B Cell Immunodominance in Antiviral Immunity

Project Information

B-DOMINANCE

Grant agreement ID: 850638

DOI

10.3030/850638

Project closed

EC signature date 28 October 2019

Start date 1 December 2019

End date 31 May 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 481 697,00

EU contribution

€ 1 481 697,00

Coordinated by

GOETEBORGS UNIVERSITET
Sweden

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

DMP: Data Management Plan

Data Management Plan

Publications

Peer reviewed articles (13)

Longitudinal single-cell analysis of SARS-CoV-2-reactive B cells uncovers persistence of early-formed, antigen specific clones

Author(s): Lydia Scharf; Hannes Axelsson; Aikaterini Emmanouilidi; Nimitha R. Mathew; Daniel J. Sheward; Susannah Leach; Pauline Isakson; Ilya V. Smirnov; Emelie Marklund; Nicolae Miron; Lars-Magnus Andersson; Magnus Gisslén; Ben Murrell; Anna Lundgren; Mats Bemark; Davide Angeletti
Published in: JCI Insights, Issue 1, 2023, ISSN 2379-3708
Publisher: American Society for Clinical Investigation (ASCI)
DOI: 10.1172/jci.insight.165299

Limited access to antigen drives generation of early B cell memory while restraining the plasmablast response

Author(s): Vassilis Glaros; Vassilis Glaros; René Rauschmeier; Artem V. Artemov; Annika Reinhardt; Annika Reinhardt; Sebastian Ols; Sebastian Ols; Aikaterini Emmanouilidi; Charlotte Gustafsson; Yuanyuan You; Yuanyuan You; Claudio Mirabello; Åsa K. Björklund; Laurent Perez; Neil P. King; Robert Månsson; Robert Månsson; Davide Angeletti; Karin Loré; Karin Loré; Igor Adameyko; Igor Adameyko; Meinrad Buss
Published in: Immunity, Issue 1, 2021, ISSN 1097-4180
Publisher: Cell Press
DOI: 10.1016/j.immuni.2021.08.017

Know your enemy or find your friend?—Induction of IgA at mucosal surfaces

Author(s): Mats Bemark, Davide Angeletti
Published in: Immunological Reviews, 2021, ISSN 1600-065X
Publisher: John Wiley & Sons Ltd
DOI: 10.1111/imr.13014

Single-cell BCR and transcriptome analysis after influenza infection reveals spatiotemporal dynamics of antigen-specific B cells

Author(s): Nimitha R. Mathew, Jayalal K. Jayanthan, Ilya V. Smirnov, Jonathan L. Robinson, Hannes Axelsson, Sravya S. Nakka, Aikaterini Emmanouilidi, Paulo Czarnewski, William T. Yewdell, Karin Schön, Cristina Lebrero-Fernández, Valentina Bernasconi, William Rodin, Ali M. Harandi, Nils Lycke, Nicholas Borcherding, Jonathan W. Yewdell, Victor Greiff, Mats Bemark, Davide Angeletti
Published in: Cell Reports, Issue 35/12, 2021, Page(s) 109286, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.109286

Pre-existing CD4 T cell help boosts antibody responses but has limited impact on germinal center, antigen-specific B cell frequencies after influenza infection

Author(s): Danica Besavilla, Laura Reusch, Josue Enriquez, Karin Schön, Davide Angeletti
Published in: Frontiers in Immunology, 2023, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2023.1243164

Memory B-cell diversity: From early generation to tissue residency and reactivation

Author(s): Laura Reusch, Davide Angeletti
Published in: European Journal of Immunology, 2023, ISSN 1521-4141
Publisher: Wiley
DOI: 10.1002/eji.202250085

Plasmablasts in previously immunologically naïve COVID-19 patients express markers indicating mucosal homing and secrete antibodies cross-reacting with SARS-CoV-2 variants and other beta-coronaviruses

Author(s): Anna Lundgren; Susannah Leach; Hannes Axelsson; Pauline Isakson; Kristina Nyström; Lydia Scharf; Bengt A Andersson; Nicolae Miron; Emelie Marklund; Lars-Magnus Andersson; Magnus Gisslén; Davide Angeletti; Mats Bemark
Published in: Clinical and Experimental Immunology, Issue 1, 2023, ISSN 1365-2249
Publisher: Oxford Academic
DOI: 10.1093/cei/uxad044

Ectopic germinal centers in the nasal turbinates contribute to B cell immunity to intranasal viral infection and vaccination

