Causative mechanisms & integrative models linking early-life-stress to psycho-cardio-metabolic multi-morbidity

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Structural equation model linking ELS to multi-morbidity outcomes

Structural equation model linking ELS to multimorbidity outcomes

Dissemination, communication & outreach strategy
Data management Plan version 2
Quantitative measures of ELS-induced metabolic alterations, endocrine response and cardiovascular parameters

Quantitative measures of ELSinduced metabolic alterations endocrine response and cardiovascular parameters

Data harmonisation process for public use
Project website and communication materials
Quantitative measures of ELS-induced behavioural symptoms

Quantitative measures of ELSinduced behavioural symptoms

Socio-economic impact assessment framework

Socioeconomic impact assessment framework

Data Coordination Centre
System for dataset incorporation into DCC

Data Management Plan version 1

Publications

Epigenetic Inheritance: Impact for Biology and Society

Auteurs: Arzate-Mejia, R. G and Mansuy, I.M.
Publié dans: Environmental Epigenetics, 2022, ISSN 2470-0991
Éditeur: Oxford University Press
DOI: 10.1093/eep/dvac021

Paternal body mass index and offspring DNA methylation: findings from the PACE consortium

Auteurs: Gemma C Sharp, Rossella Alfano, Akram Ghantous, Jose Urquiza, Sheryl L Rifas-Shiman, Christian M Page, Jianping Jin, Silvia Fernández-Barrés, Gillian Santorelli, Gwen Tindula, Gemma C Sharp, Rossella Alfano, Akram Ghantous, Jose Urquiza, Sheryl L Rifas-Shiman, Christian M Page, Jianping Jin, Silvia Fernández-Barrés, Gillian Santorelli, Gwen Tindula, Paul Yousefi, Leanne Kupers, Carlos Ruiz-Are
Publié dans: International Journal of Epidemiology, 2021, ISSN 0300-5771
Éditeur: Oxford University Press
DOI: 10.1093/ije/dyaa267

Brain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium.

Auteurs: Constantinides, C., Han, L. K., Alloza, C., Antonucci, L., Arango, C., Ayesa-Arriola, R., ... & Walton, E.
Publié dans: Molecular Psychiatry, 2023, ISSN 1359-4184
Éditeur: Nature Publishing Group
DOI: 10.1038/s41380-022-01897-w

Maternal Glycemic Dysregulation During Pregnancy and Neonatal Blood DNA Methylation: Meta-analyses of Epigenome-Wide Association Studies

Auteurs: Tobi EW, Juvinao-Quintero DL, Ronkainen J, Ott R, Alfano R, Canouil M, Geurtsen ML, Khamis A, Küpers LK, Lim IY, Perron P, Pesce G, Tuhkanen J, Starling AP, Andrew T, Binder E, Caiazzo R, Chan JKY, Gaillard R, Gluckman PD, Keikkala E, Karnani N, Mustaniemi S, Nawrot TS, Pattou F, Plusquin M, Raverdy V, Tan KH, Tzala E, Raikkonen K, Winkler C, Ziegler AG, Annesi-Maesano I, Bouchard L, Chong YS, Da
Publié dans: Diabetes Care, 2022, ISSN 1939-327X
Éditeur: American Diabetes Association
DOI: 10.2337/dc21-1701

Paternal transmission of behavioural and metabolic traits induced by postnatal stress to the 5th generation in mice.

Auteurs: Boscardin C., Manuella, F. and Mansuy, I.M.
Publié dans: Environmental Epigenetics, 2022, ISSN 2470-0991
Éditeur: Oxford University Press
DOI: 10.1093/eep/dvac024

Epigenetics of childhood trauma: Long-term sequelae and potential for treatment.

