Causative mechanisms & integrative models linking early-life-stress to psycho-cardio-metabolic multi-morbidity

Project Information

EarlyCause

Grant agreement ID: 848158

DOI 10.3030/848158

Project closed

EC signature date 6 December 2019

Start date 1 January 2020

End date 30 June 2024

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost € 5 997 381,25

EU contribution € 5 997 381,25

Coordinated by

UNIVERSITAT DE BARCELONA
Spain

Deliverables

Documents, reports (8)

Structural equation model linking ELS to multi-morbidity outcomes

Structural equation model linking ELS to multimorbidity outcomes

Dissemination, communication & outreach strategy
Data management Plan version 2
Quantitative measures of ELS-induced metabolic alterations, endocrine response and cardiovascular parameters

Quantitative measures of ELSinduced metabolic alterations endocrine response and cardiovascular parameters

Data harmonisation process for public use
Project website and communication materials
Quantitative measures of ELS-induced behavioural symptoms

Quantitative measures of ELSinduced behavioural symptoms

Socio-economic impact assessment framework

Socioeconomic impact assessment framework

Other (2)

Data Coordination Centre
System for dataset incorporation into DCC

Open Research Data Pilot (1)

Data Management Plan version 1

Publications

Peer reviewed articles (42)

Epigenetic Inheritance: Impact for Biology and Society

Author(s): Arzate-Mejia, R. G and Mansuy, I.M.
Published in: Environmental Epigenetics, 2022, ISSN 2470-0991
Publisher: Oxford University Press
DOI: 10.1093/eep/dvac021

Paternal body mass index and offspring DNA methylation: findings from the PACE consortium

Author(s): Gemma C Sharp, Rossella Alfano, Akram Ghantous, Jose Urquiza, Sheryl L Rifas-Shiman, Christian M Page, Jianping Jin, Silvia Fernández-Barrés, Gillian Santorelli, Gwen Tindula, Gemma C Sharp, Rossella Alfano, Akram Ghantous, Jose Urquiza, Sheryl L Rifas-Shiman, Christian M Page, Jianping Jin, Silvia Fernández-Barrés, Gillian Santorelli, Gwen Tindula, Paul Yousefi, Leanne Kupers, Carlos Ruiz-Are
Published in: International Journal of Epidemiology, 2021, ISSN 0300-5771
Publisher: Oxford University Press
DOI: 10.1093/ije/dyaa267

Brain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium.

Author(s): Constantinides, C., Han, L. K., Alloza, C., Antonucci, L., Arango, C., Ayesa-Arriola, R., ... & Walton, E.
Published in: Molecular Psychiatry, 2023, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-022-01897-w

Maternal Glycemic Dysregulation During Pregnancy and Neonatal Blood DNA Methylation: Meta-analyses of Epigenome-Wide Association Studies

Author(s): Tobi EW, Juvinao-Quintero DL, Ronkainen J, Ott R, Alfano R, Canouil M, Geurtsen ML, Khamis A, Küpers LK, Lim IY, Perron P, Pesce G, Tuhkanen J, Starling AP, Andrew T, Binder E, Caiazzo R, Chan JKY, Gaillard R, Gluckman PD, Keikkala E, Karnani N, Mustaniemi S, Nawrot TS, Pattou F, Plusquin M, Raverdy V, Tan KH, Tzala E, Raikkonen K, Winkler C, Ziegler AG, Annesi-Maesano I, Bouchard L, Chong YS, Da
Published in: Diabetes Care, 2022, ISSN 1939-327X
Publisher: American Diabetes Association
DOI: 10.2337/dc21-1701

Paternal transmission of behavioural and metabolic traits induced by postnatal stress to the 5th generation in mice.

Author(s): Boscardin C., Manuella, F. and Mansuy, I.M.
Published in: Environmental Epigenetics, 2022, ISSN 2470-0991
Publisher: Oxford University Press
DOI: 10.1093/eep/dvac024

Epigenetics of childhood trauma: Long-term sequelae and potential for treatment.

