max Ruiz, Elise Courtois, William F. Flynn, Santhosh Sivajothi, Emily Soja, Ginevra Caratù, German Atzin Mora-Roldan, B. Kate Dredge, Yutian Liu, Hannah Chasteen, Monika Mohenska, Juan C. Nieto, Raymond K.H. Yip, Ruvimbo D. Mishi, José M. Polo, Mohmed Abdalftt
Opublikowane w: Cell, Numer 188, 2026, Strona(/y) 5100-5117.e26, ISSN 0092-8674
Wydawca: Cell Press
DOI: 10.1016/j.cell.2025.05.027

Managing the Patient with Psoriasis and Metabolic Comorbidities

Autorzy: Francesco Bellinato, Martina Maurelli, Davide Geat, Giampiero Girolomoni, Paolo Gisondi
Opublikowane w: American Journal of Clinical Dermatology, Numer 25, 2024, Strona(/y) 527-540, ISSN 1175-0561
Wydawca: Adis International Ltd.
DOI: 10.1007/s40257-024-00857-0

Mechanistic and therapeutic advances in immune-mediated gastrointestinal disorders

Autorzy: Nahir Garabatos, Edgar Angelats, Pere Santamaria
Opublikowane w: Journal of Allergy and Clinical Immunology, Numer 156, 2025, Strona(/y) 1133-1159, ISSN 0091-6749
Wydawca: Mosby Inc.
DOI: 10.1016/j.jaci.2025.07.024

Targeting of the CD80/86 proinflammatory axis as a therapeutic strategy to prevent severe COVID-19.

Autorzy: Antonio Julià; Irene Bonafonte-Pardàs; Antonio Gomez; María López-Lasanta; Mireia López-Corbeto; Sergio H Martínez-Mateu; Jordi Lladós; Iván Rodríguez-Núñez; Richard M. Myers; S. Marsal
Opublikowane w: Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021), Numer 1, 2021, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-021-90797-0

Characteristics of Patients Experiencing a Flare of Generalized Pustular Psoriasis: A Multicenter Observational Study

Autorzy: Francesco Bellinato, Paolo Gisondi, Angelo Marzano, Stefano Piaserico, Clara De Simone, Giovanni Damiani, Giuseppe Argenziano, Marina Venturini, Paolo Dapavo, Antonio Costanzo, Matteo Megna, Francesca Prignano, Martina Burlando, Francesca Satolli, Andrea Carugno, Elena Pezzolo, Marco Romanelli, Aldo Cuccia, Giampiero Girolomoni
Opublikowane w: Vaccines, Numer 11, 2023, Strona(/y) 740, ISSN 2076-393X
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines11040740

The transition from mild to moderate‐to‐severe chronic plaque psoriasis

Autorzy: Francesco Bellinato, Paolo Gisondi, Guido Mioso, Elena Mason, Danny Straiotto, Stefano Piaserico, Giampiero Girolomoni
Opublikowane w: Journal of the European Academy of Dermatology and Venereology, Numer 37, 2024, ISSN 0926-9959
Wydawca: Elsevier BV
DOI: 10.1111/jdv.19208

POS0995 SINGLE CELL RNA-SEQ CHARACTERIZATION OF CIRCULATING IMMUNE CELLS IN SJOGREN’S SYNDROME: COMPARISON TO SLE AND RHEUMATOID ARHTRITIS

Autorzy: J.L. Andréu Sánchez, A. Gómez-Gómez, Y. Guillen Montalban, P. Vela Casasempere, M.P. Álvarez Hernandez, I. Braña Abascal, M. Fernandez Castro, M.A. López Lasanta, J.M. Pego Reigosa, C. Marras Fernandez Cid, M.J. Garcia-Villanueva, F. Blanco, P. Carreira, C. Perez-Garcia, Í. Rúa-Figueroa, H.F. Avalos Bogado, N. Boix-Martí, E. Kirkegaard-biosca, I. Alvarez Saez, N. Palau Balaña, R. Tortos
Opublikowane w: Annals of the Rheumatic Diseases, Numer 83, 2025, Strona(/y) 861, ISSN 0003-4967
Wydawca: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2024-eular.4758

Digital Twins for Predictive, Preventive Personalized, and Participatory Treatment of Immune-Mediated Diseases

Autorzy: Mikael Benson
Opublikowane w: ATVB, Numer 1, 2023, ISSN 0888-7543
Wydawca: Academic Press
DOI: 10.1161/atvbaha.122.318331

Macrophage and neutrophil heterogeneity at single-cell spatial resolution in human inflammatory bowel disease

