Causative mechanisms & integrative models linking early-life-stress to psycho-cardio-metabolic multi-morbidity

Risultati finali

Structural equation model linking ELS to multi-morbidity outcomes

Structural equation model linking ELS to multimorbidity outcomes

Dissemination, communication & outreach strategy
Data management Plan version 2
Quantitative measures of ELS-induced metabolic alterations, endocrine response and cardiovascular parameters

Quantitative measures of ELSinduced metabolic alterations endocrine response and cardiovascular parameters

Data harmonisation process for public use
Project website and communication materials
Quantitative measures of ELS-induced behavioural symptoms

Quantitative measures of ELSinduced behavioural symptoms

Socio-economic impact assessment framework

Socioeconomic impact assessment framework

Data Coordination Centre
System for dataset incorporation into DCC

Data Management Plan version 1

Pubblicazioni

Epigenetic Inheritance: Impact for Biology and Society

Autori: Arzate-Mejia, R. G and Mansuy, I.M.
Pubblicato in: Environmental Epigenetics, 2022, ISSN 2470-0991
Editore: Oxford University Press
DOI: 10.1093/eep/dvac021

Paternal body mass index and offspring DNA methylation: findings from the PACE consortium

Autori: Gemma C Sharp, Rossella Alfano, Akram Ghantous, Jose Urquiza, Sheryl L Rifas-Shiman, Christian M Page, Jianping Jin, Silvia Fernández-Barrés, Gillian Santorelli, Gwen Tindula, Gemma C Sharp, Rossella Alfano, Akram Ghantous, Jose Urquiza, Sheryl L Rifas-Shiman, Christian M Page, Jianping Jin, Silvia Fernández-Barrés, Gillian Santorelli, Gwen Tindula, Paul Yousefi, Leanne Kupers, Carlos Ruiz-Are
Pubblicato in: International Journal of Epidemiology, 2021, ISSN 0300-5771
Editore: Oxford University Press
DOI: 10.1093/ije/dyaa267

Brain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium.

Autori: Constantinides, C., Han, L. K., Alloza, C., Antonucci, L., Arango, C., Ayesa-Arriola, R., ... & Walton, E.
Pubblicato in: Molecular Psychiatry, 2023, ISSN 1359-4184
Editore: Nature Publishing Group
DOI: 10.1038/s41380-022-01897-w

Maternal Glycemic Dysregulation During Pregnancy and Neonatal Blood DNA Methylation: Meta-analyses of Epigenome-Wide Association Studies

Autori: Tobi EW, Juvinao-Quintero DL, Ronkainen J, Ott R, Alfano R, Canouil M, Geurtsen ML, Khamis A, Küpers LK, Lim IY, Perron P, Pesce G, Tuhkanen J, Starling AP, Andrew T, Binder E, Caiazzo R, Chan JKY, Gaillard R, Gluckman PD, Keikkala E, Karnani N, Mustaniemi S, Nawrot TS, Pattou F, Plusquin M, Raverdy V, Tan KH, Tzala E, Raikkonen K, Winkler C, Ziegler AG, Annesi-Maesano I, Bouchard L, Chong YS, Da
Pubblicato in: Diabetes Care, 2022, ISSN 1939-327X
Editore: American Diabetes Association
DOI: 10.2337/dc21-1701

Paternal transmission of behavioural and metabolic traits induced by postnatal stress to the 5th generation in mice.

Autori: Boscardin C., Manuella, F. and Mansuy, I.M.
Pubblicato in: Environmental Epigenetics, 2022, ISSN 2470-0991
Editore: Oxford University Press
DOI: 10.1093/eep/dvac024

Epigenetics of childhood trauma: Long-term sequelae and potential for treatment.

