Molecular Mechanisms Associating Chronic Pain with Fatigue, Affective Disorders, Cardiovascular Disease and Total Comorbidity

Informations projet

PainFACT

N° de convention de subvention: 848099

DOI

10.3030/848099

Projet clôturé

Date de signature de la CE 22 Novembre 2019

Date de début 1 Janvier 2020

Date de fin 31 Decembre 2025

Financé au titre de

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coût total

€ 7 464 296,25

Contribution de l’UE

€ 6 000 000,00

Coordonné par

FOLKEHELSEINSTITUTTET
Norway

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Open Research Data Pilot (1)

Data Management Plan delivered in accordance with FAIR principles to EC

For this deliverable we will develop harmonization protocols, i.e. develop technical and semantic data standards, and quality protocols to unify and bridge the different coding standards of target variables between databases. It will also define guidelines for addressing differences in data management systems and routines, and MR image quality control procedures to secure the efficient application and utilization of the data transfer, storage and processing system. The team will also ensure that the consortiums policy regarding gender issues is correctly implemented.

Documents, reports (1)

Quality Assurance and risk analysis procedures delivered upon establishment of a functional Project Administration

The purpose of this deliverable is to describe established procedures to recover the PainFACT project following a disruption or alert of malfunction in respect to the GA, the CA and or the agreed Work Plan, if such an event were to occur. The rapprot will consit of: theoretical framework for the PainFACT Contingency Plan; risk descriptions and contingency actions and a template to report on the activation and closing of the Contingency Plan.

Publications

Peer reviewed articles (14)

Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles

Auteurs: Heidi Hautakangas, Bendik S. Winsvold, Sanni E. Ruotsalainen, Gyda Bjornsdottir, Aster V. E. Harder, Lisette J. A. Kogelman, Laurent F. Thomas, Raymond Noordam, Christian Benner, Padhraig Gormley, Ville Artto, Karina Banasik, Anna Bjornsdottir, Dorret I. Boomsma, Ben M. Brumpton, Kristoffer Sølvsten Burgdorf, Julie E. Buring, Mona Ameri Chalmer, Irene de Boer, Martin Dichgans, Christian Erikstrup
Publié dans: Nature Genetics, Numéro 54, 2022, Page(s) 152-160, ISSN 1546-1718
Éditeur: Nature Genetics
DOI: 10.1038/s41588-021-00990-0

Variant in a Taste Receptor Locus Tied to Changes in the Use of Insomnia Medication

Auteurs: Gudmundur Einarsson, Hannes K. Arnason, Rosa S. Gisladottir, Gyda Bjornsdottir, Thorgeir E. Thorgeirsson, Astros Skuladottir, G. Bragi Walters, Saedis Saevarsdottir, Magnus K. Magnusson, Gisli H. Halldorsson, Audunn S. Snaebjarnarson, Hafsteinn Einarsson, Gardar Sveinbjornsson, Hannes Helgason, Vinicius Tragante, Gudrun A. Jonsdottir, Hildur M. Aegisdottir, Ingileif Jonsdottir, Thorarinn Gislason,
Publié dans: Biological Psychiatry Global Open Science, Numéro 6, 2026, Page(s) 100652, ISSN 2667-1743
Éditeur: Elsevier BV
DOI: 10.1016/j.bpsgos.2025.100652

Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology

Auteurs: Bjornsdottir, Gyda; Stefánsdóttir, Lilja; Thorleifsson, Gudmar; Sulem, Patrick; Norland, Kristjan; Ferkingstad, Egil; Oddsson, Asmundur; Zink, Florian; Lund, Sigrun H.; Nawaz, Muhammad S.; Bragi Walters, G.; Skuladottir, Astros Th.; Gudjonsson, Sigurjon A.; Einarsson, Gudmundur; Halldorsson, Gisli H.; Bjarnadottir, Valgerdur; Sveinbjornsson, Gardar; Helgadottir, Anna; Styrkársdóttir, Unnur; Gu
Publié dans: Nature Communications, Numéro 13/634, 2022, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-022-28167-1