Autorzy: Alba Garrido-Trigo, Ana M. Corraliza, Marisol Veny, Isabella Dotti, Elisa Melón-Ardanaz, Aina Rill, Helena L. Crowell, Ángel Corbí, Victoria Gudiño, Miriam Esteller, Iris Álvarez-Teubel, Daniel Aguilar, M. Carme Masamunt, Emily Killingbeck, Youngmi Kim, Michael Leon, Sudha Visvanathan, Domenica Marchese, Ginevra Caratù, Albert Martin-Cardona, Maria Esteve, Ingrid Ordás, Julian Panés, Elena
Opublikowane w: Nature Communications, Numer 14, 2024, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-023-40156-6

FixNCut: Single-cell genomics through reversible tissue fixation and dissociation

Autorzy: Jiménez-Gracia, Laura; Heyn, Holger
Opublikowane w: Genome Biology, Numer 5, 2023, ISSN 2692-8205
Wydawca: Cold Spring Harbor Laboratory
DOI: 10.5281/zenodo.7837624

Gender perspective in the management of psoriasis

Autorzy: Martina MAURELLI, Paolo GISONDI, Giampiero GIROLOMONI
Opublikowane w: Italian Journal of Dermatology and Venereology, Numer 160, 2025, ISSN 2784-8671
Wydawca: Edizioni Minerva Medica
DOI: 10.23736/s2784-8671.25.08147-2

scDrugPrio: a framework for the analysis of single-cell transcriptomics to address multiple problems in precision medicine in immune-mediated inflammatory diseases. Genome Med 16, 42 (2024).

Autorzy: Samuel Schäfer, Martin Smelik, Oleg Sysoev, Yelin Zhao, Desiré Eklund, Sandra Lilja, Mika Gustafsson, Holger Heyn, Antonio Julia, István A. Kovács, Joseph Loscalzo, Sara Marsal, Huan Zhang, Xinxiu Li, Danuta Gawel, Hui Wang and Mikael Benson
Opublikowane w: Genome Medicine, 2024, ISSN 0888-7543
Wydawca: Academic Press
DOI: 10.1186/s13073-024-01314-7

Interpretable inflammation landscape of circulating immune cells

Autorzy: Laura Jiménez-Gracia, Davide Maspero, Sergio Aguilar-Fernández, Francesco Craighero, Maria Boulougouri, Max Ruiz, Domenica Marchese, Ginevra Caratù, Jose Liñares-Blanco, Miren Berasategi, Ricardo O. Ramirez Flores, Angela Sanzo-Machuca, Ana M. Corraliza, Hoang A. Tran, Rachelly Normand, Jacquelyn Nestor, Yourae Hong, Tessa Kole, Petra van der Velde, Frederique Alleblas, Flaminia Pedretti, Adri
Opublikowane w: Nature Medicine, Numer 32, 2026, Strona(/y) 633-644, ISSN 1078-8956
Wydawca: Nature Publishing Group
DOI: 10.1038/s41591-025-04126-3

Sex Differences in Epidemiology, Mechanisms, and Management of Atopic Dermatitis

Autorzy: Martina Maurelli, Paolo Gisondi, Micol Del Giglio, Giampiero Girolomoni
Opublikowane w: Dermatologic Therapy, Numer 2025, 2026, ISSN 1396-0296
Wydawca: Blackwell Publishing Inc.
DOI: 10.1155/dth/6670747

Sampling time-dependent artifacts in single-cell genomics studies

Autorzy: Ramon Massoni-Badosa, Giovanni Iacono, Catia Moutinho, Marta Kulis, Núria Palau, Domenica Marchese, Javier Rodríguez-Ubreva, Esteban Ballestar, Gustavo Rodriguez-Esteban, Sara Marsal, Marta Aymerich, Dolors Colomer, Elias Campo, Antonio Julià, José Ignacio Martín-Subero, Holger Heyn
Opublikowane w: Genome Biology, Numer 21/1, 2020, ISSN 1474-760X
Wydawca: Genome Biology
DOI: 10.1186/s13059-020-02032-0

Allelic Variants of HLA-C Upstream Region, PSORS1C3, MICA, TNFA and Genes Involved in Epidermal Homeostasis and Barrier Function Influence the Clinical Response to Anti-IL-12/IL-23 Treatment of Patients with Psoriasis

Autorzy: Martina Morelli, Marco Galluzzo, Claudia Scarponi, Stefania Madonna, Giovanni Luca Scaglione, Giampiero Girolomoni, Marina Talamonti, Luca Bianchi, Cristina Albanesi
Opublikowane w: Vaccines, Numer 10, 2024, Strona(/y) 1977, ISSN 2076-393X
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines10111977