Autori: Thumfart, K., Jawaid, A., Bright, K., Flachsmann, M and Mansuy, I.M.
Pubblicato in: Neurosci Biobehav Rev, 2022, ISSN 0149-7634
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2021.10.042

Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation

Autori: Solomon O, Huen K, Yousefi P, Küpers LK, González JR, Suderman M, Reese SE, Page CM, Gruzieva O, Rzehak P, Gao L, Bakulski KM, Novoloaca A, Allard C, Pappa I, Llambrich M, Vives M, Jima DD, Kvist T, Baccarelli A, White C, Rezwan FI, Sharp GC, Tindula G, Bergström A, Grote V, Dou JF, Isaevska E, Magnus MC, Corpeleijn E, Perron P, Jaddoe VWV, Nohr EA, Maitre L, Foraster M, Hoyo C, Håberg SE, Lah
Pubblicato in: Mutat Res Rev Mutat Res, 2022, ISSN 1383-5742
Editore: Elsevier BV
DOI: 10.1016/j.mrrev.2022.108415

Long-term effects of early postnatal stress on Sertoli cells functions.

Autori: Thumfart, K, Lazzeri, S. Manuella F. and Mansuy, I.M.
Pubblicato in: Frontiers in Genetics, 2022, ISSN 1664-8021
Editore: Frontiers Media
DOI: 10.3389/fgene.2022.1024805

Maternal Psychological Problems During Pregnancy and Child Externalizing Problems: Moderated Mediation Model with Child Self-regulated Compliance and Polygenic Risk Scores for Aggression

Autori: Mannan Luo, Irene Pappa, Charlotte A. M. Cecil, Philip Jansen, Marinus H. van IJzendoorn, Rianne Kok
Pubblicato in: Child Psychiatry & Human Development, 2021, ISSN 0009-398X
Editore: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10578-021-01154-1

The association of early life stress with IQ-achievement discrepancy in children: A population-based study

Autori: Schuurmans IK, Luik AI, de Maat DA, Hillegers MHJ, Ikram MA & Cecil CAM
Pubblicato in: Child Development, 2022, ISSN 0009-3920
Editore: Blackwell Publishing Inc.
DOI: 10.1111/cdev.13825

Longitudinal associations of DNA methylation and sleep in children: a meta-analysis

Autori: Sara Sammallahti, M. Elisabeth Koopman-Verhoeff, Anne-Claire Binter, Rosa H. Mulder, Alba Cabré-Riera, Tuomas Kvist, Anni L. K. Malmberg, Giancarlo Pesce, Sabine Plancoulaine, Jonathan A. Heiss, Sheryl L. Rifas-Shiman, Stefan W. Röder, Anne P. Starling, Rory Wilson, Kathrin Guerlich, Kristine L. Haftorn, Christian M. Page, Annemarie I. Luik, Henning Tiemeier, Janine F. Felix, Katri Raikkonen, Ja
Pubblicato in: Clinical Epigenetics, 2022, ISSN 1868-7075
Editore: Springer Verlag
DOI: 10.1186/s13148-022-01298-4

Emotion Processing Differences Mediate the Link between Sex and Autistic Traits in Young Adulthood

Autori: Lucy A. Livingston, Lucy H. Waldren, Esther Walton, Punit Shah
Pubblicato in: JCPP Advances, 2022, ISSN 1469-7610
Editore: Wiley
DOI: 10.1002/jcv2.12096

Epigenomics of being bullied: changes in DNA methylation following bullying exposure

Autori: Rosa H. Mulder, Esther Walton, Alexander Neumann, Lotte C. Houtepen, Janine F. Felix, Marian J. Bakermans-Kranenburg, Matthew Suderman, Henning Tiemeier, Marinus H. van IJzendoorn, Caroline L. Relton, Charlotte A. M. Cecil
Pubblicato in: Epigenetics, Numero 15/6-7, 2020, Pagina/e 750-764, ISSN 1559-2294
Editore: Landes Bioscience
DOI: 10.1080/15592294.2020.1719303

Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills

Autori: Caramaschi D, Neumann A, Cardenas A, Tindula G, Alemany S, Zillich L, Pesce G, Lahti JMT, Havdahl A, Mulder R, Felix JF, Tiemeier H, Sirignano L, Frank J, Witt SH, Rietschel M, Deuschle M, Huen K, Eskenazi B, Send TS, Ferrer M, Gilles M, de Agostini M, Baïz N, Rifas-Shiman SL, Kvist T, Czamara D, Tuominen ST, Relton CL, Rai D, London SJ, Räikkönen K, Holland N, Annesi-Maesano I, Streit F, Hiver
Pubblicato in: Molecular psychiatry, 2022, ISSN 1359-4184
Editore: Nature Publishing Group
DOI: 10.1038/s41380-022-01441-w

Childhood maltreatment and DNA methylation: A systematic review

Autori: Charlotte A.M. Cecil, Yuning Zhang, Tobias Nolte
Pubblicato in: Neuroscience & Biobehavioral Reviews, Numero 112, 2020, Pagina/e 392-409, ISSN 0149-7634
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2020.02.019

Epigenome-wide associations between observed maternal sensitivity and offspring DNA methylation: a population-based prospective study in children

Autori: Lorenza Dall’ Aglio, Jolien Rijlaarsdam, Rosa H. Mulder, Alexander Neumann, Janine F. Felix, Rianne Kok, Marian J. Bakermans-Kranenburg, Marinus H. van Ijzendoorn, Henning Tiemeier, Charlotte A.M. Cecil
Pubblicato in: Psychological Medicine, 2020, Pagina/e 1-11, ISSN 0033-2917
Editore: Cambridge University Press
DOI: 10.1017/s0033291720004353

Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation

Autori: Sara Sammallahti, Andrea P. Cortes Hidalgo, Samuli Tuominen, Anni Malmberg, Rosa H. Mulder, Kelly J. Brunst, Silvia Alemany, Nancy S. McBride, Paul Yousefi, Jonathan A. Heiss, Nia McRae, Christian M. Page, Jianping Jin, Giancarlo Pesce, Doretta Caramaschi, Sheryl L. Rifas-Shiman, Nastassja Koen, Charleen D. Adams, Maria C. Magnus, Nour Baïz, Andrew Ratanatharathorn, Darina Czamara, Siri E. Håber
Pubblicato in: Molecular Psychiatry, 2020, ISSN 1359-4184
Editore: Nature Publishing Group
DOI: 10.1038/s41380-020-00976-0

Identifying causative mechanisms linking early-life stress to psycho-cardio-metabolic multi-morbidity: The EarlyCause project

Autori: Nicole Mariani, Alessandra Borsini, Charlotte A. M. Cecil, Janine F. Felix, Sylvain Sebert, Annamaria Cattaneo, Esther Walton, Yuri Milaneschi, Guy Cochrane, Clara Amid, Jeena Rajan, Juliette Giacobbe, Yolanda Sanz, Ana Agustí, Tania Sorg, Yann Herault, Jouko Miettunen, Priyanka Parmar, Nadia Cattane, Vincent Jaddoe, Jyrki Lötjönen, Carme Buisan, Miguel A. González Ballester, Gemma Piella, Jos
Pubblicato in: PLOS ONE, Numero 16/1, 2021, Pagina/e e0245475, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0245475

The determinants and longitudinal changes in vitamin D status in middle-age: a Northern Finland Birth Cohort 1966 study

Autori: Helmi Ikonen, Johanna Lumme, Jussi Seppälä, Paula Pesonen, Terhi Piltonen, Marjo-Riitta Järvelin, Karl-Heinz Herzig, Jouko Miettunen, Maarit Niinimäki, Saranya Palaniswamy, Sylvain Sebert, Marja Ojaniemi
Pubblicato in: European Journal of Nutrition, 2021, ISSN 1436-6207
Editore: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00394-021-02606-z

Associations between T cells and attention problems in the general pediatric population: the Generation R Study.

