CORDIS - EU research results

Molecular Mechanisms Associating Chronic Pain with Fatigue, Affective Disorders, Cardiovascular Disease and Total Comorbidity


Data Management Plan delivered in accordance with FAIR principles to EC

For this deliverable we will develop harmonization protocols, i.e. develop technical and semantic data standards, and quality protocols to unify and bridge the different coding standards of target variables between databases. It will also define guidelines for addressing differences in data management systems and routines, and MR image quality control procedures to secure the efficient application and utilization of the data transfer, storage and processing system. The team will also ensure that the consortiums policy regarding gender issues is correctly implemented.

Quality Assurance and risk analysis procedures delivered upon establishment of a functional Project Administration

The purpose of this deliverable is to describe established procedures to recover the PainFACT project following a disruption or alert of malfunction in respect to the GA, the CA and or the agreed Work Plan, if such an event were to occur. The rapprot will consit of: theoretical framework for the PainFACT Contingency Plan; risk descriptions and contingency actions and a template to report on the activation and closing of the Contingency Plan.


Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles

Author(s): Heidi Hautakangas, Bendik S. Winsvold, Sanni E. Ruotsalainen, Gyda Bjornsdottir, Aster V. E. Harder, Lisette J. A. Kogelman, Laurent F. Thomas, Raymond Noordam, Christian Benner, Padhraig Gormley, Ville Artto, Karina Banasik, Anna Bjornsdottir, Dorret I. Boomsma, Ben M. Brumpton, Kristoffer Sølvsten Burgdorf, Julie E. Buring, Mona Ameri Chalmer, Irene de Boer, Martin Dichgans, Christian Erikstrup
Published in: Nature Genetics, Issue 54, 2022, Page(s) 152-160, ISSN 1546-1718
Publisher: Nature Genetics
DOI: 10.1038/s41588-021-00990-0

Presence of Blastocystis in gut microbiota is associated with cognitive traits and decreased executive function.

Author(s): Jordi Mayneris-Perxachs; María Arnoriaga-Rodríguez; Josep Garre-Olmo; Josep Puig; Rafael Ramos; Maria Trelis; Aurelijus Burokas; Clàudia Coll; Cristina Zapata-Tona; Salvador Pedraza; Vicente Pérez-Brocal; Lluís Ramió; Wifredo Ricart; Andrés Moya; Mariona Jové; Joaquim Sol; Manuel Portero-Otin; Reinald Pamplona; Rafael Maldonado; José Manuel Fernández-Real
Published in: ISME Journal, Issue 16, 2022, Page(s) 2181-2197, ISSN 1751-7370
Publisher: Springer Nature
DOI: 10.1038/s41396-022-01262-3

Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology

Author(s): Bjornsdottir, Gyda; Stefánsdóttir, Lilja; Thorleifsson, Gudmar; Sulem, Patrick; Norland, Kristjan; Ferkingstad, Egil; Oddsson, Asmundur; Zink, Florian; Lund, Sigrun H.; Nawaz, Muhammad S.; Bragi Walters, G.; Skuladottir, Astros Th.; Gudjonsson, Sigurjon A.; Einarsson, Gudmundur; Halldorsson, Gisli H.; Bjarnadottir, Valgerdur; Sveinbjornsson, Gardar; Helgadottir, Anna; Styrkársdóttir, Unnur; Gu
Published in: Nature Communications, Issue 13/634, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-28167-1

Thirty novel sequence variants impacting human intracranial volume

Author(s): Muhammad Sulaman Nawaz, Gudmundur Einarsson, Mariana Bustamante, Rosa S. Gisladottir, G. Bragi Walters, Gudrun A. Jonsdottir, Astros Th. Skuladottir, Gyda Bjornsdottir, Sigurdur H. Magnusson, Bergrun Asbjornsdottir, Unnur Unnsteinsdottir, Engilbert Sigurdsson, Palmi V. Jonsson, Vala Kolbrun Palmadottir, Sigurjon A. Gudjonsson,Gisli H. Halldorsson, Egil Ferkingstad, Ingileif Jonsdottir, Gudmar Tho
Published in: Brain Communications, Issue Volume 4, Issue 6, 2022, ISSN 2632-1297
Publisher: Oxford Academic
DOI: 10.1093/braincomms/fcac271

A genome-wide meta-analysis identifies 50 genetic loci associated with carpal tunnel syndrome