OP0260 DoCTIS: A SINGLE CELL RNA-Seq ATLAS OF DRUG RESPONSE TO TARGETED THERAPIES

Autorzy: A. Julià, Y. Guillén, J.A. Patiño Galindo, S.H. Martínez-Mateu, P. Vela Casasempere, A. Fernández Nebro, C. Marras, S. Castañeda, J. Calvo Alén, J. Tornero Molina, J.D.D. Cañete Crespillo, E. Domènech, J.P. Gisbert, J.M. Carrascosa, E. Fonseca, L. Bujanda Fernández de Pierola, V. García Sánchez, B. Siegmund, G. Girolomoni, H. Heyn, L. Jimenez, P. Santamaría, E. Angelats, R. Myers, E.
Opublikowane w: Annals of the Rheumatic Diseases, Numer 84, 2025, Strona(/y) 214, ISSN 0003-4967
Wydawca: BMJ Publishing Group
DOI: 10.1016/j.ard.2025.05.270

<i>HLA-Cw6</i> and other HLA-C alleles, as well as <i>MICB-DT, DDX58,</i> and <i>TYK2</i> genetic variants associate with optimal response to anti-IL-17A treatment in patients with psoriasis

Autorzy: Martina Morelli, Marco Galluzzo, Stefania Madonna, Claudia Scarponi, Giovanni Luca Scaglione, Tiziana Galluccio, Marco Andreani, Sabatino Pallotta, Giampiero Girolomoni, Luca Bianchi, Marina Talamonti, Cristina Albanesi
Opublikowane w: Expert Opinion on Biological Therapy, Numer 21, 2021, Strona(/y) 259-270, ISSN 1471-2598
Wydawca: Ashley Publications Ltd.
DOI: 10.1080/14712598.2021.1862082

ABS0280 UNVEILING SYNERGISTIC DRUG COMBINATIONS FOR IMMUNE-MEDIATED INFLAMMATORY DISEASES: INSIGHTS FROM THE DoCTIS CONSORTIUM USING SYSTEMS BIOLOGY APPROACHES

Autorzy: A. Julià, E. Choy, M.A. López Lasanta, P. Vela Casasempere, A. Fernández Nebro, S. Castañeda, C. Marras, J. Calvo Alén, J. Tornero Molina, J.D.D. Cañete Crespillo, E. Domènech, J.P. Gisbert, J.M. Carrascosa, E. Fonseca, L. Bujanda Fernández de Pierola, V. García Sánchez, B. Siegmund, G. Girolomoni, H. Heyn, L. Jimenez, P. Santamaría, E. Angelats, R. Myers, Y. Guillén, S.H. Martínez-Ma
Opublikowane w: Annals of the Rheumatic Diseases, Numer 84, 2025, Strona(/y) 1509-1510, ISSN 0003-4967
Wydawca: BMJ Publishing Group
DOI: 10.1016/j.ard.2025.06.869

An interactive atlas of genomic, proteomic, and metabolomic biomarkers promotes the potential of proteins to predict complex diseases

Autorzy: Martin Smelik , Yelin Zhao , Xinxiu Li , Joseph Loscalzo , Oleg Sysoev , Firoj Mahmud , Dina Mansour Aly , Mikael Benson
Opublikowane w: Scientific Reports, 2024, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-024-63399-9

Conference proceedings (2)

Exploring Query-to-reference Mapping Challenges for Automated Single-Cell Atlas-based Diagnostics

Autorzy: Craighero, Francesco - Maspero, Davide - Jiménez-Gracia, Laura - Aguilar-Fernández, Sergio - Boulougouri, Maria - Nieto, Juan - Heyn, Holger
Opublikowane w: 2025
Wydawca: Learning Meaningful Representations of Life (LMRL) Workshop at ICLR 2025

DoCTIS: a single cell RNA-seq atlas of drug response to targeted therapies in immune-mediated inflammatory diseases

Autorzy: B Siegmund, A Julia, Y Guillén, E Domenech Morral, J Gisbert, P Vela Casasempere, A Fernandez Nebro, C Marras, S Castaneda, J Calvo Alen, J Tornero Molino, J Canete Crespillo, J M Carrascosa, E Fonseca, L Bujunda Fernandez de Pierola, V García, G Girolomoni, H Heyn, P SantaMaria, S H Martinez Mateu, R Myers, J A Patino Galindo, E Choy, S Marsal
Opublikowane w: Zeitschrift für Gastroenterologie, 79. Jahrestagung der DGVS mit Sektion Endoskopie Jahrestagung der Deutschen Gesellschaft für Allgemein- und Viszeralchirurgie mit den Arbeitsgemeinschaften der DGAV und Jahrestagung der CACP, Numer 63, 2025
Wydawca: Georg Thieme Verlag KG
DOI: 10.1055/s-0045-1810718