Thirty novel sequence variants impacting human intracranial volume

Auteurs: Muhammad Sulaman Nawaz, Gudmundur Einarsson, Mariana Bustamante, Rosa S. Gisladottir, G. Bragi Walters, Gudrun A. Jonsdottir, Astros Th. Skuladottir, Gyda Bjornsdottir, Sigurdur H. Magnusson, Bergrun Asbjornsdottir, Unnur Unnsteinsdottir, Engilbert Sigurdsson, Palmi V. Jonsson, Vala Kolbrun Palmadottir, Sigurjon A. Gudjonsson,Gisli H. Halldorsson, Egil Ferkingstad, Ingileif Jonsdottir, Gudmar Tho
Publié dans: Brain Communications, Numéro Volume 4, Numéro 6, 2022, ISSN 2632-1297
Éditeur: Oxford Academic
DOI: 10.1093/braincomms/fcac271

Atherosclerosis burden correlates with acquired pain sensitivity in diversity outbred mice

Auteurs: Xiang Yi Kong, Sverre Holm, Andrea Rodriguez-Lopez, Beltran Alvarez-Perez, Rafael Maldonado, Laetitia Degiorgis, Laura Harsan, Christopher Nielsen, Bente Halvorsen
Publié dans: Atherosclerosis, Numéro 407, 2025, Page(s) 119803, ISSN 0021-9150
Éditeur: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2025.119803

A genome-wide meta-analysis identifies 50 genetic loci associated with carpal tunnel syndrome

Auteurs: Astros Th Skuladottir, Gyda Bjornsdottir, Egil Ferkingstad, Gudmundur Einarsson, Lilja Stefansdottir, Muhammad Sulaman Nawaz, Asmundur Oddsson, Thorunn A Olafsdottir, Saedis Saevarsdottir, G Bragi Walters, Sigurdur H Magnusson, Anna Bjornsdottir, Olafur A Sveinsson, Arnor Vikingsson , Thomas Folkmann Hansen, Rikke Louise Jacobsen, Christian Erikstrup, Michael Schwinn, Søren Brunak, Karina Banasik
Publié dans: Nature Communications, Numéro 13(1):1598, 2022, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-022-29133-7

Rare variants with large effects provide functional insights into the pathology of migraine subtypes, with and without aura

Auteurs: Gyda Bjornsdottir, Mona A. Chalmer, Lilja Stefansdottir, Astros Th. Skuladottir, Gudmundur Einarsson, Margret Andresdottir, Doruk Beyter, Egil Ferkingstad, Solveig Gretarsdottir, Bjarni V. Halldorsson, Gisli H. Halldorsson, Anna Helgadottir, Hannes Helgason, Grimur Hjorleifsson Eldjarn, Adalbjorg Jonasdottir, Aslaug Jonasdottir, Ingileif Jonsdottir, Kirk U. Knowlton, Lincoln D. Nadauld, Sigrun H.
Publié dans: Nature Genetics, Numéro 55, 2023, Page(s) 1843-1853, ISSN 1061-4036
Éditeur: Nature Publishing Group
DOI: 10.1038/s41588-023-01538-0

A meta-analysis uncovers the first sequence variant conferring risk of Bell’s palsy

Auteurs: Astros Th. Skuladottir, Gyda Bjornsdottir, Gudmar Thorleifsson, G. Bragi Walters, Muhammad Sulaman Nawaz, Kristjan Helgi Swerford Moore, Pall I. Olason, Thorgeir E. Thorgeirsson, Brynja Sigurpalsdottir, Gardar Sveinbjornsson, Hannes P. Eggertsson, Sigurdur H. Magnusson, Asmundur Oddsson, Anna Bjornsdottir, Arnor Vikingsson, Olafur A. Sveinsson, Maria G. Hrafnsdottir, Gudrun R. Sigurdardottir, Bjar
Publié dans: Scientific Reports, Numéro 11/1, 2021, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-021-82736-w

Reduced heart rate variability is related to the number of metabolic syndrome components and manifest diabetes in the sixth Tromsø study 2007–2008

Auteurs: Naomi Azulay; Roy Bjørkholt Olsen; Christopher Sivert Nielsen; Audun Stubhaug; Trond Geir Jenssen; Henrik Schirmer; Arnoldo Frigessi; Leiv Arne Rosseland; Christian Tronstad
Publié dans: Scientific Reports, Numéro 12/11998, 2022, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-022-15824-0