Autori: Looman KIM, Cecil CAM, Grosserichter-Wagener C, Kiefte de Jong JC, van Zelm MC & Moll HA
Pubblicato in: JCPP Advances, 2022, ISSN 1469-7610
Editore: Wiley
DOI: 10.1002/jcv2.12038

Brain Structure in Acutely Underweight and Partially Weight-Restored Individuals With Anorexia Nervosa: A Coordinated Analysis by the ENIGMA Eating Disorders Working Group

Autori: Walton, E., Bernardoni, F., Batury, V. L., Bahnsen, K., Larivière, S., Abbate-Daga, G., ... & Ehrlich, S. (2022).
Pubblicato in: Biological Psychiatry, 2022, ISSN 0006-3223
Editore: Elsevier BV
DOI: 10.1016/j.biopsych.2022.04.022

Epigenetics applied to child and adolescent mental health: Progress, challenges and opportunities

Autori: Cecil C, Neumann A, Walton E
Pubblicato in: JCPP Advances, 2022, ISSN 1469-7610
Editore: Wiley
DOI: 10.1002/jcv2.12133

Schizophrenia polygenic risk is associated with child mental health problems through early childhood adversity: evidence for a gene–environment correlation

Autori: Koen Bolhuis, Lisa R. Steenkamp, Laura M. E. Blanken, Alexander Neumann, Philip R. Jansen, Manon H. J. Hillegers, Charlotte A. M. Cecil, Henning Tiemeier, Steven A. Kushner
Pubblicato in: European Child & Adolescent Psychiatry, 2021, ISSN 1018-8827
Editore: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00787-021-01727-4

Genome-wide DNA methylation patterns associated with general psychopathology in children

Autori: Jolien Rijlaarsdam, Edward D. Barker, Chiara Caserini, M. Elisabeth Koopman-Verhoeff, Rosa H. Mulder, Janine F. Felix, Charlotte A.M. Cecil
Pubblicato in: Journal of Psychiatric Research, Numero 140, 2021, Pagina/e 214-220, ISSN 0022-3956
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.jpsychires.2021.05.029

Epigenetics and ADHD: Reflections on Current Knowledge, Research Priorities and Translational Potential

Autori: Cecil CAM & Nigg JT
Pubblicato in: Molecular Diagnosis & Therapy, 2022, ISSN 1177-1062
Editore: Adis International Ltd.
DOI: 10.1007/s40291-022-00609-y

Single-cell multiomics techniques: from conception to applications.

Autori: Dimitriu, M, Lazar-Contes, I., Roszkowski, M. and Mansuy, I.M.
Pubblicato in: Front. Cell. Dev. Biol., 2022, ISSN 2296-634X
Editore: Frontiers in Cell and Developmental Biology
DOI: 10.3389/fcell.2022.854317

Association of Maternal Tobacco Use During Pregnancy With Preadolescent Brain Morphology Among Offspring

Autori: Zou R, Boer OD, Felix JF, Muetzel R, Franken IHA, Cecil CAM & El Marroun H .
Pubblicato in: JAMA Network Open., 2022, ISSN 2574-3805
Editore: JAMA network open
DOI: 10.1001/jamanetworkopen.2022.24701

The European Nucleotide Archive in 2020

Autori: Peter W Harrison, Alisha Ahamed, Raheela Aslam, Blaise T F Alako, Josephine Burgin, Nicola Buso, Mélanie Courtot, Jun Fan, Dipayan Gupta, Muhammad Haseeb, Sam Holt, Talal Ibrahim, Eugene Ivanov, Suran Jayathilaka, Vishnukumar Balavenkataraman Kadhirvelu, Manish Kumar, Rodrigo Lopez, Simon Kay, Rasko Leinonen, Xin Liu, Colman O’Cathail, Amir Pakseresht, Youngmi Park, Stephane Pesant, Nadim Rahm
Pubblicato in: Nucleic Acids Research, Numero 49/D1, 2020, Pagina/e D82-D85, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkaa1028

Complete Genome Sequence of Phascolarctobacterium faecium G 104, Isolated from the Stools of a Healthy Lean Donor

Autori: Sadjia Rachek, Naghmeh Nikpoor, Eva M. Gómez del Pulgar, Aitor Gonzaga, Yolanda Sanz, Thomas A. Tompkins
Pubblicato in: Microbiology Resource Announcements, Numero 10/4, 2021, ISSN 2576-098X
Editore: ASM Journals (American Society for Microbiology)
DOI: 10.1128/mra.01054-20

Family Aggression Screening Tool (FAST): factor structure and psychometric properties of subscales.

