Causative mechanisms & integrative models linking early-life-stress to psycho-cardio-metabolic multi-morbidity

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Data and experimental guidelines
Structural equation model linking ELS to multi-morbidity outcomes

Structural equation model linking ELS to multimorbidity outcomes

Analysis of the omics data generated by the in vitro models
"White paper ""Blueprint for new prevention and treatment strategies"""

White paper “Blueprint for new prevention and treatment strategies”

Technological impact evaluation report
Candidate genes and molecular pathways components altered by pre- and/or postnatal stress in different tissues
Contribution of ELS-induced microbiota deviations to multi-morbidity development
Dissemination, communication & outreach strategy
Identified sex differences in the in vitro experimental system
Top-hit mechanisms replicated in selected cellular models
Data management Plan version 2
Quantitative measures of ELS-induced metabolic alterations, endocrine response and cardiovascular parameters

Quantitative measures of ELSinduced metabolic alterations endocrine response and cardiovascular parameters

Report on ELS-related stress-induced insults in human cell lines derived from human brain, blood, heart, pancreas, liver, and blood immune cells
Modifiers linked to life conditions with beneficial effects on multi-morbidity
EarlyCause final workshop programme
Multi-omics signatures of ELS-induced multi-morbidity
Data harmonisation process for public use
Project website and communication materials
"White paper ""Potential clinical impact of new biomarkers and causative pathways"""

White paper “Potential clinical impact of new biomarkers and causative pathways”

Quantitative measures of ELS-induced behavioural symptoms

Quantitative measures of ELSinduced behavioural symptoms

Candidates functionally linked to comorbid symptoms
Socio-economic impact assessment framework

Socioeconomic impact assessment framework

Machine learning model of multi-morbidity trajectories

Data Coordination Centre
Final EarlyCause web-portal
System for dataset incorporation into DCC
Development and evaluation of the multimorbidity open-access tool

Deliverables D7.5 and D7.6 will be merged into D7.5.Description: this deliverable will include pilot software with all the information and also a report on accuracy and sensitivity of multi-morbidity predictions.

Data Management Plan version 1

Pubblicazioni

DNA methylation at birth and fine motor ability in childhood: an epigenome-wide association study with replication

Autori: Fadila Serdarevic, Mannan Luo, Irma Karabegović, Anne-Claire Binter, Silvia Alemany, Ryan Mutzel, Monica Guxens, Mariona Bustamante, Aida Hajdarpasic, Tonya White, Janine F Felix, Charlotte A.M. Cecil, Henning Tiemeier
Pubblicato in: Epigenetics, Numero 18, 2023, ISSN 1559-2294
Editore: Landes Bioscience
DOI: 10.1080/15592294.2023.2207253

Epigenetic Inheritance: Impact for Biology and Society

Autori: Arzate-Mejia, R. G and Mansuy, I.M.
Pubblicato in: Environmental Epigenetics, 2022, ISSN 2470-0991
Editore: Oxford University Press
DOI: 10.1093/eep/dvac021

Gestational epigenetic age and ADHD symptoms in childhood: a prospective, multi-cohort study

Autori: Kristina Salontaji, Kristine L. Haftorn, Faye Sanders, Christian M. Page, Esther Walton, Janine F. Felix, Mona Bekkhus, Jon Bohlin, Henning Tiemeier, Charlotte A. M. Cecil
Pubblicato in: Molecular Psychiatry, 2024, ISSN 1359-4184
Editore: Nature Publishing Group
DOI: 10.1038/s41380-024-02544-2

Arterial Health Markers in Relation to Behavior and Cognitive Outcomes at School Age

Autori: Romy Gonçalves, Romy Gaillard, Charlotte Cecil, Serena Defina, Eric. A. P. Steegers, Vincent W. V. Jaddoe
Pubblicato in: Journal of the American Heart Association, Numero 13, 2024, ISSN 2047-9980
Editore: Wiley-Blackwell
DOI: 10.1161/jaha.123.029771

Paternal body mass index and offspring DNA methylation: findings from the PACE consortium

Autori: Gemma C Sharp, Rossella Alfano, Akram Ghantous, Jose Urquiza, Sheryl L Rifas-Shiman, Christian M Page, Jianping Jin, Silvia Fernández-Barrés, Gillian Santorelli, Gwen Tindula, Gemma C Sharp, Rossella Alfano, Akram Ghantous, Jose Urquiza, Sheryl L Rifas-Shiman, Christian M Page, Jianping Jin, Silvia Fernández-Barrés, Gillian Santorelli, Gwen Tindula, Paul Yousefi, Leanne Kupers, Carlos Ruiz-Are
Pubblicato in: International Journal of Epidemiology, 2021, ISSN 0300-5771
Editore: Oxford University Press
DOI: 10.1093/ije/dyaa267

Exposure to prenatal infection and the development of internalizing and externalizing problems in children: a longitudinal population‐based study

Autori: Anna Suleri, Anna‐Sophie Rommel, Alexander Neumann, Mannan Luo, Manon Hillegers, Lotje de Witte, Veerle Bergink, Charlotte A. M. Cecil
Pubblicato in: Journal of Child Psychology and Psychiatry, Numero 65, 2024, Pagina/e 874-886, ISSN 0021-9630
Editore: Blackwell Publishing Inc.
DOI: 10.1111/jcpp.13923

The impact of early adversity and education on genetic and brain morphological predictors of cognitive ability

Autori: Emma Corley, Laura Fahey, Joan Fitzgerald, Laurena Holleran, Esther Walton, Derek W. Morris, Gary Donohoe
Pubblicato in: Genes, Brain and Behavior, Numero 22, 2023, ISSN 1601-1848
Editore: Blackwell Publishing Inc.
DOI: 10.1111/gbb.12850

The epigenome under pressure: On regulatory adaptation to chronic stress in the brain

Autori: Rodrigo G. Arzate-Mejia, Nancy V.N. Carullo, Isabelle M. Mansuy
Pubblicato in: Current Opinion in Neurobiology, Numero 84, 2024, Pagina/e 102832, ISSN 0959-4388
Editore: Elsevier BV
DOI: 10.1016/j.conb.2023.102832

Brain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium.

