B Cell Immunodominance in Antiviral Immunity

Información del proyecto

B-DOMINANCE

Identificador del acuerdo de subvención: 850638

DOI

10.3030/850638

Proyecto cerrado

Fecha de la firma de la CE 28 Octubre 2019

Fecha de inicio 1 Diciembre 2019

Fecha de finalización 31 Mayo 2025

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 481 697,00

Aportación de la UE

€ 1 481 697,00

Coordinado por

GOETEBORGS UNIVERSITET
Sweden

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Open Research Data Pilot (1)

DMP: Data Management Plan

Data Management Plan

Publicaciones

Peer reviewed articles (13)

Longitudinal single-cell analysis of SARS-CoV-2-reactive B cells uncovers persistence of early-formed, antigen specific clones

Autores: Lydia Scharf; Hannes Axelsson; Aikaterini Emmanouilidi; Nimitha R. Mathew; Daniel J. Sheward; Susannah Leach; Pauline Isakson; Ilya V. Smirnov; Emelie Marklund; Nicolae Miron; Lars-Magnus Andersson; Magnus Gisslén; Ben Murrell; Anna Lundgren; Mats Bemark; Davide Angeletti
Publicado en: JCI Insights, Edición 1, 2023, ISSN 2379-3708
Editor: American Society for Clinical Investigation (ASCI)
DOI: 10.1172/jci.insight.165299

Limited access to antigen drives generation of early B cell memory while restraining the plasmablast response

Autores: Vassilis Glaros; Vassilis Glaros; René Rauschmeier; Artem V. Artemov; Annika Reinhardt; Annika Reinhardt; Sebastian Ols; Sebastian Ols; Aikaterini Emmanouilidi; Charlotte Gustafsson; Yuanyuan You; Yuanyuan You; Claudio Mirabello; Åsa K. Björklund; Laurent Perez; Neil P. King; Robert Månsson; Robert Månsson; Davide Angeletti; Karin Loré; Karin Loré; Igor Adameyko; Igor Adameyko; Meinrad Buss
Publicado en: Immunity, Edición 1, 2021, ISSN 1097-4180
Editor: Cell Press
DOI: 10.1016/j.immuni.2021.08.017

Know your enemy or find your friend?—Induction of IgA at mucosal surfaces

Autores: Mats Bemark, Davide Angeletti
Publicado en: Immunological Reviews, 2021, ISSN 1600-065X
Editor: John Wiley & Sons Ltd
DOI: 10.1111/imr.13014

Single-cell BCR and transcriptome analysis after influenza infection reveals spatiotemporal dynamics of antigen-specific B cells

Autores: Nimitha R. Mathew, Jayalal K. Jayanthan, Ilya V. Smirnov, Jonathan L. Robinson, Hannes Axelsson, Sravya S. Nakka, Aikaterini Emmanouilidi, Paulo Czarnewski, William T. Yewdell, Karin Schön, Cristina Lebrero-Fernández, Valentina Bernasconi, William Rodin, Ali M. Harandi, Nils Lycke, Nicholas Borcherding, Jonathan W. Yewdell, Victor Greiff, Mats Bemark, Davide Angeletti
Publicado en: Cell Reports, Edición 35/12, 2021, Página(s) 109286, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2021.109286

Pre-existing CD4 T cell help boosts antibody responses but has limited impact on germinal center, antigen-specific B cell frequencies after influenza infection

Autores: Danica Besavilla, Laura Reusch, Josue Enriquez, Karin Schön, Davide Angeletti
Publicado en: Frontiers in Immunology, 2023, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2023.1243164

Memory B-cell diversity: From early generation to tissue residency and reactivation

Autores: Laura Reusch, Davide Angeletti
Publicado en: European Journal of Immunology, 2023, ISSN 1521-4141
Editor: Wiley
DOI: 10.1002/eji.202250085

Plasmablasts in previously immunologically naïve COVID-19 patients express markers indicating mucosal homing and secrete antibodies cross-reacting with SARS-CoV-2 variants and other beta-coronaviruses

Autores: Anna Lundgren; Susannah Leach; Hannes Axelsson; Pauline Isakson; Kristina Nyström; Lydia Scharf; Bengt A Andersson; Nicolae Miron; Emelie Marklund; Lars-Magnus Andersson; Magnus Gisslén; Davide Angeletti; Mats Bemark
Publicado en: Clinical and Experimental Immunology, Edición 1, 2023, ISSN 1365-2249
Editor: Oxford Academic
DOI: 10.1093/cei/uxad044

Ectopic germinal centers in the nasal turbinates contribute to B cell immunity to intranasal viral infection and vaccination