Author(s): Romain Gailleton, Nimitha R. Mathew, Laura Reusch, Karin Schön, Lydia Scharf, Anneli Strömberg, Andrea Cvjetkovic, Luaay Aziz, Johan Hellgren, Ka-Wei Tang, Mats Bemark, Davide Angeletti
Published in: Proceedings of the National Academy of Sciences, Issue 122, 2025, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2421724122

Influenza A Virus H7 nanobody recognizes a conserved immunodominant epitope on hemagglutinin head and confers heterosubtypic protection

Author(s): Zhao-Shan Chen, Hsiang-Chi Huang, Xiangkun Wang, Karin Schön, Yane Jia, Michael Lebens, Danica F. Besavilla, Janarthan R. Murti, Yanhong Ji, Aishe A. Sarshad, Guohua Deng, Qiyun Zhu, Davide Angeletti
Published in: Nature Communications, 2025, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1101/2024.10.31.621368

Temporal dynamics of persistent germinal centers and memory B cell differentiation following respiratory virus infection

Author(s): William T.Yewdell, Ryan M.Smolkin, Kalina T.Belcheva, Alejandra Mendoza, Anthony J.Michaels, Montserrat Cols, DavideAngeletti, Jonathan W.Yewdell, JayantaChaudhuri
Published in: Cell Reports, 2021, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.109961

Nuclear AGO2 supports influenza A virus replication through type-I interferon regulation

Author(s): Hsiang-Chi Huang, Michelle Fong, Iwona Nowak, Evgeniia Shcherbinina, Vivian Lobo, Danica F Besavilla, Hang T Huynh, Karin Schön, Jakub O Westholm, Carola Fernandez, Angana A H Patel, Clotilde Wiel, Volkan I Sayin, Dimitrios G Anastasakis, Davide Angeletti, Aishe A Sarshad
Published in: Nucleic Acids Research, Issue 53, 2025, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkaf268

Loss of Lamin A leads to the nuclear translocation of AGO2 and compromised RNA interference

Author(s): Vivian Lobo, Iwona Nowak, Carola Fernandez, Ana Iris Correa Muler, Jakub O Westholm, Hsiang-Chi Huang, Ivo Fabrik, Hang T Huynh, Evgeniia Shcherbinina, Melis Poyraz, Anetta Härtlova, Daniel Benhalevy, Davide Angeletti, Aishe A Sarshad
Published in: Nucleic Acids Research, Issue 52, 2024, Page(s) 9917-9935, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkae589

Kinetic MUNANA assay reveals functionally relevant antibody epitopes on Influenza A virus neuraminidase

Author(s): Ilya V. Smirnov, Danica F. Besavilla, Karin Schön, Hannes Axelsson, Davide Angeletti
Published in: npj Viruses, Issue 3, 2025, ISSN 2948-1767
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s44298-025-00123-y

Other (3)

Nasal tissue-resident memory CD4⁺T cells persist after influenza A virus infection and provide heterosubtypic protection

Author(s): Nimitha R. Mathew, Romain Gailleton, Lydia Scharf, Karin Schön, Anneli Strömberg, Nils Lycke, Mats Bemark, Ka-Wei Tang, Davide Angeletti
Published in: biorXiv, 2024
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.07.06.602325

Integrated single-cell analyses of affinity-tested B-cells enable the identification of a gene signature to predict antibody affinity

Author(s): Michele Chirichella, Matthew Ratcliff, Shuang Gu, Ricardo Miragaia, Massimo Sammito, Valentina Cutano, Suzanne Cohen, Davide Angeletti, Xavier Romero-Ros, Darren J. Schofield
Published in: biorXiv, 2025
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.01.15.633143

Computationally designed stem-epitope mimetics elicit broadly reactive antibodies

Author(s): Sarah Wehrle, Andreas Scheck, Laura Reusch, Flavio Matassoli, Sandrine Georgeon, Karla M. Castro, Johannes Cramer, Wayne Harshbarger, Stéphane Rosset, Sarah F. Andrews, Karin Schön, Badiaa Bouzya, Ronan Rouxel, Normand Blais, Enrico Malito, Adrian McDermott, Thomas Krey, Corey P. Mallett, Ventzislav Vassilev, Davide Angeletti, Bruno E. Correia
Published in: biorXiv, 2025
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.01.22.634229

Non-peer reviewed articles (1)

Monoclonal antibodies lock down SARS-CoV-2 spike

Author(s): Hsiang-Chi Huang, Davide Angeletti
Published in: Trends in Immunology, 2023, ISSN 1471-4906
Publisher: Elsevier BV
DOI: 10.1016/j.it.2023.09.006