Auteurs: Thumfart, K., Jawaid, A., Bright, K., Flachsmann, M and Mansuy, I.M.
Publié dans: Neurosci Biobehav Rev, 2022, ISSN 0149-7634
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2021.10.042

Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation

Auteurs: Solomon O, Huen K, Yousefi P, Küpers LK, González JR, Suderman M, Reese SE, Page CM, Gruzieva O, Rzehak P, Gao L, Bakulski KM, Novoloaca A, Allard C, Pappa I, Llambrich M, Vives M, Jima DD, Kvist T, Baccarelli A, White C, Rezwan FI, Sharp GC, Tindula G, Bergström A, Grote V, Dou JF, Isaevska E, Magnus MC, Corpeleijn E, Perron P, Jaddoe VWV, Nohr EA, Maitre L, Foraster M, Hoyo C, Håberg SE, Lah
Publié dans: Mutat Res Rev Mutat Res, 2022, ISSN 1383-5742
Éditeur: Elsevier BV
DOI: 10.1016/j.mrrev.2022.108415

Long-term effects of early postnatal stress on Sertoli cells functions.

Auteurs: Thumfart, K, Lazzeri, S. Manuella F. and Mansuy, I.M.
Publié dans: Frontiers in Genetics, 2022, ISSN 1664-8021
Éditeur: Frontiers Media
DOI: 10.3389/fgene.2022.1024805

Maternal Psychological Problems During Pregnancy and Child Externalizing Problems: Moderated Mediation Model with Child Self-regulated Compliance and Polygenic Risk Scores for Aggression

Auteurs: Mannan Luo, Irene Pappa, Charlotte A. M. Cecil, Philip Jansen, Marinus H. van IJzendoorn, Rianne Kok
Publié dans: Child Psychiatry & Human Development, 2021, ISSN 0009-398X
Éditeur: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10578-021-01154-1

The association of early life stress with IQ-achievement discrepancy in children: A population-based study

Auteurs: Schuurmans IK, Luik AI, de Maat DA, Hillegers MHJ, Ikram MA & Cecil CAM
Publié dans: Child Development, 2022, ISSN 0009-3920
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/cdev.13825

Longitudinal associations of DNA methylation and sleep in children: a meta-analysis

Auteurs: Sara Sammallahti, M. Elisabeth Koopman-Verhoeff, Anne-Claire Binter, Rosa H. Mulder, Alba Cabré-Riera, Tuomas Kvist, Anni L. K. Malmberg, Giancarlo Pesce, Sabine Plancoulaine, Jonathan A. Heiss, Sheryl L. Rifas-Shiman, Stefan W. Röder, Anne P. Starling, Rory Wilson, Kathrin Guerlich, Kristine L. Haftorn, Christian M. Page, Annemarie I. Luik, Henning Tiemeier, Janine F. Felix, Katri Raikkonen, Ja
Publié dans: Clinical Epigenetics, 2022, ISSN 1868-7075
Éditeur: Springer Verlag
DOI: 10.1186/s13148-022-01298-4

Emotion Processing Differences Mediate the Link between Sex and Autistic Traits in Young Adulthood

Auteurs: Lucy A. Livingston, Lucy H. Waldren, Esther Walton, Punit Shah
Publié dans: JCPP Advances, 2022, ISSN 1469-7610
Éditeur: Wiley
DOI: 10.1002/jcv2.12096

Epigenomics of being bullied: changes in DNA methylation following bullying exposure

Auteurs: Rosa H. Mulder, Esther Walton, Alexander Neumann, Lotte C. Houtepen, Janine F. Felix, Marian J. Bakermans-Kranenburg, Matthew Suderman, Henning Tiemeier, Marinus H. van IJzendoorn, Caroline L. Relton, Charlotte A. M. Cecil
Publié dans: Epigenetics, Numéro 15/6-7, 2020, Page(s) 750-764, ISSN 1559-2294
Éditeur: Landes Bioscience
DOI: 10.1080/15592294.2020.1719303

Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills

Auteurs: Caramaschi D, Neumann A, Cardenas A, Tindula G, Alemany S, Zillich L, Pesce G, Lahti JMT, Havdahl A, Mulder R, Felix JF, Tiemeier H, Sirignano L, Frank J, Witt SH, Rietschel M, Deuschle M, Huen K, Eskenazi B, Send TS, Ferrer M, Gilles M, de Agostini M, Baïz N, Rifas-Shiman SL, Kvist T, Czamara D, Tuominen ST, Relton CL, Rai D, London SJ, Räikkönen K, Holland N, Annesi-Maesano I, Streit F, Hiver
Publié dans: Molecular psychiatry, 2022, ISSN 1359-4184
Éditeur: Nature Publishing Group
DOI: 10.1038/s41380-022-01441-w

Childhood maltreatment and DNA methylation: A systematic review

Auteurs: Charlotte A.M. Cecil, Yuning Zhang, Tobias Nolte
Publié dans: Neuroscience & Biobehavioral Reviews, Numéro 112, 2020, Page(s) 392-409, ISSN 0149-7634
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2020.02.019

Epigenome-wide associations between observed maternal sensitivity and offspring DNA methylation: a population-based prospective study in children

Auteurs: Lorenza Dall’ Aglio, Jolien Rijlaarsdam, Rosa H. Mulder, Alexander Neumann, Janine F. Felix, Rianne Kok, Marian J. Bakermans-Kranenburg, Marinus H. van Ijzendoorn, Henning Tiemeier, Charlotte A.M. Cecil
Publié dans: Psychological Medicine, 2020, Page(s) 1-11, ISSN 0033-2917
Éditeur: Cambridge University Press
DOI: 10.1017/s0033291720004353

Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation

Auteurs: Sara Sammallahti, Andrea P. Cortes Hidalgo, Samuli Tuominen, Anni Malmberg, Rosa H. Mulder, Kelly J. Brunst, Silvia Alemany, Nancy S. McBride, Paul Yousefi, Jonathan A. Heiss, Nia McRae, Christian M. Page, Jianping Jin, Giancarlo Pesce, Doretta Caramaschi, Sheryl L. Rifas-Shiman, Nastassja Koen, Charleen D. Adams, Maria C. Magnus, Nour Baïz, Andrew Ratanatharathorn, Darina Czamara, Siri E. Håber
Publié dans: Molecular Psychiatry, 2020, ISSN 1359-4184
Éditeur: Nature Publishing Group
DOI: 10.1038/s41380-020-00976-0

Identifying causative mechanisms linking early-life stress to psycho-cardio-metabolic multi-morbidity: The EarlyCause project

Auteurs: Nicole Mariani, Alessandra Borsini, Charlotte A. M. Cecil, Janine F. Felix, Sylvain Sebert, Annamaria Cattaneo, Esther Walton, Yuri Milaneschi, Guy Cochrane, Clara Amid, Jeena Rajan, Juliette Giacobbe, Yolanda Sanz, Ana Agustí, Tania Sorg, Yann Herault, Jouko Miettunen, Priyanka Parmar, Nadia Cattane, Vincent Jaddoe, Jyrki Lötjönen, Carme Buisan, Miguel A. González Ballester, Gemma Piella, Jos
Publié dans: PLOS ONE, Numéro 16/1, 2021, Page(s) e0245475, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0245475

The determinants and longitudinal changes in vitamin D status in middle-age: a Northern Finland Birth Cohort 1966 study

Auteurs: Helmi Ikonen, Johanna Lumme, Jussi Seppälä, Paula Pesonen, Terhi Piltonen, Marjo-Riitta Järvelin, Karl-Heinz Herzig, Jouko Miettunen, Maarit Niinimäki, Saranya Palaniswamy, Sylvain Sebert, Marja Ojaniemi
Publié dans: European Journal of Nutrition, 2021, ISSN 1436-6207
Éditeur: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00394-021-02606-z

Associations between T cells and attention problems in the general pediatric population: the Generation R Study.