Autori: Constantinides, C., Han, L. K., Alloza, C., Antonucci, L., Arango, C., Ayesa-Arriola, R., ... & Walton, E.
Pubblicato in: Molecular Psychiatry, 2023, ISSN 1359-4184
Editore: Nature Publishing Group
DOI: 10.1038/s41380-022-01897-w

10-Year trajectories of depressive symptoms and subsequent brain health in middle-aged adults

Autori: Isabel K. Schuurmans, Sander Lamballais, Runyu Zou, Ryan L. Muetzel, Manon H.J. Hillegers, Charlotte A.M. Cecil, Annemarie I. Luik
Pubblicato in: Journal of Psychiatric Research, Numero 158, 2023, Pagina/e 126-133, ISSN 0022-3956
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.jpsychires.2022.12.018

Maternal Glycemic Dysregulation During Pregnancy and Neonatal Blood DNA Methylation: Meta-analyses of Epigenome-Wide Association Studies

Autori: Tobi EW, Juvinao-Quintero DL, Ronkainen J, Ott R, Alfano R, Canouil M, Geurtsen ML, Khamis A, Küpers LK, Lim IY, Perron P, Pesce G, Tuhkanen J, Starling AP, Andrew T, Binder E, Caiazzo R, Chan JKY, Gaillard R, Gluckman PD, Keikkala E, Karnani N, Mustaniemi S, Nawrot TS, Pattou F, Plusquin M, Raverdy V, Tan KH, Tzala E, Raikkonen K, Winkler C, Ziegler AG, Annesi-Maesano I, Bouchard L, Chong YS, Da
Pubblicato in: Diabetes Care, 2022, ISSN 1939-327X
Editore: American Diabetes Association
DOI: 10.2337/dc21-1701

Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence

Autori: Priyanka Choudhary, Giulietta S. Monasso, Ville Karhunen, Justiina Ronkainen, Giulia Mancano, Caitlin G. Howe, Zhongzheng Niu, Xuehuo Zeng, Weihua Guan, John Dou, Jason I. Feinberg, Charles Mordaunt, Giancarlo Pesce, Nour Baïz, Rossella Alfano, Dries S. Martens, Congrong Wang, Elena Isaevska, Elina Keikkala, Sanna Mustaniemi, Chris H. L. Thio, Eliza Fraszczyk, Elmar W. Tobi, Anne P. Starling, Mar
Pubblicato in: Molecular Psychiatry, Numero 29, 2024, Pagina/e 348-358, ISSN 1359-4184
Editore: Nature Publishing Group
DOI: 10.1038/s41380-023-02331-5

Paternal transmission of behavioural and metabolic traits induced by postnatal stress to the 5th generation in mice.

Autori: Boscardin C., Manuella, F. and Mansuy, I.M.
Pubblicato in: Environmental Epigenetics, 2022, ISSN 2470-0991
Editore: Oxford University Press
DOI: 10.1093/eep/dvac024

Epigenetics of childhood trauma: Long-term sequelae and potential for treatment.

Autori: Thumfart, K., Jawaid, A., Bright, K., Flachsmann, M and Mansuy, I.M.
Pubblicato in: Neurosci Biobehav Rev, 2022, ISSN 0149-7634
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2021.10.042

Childhood abuse <i>v.</i> neglect and risk for major psychiatric disorders

Autori: Anne Alkema, Mattia Marchi, Jeroen A. J. van der Zaag, Daniëlle van der Sluis, Varun Warrier, null null, Roel A. Ophoff, René S. Kahn, Wiepke Cahn, Jacqueline G. F. M. Hovens, Harriëtte Riese, Floortje Scheepers, Brenda W. J. H. Penninx, Charlotte Cecil, Albertine J. Oldehinkel, Christiaan H. Vinkers, Marco P. M. Boks
Pubblicato in: Psychological Medicine, Numero 54, 2024, Pagina/e 1598-1609, ISSN 0033-2917
Editore: Cambridge University Press
DOI: 10.1017/s0033291723003471

Associations of prenatal maternal depressive symptoms with cord blood glucocorticoids and child hair cortisol levels in the project viva and the generation R cohorts: a prospective cohort study

Autori: Nathan J. Cohen, Serena Defina, Sheryl L. Rifas-Shiman, Sabrina Faleschini, Russell S. Kirby, Henian Chen, Ronee Wilson, Kimberly Fryer, Hanan El Marroun, Charlotte A.M. Cecil, Marie-France Hivert, Emily Oken, Henning Tiemeier, Amy C. Alman
Pubblicato in: BMC Pediatrics, Numero 23, 2023, ISSN 1471-2431
Editore: BioMed Central
DOI: 10.1186/s12887-023-04372-9

Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude

Autori: Latha Kadalayil, Md. Zahangir Alam, Cory Haley White, Akram Ghantous, Esther Walton, Olena Gruzieva, Simon Kebede Merid, Ashish Kumar, Ritu P. Roy, Olivia Solomon, Karen Huen, Brenda Eskenazi, Peter Rzehak, Veit Grote, Jean-Paul Langhendries, Elvira Verduci, Natalia Ferre, Darek Gruszfeld, Lu Gao, Weihua Guan, Xuehuo Zeng, Enrique F. Schisterman, John F. Dou, Kelly M. Bakulski, Jason I. Feinberg,
Pubblicato in: Clinical Epigenetics, Numero 15, 2023, Pagina/e 148, ISSN 1868-7083
Editore: BMC
DOI: 10.1186/s13148-023-01542-5

Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation

Autori: Solomon O, Huen K, Yousefi P, Küpers LK, González JR, Suderman M, Reese SE, Page CM, Gruzieva O, Rzehak P, Gao L, Bakulski KM, Novoloaca A, Allard C, Pappa I, Llambrich M, Vives M, Jima DD, Kvist T, Baccarelli A, White C, Rezwan FI, Sharp GC, Tindula G, Bergström A, Grote V, Dou JF, Isaevska E, Magnus MC, Corpeleijn E, Perron P, Jaddoe VWV, Nohr EA, Maitre L, Foraster M, Hoyo C, Håberg SE, Lah
Pubblicato in: Mutat Res Rev Mutat Res, 2022, ISSN 1383-5742
Editore: Elsevier BV
DOI: 10.1016/j.mrrev.2022.108415

Long-term effects of early postnatal stress on Sertoli cells functions.

Autori: Thumfart, K, Lazzeri, S. Manuella F. and Mansuy, I.M.
Pubblicato in: Frontiers in Genetics, 2022, ISSN 1664-8021
Editore: Frontiers Media
DOI: 10.3389/fgene.2022.1024805

An epigenome-wide association study of child appetitive traits and DNA methylation

Autori: Holly A. Harris, Chloe Friedman, Anne P. Starling, Dana Dabelea, Susan L. Johnson, Bernard F. Fuemmeler, Dereje Jima, Susan K. Murphy, Cathrine Hoyo, Pauline W. Jansen, Janine F. Felix, Rosa H. Mulder
Pubblicato in: Appetite, Numero 191, 2023, Pagina/e 107086, ISSN 0195-6663
Editore: Elsevier BV
DOI: 10.1016/j.appet.2023.107086

The Association of Life Stress with Subsequent Brain and Cognitive Reserve in Middle-Aged Women

Autori: Isabel K. Schuurmans, Sanne J.W. Hoepel, Charlotte A.M. Cecil, Manon H.J. Hillegers, M. Arfan Ikram, Annemarie I. Luik
Pubblicato in: Journal of Alzheimer's Disease, Numero 93, 2023, Pagina/e 97-106, ISSN 1387-2877
Editore: IOS Press
DOI: 10.3233/jad-220923

Maternal Psychological Problems During Pregnancy and Child Externalizing Problems: Moderated Mediation Model with Child Self-regulated Compliance and Polygenic Risk Scores for Aggression

Autori: Mannan Luo, Irene Pappa, Charlotte A. M. Cecil, Philip Jansen, Marinus H. van IJzendoorn, Rianne Kok
Pubblicato in: Child Psychiatry & Human Development, 2021, ISSN 0009-398X
Editore: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10578-021-01154-1

The role of lifestyle factors in the association between early-life stress and adolescent psycho-physical health: Moderation analysis in two European birth cohorts

Autori: Serena Defina, Tom Woofenden, Vilte Baltramonaityte, Henning Tiemeier, Graeme Fairchild, Janine F. Felix, Charlotte A.M. Cecil, Esther Walton
Pubblicato in: Preventive Medicine, Numero 182, 2024, Pagina/e 107926, ISSN 0091-7435
Editore: Academic Press
DOI: 10.1016/j.ypmed.2024.107926

The association of early life stress with IQ-achievement discrepancy in children: A population-based study

Autori: Schuurmans IK, Luik AI, de Maat DA, Hillegers MHJ, Ikram MA & Cecil CAM
Pubblicato in: Child Development, 2022, ISSN 0009-3920
Editore: Blackwell Publishing Inc.
DOI: 10.1111/cdev.13825

Cord Blood Metabolite Profiles and Their Association with Autistic Traits in Childhood

Autori: Christin S. Kaupper, Sophia M. Blaauwendraad, Charlotte A. M. Cecil, Rosa H. Mulder, Romy Gaillard, Romy Goncalves, Ingo Borggraefe, Berthold Koletzko, Vincent W. V. Jaddoe
Pubblicato in: Metabolites, Numero 13, 2023, Pagina/e 1140, ISSN 2218-1989
Editore: MDPI
DOI: 10.3390/metabo13111140

Longitudinal associations of DNA methylation and sleep in children: a meta-analysis

Autori: Sara Sammallahti, M. Elisabeth Koopman-Verhoeff, Anne-Claire Binter, Rosa H. Mulder, Alba Cabré-Riera, Tuomas Kvist, Anni L. K. Malmberg, Giancarlo Pesce, Sabine Plancoulaine, Jonathan A. Heiss, Sheryl L. Rifas-Shiman, Stefan W. Röder, Anne P. Starling, Rory Wilson, Kathrin Guerlich, Kristine L. Haftorn, Christian M. Page, Annemarie I. Luik, Henning Tiemeier, Janine F. Felix, Katri Raikkonen, Ja
Pubblicato in: Clinical Epigenetics, 2022, ISSN 1868-7075
Editore: Springer Verlag
DOI: 10.1186/s13148-022-01298-4

Plasma neurofilament light chain in association to late‐life depression in the general population

Autori: Isabel K. Schuurmans, Mohsen Ghanbari, Charlotte A. M. Cecil, M. Arfan Ikram, Annemarie I. Luik
Pubblicato in: Psychiatry and Clinical Neurosciences, Numero 78, 2024, Pagina/e 97-103, ISSN 1323-1316
Editore: Blackwell Publishing Inc.
DOI: 10.1111/pcn.13608

Effects of Pre- and Postnatal Early-Life Stress on Internalizing, Adiposity, and Their Comorbidity

