B Cell Immunodominance in Antiviral Immunity

Informazioni relative al progetto

B-DOMINANCE

ID dell’accordo di sovvenzione: 850638

DOI

10.3030/850638

Progetto chiuso

Data della firma CE 28 Ottobre 2019

Data di avvio 1 Dicembre 2019

Data di completamento 31 Maggio 2025

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 481 697,00

Contributo UE

€ 1 481 697,00

Coordinato da

GOETEBORGS UNIVERSITET
Sweden

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Open Research Data Pilot (1)

DMP: Data Management Plan

Data Management Plan

Pubblicazioni

Peer reviewed articles (13)

Longitudinal single-cell analysis of SARS-CoV-2-reactive B cells uncovers persistence of early-formed, antigen specific clones

Autori: Lydia Scharf; Hannes Axelsson; Aikaterini Emmanouilidi; Nimitha R. Mathew; Daniel J. Sheward; Susannah Leach; Pauline Isakson; Ilya V. Smirnov; Emelie Marklund; Nicolae Miron; Lars-Magnus Andersson; Magnus Gisslén; Ben Murrell; Anna Lundgren; Mats Bemark; Davide Angeletti
Pubblicato in: JCI Insights, Numero 1, 2023, ISSN 2379-3708
Editore: American Society for Clinical Investigation (ASCI)
DOI: 10.1172/jci.insight.165299

Limited access to antigen drives generation of early B cell memory while restraining the plasmablast response

Autori: Vassilis Glaros; Vassilis Glaros; René Rauschmeier; Artem V. Artemov; Annika Reinhardt; Annika Reinhardt; Sebastian Ols; Sebastian Ols; Aikaterini Emmanouilidi; Charlotte Gustafsson; Yuanyuan You; Yuanyuan You; Claudio Mirabello; Åsa K. Björklund; Laurent Perez; Neil P. King; Robert Månsson; Robert Månsson; Davide Angeletti; Karin Loré; Karin Loré; Igor Adameyko; Igor Adameyko; Meinrad Buss
Pubblicato in: Immunity, Numero 1, 2021, ISSN 1097-4180
Editore: Cell Press
DOI: 10.1016/j.immuni.2021.08.017

Know your enemy or find your friend?—Induction of IgA at mucosal surfaces

Autori: Mats Bemark, Davide Angeletti
Pubblicato in: Immunological Reviews, 2021, ISSN 1600-065X
Editore: John Wiley & Sons Ltd
DOI: 10.1111/imr.13014

Single-cell BCR and transcriptome analysis after influenza infection reveals spatiotemporal dynamics of antigen-specific B cells

Autori: Nimitha R. Mathew, Jayalal K. Jayanthan, Ilya V. Smirnov, Jonathan L. Robinson, Hannes Axelsson, Sravya S. Nakka, Aikaterini Emmanouilidi, Paulo Czarnewski, William T. Yewdell, Karin Schön, Cristina Lebrero-Fernández, Valentina Bernasconi, William Rodin, Ali M. Harandi, Nils Lycke, Nicholas Borcherding, Jonathan W. Yewdell, Victor Greiff, Mats Bemark, Davide Angeletti
Pubblicato in: Cell Reports, Numero 35/12, 2021, Pagina/e 109286, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2021.109286

Pre-existing CD4 T cell help boosts antibody responses but has limited impact on germinal center, antigen-specific B cell frequencies after influenza infection

Autori: Danica Besavilla, Laura Reusch, Josue Enriquez, Karin Schön, Davide Angeletti
Pubblicato in: Frontiers in Immunology, 2023, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2023.1243164

Memory B-cell diversity: From early generation to tissue residency and reactivation

Autori: Laura Reusch, Davide Angeletti
Pubblicato in: European Journal of Immunology, 2023, ISSN 1521-4141
Editore: Wiley
DOI: 10.1002/eji.202250085

Plasmablasts in previously immunologically naïve COVID-19 patients express markers indicating mucosal homing and secrete antibodies cross-reacting with SARS-CoV-2 variants and other beta-coronaviruses

Autori: Anna Lundgren; Susannah Leach; Hannes Axelsson; Pauline Isakson; Kristina Nyström; Lydia Scharf; Bengt A Andersson; Nicolae Miron; Emelie Marklund; Lars-Magnus Andersson; Magnus Gisslén; Davide Angeletti; Mats Bemark
Pubblicato in: Clinical and Experimental Immunology, Numero 1, 2023, ISSN 1365-2249
Editore: Oxford Academic
DOI: 10.1093/cei/uxad044

Ectopic germinal centers in the nasal turbinates contribute to B cell immunity to intranasal viral infection and vaccination