Auteurs: Looman KIM, Cecil CAM, Grosserichter-Wagener C, Kiefte de Jong JC, van Zelm MC & Moll HA
Publié dans: JCPP Advances, 2022, ISSN 1469-7610
Éditeur: Wiley
DOI: 10.1002/jcv2.12038

Brain Structure in Acutely Underweight and Partially Weight-Restored Individuals With Anorexia Nervosa: A Coordinated Analysis by the ENIGMA Eating Disorders Working Group

Auteurs: Walton, E., Bernardoni, F., Batury, V. L., Bahnsen, K., Larivière, S., Abbate-Daga, G., ... & Ehrlich, S. (2022).
Publié dans: Biological Psychiatry, 2022, ISSN 0006-3223
Éditeur: Elsevier BV
DOI: 10.1016/j.biopsych.2022.04.022

Epigenetics applied to child and adolescent mental health: Progress, challenges and opportunities

Auteurs: Cecil C, Neumann A, Walton E
Publié dans: JCPP Advances, 2022, ISSN 1469-7610
Éditeur: Wiley
DOI: 10.1002/jcv2.12133

Schizophrenia polygenic risk is associated with child mental health problems through early childhood adversity: evidence for a gene–environment correlation

Auteurs: Koen Bolhuis, Lisa R. Steenkamp, Laura M. E. Blanken, Alexander Neumann, Philip R. Jansen, Manon H. J. Hillegers, Charlotte A. M. Cecil, Henning Tiemeier, Steven A. Kushner
Publié dans: European Child & Adolescent Psychiatry, 2021, ISSN 1018-8827
Éditeur: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00787-021-01727-4

Genome-wide DNA methylation patterns associated with general psychopathology in children

Auteurs: Jolien Rijlaarsdam, Edward D. Barker, Chiara Caserini, M. Elisabeth Koopman-Verhoeff, Rosa H. Mulder, Janine F. Felix, Charlotte A.M. Cecil
Publié dans: Journal of Psychiatric Research, Numéro 140, 2021, Page(s) 214-220, ISSN 0022-3956
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.jpsychires.2021.05.029

Epigenetics and ADHD: Reflections on Current Knowledge, Research Priorities and Translational Potential

Auteurs: Cecil CAM & Nigg JT
Publié dans: Molecular Diagnosis & Therapy, 2022, ISSN 1177-1062
Éditeur: Adis International Ltd.
DOI: 10.1007/s40291-022-00609-y

Single-cell multiomics techniques: from conception to applications.

Auteurs: Dimitriu, M, Lazar-Contes, I., Roszkowski, M. and Mansuy, I.M.
Publié dans: Front. Cell. Dev. Biol., 2022, ISSN 2296-634X
Éditeur: Frontiers in Cell and Developmental Biology
DOI: 10.3389/fcell.2022.854317

Association of Maternal Tobacco Use During Pregnancy With Preadolescent Brain Morphology Among Offspring

Auteurs: Zou R, Boer OD, Felix JF, Muetzel R, Franken IHA, Cecil CAM & El Marroun H .
Publié dans: JAMA Network Open., 2022, ISSN 2574-3805
Éditeur: JAMA network open
DOI: 10.1001/jamanetworkopen.2022.24701

The European Nucleotide Archive in 2020

Auteurs: Peter W Harrison, Alisha Ahamed, Raheela Aslam, Blaise T F Alako, Josephine Burgin, Nicola Buso, Mélanie Courtot, Jun Fan, Dipayan Gupta, Muhammad Haseeb, Sam Holt, Talal Ibrahim, Eugene Ivanov, Suran Jayathilaka, Vishnukumar Balavenkataraman Kadhirvelu, Manish Kumar, Rodrigo Lopez, Simon Kay, Rasko Leinonen, Xin Liu, Colman O’Cathail, Amir Pakseresht, Youngmi Park, Stephane Pesant, Nadim Rahm
Publié dans: Nucleic Acids Research, Numéro 49/D1, 2020, Page(s) D82-D85, ISSN 0305-1048
Éditeur: Oxford University Press
DOI: 10.1093/nar/gkaa1028

Complete Genome Sequence of Phascolarctobacterium faecium G 104, Isolated from the Stools of a Healthy Lean Donor

Auteurs: Sadjia Rachek, Naghmeh Nikpoor, Eva M. Gómez del Pulgar, Aitor Gonzaga, Yolanda Sanz, Thomas A. Tompkins
Publié dans: Microbiology Resource Announcements, Numéro 10/4, 2021, ISSN 2576-098X
Éditeur: ASM Journals (American Society for Microbiology)
DOI: 10.1128/mra.01054-20

Family Aggression Screening Tool (FAST): factor structure and psychometric properties of subscales.