Autori: Serena Defina, Tom Woofenden, Vilte Baltramonaityte, Carmine M. Pariante, Karim Lekadir, Vincent W.V. Jaddoe, Fadila Serdarevic, Henning Tiemeier, Esther Walton, Janine F. Felix, Charlotte A.M. Cecil
Pubblicato in: Journal of the American Academy of Child & Adolescent Psychiatry, Numero 63, 2024, Pagina/e 255-265, ISSN 0890-8567
Editore: Elsevier BV
DOI: 10.1016/j.jaac.2023.05.034

Fairness and bias correction in machine learning for depression prediction across four study populations

Autori: Vien Ngoc Dang, Anna Cascarano, Rosa H. Mulder, Charlotte Cecil, Maria A. Zuluaga, Jerónimo Hernández-González, Karim Lekadir
Pubblicato in: Scientific Reports, Numero 14, 2024, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-024-58427-7

Emotion Processing Differences Mediate the Link between Sex and Autistic Traits in Young Adulthood

Autori: Lucy A. Livingston, Lucy H. Waldren, Esther Walton, Punit Shah
Pubblicato in: JCPP Advances, 2022, ISSN 1469-7610
Editore: Wiley
DOI: 10.1002/jcv2.12096

Epigenomics of being bullied: changes in DNA methylation following bullying exposure

Autori: Rosa H. Mulder, Esther Walton, Alexander Neumann, Lotte C. Houtepen, Janine F. Felix, Marian J. Bakermans-Kranenburg, Matthew Suderman, Henning Tiemeier, Marinus H. van IJzendoorn, Caroline L. Relton, Charlotte A. M. Cecil
Pubblicato in: Epigenetics, Numero 15/6-7, 2020, Pagina/e 750-764, ISSN 1559-2294
Editore: Landes Bioscience
DOI: 10.1080/15592294.2020.1719303

Epigenome-wide meta-analysis of prenatal maternal stressful life events and newborn DNA methylation

Autori: Anna Kotsakis Ruehlmann, Sara Sammallahti, Andrea P. Cortés Hidalgo, Kelly M. Bakulski, Elisabeth B. Binder, Megan Loraine Campbell, Doretta Caramaschi, Charlotte A. M. Cecil, Elena Colicino, Cristiana Cruceanu, Darina Czamara, Linda Dieckmann, John Dou, Janine F. Felix, Josef Frank, Siri E. Håberg, Gunda Herberth, Thanh T. Hoang, Lotte C. Houtepen, Anke Hüls, Nastassja Koen, Stephanie J. Londo
Pubblicato in: Molecular Psychiatry, Numero 28, 2024, Pagina/e 5090-5100, ISSN 1359-4184
Editore: Nature Publishing Group
DOI: 10.1038/s41380-023-02010-5

Experiences of acquired brain injury survivors participating in online and hybrid performance arts programmes: an ethnographic study

Autori: Elizabeth Rose Taylor, Carolina Estevao, Lucinda Jarrett, Anthony Woods, Nikki Crane, Daisy Fancourt, Carmine Pariante, Fiona Jones
Pubblicato in: Arts & Health, Numero 16, 2024, Pagina/e 189-205, ISSN 1753-3015
Editore: Taylor and Francis Inc.
DOI: 10.1080/17533015.2023.2226697

The Gut Microbiome in Early Life Stress: A Systematic Review

Autori: Ana Agusti, Femke Lamers, Maria Tamayo, Carlos Benito-Amat, Gara V. Molina-Mendoza, Brenda W. J. H. Penninx, Yolanda Sanz
Pubblicato in: Nutrients, Numero 15, 2023, Pagina/e 2566, ISSN 2072-6643
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu15112566

Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills

Autori: Caramaschi D, Neumann A, Cardenas A, Tindula G, Alemany S, Zillich L, Pesce G, Lahti JMT, Havdahl A, Mulder R, Felix JF, Tiemeier H, Sirignano L, Frank J, Witt SH, Rietschel M, Deuschle M, Huen K, Eskenazi B, Send TS, Ferrer M, Gilles M, de Agostini M, Baïz N, Rifas-Shiman SL, Kvist T, Czamara D, Tuominen ST, Relton CL, Rai D, London SJ, Räikkönen K, Holland N, Annesi-Maesano I, Streit F, Hiver
Pubblicato in: Molecular psychiatry, 2022, ISSN 1359-4184
Editore: Nature Publishing Group
DOI: 10.1038/s41380-022-01441-w

Childhood maltreatment and DNA methylation: A systematic review

Autori: Charlotte A.M. Cecil, Yuning Zhang, Tobias Nolte
Pubblicato in: Neuroscience & Biobehavioral Reviews, Numero 112, 2020, Pagina/e 392-409, ISSN 0149-7634
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2020.02.019

Epigenome-wide associations between observed maternal sensitivity and offspring DNA methylation: a population-based prospective study in children

Autori: Lorenza Dall’ Aglio, Jolien Rijlaarsdam, Rosa H. Mulder, Alexander Neumann, Janine F. Felix, Rianne Kok, Marian J. Bakermans-Kranenburg, Marinus H. van Ijzendoorn, Henning Tiemeier, Charlotte A.M. Cecil
Pubblicato in: Psychological Medicine, 2020, Pagina/e 1-11, ISSN 0033-2917
Editore: Cambridge University Press
DOI: 10.1017/s0033291720004353

Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation

Autori: Sara Sammallahti, Andrea P. Cortes Hidalgo, Samuli Tuominen, Anni Malmberg, Rosa H. Mulder, Kelly J. Brunst, Silvia Alemany, Nancy S. McBride, Paul Yousefi, Jonathan A. Heiss, Nia McRae, Christian M. Page, Jianping Jin, Giancarlo Pesce, Doretta Caramaschi, Sheryl L. Rifas-Shiman, Nastassja Koen, Charleen D. Adams, Maria C. Magnus, Nour Baïz, Andrew Ratanatharathorn, Darina Czamara, Siri E. Håber
Pubblicato in: Molecular Psychiatry, 2020, ISSN 1359-4184
Editore: Nature Publishing Group
DOI: 10.1038/s41380-020-00976-0

Identifying causative mechanisms linking early-life stress to psycho-cardio-metabolic multi-morbidity: The EarlyCause project

Autori: Nicole Mariani, Alessandra Borsini, Charlotte A. M. Cecil, Janine F. Felix, Sylvain Sebert, Annamaria Cattaneo, Esther Walton, Yuri Milaneschi, Guy Cochrane, Clara Amid, Jeena Rajan, Juliette Giacobbe, Yolanda Sanz, Ana Agustí, Tania Sorg, Yann Herault, Jouko Miettunen, Priyanka Parmar, Nadia Cattane, Vincent Jaddoe, Jyrki Lötjönen, Carme Buisan, Miguel A. González Ballester, Gemma Piella, Jos
Pubblicato in: PLOS ONE, Numero 16/1, 2021, Pagina/e e0245475, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0245475

Genome-Wide Analyses of Vocabulary Size in Infancy and Toddlerhood: Associations With Attention-Deficit/Hyperactivity Disorder, Literacy, and Cognition-Related Traits

Autori: Ellen Verhoef, Andrea G. Allegrini, Philip R. Jansen, Katherine Lange, Carol A. Wang, Angela T. Morgan, Tarunveer S. Ahluwalia, Christos Symeonides, Ole A. Andreassen, Meike Bartels, Dorret Boomsma, Philip S. Dale, Erik Ehli, Dietmar Fernandez-Orth, Mònica Guxens, Christian Hakulinen, Kathleen Mullan Harris, Simon Haworth, Lucía de Hoyos, Vincent Jaddoe, Liisa Keltikangas-Järvinen, Terho Lehtim
Pubblicato in: Biological Psychiatry, Numero 95, 2024, Pagina/e 859-869, ISSN 0006-3223
Editore: Elsevier BV
DOI: 10.1016/j.biopsych.2023.11.025

Life stress and adiposity in mothers: A 14‐year follow‐up in the general population

Autori: Sanne J. W. Hoepel, Isabel K. Schuurmans, Charlotte A. M. Cecil, Vincent W. V. Jaddoe, Annemarie I. Luik
Pubblicato in: Stress and Health, Numero 40, 2024, ISSN 1532-2998
Editore: John Wiley & Sons Inc.
DOI: 10.1002/smi.3290

Genetic patterning for child psychopathology is distinct from that for adults and implicates fetal cerebellar development

Autori: Dylan E. Hughes, Keiko Kunitoki, Safia Elyounssi, Mannan Luo, Oren M. Bazer, Casey E. Hopkinson, Kevin F. Dowling, Alysa E. Doyle, Erin C. Dunn, Hamdi Eryilmaz, Jodi M. Gilman, Daphne J. Holt, Eve M. Valera, Jordan W. Smoller, Charlotte A. M. Cecil, Henning Tiemeier, Phil H. Lee, Joshua L. Roffman
Pubblicato in: Nature Neuroscience, Numero 26, 2023, Pagina/e 959-969, ISSN 1097-6256
Editore: Nature Publishing Group
DOI: 10.1038/s41593-023-01321-8

The determinants and longitudinal changes in vitamin D status in middle-age: a Northern Finland Birth Cohort 1966 study

Autori: Helmi Ikonen, Johanna Lumme, Jussi Seppälä, Paula Pesonen, Terhi Piltonen, Marjo-Riitta Järvelin, Karl-Heinz Herzig, Jouko Miettunen, Maarit Niinimäki, Saranya Palaniswamy, Sylvain Sebert, Marja Ojaniemi
Pubblicato in: European Journal of Nutrition, 2021, ISSN 1436-6207
Editore: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00394-021-02606-z

Keeping It in the Family: Consanguinity Reveals <i>P4HTM</i> as a Novel Syndromic Obesity Gene

Autori: Janine F. Felix, Struan F.A. Grant
Pubblicato in: Diabetes, Numero 72, 2023, Pagina/e 1184-1186, ISSN 0012-1797
Editore: American Diabetes Association
DOI: 10.2337/dbi23-0010

Associations between T cells and attention problems in the general pediatric population: the Generation R Study.

Autori: Looman KIM, Cecil CAM, Grosserichter-Wagener C, Kiefte de Jong JC, van Zelm MC & Moll HA
Pubblicato in: JCPP Advances, 2022, ISSN 1469-7610
Editore: Wiley
DOI: 10.1002/jcv2.12038

Brain Structure in Acutely Underweight and Partially Weight-Restored Individuals With Anorexia Nervosa: A Coordinated Analysis by the ENIGMA Eating Disorders Working Group

Autori: Walton, E., Bernardoni, F., Batury, V. L., Bahnsen, K., Larivière, S., Abbate-Daga, G., ... & Ehrlich, S. (2022).
Pubblicato in: Biological Psychiatry, 2022, ISSN 0006-3223
Editore: Elsevier BV
DOI: 10.1016/j.biopsych.2022.04.022

Associations of Arterial Thickness, Stiffness, and Blood Pressure With Brain Morphology in Early Adolescence: A Prospective Population-Based Study

Autori: Serena Defina, Carolina C.V. Silva, Charlotte A.M. Cecil, Henning Tiemeier, Janine F. Felix, Ryan L. Mutzel, Vincent W.V. Jaddoe
Pubblicato in: Hypertension, Numero 81, 2024, Pagina/e 162-171, ISSN 0194-911X
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/hypertensionaha.123.21672