Author(s): Thumfart, K., Jawaid, A., Bright, K., Flachsmann, M and Mansuy, I.M.
Published in: Neurosci Biobehav Rev, 2022, ISSN 0149-7634
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2021.10.042

Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation

Author(s): Solomon O, Huen K, Yousefi P, Küpers LK, González JR, Suderman M, Reese SE, Page CM, Gruzieva O, Rzehak P, Gao L, Bakulski KM, Novoloaca A, Allard C, Pappa I, Llambrich M, Vives M, Jima DD, Kvist T, Baccarelli A, White C, Rezwan FI, Sharp GC, Tindula G, Bergström A, Grote V, Dou JF, Isaevska E, Magnus MC, Corpeleijn E, Perron P, Jaddoe VWV, Nohr EA, Maitre L, Foraster M, Hoyo C, Håberg SE, Lah
Published in: Mutat Res Rev Mutat Res, 2022, ISSN 1383-5742
Publisher: Elsevier BV
DOI: 10.1016/j.mrrev.2022.108415

Long-term effects of early postnatal stress on Sertoli cells functions.

Author(s): Thumfart, K, Lazzeri, S. Manuella F. and Mansuy, I.M.
Published in: Frontiers in Genetics, 2022, ISSN 1664-8021
Publisher: Frontiers Media
DOI: 10.3389/fgene.2022.1024805

Maternal Psychological Problems During Pregnancy and Child Externalizing Problems: Moderated Mediation Model with Child Self-regulated Compliance and Polygenic Risk Scores for Aggression

Author(s): Mannan Luo, Irene Pappa, Charlotte A. M. Cecil, Philip Jansen, Marinus H. van IJzendoorn, Rianne Kok
Published in: Child Psychiatry & Human Development, 2021, ISSN 0009-398X
Publisher: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10578-021-01154-1

The association of early life stress with IQ-achievement discrepancy in children: A population-based study

Author(s): Schuurmans IK, Luik AI, de Maat DA, Hillegers MHJ, Ikram MA & Cecil CAM
Published in: Child Development, 2022, ISSN 0009-3920
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/cdev.13825

Longitudinal associations of DNA methylation and sleep in children: a meta-analysis

Author(s): Sara Sammallahti, M. Elisabeth Koopman-Verhoeff, Anne-Claire Binter, Rosa H. Mulder, Alba Cabré-Riera, Tuomas Kvist, Anni L. K. Malmberg, Giancarlo Pesce, Sabine Plancoulaine, Jonathan A. Heiss, Sheryl L. Rifas-Shiman, Stefan W. Röder, Anne P. Starling, Rory Wilson, Kathrin Guerlich, Kristine L. Haftorn, Christian M. Page, Annemarie I. Luik, Henning Tiemeier, Janine F. Felix, Katri Raikkonen, Ja
Published in: Clinical Epigenetics, 2022, ISSN 1868-7075
Publisher: Springer Verlag
DOI: 10.1186/s13148-022-01298-4

Emotion Processing Differences Mediate the Link between Sex and Autistic Traits in Young Adulthood

Author(s): Lucy A. Livingston, Lucy H. Waldren, Esther Walton, Punit Shah
Published in: JCPP Advances, 2022, ISSN 1469-7610
Publisher: Wiley
DOI: 10.1002/jcv2.12096

Epigenomics of being bullied: changes in DNA methylation following bullying exposure

Author(s): Rosa H. Mulder, Esther Walton, Alexander Neumann, Lotte C. Houtepen, Janine F. Felix, Marian J. Bakermans-Kranenburg, Matthew Suderman, Henning Tiemeier, Marinus H. van IJzendoorn, Caroline L. Relton, Charlotte A. M. Cecil
Published in: Epigenetics, Issue 15/6-7, 2020, Page(s) 750-764, ISSN 1559-2294
Publisher: Landes Bioscience
DOI: 10.1080/15592294.2020.1719303

Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills

Author(s): Caramaschi D, Neumann A, Cardenas A, Tindula G, Alemany S, Zillich L, Pesce G, Lahti JMT, Havdahl A, Mulder R, Felix JF, Tiemeier H, Sirignano L, Frank J, Witt SH, Rietschel M, Deuschle M, Huen K, Eskenazi B, Send TS, Ferrer M, Gilles M, de Agostini M, Baïz N, Rifas-Shiman SL, Kvist T, Czamara D, Tuominen ST, Relton CL, Rai D, London SJ, Räikkönen K, Holland N, Annesi-Maesano I, Streit F, Hiver
Published in: Molecular psychiatry, 2022, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-022-01441-w

Childhood maltreatment and DNA methylation: A systematic review

Author(s): Charlotte A.M. Cecil, Yuning Zhang, Tobias Nolte
Published in: Neuroscience & Biobehavioral Reviews, Issue 112, 2020, Page(s) 392-409, ISSN 0149-7634
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2020.02.019

Epigenome-wide associations between observed maternal sensitivity and offspring DNA methylation: a population-based prospective study in children

Author(s): Lorenza Dall’ Aglio, Jolien Rijlaarsdam, Rosa H. Mulder, Alexander Neumann, Janine F. Felix, Rianne Kok, Marian J. Bakermans-Kranenburg, Marinus H. van Ijzendoorn, Henning Tiemeier, Charlotte A.M. Cecil
Published in: Psychological Medicine, 2020, Page(s) 1-11, ISSN 0033-2917
Publisher: Cambridge University Press
DOI: 10.1017/s0033291720004353

Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation

Author(s): Sara Sammallahti, Andrea P. Cortes Hidalgo, Samuli Tuominen, Anni Malmberg, Rosa H. Mulder, Kelly J. Brunst, Silvia Alemany, Nancy S. McBride, Paul Yousefi, Jonathan A. Heiss, Nia McRae, Christian M. Page, Jianping Jin, Giancarlo Pesce, Doretta Caramaschi, Sheryl L. Rifas-Shiman, Nastassja Koen, Charleen D. Adams, Maria C. Magnus, Nour Baïz, Andrew Ratanatharathorn, Darina Czamara, Siri E. Håber
Published in: Molecular Psychiatry, 2020, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-020-00976-0

Identifying causative mechanisms linking early-life stress to psycho-cardio-metabolic multi-morbidity: The EarlyCause project

Author(s): Nicole Mariani, Alessandra Borsini, Charlotte A. M. Cecil, Janine F. Felix, Sylvain Sebert, Annamaria Cattaneo, Esther Walton, Yuri Milaneschi, Guy Cochrane, Clara Amid, Jeena Rajan, Juliette Giacobbe, Yolanda Sanz, Ana Agustí, Tania Sorg, Yann Herault, Jouko Miettunen, Priyanka Parmar, Nadia Cattane, Vincent Jaddoe, Jyrki Lötjönen, Carme Buisan, Miguel A. González Ballester, Gemma Piella, Jos
Published in: PLOS ONE, Issue 16/1, 2021, Page(s) e0245475, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0245475

The determinants and longitudinal changes in vitamin D status in middle-age: a Northern Finland Birth Cohort 1966 study

Author(s): Helmi Ikonen, Johanna Lumme, Jussi Seppälä, Paula Pesonen, Terhi Piltonen, Marjo-Riitta Järvelin, Karl-Heinz Herzig, Jouko Miettunen, Maarit Niinimäki, Saranya Palaniswamy, Sylvain Sebert, Marja Ojaniemi
Published in: European Journal of Nutrition, 2021, ISSN 1436-6207
Publisher: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00394-021-02606-z

Associations between T cells and attention problems in the general pediatric population: the Generation R Study.

