Molecular Mechanisms Associating Chronic Pain with Fatigue, Affective Disorders, Cardiovascular Disease and Total Comorbidity

Informazioni relative al progetto

PainFACT

ID dell’accordo di sovvenzione: 848099

DOI

10.3030/848099

Progetto chiuso

Data della firma CE 22 Novembre 2019

Data di avvio 1 Gennaio 2020

Data di completamento 31 Dicembre 2025

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale

€ 7 464 296,25

Contributo UE

€ 6 000 000,00

Coordinato da

FOLKEHELSEINSTITUTTET
Norway

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Open Research Data Pilot (1)

Data Management Plan delivered in accordance with FAIR principles to EC

For this deliverable we will develop harmonization protocols, i.e. develop technical and semantic data standards, and quality protocols to unify and bridge the different coding standards of target variables between databases. It will also define guidelines for addressing differences in data management systems and routines, and MR image quality control procedures to secure the efficient application and utilization of the data transfer, storage and processing system. The team will also ensure that the consortiums policy regarding gender issues is correctly implemented.

Documents, reports (1)

Quality Assurance and risk analysis procedures delivered upon establishment of a functional Project Administration

The purpose of this deliverable is to describe established procedures to recover the PainFACT project following a disruption or alert of malfunction in respect to the GA, the CA and or the agreed Work Plan, if such an event were to occur. The rapprot will consit of: theoretical framework for the PainFACT Contingency Plan; risk descriptions and contingency actions and a template to report on the activation and closing of the Contingency Plan.

Pubblicazioni

Peer reviewed articles (14)

Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles

Autori: Heidi Hautakangas, Bendik S. Winsvold, Sanni E. Ruotsalainen, Gyda Bjornsdottir, Aster V. E. Harder, Lisette J. A. Kogelman, Laurent F. Thomas, Raymond Noordam, Christian Benner, Padhraig Gormley, Ville Artto, Karina Banasik, Anna Bjornsdottir, Dorret I. Boomsma, Ben M. Brumpton, Kristoffer Sølvsten Burgdorf, Julie E. Buring, Mona Ameri Chalmer, Irene de Boer, Martin Dichgans, Christian Erikstrup
Pubblicato in: Nature Genetics, Numero 54, 2022, Pagina/e 152-160, ISSN 1546-1718
Editore: Nature Genetics
DOI: 10.1038/s41588-021-00990-0

Variant in a Taste Receptor Locus Tied to Changes in the Use of Insomnia Medication

Autori: Gudmundur Einarsson, Hannes K. Arnason, Rosa S. Gisladottir, Gyda Bjornsdottir, Thorgeir E. Thorgeirsson, Astros Skuladottir, G. Bragi Walters, Saedis Saevarsdottir, Magnus K. Magnusson, Gisli H. Halldorsson, Audunn S. Snaebjarnarson, Hafsteinn Einarsson, Gardar Sveinbjornsson, Hannes Helgason, Vinicius Tragante, Gudrun A. Jonsdottir, Hildur M. Aegisdottir, Ingileif Jonsdottir, Thorarinn Gislason,
Pubblicato in: Biological Psychiatry Global Open Science, Numero 6, 2026, Pagina/e 100652, ISSN 2667-1743
Editore: Elsevier BV
DOI: 10.1016/j.bpsgos.2025.100652

Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology

Autori: Bjornsdottir, Gyda; Stefánsdóttir, Lilja; Thorleifsson, Gudmar; Sulem, Patrick; Norland, Kristjan; Ferkingstad, Egil; Oddsson, Asmundur; Zink, Florian; Lund, Sigrun H.; Nawaz, Muhammad S.; Bragi Walters, G.; Skuladottir, Astros Th.; Gudjonsson, Sigurjon A.; Einarsson, Gudmundur; Halldorsson, Gisli H.; Bjarnadottir, Valgerdur; Sveinbjornsson, Gardar; Helgadottir, Anna; Styrkársdóttir, Unnur; Gu
Pubblicato in: Nature Communications, Numero 13/634, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-28167-1