Epigenetics applied to child and adolescent mental health: Progress, challenges and opportunities

Autori: Cecil C, Neumann A, Walton E
Pubblicato in: JCPP Advances, 2022, ISSN 1469-7610
Editore: Wiley
DOI: 10.1002/jcv2.12133

Schizophrenia polygenic risk is associated with child mental health problems through early childhood adversity: evidence for a gene–environment correlation

Autori: Koen Bolhuis, Lisa R. Steenkamp, Laura M. E. Blanken, Alexander Neumann, Philip R. Jansen, Manon H. J. Hillegers, Charlotte A. M. Cecil, Henning Tiemeier, Steven A. Kushner
Pubblicato in: European Child & Adolescent Psychiatry, 2021, ISSN 1018-8827
Editore: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00787-021-01727-4

What are Sertoli cells? Historical, methodological, and functional aspects

Autori: Kristina M. Thumfart, Isabelle M. Mansuy
Pubblicato in: Andrology, Numero 11, 2023, Pagina/e 849-859, ISSN 2047-2919
Editore: Wiley Periodicals LLC
DOI: 10.1111/andr.13386

Metabolic syndrome after childhood trauma: a 9-year longitudinal analysis

Autori: Camille Souama, Yuri Milaneschi, Femke Lamers, Christiaan H. Vinkers, Erik J. Giltay, Edith J. Liemburg, Brenda W. J. H. Penninx
Pubblicato in: Psychological Medicine, Numero 54, 2024, Pagina/e 1373-1381, ISSN 0033-2917
Editore: Cambridge University Press
DOI: 10.1017/s0033291723003264

Genome-wide DNA methylation patterns associated with general psychopathology in children

Autori: Jolien Rijlaarsdam, Edward D. Barker, Chiara Caserini, M. Elisabeth Koopman-Verhoeff, Rosa H. Mulder, Janine F. Felix, Charlotte A.M. Cecil
Pubblicato in: Journal of Psychiatric Research, Numero 140, 2021, Pagina/e 214-220, ISSN 0022-3956
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.jpsychires.2021.05.029

Epigenetics and ADHD: Reflections on Current Knowledge, Research Priorities and Translational Potential

Autori: Cecil CAM & Nigg JT
Pubblicato in: Molecular Diagnosis & Therapy, 2022, ISSN 1177-1062
Editore: Adis International Ltd.
DOI: 10.1007/s40291-022-00609-y

A multivariate genome-wide association study of psycho-cardiometabolic multimorbidity

Autori: Vilte Baltramonaityte, Jean-Baptiste Pingault, Charlotte A. M. Cecil, Priyanka Choudhary, Marjo-Riitta Järvelin, Brenda W. J. H. Penninx, Janine Felix, Sylvain Sebert, Yuri Milaneschi, Esther Walton, null null
Pubblicato in: PLOS Genetics, Numero 19, 2023, Pagina/e e1010508, ISSN 1553-7404
Editore: PLOS Genetics
DOI: 10.1371/journal.pgen.1010508

Single-cell multiomics techniques: from conception to applications.

Autori: Dimitriu, M, Lazar-Contes, I., Roszkowski, M. and Mansuy, I.M.
Pubblicato in: Front. Cell. Dev. Biol., 2022, ISSN 2296-634X
Editore: Frontiers in Cell and Developmental Biology
DOI: 10.3389/fcell.2022.854317

Dynamics of transcriptional programs and chromatin accessibility in mouse spermatogonial cells from early postnatal to adult life

Autori: Irina Lazar-Contes, Deepak K. Tanwar, Rodrigo G. Arzate-Mejia, Leonard C. Steg, Olivier Ulrich Feudjio, Marion Crespo, Pierre-Luc Germain, Isabelle M. Mansuy
Pubblicato in: Genetics and Genomics, 2024, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.91528.1

Association of Maternal Tobacco Use During Pregnancy With Preadolescent Brain Morphology Among Offspring

Autori: Zou R, Boer OD, Felix JF, Muetzel R, Franken IHA, Cecil CAM & El Marroun H .
Pubblicato in: JAMA Network Open., 2022, ISSN 2574-3805
Editore: JAMA network open
DOI: 10.1001/jamanetworkopen.2022.24701

The European Nucleotide Archive in 2020

Autori: Peter W Harrison, Alisha Ahamed, Raheela Aslam, Blaise T F Alako, Josephine Burgin, Nicola Buso, Mélanie Courtot, Jun Fan, Dipayan Gupta, Muhammad Haseeb, Sam Holt, Talal Ibrahim, Eugene Ivanov, Suran Jayathilaka, Vishnukumar Balavenkataraman Kadhirvelu, Manish Kumar, Rodrigo Lopez, Simon Kay, Rasko Leinonen, Xin Liu, Colman O’Cathail, Amir Pakseresht, Youngmi Park, Stephane Pesant, Nadim Rahm
Pubblicato in: Nucleic Acids Research, Numero 49/D1, 2020, Pagina/e D82-D85, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkaa1028

Developmental origins of psycho-cardiometabolic multimorbidity in adolescence and their underlying pathways through methylation markers: a two-cohort study

Autori: Priyanka Choudhary, Justiina Ronkainen, Jennie Carson, Ville Karhunen, Ashleigh Lin, Phillip E. Melton, Marjo-Riitta Jarvelin, Jouko Miettunen, Rae-Chi Huang, Sylvain Sebert
Pubblicato in: European Child & Adolescent Psychiatry, 2024, ISSN 1018-8827
Editore: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00787-024-02390-1

Complete Genome Sequence of Phascolarctobacterium faecium G 104, Isolated from the Stools of a Healthy Lean Donor

Autori: Sadjia Rachek, Naghmeh Nikpoor, Eva M. Gómez del Pulgar, Aitor Gonzaga, Yolanda Sanz, Thomas A. Tompkins
Pubblicato in: Microbiology Resource Announcements, Numero 10/4, 2021, ISSN 2576-098X
Editore: ASM Journals (American Society for Microbiology)
DOI: 10.1128/mra.01054-20

Family Aggression Screening Tool (FAST): factor structure and psychometric properties of subscales.