Autori: Vieira R, Pires PP, Cecil CAM, Barker E, Reis D, Couto I, Cypriano C & de Oliveira IR.
Pubblicato in: Child Abuse & Neglect, 2022, ISSN 0145-2134
Editore: Elsevier BV
DOI: 10.1016/j.chiabu.2022.105548

Mapping gene by early life stress interactions on child subcortical brain structures: A genome-wide prospective study.

Autori: Bolhuis K*, Mulder RH*, de Mol CL, Defina S, Warrier V, White T, Tiemeier H, Muetzel RL & Cecil CAM†
Pubblicato in: JCPP Advances, 2022, ISSN 0021-9630
Editore: Blackwell Publishing Inc.
DOI: 10.1002/jcv2.12113

Examining the epigenetic mechanisms of childhood adversity and sensitive periods: a gene set-based approach

Autori: Zhu, Y., Lussier, A. A., Smith, A. D., Simpkin, A. J., Suderman, M. J., Walton, E., ... & Dunn, E. C. (2022). Examining the epigenetic mechanisms of childhood adversity and sensitive periods: a gene set-based approach. Psychoneuroendocrinology, 144, 105854.
Pubblicato in: Psychoneuroendocrinology, 2022, ISSN 0306-4530
Editore: Pergamon Press
DOI: 10.1016/j.psyneuen.2022.105854

Obesity and brain structure in schizophrenia - ENIGMA study in 3021 individuals

Autori: McWhinney, S.R., Brosch, K., Calhoun, V.D. et al.
Pubblicato in: Molecular Psychiatry, 2022, ISSN 1359-4184
Editore: Nature Publishing Group
DOI: 10.1038/s41380-022-01616-5

Child mental health problems as a risk factor for academic underachievement: a multi-informant, population-based study.

Autori: Schuurmans IK, Tamayo Martinez N, Blok E, Hillegers MHJ, Ikram MA, Luik AI & Cecil CAM
Pubblicato in: Acta Psychiatrica Scandinavica, 2022, ISSN 0001-690X
Editore: Blackwell Publishing Inc.
DOI: 10.1111/acps.13426

Epigenome-wide change and variation in DNA methylation in childhood: trajectories from birth to late adolescence

Autori: Rosa H Mulder, Alexander Neumann, Charlotte A M Cecil, Esther Walton, Lotte C Houtepen, Andrew J Simpkin, Jolien Rijlaarsdam, Bastiaan T Heijmans, Tom R Gaunt, Janine F Felix, Vincent W V Jaddoe, Marian J Bakermans-Kranenburg, Henning Tiemeier, Caroline L Relton, Marinus H van IJzendoorn, Matthew Suderman
Pubblicato in: Human Molecular Genetics, Numero 30/1, 2021, Pagina/e 119-134, ISSN 0964-6906
Editore: Oxford University Press
DOI: 10.1093/hmg/ddaa280

The gut microbiome and child mental health: a population-based study.