Auteurs: Vieira R, Pires PP, Cecil CAM, Barker E, Reis D, Couto I, Cypriano C & de Oliveira IR.
Publié dans: Child Abuse & Neglect, 2022, ISSN 0145-2134
Éditeur: Elsevier BV
DOI: 10.1016/j.chiabu.2022.105548

Mapping gene by early life stress interactions on child subcortical brain structures: A genome-wide prospective study.

Auteurs: Bolhuis K*, Mulder RH*, de Mol CL, Defina S, Warrier V, White T, Tiemeier H, Muetzel RL & Cecil CAM†
Publié dans: JCPP Advances, 2022, ISSN 0021-9630
Éditeur: Blackwell Publishing Inc.
DOI: 10.1002/jcv2.12113

Examining the epigenetic mechanisms of childhood adversity and sensitive periods: a gene set-based approach

Auteurs: Zhu, Y., Lussier, A. A., Smith, A. D., Simpkin, A. J., Suderman, M. J., Walton, E., ... & Dunn, E. C. (2022). Examining the epigenetic mechanisms of childhood adversity and sensitive periods: a gene set-based approach. Psychoneuroendocrinology, 144, 105854.
Publié dans: Psychoneuroendocrinology, 2022, ISSN 0306-4530
Éditeur: Pergamon Press
DOI: 10.1016/j.psyneuen.2022.105854

Obesity and brain structure in schizophrenia - ENIGMA study in 3021 individuals

Auteurs: McWhinney, S.R., Brosch, K., Calhoun, V.D. et al.
Publié dans: Molecular Psychiatry, 2022, ISSN 1359-4184
Éditeur: Nature Publishing Group
DOI: 10.1038/s41380-022-01616-5

Child mental health problems as a risk factor for academic underachievement: a multi-informant, population-based study.

Auteurs: Schuurmans IK, Tamayo Martinez N, Blok E, Hillegers MHJ, Ikram MA, Luik AI & Cecil CAM
Publié dans: Acta Psychiatrica Scandinavica, 2022, ISSN 0001-690X
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/acps.13426

Epigenome-wide change and variation in DNA methylation in childhood: trajectories from birth to late adolescence

Auteurs: Rosa H Mulder, Alexander Neumann, Charlotte A M Cecil, Esther Walton, Lotte C Houtepen, Andrew J Simpkin, Jolien Rijlaarsdam, Bastiaan T Heijmans, Tom R Gaunt, Janine F Felix, Vincent W V Jaddoe, Marian J Bakermans-Kranenburg, Henning Tiemeier, Caroline L Relton, Marinus H van IJzendoorn, Matthew Suderman
Publié dans: Human Molecular Genetics, Numéro 30/1, 2021, Page(s) 119-134, ISSN 0964-6906
Éditeur: Oxford University Press
DOI: 10.1093/hmg/ddaa280

The gut microbiome and child mental health: a population-based study.