Autori: Vieira R, Pires PP, Cecil CAM, Barker E, Reis D, Couto I, Cypriano C & de Oliveira IR.
Pubblicato in: Child Abuse & Neglect, 2022, ISSN 0145-2134
Editore: Elsevier BV
DOI: 10.1016/j.chiabu.2022.105548

Mapping gene by early life stress interactions on child subcortical brain structures: A genome-wide prospective study.

Autori: Bolhuis K*, Mulder RH*, de Mol CL, Defina S, Warrier V, White T, Tiemeier H, Muetzel RL & Cecil CAM†
Pubblicato in: JCPP Advances, 2022, ISSN 0021-9630
Editore: Blackwell Publishing Inc.
DOI: 10.1002/jcv2.12113

Remembering through the genome: the role of chromatin states in brain functions and diseases

Autori: Rodrigo G. Arzate-Mejia, Isabelle M. Mansuy
Pubblicato in: Translational Psychiatry, Numero 13, 2023, ISSN 2158-3188
Editore: Nature Publishing Group
DOI: 10.1038/s41398-023-02415-4

<scp>DNA</scp> methylation at birth and lateral ventricular volume in childhood: a neuroimaging epigenetics study

Autori: Mannan Luo, Esther Walton, Alexander Neumann, Chris H. L. Thio, Janine F. Felix, Marinus H. van IJzendoorn, Irene Pappa, Charlotte A. M. Cecil
Pubblicato in: Journal of Child Psychology and Psychiatry, Numero 65, 2023, Pagina/e 77-90, ISSN 0021-9630
Editore: Blackwell Publishing Inc.
DOI: 10.1111/jcpp.13866

Examining the epigenetic mechanisms of childhood adversity and sensitive periods: a gene set-based approach

Autori: Zhu, Y., Lussier, A. A., Smith, A. D., Simpkin, A. J., Suderman, M. J., Walton, E., ... & Dunn, E. C. (2022). Examining the epigenetic mechanisms of childhood adversity and sensitive periods: a gene set-based approach. Psychoneuroendocrinology, 144, 105854.
Pubblicato in: Psychoneuroendocrinology, 2022, ISSN 0306-4530
Editore: Pergamon Press
DOI: 10.1016/j.psyneuen.2022.105854

Obesity and brain structure in schizophrenia - ENIGMA study in 3021 individuals

Autori: McWhinney, S.R., Brosch, K., Calhoun, V.D. et al.
Pubblicato in: Molecular Psychiatry, 2022, ISSN 1359-4184
Editore: Nature Publishing Group
DOI: 10.1038/s41380-022-01616-5

Child mental health problems as a risk factor for academic underachievement: a multi-informant, population-based study.

Autori: Schuurmans IK, Tamayo Martinez N, Blok E, Hillegers MHJ, Ikram MA, Luik AI & Cecil CAM
Pubblicato in: Acta Psychiatrica Scandinavica, 2022, ISSN 0001-690X
Editore: Blackwell Publishing Inc.
DOI: 10.1111/acps.13426

On Navigating Analytical Choices in Research on Early Life Adversity: A Commentary on Sisitsky et al. (2023)

Autori: Charlotte A. M. Cecil, Isabel K. Schuurmans
Pubblicato in: Research on Child and Adolescent Psychopathology, Numero 51, 2023, Pagina/e 1805-1808, ISSN 2730-7166
Editore: Springer
DOI: 10.1007/s10802-023-01103-7

Epigenome-wide change and variation in DNA methylation in childhood: trajectories from birth to late adolescence

Autori: Rosa H Mulder, Alexander Neumann, Charlotte A M Cecil, Esther Walton, Lotte C Houtepen, Andrew J Simpkin, Jolien Rijlaarsdam, Bastiaan T Heijmans, Tom R Gaunt, Janine F Felix, Vincent W V Jaddoe, Marian J Bakermans-Kranenburg, Henning Tiemeier, Caroline L Relton, Marinus H van IJzendoorn, Matthew Suderman
Pubblicato in: Human Molecular Genetics, Numero 30/1, 2021, Pagina/e 119-134, ISSN 0964-6906
Editore: Oxford University Press
DOI: 10.1093/hmg/ddaa280

The gut microbiome and child mental health: a population-based study.

Autori: Kraaij R, Schuurmans IK, Radjabzadeh D, Tiemeier H, Dinan TG, Uitterlinden AG, Hillegers M, Jaddoe VWV, Duijts L, Moll H, Rivadeneira F, Medina-Gomez C, Jansen PW, Cecil CAM†
Pubblicato in: Brain, Behavior and Immunity, 2023, ISSN 0889-1591
Editore: Academic Press
DOI: 10.1016/j.bbi.2022.12.006

Neonatal DNA methylation and childhood low prosocial behavior: An epigenome‐wide association meta‐analysis

Autori: Mannan Luo, Alan J. Meehan, Esther Walton, Stefan Röder, Gunda Herberth, Ana C. Zenclussen, Marta Cosín‐Tomás, Jordi Sunyer, Rosa H. Mulder, Andrea P. Cortes Hidalgo, Marian J. Bakermans‐Kranenburg, Janine F. Felix, Caroline Relton, Matthew Suderman, Irene Pappa, Rianne Kok, Henning Tiemeier, Marinus H. IJzendoorn, Edward D. Barker, Charlotte A. M. Cecil
Pubblicato in: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Numero 186/4, 2021, Pagina/e 228-241, ISSN 1552-4841
Editore: Wiley-Liss Inc
DOI: 10.1002/ajmg.b.32862