Autores: Romain Gailleton, Nimitha R. Mathew, Laura Reusch, Karin Schön, Lydia Scharf, Anneli Strömberg, Andrea Cvjetkovic, Luaay Aziz, Johan Hellgren, Ka-Wei Tang, Mats Bemark, Davide Angeletti
Publicado en: Proceedings of the National Academy of Sciences, Edición 122, 2025, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2421724122

Influenza A Virus H7 nanobody recognizes a conserved immunodominant epitope on hemagglutinin head and confers heterosubtypic protection

Autores: Zhao-Shan Chen, Hsiang-Chi Huang, Xiangkun Wang, Karin Schön, Yane Jia, Michael Lebens, Danica F. Besavilla, Janarthan R. Murti, Yanhong Ji, Aishe A. Sarshad, Guohua Deng, Qiyun Zhu, Davide Angeletti
Publicado en: Nature Communications, 2025, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1101/2024.10.31.621368

Temporal dynamics of persistent germinal centers and memory B cell differentiation following respiratory virus infection

Autores: William T.Yewdell, Ryan M.Smolkin, Kalina T.Belcheva, Alejandra Mendoza, Anthony J.Michaels, Montserrat Cols, DavideAngeletti, Jonathan W.Yewdell, JayantaChaudhuri
Publicado en: Cell Reports, 2021, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2021.109961

Nuclear AGO2 supports influenza A virus replication through type-I interferon regulation

Autores: Hsiang-Chi Huang, Michelle Fong, Iwona Nowak, Evgeniia Shcherbinina, Vivian Lobo, Danica F Besavilla, Hang T Huynh, Karin Schön, Jakub O Westholm, Carola Fernandez, Angana A H Patel, Clotilde Wiel, Volkan I Sayin, Dimitrios G Anastasakis, Davide Angeletti, Aishe A Sarshad
Publicado en: Nucleic Acids Research, Edición 53, 2025, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkaf268

Loss of Lamin A leads to the nuclear translocation of AGO2 and compromised RNA interference

Autores: Vivian Lobo, Iwona Nowak, Carola Fernandez, Ana Iris Correa Muler, Jakub O Westholm, Hsiang-Chi Huang, Ivo Fabrik, Hang T Huynh, Evgeniia Shcherbinina, Melis Poyraz, Anetta Härtlova, Daniel Benhalevy, Davide Angeletti, Aishe A Sarshad
Publicado en: Nucleic Acids Research, Edición 52, 2024, Página(s) 9917-9935, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkae589

Kinetic MUNANA assay reveals functionally relevant antibody epitopes on Influenza A virus neuraminidase

Autores: Ilya V. Smirnov, Danica F. Besavilla, Karin Schön, Hannes Axelsson, Davide Angeletti
Publicado en: npj Viruses, Edición 3, 2025, ISSN 2948-1767
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s44298-025-00123-y

Other (3)

Nasal tissue-resident memory CD4⁺T cells persist after influenza A virus infection and provide heterosubtypic protection

Autores: Nimitha R. Mathew, Romain Gailleton, Lydia Scharf, Karin Schön, Anneli Strömberg, Nils Lycke, Mats Bemark, Ka-Wei Tang, Davide Angeletti
Publicado en: biorXiv, 2024
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.07.06.602325

Integrated single-cell analyses of affinity-tested B-cells enable the identification of a gene signature to predict antibody affinity

Autores: Michele Chirichella, Matthew Ratcliff, Shuang Gu, Ricardo Miragaia, Massimo Sammito, Valentina Cutano, Suzanne Cohen, Davide Angeletti, Xavier Romero-Ros, Darren J. Schofield
Publicado en: biorXiv, 2025
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.01.15.633143

Computationally designed stem-epitope mimetics elicit broadly reactive antibodies

Autores: Sarah Wehrle, Andreas Scheck, Laura Reusch, Flavio Matassoli, Sandrine Georgeon, Karla M. Castro, Johannes Cramer, Wayne Harshbarger, Stéphane Rosset, Sarah F. Andrews, Karin Schön, Badiaa Bouzya, Ronan Rouxel, Normand Blais, Enrico Malito, Adrian McDermott, Thomas Krey, Corey P. Mallett, Ventzislav Vassilev, Davide Angeletti, Bruno E. Correia
Publicado en: biorXiv, 2025
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.01.22.634229

Non-peer reviewed articles (1)

Monoclonal antibodies lock down SARS-CoV-2 spike

Autores: Hsiang-Chi Huang, Davide Angeletti
Publicado en: Trends in Immunology, 2023, ISSN 1471-4906
Editor: Elsevier BV
DOI: 10.1016/j.it.2023.09.006