Autori: Romain Gailleton, Nimitha R. Mathew, Laura Reusch, Karin Schön, Lydia Scharf, Anneli Strömberg, Andrea Cvjetkovic, Luaay Aziz, Johan Hellgren, Ka-Wei Tang, Mats Bemark, Davide Angeletti
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 122, 2025, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2421724122

Influenza A Virus H7 nanobody recognizes a conserved immunodominant epitope on hemagglutinin head and confers heterosubtypic protection

Autori: Zhao-Shan Chen, Hsiang-Chi Huang, Xiangkun Wang, Karin Schön, Yane Jia, Michael Lebens, Danica F. Besavilla, Janarthan R. Murti, Yanhong Ji, Aishe A. Sarshad, Guohua Deng, Qiyun Zhu, Davide Angeletti
Pubblicato in: Nature Communications, 2025, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1101/2024.10.31.621368

Temporal dynamics of persistent germinal centers and memory B cell differentiation following respiratory virus infection

Autori: William T.Yewdell, Ryan M.Smolkin, Kalina T.Belcheva, Alejandra Mendoza, Anthony J.Michaels, Montserrat Cols, DavideAngeletti, Jonathan W.Yewdell, JayantaChaudhuri
Pubblicato in: Cell Reports, 2021, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2021.109961

Nuclear AGO2 supports influenza A virus replication through type-I interferon regulation

Autori: Hsiang-Chi Huang, Michelle Fong, Iwona Nowak, Evgeniia Shcherbinina, Vivian Lobo, Danica F Besavilla, Hang T Huynh, Karin Schön, Jakub O Westholm, Carola Fernandez, Angana A H Patel, Clotilde Wiel, Volkan I Sayin, Dimitrios G Anastasakis, Davide Angeletti, Aishe A Sarshad
Pubblicato in: Nucleic Acids Research, Numero 53, 2025, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkaf268

Loss of Lamin A leads to the nuclear translocation of AGO2 and compromised RNA interference

Autori: Vivian Lobo, Iwona Nowak, Carola Fernandez, Ana Iris Correa Muler, Jakub O Westholm, Hsiang-Chi Huang, Ivo Fabrik, Hang T Huynh, Evgeniia Shcherbinina, Melis Poyraz, Anetta Härtlova, Daniel Benhalevy, Davide Angeletti, Aishe A Sarshad
Pubblicato in: Nucleic Acids Research, Numero 52, 2024, Pagina/e 9917-9935, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkae589

Kinetic MUNANA assay reveals functionally relevant antibody epitopes on Influenza A virus neuraminidase

Autori: Ilya V. Smirnov, Danica F. Besavilla, Karin Schön, Hannes Axelsson, Davide Angeletti
Pubblicato in: npj Viruses, Numero 3, 2025, ISSN 2948-1767
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s44298-025-00123-y

Other (3)

Nasal tissue-resident memory CD4⁺T cells persist after influenza A virus infection and provide heterosubtypic protection

Autori: Nimitha R. Mathew, Romain Gailleton, Lydia Scharf, Karin Schön, Anneli Strömberg, Nils Lycke, Mats Bemark, Ka-Wei Tang, Davide Angeletti
Pubblicato in: biorXiv, 2024
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.07.06.602325

Integrated single-cell analyses of affinity-tested B-cells enable the identification of a gene signature to predict antibody affinity

Autori: Michele Chirichella, Matthew Ratcliff, Shuang Gu, Ricardo Miragaia, Massimo Sammito, Valentina Cutano, Suzanne Cohen, Davide Angeletti, Xavier Romero-Ros, Darren J. Schofield
Pubblicato in: biorXiv, 2025
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.01.15.633143

Computationally designed stem-epitope mimetics elicit broadly reactive antibodies

Autori: Sarah Wehrle, Andreas Scheck, Laura Reusch, Flavio Matassoli, Sandrine Georgeon, Karla M. Castro, Johannes Cramer, Wayne Harshbarger, Stéphane Rosset, Sarah F. Andrews, Karin Schön, Badiaa Bouzya, Ronan Rouxel, Normand Blais, Enrico Malito, Adrian McDermott, Thomas Krey, Corey P. Mallett, Ventzislav Vassilev, Davide Angeletti, Bruno E. Correia
Pubblicato in: biorXiv, 2025
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.01.22.634229

Non-peer reviewed articles (1)

Monoclonal antibodies lock down SARS-CoV-2 spike

Autori: Hsiang-Chi Huang, Davide Angeletti
Pubblicato in: Trends in Immunology, 2023, ISSN 1471-4906
Editore: Elsevier BV
DOI: 10.1016/j.it.2023.09.006