Long-Term Impact of Social Isolation and Molecular Underpinnings

Autori: Rodrigo G. Arzate-Mejía, Zuzanna Lottenbach, Vincent Schindler, Ali Jawaid, Isabelle M. Mansuy
Pubblicato in: Frontiers in Genetics, Numero 11, 2020, ISSN 1664-8021
Editore: Frontiers Media
DOI: 10.3389/fgene.2020.589621

Depression, cardiometabolic disease, and their co-occurrence after childhood maltreatment: an individual participant data meta-analysis including over 200,000 participants

Autori: Camille Souama, Femke Lamers, Yuri Milaneschi, Christiaan H. Vinkers, Serena Defina, Linda Garvert, Frederike Stein, Tom Woofenden, Katharina Brosch, Udo Dannlowski, Henrike Galenkamp, Ron de Graaf, Vincent W. V. Jaddoe, Anja Lok, Bas B. van Rijn, Henry Völzke, Charlotte A. M. Cecil, Janine F. Felix, Hans J. Grabe, Tilo Kircher, Karim Lekadir, Margreet ten Have, Esther Walton, Brenda W. J. H. Pen
Pubblicato in: BMC Medicine, Numero 21, 2023, ISSN 1741-7015
Editore: BioMed Central
DOI: 10.1186/s12916-023-02769-y

Effectiveness of psychological and/or educational interventions in reducing anxiety and depression in people with type 2 diabetes: A systematic review and meta-analysis

Autori: Kristina M.Thumfarta, Ali Jawaidab, Kristina Bright, Marc Flachsmann, Isabelle M.Mansuy
Pubblicato in: Diabetes Research and Clinical Practice, 2021, ISSN 0168-8227
Editore: Elsevier BV
DOI: 10.1016/j.diabres.2021.108922

Early-life stress and the gut microbiome: A comprehensive population-based investigation

Autori: Rosa H. Mulder, Robert Kraaij, Isabel K. Schuurmans, Carlos Frances-Cuesta, Yolanda Sanz, Carolina Medina-Gomez, Liesbeth Duijts, Fernando Rivadeneira, Henning Tiemeier, Vincent W.V. Jaddoe, Janine F. Felix, Charlotte A.M. Cecil
Pubblicato in: Brain, Behavior, and Immunity, Numero 118, 2024, Pagina/e 117-127, ISSN 0889-1591
Editore: Academic Press
DOI: 10.1016/j.bbi.2024.02.024

EXPLORE: a novel deep learning-based analysis method for exploration behaviour in object recognition tests

Autori: Victor Ibañez, Laurens Bohlen, Francesca Manuella, Isabelle Mansuy, Fritjof Helmchen, Anna-Sophia Wahl
Pubblicato in: Scientific Reports, Numero 13, 2023, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-023-31094-w

Associations of Hair Cortisol Concentrations With Cardiometabolic Risk Factors in Childhood

Autori: Florianne O L Vehmeijer, Susana Santos, Yolanda B de Rijke, Erica L T van den Akker, Janine F Felix, Elisabeth F C van Rossum, Vincent W V Jaddoe
Pubblicato in: The Journal of Clinical Endocrinology & Metabolism, 2021, ISSN 0021-972X
Editore: The Endocrine Society
DOI: 10.1210/clinem/dgab379

Gene–environment correlations and causal effects of childhood maltreatment on physical and mental health: a genetically informed approach

Autori: Varun Warrier, Alex S F Kwong, Mannan Luo, Shareefa Dalvie, Jazz Croft, Hannah M Sallis, Jessie Baldwin, Marcus R Munafò, Caroline M Nievergelt, Andrew J Grant, Stephen Burgess, Tyler M Moore, Ran Barzilay, Andrew McIntosh, Marinus H van IJzendoorn, Charlotte A M Cecil
Pubblicato in: The Lancet Psychiatry, Numero 8/5, 2021, Pagina/e 373-386, ISSN 2215-0366
Editore: Elsevier Limited
DOI: 10.1016/s2215-0366(20)30569-1

A systematic review of neuroimaging epigenetic research: calling for an increased focus on development

Autori: Esther Walton, Vilte Baltramonaityte, Vince Calhoun, Bastiaan T. Heijmans, Paul M. Thompson, Charlotte A. M. Cecil
Pubblicato in: Molecular Psychiatry, Numero 28, 2023, Pagina/e 2839-2847, ISSN 1359-4184
Editore: Nature Publishing Group
DOI: 10.1038/s41380-023-02067-2

ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries

Autori: Paul M. Thompson, Neda Jahanshad, Christopher R. K. Ching, Lauren E. Salminen, Sophia I. Thomopoulos, Joanna Bright, Bernhard T. Baune, Sara Bertolín, Janita Bralten, Willem B. Bruin, Robin Bülow, Jian Chen, Yann Chye, Udo Dannlowski, Carolien G. F. de Kovel, Gary Donohoe, Lisa T. Eyler, Stephen V. Faraone, Pauline Favre, Courtney A. Filippi, Thomas Frodl, Daniel Garijo, Yolanda Gil, Hans J. Gra
Pubblicato in: Translational Psychiatry, Numero 10/1, 2020, ISSN 2158-3188
Editore: Nature Publishing Group
DOI: 10.1038/s41398-020-0705-1

Wir können unsere Gene steuern!

Autori: Mansuy, I.M., Gurret, J.M. Lelief, A.
Pubblicato in: 2020
Editore: Berlin Verlag

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