Author(s): Looman KIM, Cecil CAM, Grosserichter-Wagener C, Kiefte de Jong JC, van Zelm MC & Moll HA
Published in: JCPP Advances, 2022, ISSN 1469-7610
Publisher: Wiley
DOI: 10.1002/jcv2.12038

Brain Structure in Acutely Underweight and Partially Weight-Restored Individuals With Anorexia Nervosa: A Coordinated Analysis by the ENIGMA Eating Disorders Working Group

Author(s): Walton, E., Bernardoni, F., Batury, V. L., Bahnsen, K., Larivière, S., Abbate-Daga, G., ... & Ehrlich, S. (2022).
Published in: Biological Psychiatry, 2022, ISSN 0006-3223
Publisher: Elsevier BV
DOI: 10.1016/j.biopsych.2022.04.022

Epigenetics applied to child and adolescent mental health: Progress, challenges and opportunities

Author(s): Cecil C, Neumann A, Walton E
Published in: JCPP Advances, 2022, ISSN 1469-7610
Publisher: Wiley
DOI: 10.1002/jcv2.12133

Schizophrenia polygenic risk is associated with child mental health problems through early childhood adversity: evidence for a gene–environment correlation

Author(s): Koen Bolhuis, Lisa R. Steenkamp, Laura M. E. Blanken, Alexander Neumann, Philip R. Jansen, Manon H. J. Hillegers, Charlotte A. M. Cecil, Henning Tiemeier, Steven A. Kushner
Published in: European Child & Adolescent Psychiatry, 2021, ISSN 1018-8827
Publisher: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00787-021-01727-4

Genome-wide DNA methylation patterns associated with general psychopathology in children

Author(s): Jolien Rijlaarsdam, Edward D. Barker, Chiara Caserini, M. Elisabeth Koopman-Verhoeff, Rosa H. Mulder, Janine F. Felix, Charlotte A.M. Cecil
Published in: Journal of Psychiatric Research, Issue 140, 2021, Page(s) 214-220, ISSN 0022-3956
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.jpsychires.2021.05.029

Epigenetics and ADHD: Reflections on Current Knowledge, Research Priorities and Translational Potential

Author(s): Cecil CAM & Nigg JT
Published in: Molecular Diagnosis & Therapy, 2022, ISSN 1177-1062
Publisher: Adis International Ltd.
DOI: 10.1007/s40291-022-00609-y

Single-cell multiomics techniques: from conception to applications.

Author(s): Dimitriu, M, Lazar-Contes, I., Roszkowski, M. and Mansuy, I.M.
Published in: Front. Cell. Dev. Biol., 2022, ISSN 2296-634X
Publisher: Frontiers in Cell and Developmental Biology
DOI: 10.3389/fcell.2022.854317

Association of Maternal Tobacco Use During Pregnancy With Preadolescent Brain Morphology Among Offspring

Author(s): Zou R, Boer OD, Felix JF, Muetzel R, Franken IHA, Cecil CAM & El Marroun H .
Published in: JAMA Network Open., 2022, ISSN 2574-3805
Publisher: JAMA network open
DOI: 10.1001/jamanetworkopen.2022.24701

The European Nucleotide Archive in 2020

Author(s): Peter W Harrison, Alisha Ahamed, Raheela Aslam, Blaise T F Alako, Josephine Burgin, Nicola Buso, Mélanie Courtot, Jun Fan, Dipayan Gupta, Muhammad Haseeb, Sam Holt, Talal Ibrahim, Eugene Ivanov, Suran Jayathilaka, Vishnukumar Balavenkataraman Kadhirvelu, Manish Kumar, Rodrigo Lopez, Simon Kay, Rasko Leinonen, Xin Liu, Colman O’Cathail, Amir Pakseresht, Youngmi Park, Stephane Pesant, Nadim Rahm
Published in: Nucleic Acids Research, Issue 49/D1, 2020, Page(s) D82-D85, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkaa1028