Thirty novel sequence variants impacting human intracranial volume

Autori: Muhammad Sulaman Nawaz, Gudmundur Einarsson, Mariana Bustamante, Rosa S. Gisladottir, G. Bragi Walters, Gudrun A. Jonsdottir, Astros Th. Skuladottir, Gyda Bjornsdottir, Sigurdur H. Magnusson, Bergrun Asbjornsdottir, Unnur Unnsteinsdottir, Engilbert Sigurdsson, Palmi V. Jonsson, Vala Kolbrun Palmadottir, Sigurjon A. Gudjonsson,Gisli H. Halldorsson, Egil Ferkingstad, Ingileif Jonsdottir, Gudmar Tho
Pubblicato in: Brain Communications, Numero Volume 4, Numero 6, 2022, ISSN 2632-1297
Editore: Oxford Academic
DOI: 10.1093/braincomms/fcac271

Atherosclerosis burden correlates with acquired pain sensitivity in diversity outbred mice

Autori: Xiang Yi Kong, Sverre Holm, Andrea Rodriguez-Lopez, Beltran Alvarez-Perez, Rafael Maldonado, Laetitia Degiorgis, Laura Harsan, Christopher Nielsen, Bente Halvorsen
Pubblicato in: Atherosclerosis, Numero 407, 2025, Pagina/e 119803, ISSN 0021-9150
Editore: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2025.119803

A genome-wide meta-analysis identifies 50 genetic loci associated with carpal tunnel syndrome

Autori: Astros Th Skuladottir, Gyda Bjornsdottir, Egil Ferkingstad, Gudmundur Einarsson, Lilja Stefansdottir, Muhammad Sulaman Nawaz, Asmundur Oddsson, Thorunn A Olafsdottir, Saedis Saevarsdottir, G Bragi Walters, Sigurdur H Magnusson, Anna Bjornsdottir, Olafur A Sveinsson, Arnor Vikingsson , Thomas Folkmann Hansen, Rikke Louise Jacobsen, Christian Erikstrup, Michael Schwinn, Søren Brunak, Karina Banasik
Pubblicato in: Nature Communications, Numero 13(1):1598, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-29133-7

Rare variants with large effects provide functional insights into the pathology of migraine subtypes, with and without aura

Autori: Gyda Bjornsdottir, Mona A. Chalmer, Lilja Stefansdottir, Astros Th. Skuladottir, Gudmundur Einarsson, Margret Andresdottir, Doruk Beyter, Egil Ferkingstad, Solveig Gretarsdottir, Bjarni V. Halldorsson, Gisli H. Halldorsson, Anna Helgadottir, Hannes Helgason, Grimur Hjorleifsson Eldjarn, Adalbjorg Jonasdottir, Aslaug Jonasdottir, Ingileif Jonsdottir, Kirk U. Knowlton, Lincoln D. Nadauld, Sigrun H.
Pubblicato in: Nature Genetics, Numero 55, 2023, Pagina/e 1843-1853, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/s41588-023-01538-0

A meta-analysis uncovers the first sequence variant conferring risk of Bell’s palsy

Autori: Astros Th. Skuladottir, Gyda Bjornsdottir, Gudmar Thorleifsson, G. Bragi Walters, Muhammad Sulaman Nawaz, Kristjan Helgi Swerford Moore, Pall I. Olason, Thorgeir E. Thorgeirsson, Brynja Sigurpalsdottir, Gardar Sveinbjornsson, Hannes P. Eggertsson, Sigurdur H. Magnusson, Asmundur Oddsson, Anna Bjornsdottir, Arnor Vikingsson, Olafur A. Sveinsson, Maria G. Hrafnsdottir, Gudrun R. Sigurdardottir, Bjar
Pubblicato in: Scientific Reports, Numero 11/1, 2021, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-021-82736-w

Reduced heart rate variability is related to the number of metabolic syndrome components and manifest diabetes in the sixth Tromsø study 2007–2008

Autori: Naomi Azulay; Roy Bjørkholt Olsen; Christopher Sivert Nielsen; Audun Stubhaug; Trond Geir Jenssen; Henrik Schirmer; Arnoldo Frigessi; Leiv Arne Rosseland; Christian Tronstad
Pubblicato in: Scientific Reports, Numero 12/11998, 2022, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-022-15824-0