Autori: Kraaij R, Schuurmans IK, Radjabzadeh D, Tiemeier H, Dinan TG, Uitterlinden AG, Hillegers M, Jaddoe VWV, Duijts L, Moll H, Rivadeneira F, Medina-Gomez C, Jansen PW, Cecil CAM†
Pubblicato in: Brain, Behavior and Immunity, 2023, ISSN 0889-1591
Editore: Academic Press
DOI: 10.1016/j.bbi.2022.12.006

Neonatal DNA methylation and childhood low prosocial behavior: An epigenome‐wide association meta‐analysis

Autori: Mannan Luo, Alan J. Meehan, Esther Walton, Stefan Röder, Gunda Herberth, Ana C. Zenclussen, Marta Cosín‐Tomás, Jordi Sunyer, Rosa H. Mulder, Andrea P. Cortes Hidalgo, Marian J. Bakermans‐Kranenburg, Janine F. Felix, Caroline Relton, Matthew Suderman, Irene Pappa, Rianne Kok, Henning Tiemeier, Marinus H. IJzendoorn, Edward D. Barker, Charlotte A. M. Cecil
Pubblicato in: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Numero 186/4, 2021, Pagina/e 228-241, ISSN 1552-4841
Editore: Wiley-Liss Inc
DOI: 10.1002/ajmg.b.32862

Long-Term Impact of Social Isolation and Molecular Underpinnings

Autori: Rodrigo G. Arzate-Mejía, Zuzanna Lottenbach, Vincent Schindler, Ali Jawaid, Isabelle M. Mansuy
Pubblicato in: Frontiers in Genetics, Numero 11, 2020, ISSN 1664-8021
Editore: Frontiers Media
DOI: 10.3389/fgene.2020.589621

Effectiveness of psychological and/or educational interventions in reducing anxiety and depression in people with type 2 diabetes: A systematic review and meta-analysis

Autori: Kristina M.Thumfarta, Ali Jawaidab, Kristina Bright, Marc Flachsmann, Isabelle M.Mansuy
Pubblicato in: Diabetes Research and Clinical Practice, 2021, ISSN 0168-8227
Editore: Elsevier BV
DOI: 10.1016/j.diabres.2021.108922

Associations of Hair Cortisol Concentrations With Cardiometabolic Risk Factors in Childhood

Autori: Florianne O L Vehmeijer, Susana Santos, Yolanda B de Rijke, Erica L T van den Akker, Janine F Felix, Elisabeth F C van Rossum, Vincent W V Jaddoe
Pubblicato in: The Journal of Clinical Endocrinology & Metabolism, 2021, ISSN 0021-972X
Editore: The Endocrine Society
DOI: 10.1210/clinem/dgab379

Gene–environment correlations and causal effects of childhood maltreatment on physical and mental health: a genetically informed approach

Autori: Varun Warrier, Alex S F Kwong, Mannan Luo, Shareefa Dalvie, Jazz Croft, Hannah M Sallis, Jessie Baldwin, Marcus R Munafò, Caroline M Nievergelt, Andrew J Grant, Stephen Burgess, Tyler M Moore, Ran Barzilay, Andrew McIntosh, Marinus H van IJzendoorn, Charlotte A M Cecil
Pubblicato in: The Lancet Psychiatry, Numero 8/5, 2021, Pagina/e 373-386, ISSN 2215-0366
Editore: Elsevier Limited
DOI: 10.1016/s2215-0366(20)30569-1

ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries

Autori: Paul M. Thompson, Neda Jahanshad, Christopher R. K. Ching, Lauren E. Salminen, Sophia I. Thomopoulos, Joanna Bright, Bernhard T. Baune, Sara Bertolín, Janita Bralten, Willem B. Bruin, Robin Bülow, Jian Chen, Yann Chye, Udo Dannlowski, Carolien G. F. de Kovel, Gary Donohoe, Lisa T. Eyler, Stephen V. Faraone, Pauline Favre, Courtney A. Filippi, Thomas Frodl, Daniel Garijo, Yolanda Gil, Hans J. Gra
Pubblicato in: Translational Psychiatry, Numero 10/1, 2020, ISSN 2158-3188
Editore: Nature Publishing Group
DOI: 10.1038/s41398-020-0705-1

Wir können unsere Gene steuern!

Autori: Mansuy, I.M., Gurret, J.M. Lelief, A.
Pubblicato in: 2020
Editore: Berlin Verlag

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