Complete Genome Sequence of Phascolarctobacterium faecium G 104, Isolated from the Stools of a Healthy Lean Donor

Author(s): Sadjia Rachek, Naghmeh Nikpoor, Eva M. Gómez del Pulgar, Aitor Gonzaga, Yolanda Sanz, Thomas A. Tompkins
Published in: Microbiology Resource Announcements, Issue 10/4, 2021, ISSN 2576-098X
Publisher: ASM Journals (American Society for Microbiology)
DOI: 10.1128/mra.01054-20

Family Aggression Screening Tool (FAST): factor structure and psychometric properties of subscales.

Author(s): Vieira R, Pires PP, Cecil CAM, Barker E, Reis D, Couto I, Cypriano C & de Oliveira IR.
Published in: Child Abuse & Neglect, 2022, ISSN 0145-2134
Publisher: Elsevier BV
DOI: 10.1016/j.chiabu.2022.105548

Mapping gene by early life stress interactions on child subcortical brain structures: A genome-wide prospective study.

Author(s): Bolhuis K*, Mulder RH*, de Mol CL, Defina S, Warrier V, White T, Tiemeier H, Muetzel RL & Cecil CAM†
Published in: JCPP Advances, 2022, ISSN 0021-9630
Publisher: Blackwell Publishing Inc.
DOI: 10.1002/jcv2.12113

Examining the epigenetic mechanisms of childhood adversity and sensitive periods: a gene set-based approach

Author(s): Zhu, Y., Lussier, A. A., Smith, A. D., Simpkin, A. J., Suderman, M. J., Walton, E., ... & Dunn, E. C. (2022). Examining the epigenetic mechanisms of childhood adversity and sensitive periods: a gene set-based approach. Psychoneuroendocrinology, 144, 105854.
Published in: Psychoneuroendocrinology, 2022, ISSN 0306-4530
Publisher: Pergamon Press
DOI: 10.1016/j.psyneuen.2022.105854

Obesity and brain structure in schizophrenia - ENIGMA study in 3021 individuals

Author(s): McWhinney, S.R., Brosch, K., Calhoun, V.D. et al.
Published in: Molecular Psychiatry, 2022, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-022-01616-5

Child mental health problems as a risk factor for academic underachievement: a multi-informant, population-based study.

Author(s): Schuurmans IK, Tamayo Martinez N, Blok E, Hillegers MHJ, Ikram MA, Luik AI & Cecil CAM
Published in: Acta Psychiatrica Scandinavica, 2022, ISSN 0001-690X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/acps.13426

Epigenome-wide change and variation in DNA methylation in childhood: trajectories from birth to late adolescence

Author(s): Rosa H Mulder, Alexander Neumann, Charlotte A M Cecil, Esther Walton, Lotte C Houtepen, Andrew J Simpkin, Jolien Rijlaarsdam, Bastiaan T Heijmans, Tom R Gaunt, Janine F Felix, Vincent W V Jaddoe, Marian J Bakermans-Kranenburg, Henning Tiemeier, Caroline L Relton, Marinus H van IJzendoorn, Matthew Suderman
Published in: Human Molecular Genetics, Issue 30/1, 2021, Page(s) 119-134, ISSN 0964-6906
Publisher: Oxford University Press
DOI: 10.1093/hmg/ddaa280

The gut microbiome and child mental health: a population-based study.