Cluster Headache Genomewide Association Study and Meta‐Analysis Identifies Eight Loci and Implicates Smoking as Causal Risk Factor

Autori: Bendik S. Winsvold, Aster V. E. Harder, Caroline Ran, Mona A. Chalmer, Maria Carolina Dalmasso, Egil Ferkingstad, Kumar Parijat Tripathi, Elena Bacchelli, Sigrid Børte, Carmen Fourier, Anja S. Petersen, Lisanne S. Vijfhuizen, Sigurdur H. Magnusson, Emer O'Connor, Gyda Bjornsdottir, Paavo Häppölä, Yen‐Feng Wang, Ida Callesen, Tim Kelderman, Victor J Gallardo, Irene de Boer, Felicia Jennysdott
Pubblicato in: Annals of Neurology, Numero 94, 2023, Pagina/e 713-726, ISSN 0364-5134
Editore: John Wiley & Sons Inc.
DOI: 10.1002/ana.26743

Missense variants in FRS3 affect body mass index in populations of diverse ancestries

Autori: Andrea B. Jonsdottir, Gardar Sveinbjornsson, Rosa B. Thorolfsdottir, Max Tamlander, Vinicius Tragante, Thorhildur Olafsdottir, Solvi Rognvaldsson, Asgeir Sigurdsson, Hannes P. Eggertsson, Hildur M. Aegisdottir, David O. Arnar, Karina Banasik, Doruk Beyter, Ragnar G. Bjarnason, Gyda Bjornsdottir, Søren Brunak, Mie Topholm Bruun, Joseph Dowsett, Eythor Einarsson, Gudmundur Einarsson, Christian Erik
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-025-57753-2

A genome-wide meta-analysis uncovers six sequence variants conferring risk of vertigo

Autori: Astros Th. Skuladottir, Gyda Bjornsdottir, Muhammad Sulaman Nawaz, Hannes Petersen, Solvi Rognvaldsson, Kristjan Helgi Swerford Moore, Pall I. Olafsson, Sigurður H. Magnusson, Anna Bjornsdottir, Olafur A. Sveinsson, Gudrun R. Sigurdardottir, Saedis Saevarsdottir, Erna V. Ivarsdottir, Lilja Stefansdottir, Bjarni Gunnarsson, Joseph B. Muhlestein, Kirk U. Knowlton, David A. Jones, Lincoln D. Nadauld
Pubblicato in: Communications Biology, Numero 4, 2022, ISSN 2399-3642
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s42003-021-02673-2

Pain tolerance after stroke: The Tromsø study

Autori: Tonje Anita Melum, Anders P. Årnes, Hein Stigum, Audun Stubhaug, Ólöf Anna Steingrímsdóttir, Ellisiv B. Mathiesen, Christopher S. Nielsen
Pubblicato in: European Journal of Pain, Numero 27, 2023, Pagina/e 912-921, ISSN 1090-3801
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1002/ejp.2124

Genome-wide association meta-analysis of knee and hip osteoarthritis uncovers genetic differences between patients treated with joint replacement and patients without joint replacement

Autori: Cecilie Henkel, Unnur Styrkársdóttir, Gudmar Thorleifsson, Lilja Stefánsdóttir, Gyda Björnsdóttir, Karina Banasik, Søren Brunak, Christian Erikstrup, Khoa Manh Dinh, Thomas Folkmann Hansen, Kaspar René Nielsen, Mie Topholm Bruun, Joseph Dowsett, Thorsten Brodersen, Thorgeir E Thorgeirsson, Kirill Gromov, Mikael Ploug Boesen, Henrik Ullum, Sisse Rye Ostrowski, Ole Birger Pedersen, Kári Ste
Pubblicato in: Annals of the Rheumatic Diseases, Numero 82, 2025, Pagina/e 384-392, ISSN 0003-4967
Editore: BMJ Publishing Group
DOI: 10.1136/ard-2022-223199