Auteurs: Kraaij R, Schuurmans IK, Radjabzadeh D, Tiemeier H, Dinan TG, Uitterlinden AG, Hillegers M, Jaddoe VWV, Duijts L, Moll H, Rivadeneira F, Medina-Gomez C, Jansen PW, Cecil CAM†
Publié dans: Brain, Behavior and Immunity, 2023, ISSN 0889-1591
Éditeur: Academic Press
DOI: 10.1016/j.bbi.2022.12.006

Neonatal DNA methylation and childhood low prosocial behavior: An epigenome‐wide association meta‐analysis

Auteurs: Mannan Luo, Alan J. Meehan, Esther Walton, Stefan Röder, Gunda Herberth, Ana C. Zenclussen, Marta Cosín‐Tomás, Jordi Sunyer, Rosa H. Mulder, Andrea P. Cortes Hidalgo, Marian J. Bakermans‐Kranenburg, Janine F. Felix, Caroline Relton, Matthew Suderman, Irene Pappa, Rianne Kok, Henning Tiemeier, Marinus H. IJzendoorn, Edward D. Barker, Charlotte A. M. Cecil
Publié dans: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Numéro 186/4, 2021, Page(s) 228-241, ISSN 1552-4841
Éditeur: Wiley-Liss Inc
DOI: 10.1002/ajmg.b.32862

Long-Term Impact of Social Isolation and Molecular Underpinnings

Auteurs: Rodrigo G. Arzate-Mejía, Zuzanna Lottenbach, Vincent Schindler, Ali Jawaid, Isabelle M. Mansuy
Publié dans: Frontiers in Genetics, Numéro 11, 2020, ISSN 1664-8021
Éditeur: Frontiers Media
DOI: 10.3389/fgene.2020.589621

Effectiveness of psychological and/or educational interventions in reducing anxiety and depression in people with type 2 diabetes: A systematic review and meta-analysis

Auteurs: Kristina M.Thumfarta, Ali Jawaidab, Kristina Bright, Marc Flachsmann, Isabelle M.Mansuy
Publié dans: Diabetes Research and Clinical Practice, 2021, ISSN 0168-8227
Éditeur: Elsevier BV
DOI: 10.1016/j.diabres.2021.108922

Associations of Hair Cortisol Concentrations With Cardiometabolic Risk Factors in Childhood

Auteurs: Florianne O L Vehmeijer, Susana Santos, Yolanda B de Rijke, Erica L T van den Akker, Janine F Felix, Elisabeth F C van Rossum, Vincent W V Jaddoe
Publié dans: The Journal of Clinical Endocrinology & Metabolism, 2021, ISSN 0021-972X
Éditeur: The Endocrine Society
DOI: 10.1210/clinem/dgab379

Gene–environment correlations and causal effects of childhood maltreatment on physical and mental health: a genetically informed approach

Auteurs: Varun Warrier, Alex S F Kwong, Mannan Luo, Shareefa Dalvie, Jazz Croft, Hannah M Sallis, Jessie Baldwin, Marcus R Munafò, Caroline M Nievergelt, Andrew J Grant, Stephen Burgess, Tyler M Moore, Ran Barzilay, Andrew McIntosh, Marinus H van IJzendoorn, Charlotte A M Cecil
Publié dans: The Lancet Psychiatry, Numéro 8/5, 2021, Page(s) 373-386, ISSN 2215-0366
Éditeur: Elsevier Limited
DOI: 10.1016/s2215-0366(20)30569-1

ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries

Auteurs: Paul M. Thompson, Neda Jahanshad, Christopher R. K. Ching, Lauren E. Salminen, Sophia I. Thomopoulos, Joanna Bright, Bernhard T. Baune, Sara Bertolín, Janita Bralten, Willem B. Bruin, Robin Bülow, Jian Chen, Yann Chye, Udo Dannlowski, Carolien G. F. de Kovel, Gary Donohoe, Lisa T. Eyler, Stephen V. Faraone, Pauline Favre, Courtney A. Filippi, Thomas Frodl, Daniel Garijo, Yolanda Gil, Hans J. Gra
Publié dans: Translational Psychiatry, Numéro 10/1, 2020, ISSN 2158-3188
Éditeur: Nature Publishing Group
DOI: 10.1038/s41398-020-0705-1

Wir können unsere Gene steuern!

Auteurs: Mansuy, I.M., Gurret, J.M. Lelief, A.
Publié dans: 2020
Éditeur: Berlin Verlag

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