Author(s): Kraaij R, Schuurmans IK, Radjabzadeh D, Tiemeier H, Dinan TG, Uitterlinden AG, Hillegers M, Jaddoe VWV, Duijts L, Moll H, Rivadeneira F, Medina-Gomez C, Jansen PW, Cecil CAM†
Published in: Brain, Behavior and Immunity, 2023, ISSN 0889-1591
Publisher: Academic Press
DOI: 10.1016/j.bbi.2022.12.006

Neonatal DNA methylation and childhood low prosocial behavior: An epigenome‐wide association meta‐analysis

Author(s): Mannan Luo, Alan J. Meehan, Esther Walton, Stefan Röder, Gunda Herberth, Ana C. Zenclussen, Marta Cosín‐Tomás, Jordi Sunyer, Rosa H. Mulder, Andrea P. Cortes Hidalgo, Marian J. Bakermans‐Kranenburg, Janine F. Felix, Caroline Relton, Matthew Suderman, Irene Pappa, Rianne Kok, Henning Tiemeier, Marinus H. IJzendoorn, Edward D. Barker, Charlotte A. M. Cecil
Published in: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Issue 186/4, 2021, Page(s) 228-241, ISSN 1552-4841
Publisher: Wiley-Liss Inc
DOI: 10.1002/ajmg.b.32862

Long-Term Impact of Social Isolation and Molecular Underpinnings

Author(s): Rodrigo G. Arzate-Mejía, Zuzanna Lottenbach, Vincent Schindler, Ali Jawaid, Isabelle M. Mansuy
Published in: Frontiers in Genetics, Issue 11, 2020, ISSN 1664-8021
Publisher: Frontiers Media
DOI: 10.3389/fgene.2020.589621

Effectiveness of psychological and/or educational interventions in reducing anxiety and depression in people with type 2 diabetes: A systematic review and meta-analysis

Author(s): Kristina M.Thumfarta, Ali Jawaidab, Kristina Bright, Marc Flachsmann, Isabelle M.Mansuy
Published in: Diabetes Research and Clinical Practice, 2021, ISSN 0168-8227
Publisher: Elsevier BV
DOI: 10.1016/j.diabres.2021.108922

Associations of Hair Cortisol Concentrations With Cardiometabolic Risk Factors in Childhood

Author(s): Florianne O L Vehmeijer, Susana Santos, Yolanda B de Rijke, Erica L T van den Akker, Janine F Felix, Elisabeth F C van Rossum, Vincent W V Jaddoe
Published in: The Journal of Clinical Endocrinology & Metabolism, 2021, ISSN 0021-972X
Publisher: The Endocrine Society
DOI: 10.1210/clinem/dgab379

Gene–environment correlations and causal effects of childhood maltreatment on physical and mental health: a genetically informed approach

Author(s): Varun Warrier, Alex S F Kwong, Mannan Luo, Shareefa Dalvie, Jazz Croft, Hannah M Sallis, Jessie Baldwin, Marcus R Munafò, Caroline M Nievergelt, Andrew J Grant, Stephen Burgess, Tyler M Moore, Ran Barzilay, Andrew McIntosh, Marinus H van IJzendoorn, Charlotte A M Cecil
Published in: The Lancet Psychiatry, Issue 8/5, 2021, Page(s) 373-386, ISSN 2215-0366
Publisher: Elsevier Limited
DOI: 10.1016/s2215-0366(20)30569-1

ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries

Author(s): Paul M. Thompson, Neda Jahanshad, Christopher R. K. Ching, Lauren E. Salminen, Sophia I. Thomopoulos, Joanna Bright, Bernhard T. Baune, Sara Bertolín, Janita Bralten, Willem B. Bruin, Robin Bülow, Jian Chen, Yann Chye, Udo Dannlowski, Carolien G. F. de Kovel, Gary Donohoe, Lisa T. Eyler, Stephen V. Faraone, Pauline Favre, Courtney A. Filippi, Thomas Frodl, Daniel Garijo, Yolanda Gil, Hans J. Gra
Published in: Translational Psychiatry, Issue 10/1, 2020, ISSN 2158-3188
Publisher: Nature Publishing Group
DOI: 10.1038/s41398-020-0705-1

Monographic books (1)

Wir können unsere Gene steuern!

Author(s): Mansuy, I.M., Gurret, J.M. Lelief, A.
Published in: 2020
Publisher: Berlin Verlag