Author(s): Astros Th Skuladottir, Gyda Bjornsdottir, Egil Ferkingstad, Gudmundur Einarsson, Lilja Stefansdottir, Muhammad Sulaman Nawaz, Asmundur Oddsson, Thorunn A Olafsdottir, Saedis Saevarsdottir, G Bragi Walters, Sigurdur H Magnusson, Anna Bjornsdottir, Olafur A Sveinsson, Arnor Vikingsson , Thomas Folkmann Hansen, Rikke Louise Jacobsen, Christian Erikstrup, Michael Schwinn, Søren Brunak, Karina Banasik
Published in: Nature Communications, Issue 13(1):1598, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-29133-7

A meta-analysis uncovers the first sequence variant conferring risk of Bell’s palsy

Author(s): Astros Th. Skuladottir, Gyda Bjornsdottir, Gudmar Thorleifsson, G. Bragi Walters, Muhammad Sulaman Nawaz, Kristjan Helgi Swerford Moore, Pall I. Olason, Thorgeir E. Thorgeirsson, Brynja Sigurpalsdottir, Gardar Sveinbjornsson, Hannes P. Eggertsson, Sigurdur H. Magnusson, Asmundur Oddsson, Anna Bjornsdottir, Arnor Vikingsson, Olafur A. Sveinsson, Maria G. Hrafnsdottir, Gudrun R. Sigurdardottir, Bjar
Published in: Scientific Reports, Issue 11/1, 2021, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-82736-w

miRNA signatures associated with vulnerability to food addiction in mice and humans

Author(s): Alejandra García-Blanco; Laura Domingo-Rodriguez; Judit Cabana-Domínguez; Noèlia Fernández-Castillo; Laura Pineda-Cirera; Jordi Mayneris-Perxachs; Aurelijus Burokas; Jose Espinosa-Carrasco; Silvia Arboleya; Jessica Latorre; Catherine Stanton; Bru Cormand; Jose-Manuel Fernández-Real; Elena Martín-García; Rafael Maldonado
Published in: JCI - The Journal of Clinical Investigation, Issue 132/10, 2022, ISSN 1558-8238
Publisher: JCI
DOI: 10.1172/jci156281

Reduced heart rate variability is related to the number of metabolic syndrome components and manifest diabetes in the sixth Tromsø study 2007–2008

Author(s): Naomi Azulay; Roy Bjørkholt Olsen; Christopher Sivert Nielsen; Audun Stubhaug; Trond Geir Jenssen; Henrik Schirmer; Arnoldo Frigessi; Leiv Arne Rosseland; Christian Tronstad
Published in: Scientific Reports, Issue 12/11998, 2022, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-022-15824-0

Gut microbiota steroid sexual dimorphism and its impact on gonadal steroids: influences of obesity and menopausal status

Author(s): Jordi Mayneris-Perxachs; Jordi Mayneris-Perxachs; María Arnoriaga-Rodríguez; María Arnoriaga-Rodríguez; Diego Luque-Córdoba; Diego Luque-Córdoba; Feliciano Priego-Capote; Feliciano Priego-Capote; Vicente Pérez-Brocal; Andrés Moya; Aurelijus Burokas; Aurelijus Burokas; Rafael Maldonado; José Manuel Fernández-Real; José Manuel Fernández-Real
Published in: Microbiome, Issue 8/136, 2020, Page(s) 1-15, ISSN 2049-2618
Publisher: BioMed Central (BMC, Part of Springer Nature
DOI: 10.1186/s40168-020-00913-x

A genome-wide meta-analysis uncovers six sequence variants conferring risk of vertigo

Author(s): Astros Th. Skuladottir, Gyda Bjornsdottir, Muhammad Sulaman Nawaz, Hannes Petersen, Solvi Rognvaldsson, Kristjan Helgi Swerford Moore, Pall I. Olafsson, Sigurður H. Magnusson, Anna Bjornsdottir, Olafur A. Sveinsson, Gudrun R. Sigurdardottir, Saedis Saevarsdottir, Erna V. Ivarsdottir, Lilja Stefansdottir, Bjarni Gunnarsson, Joseph B. Muhlestein, Kirk U. Knowlton, David A. Jones, Lincoln D. Nadauld
Published in: Communications Biology, Issue 4/1148, 2021, ISSN 2399-3642
Publisher: Springer Nature
DOI: 10.1038/s42003-021-02673-2

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