Cluster Headache Genomewide Association Study and Meta‐Analysis Identifies Eight Loci and Implicates Smoking as Causal Risk Factor

Auteurs: Bendik S. Winsvold, Aster V. E. Harder, Caroline Ran, Mona A. Chalmer, Maria Carolina Dalmasso, Egil Ferkingstad, Kumar Parijat Tripathi, Elena Bacchelli, Sigrid Børte, Carmen Fourier, Anja S. Petersen, Lisanne S. Vijfhuizen, Sigurdur H. Magnusson, Emer O'Connor, Gyda Bjornsdottir, Paavo Häppölä, Yen‐Feng Wang, Ida Callesen, Tim Kelderman, Victor J Gallardo, Irene de Boer, Felicia Jennysdott
Publié dans: Annals of Neurology, Numéro 94, 2023, Page(s) 713-726, ISSN 0364-5134
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/ana.26743

Missense variants in FRS3 affect body mass index in populations of diverse ancestries

Auteurs: Andrea B. Jonsdottir, Gardar Sveinbjornsson, Rosa B. Thorolfsdottir, Max Tamlander, Vinicius Tragante, Thorhildur Olafsdottir, Solvi Rognvaldsson, Asgeir Sigurdsson, Hannes P. Eggertsson, Hildur M. Aegisdottir, David O. Arnar, Karina Banasik, Doruk Beyter, Ragnar G. Bjarnason, Gyda Bjornsdottir, Søren Brunak, Mie Topholm Bruun, Joseph Dowsett, Eythor Einarsson, Gudmundur Einarsson, Christian Erik
Publié dans: Nature Communications, Numéro 16, 2025, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-025-57753-2

A genome-wide meta-analysis uncovers six sequence variants conferring risk of vertigo

Auteurs: Astros Th. Skuladottir, Gyda Bjornsdottir, Muhammad Sulaman Nawaz, Hannes Petersen, Solvi Rognvaldsson, Kristjan Helgi Swerford Moore, Pall I. Olafsson, Sigurður H. Magnusson, Anna Bjornsdottir, Olafur A. Sveinsson, Gudrun R. Sigurdardottir, Saedis Saevarsdottir, Erna V. Ivarsdottir, Lilja Stefansdottir, Bjarni Gunnarsson, Joseph B. Muhlestein, Kirk U. Knowlton, David A. Jones, Lincoln D. Nadauld
Publié dans: Communications Biology, Numéro 4, 2022, ISSN 2399-3642
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/s42003-021-02673-2

Pain tolerance after stroke: The Tromsø study

Auteurs: Tonje Anita Melum, Anders P. Årnes, Hein Stigum, Audun Stubhaug, Ólöf Anna Steingrímsdóttir, Ellisiv B. Mathiesen, Christopher S. Nielsen
Publié dans: European Journal of Pain, Numéro 27, 2023, Page(s) 912-921, ISSN 1090-3801
Éditeur: W. B. Saunders Co., Ltd.
DOI: 10.1002/ejp.2124

Genome-wide association meta-analysis of knee and hip osteoarthritis uncovers genetic differences between patients treated with joint replacement and patients without joint replacement

Auteurs: Cecilie Henkel, Unnur Styrkársdóttir, Gudmar Thorleifsson, Lilja Stefánsdóttir, Gyda Björnsdóttir, Karina Banasik, Søren Brunak, Christian Erikstrup, Khoa Manh Dinh, Thomas Folkmann Hansen, Kaspar René Nielsen, Mie Topholm Bruun, Joseph Dowsett, Thorsten Brodersen, Thorgeir E Thorgeirsson, Kirill Gromov, Mikael Ploug Boesen, Henrik Ullum, Sisse Rye Ostrowski, Ole Birger Pedersen, Kári Ste
Publié dans: Annals of the Rheumatic Diseases, Numéro 82, 2025, Page(s) 384-392, ISSN 0003-4967
Éditeur: BMJ Publishing Group
DOI: 10.1136/ard-2022-223199