Monoclonal Antibodies with Binding Sensitive To Environmental Regulation

Project Information

MABSTER

Grant agreement ID: 850974

DOI 10.3030/850974

EC signature date 8 October 2019

Start date 1 January 2020

End date 31 December 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 500 000,00

EU contribution € 1 500 000,00

Coordinated by

DANMARKS TEKNISKE UNIVERSITET
Denmark

Publications

Peer reviewed articles (13)

Generation of Multivalent Nanobody-Based Proteins with Improved Neutralization of Long α-Neurotoxins from Elapid Snakes

Author(s): Jack Wade, Charlotte Rimbault, Hanif Ali, Line Ledsgaard, Esperanza Rivera-de-Torre, Maher Abou Hachem, Kim Boddum, Nadia Mirza, Markus-Frederik Bohn, Siri A. Sakya, Fulgencio Ruso-Julve, Jan Terje Andersen, Andreas H. Laustsen
Published in: Bioconjugate Chemistry, 2022, ISSN 1043-1802
Publisher: American Chemical Society
DOI: 10.1021/acs.bioconjchem.2c00220

The rise of genomics in snake venom research: recent advances and future perspectives

Author(s): Wei-qiao Rao, Konstantinos Kalogeropoulos, Morten E Allentoft, Shyam Gopalakrishnan, Wei-ning Zhao, Christopher T. Workman, Cecilie Knudsen, Belén Jiménez-Mena, Lorenzo Seneci, Mahsa Mousavi-Derazmahalleh, Timothy P Jenkins, Esperanza Rivera-de-Torre, Si-qi Liu, Andreas H. Laustsen
Published in: GigaScience, 2022, ISSN 2047-217X
Publisher: Oxford Academic
DOI: 10.1093/gigascience/giac024

Causes and Consequences of Snake Venom Variation

Author(s): Nicholas R. Casewell, Timothy N.W. Jackson, Andreas H. Laustsen, Kartik Sunagar
Published in: Trends in Pharmacological Sciences, 2020, ISSN 2423-3722
Publisher: Elsevier
DOI: 10.1016/j.tips.2020.05.006

Neutralization capacity of recombinant antivenoms based on monoclonal antibodies and nanobodies

Author(s): Anne Ljungars, Andreas H. Laustsen
Published in: Toxicon, 2022, Page(s) 106991, ISSN 0041-0101
Publisher: Pergamon Press
DOI: 10.1016/j.toxicon.2022.106991

Synthetic antibodies block receptor binding and current‐inhibiting effects of α‐cobratoxin from <i>Naja kaouthia</i>

Author(s): Shane Miersch; Guillermo de la Rosa; Rasmus Friis; Line Ledsgaard; Kim Boddum; Andreas H. Laustsen; Sachdev S. Sidhu
Published in: Protein Science, 2022, ISSN 1469-896X
Publisher: Wiley
DOI: 10.1002/pro.4296

In vitro discovery of a human monoclonal antibody that neutralizes lethality of cobra snake venom

Author(s): Line Ledsgaard, Andreas H. Laustsen, Urska Pus, Jack Wade, Pedro Villar, Kim Boddum, Peter Slavny, Edward W. Masters, Ana S. Arias, Saioa Oscoz, Daniel T. Griffiths, Alice M. Luther, Majken Lindholm, Rachael A. Leah, Marie Sofie Møller, Hanif Ali, John McCafferty, Bruno Lomonte, José M. Gutiérrez, Aneesh Karatt-Vellatt
Published in: mAbs, 2022, ISSN 1942-0862
Publisher: Taylor & Francis
DOI: 10.1080/19420862.2022.2085536

Advances in antibody phage display technology

Author(s): Line Ledsgaard, AnneLjungars, Charlotte Rimbault, Christoffer V. Sørensen, Tulika Tulika, Jack Wade, Yessica Wouters, John McCafferty, Andreas H. Laustsen
Published in: Drug Discovery Today, 2022, ISSN 1359-6446
Publisher: Elsevier BV
DOI: 10.1016/j.drudis.2022.05.002

Current Knowledge on Snake Dry Bites

Author(s): Manuela B. Pucca, Cecilie Knudsen, Isadora S. Oliveira, Charlotte Rimbault, Felipe A. Cerni, Fan Hui Wen, Jacqueline Sachett, Marco A. Sartim, Andreas H. Laustsen, Wuelton M. Monteiro
Published in: Toxins, 2020, ISSN 2072-6651
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/toxins12110668

Strategies for Heterologous Expression, Synthesis, and Purification of Animal Venom Toxins

Author(s): Esperanza Rivera-de-Torre; Charlotte Rimbault; Timothy P. Jenkins; Christoffer V. Sørensen; Anna Damsbo; Natalie J. Saez; Yoan Duhoo; Celeste Menuet Hackney; Lars Ellgaard; Andreas H. Laustsen
Published in: Frontiers in Bioengineering and Biotechnology, 2022, ISSN 2296-4185
Publisher: Frontiers Media
DOI: 10.3389/fbioe.2021.811905

Animal Immunization, in Vitro Display Technologies, and Machine Learning for Antibody Discovery.

Author(s): Andreas Hougaard Laustsen; Victor Greiff; Aneesh Karatt-Vellatt; Serge Muyldermans; Timothy P. Jenkins
Published in: Trends in Biotechnology, 2021, ISSN 1879-3096
Publisher: Elsevier
DOI: 10.1016/j.tibtech.2021.03.003

The challenges with developing therapeutic monoclonal antibodies for pandemic application

Author(s): Andreas H. Laustsen, Markus-Frederik Bohn, Anne Ljungars
Published in: Expert Opinion on Drug Discovery, 2021, ISSN 1746-0441
Publisher: Informa Healthcare
DOI: 10.1080/17460441.2021.1976141

AHA: AI-guided tool for the quantification of venom-induced haemorrhage in mice

Author(s): Timothy P. Jenkins1, William Michael Laprade, Andrés Sánchez, Tulika Tulika, Carol O’Brien, Christoffer V. Sørensen, Trenton K. Stewart, Thomas Fryer, Andreas H. Laustsen, José María Gutiérrez
Published in: Frontiers in Tropical Diseases, 2022, ISSN 2673-7515
Publisher: Frontiers
DOI: 10.3389/fitd.2022.1063640

Terrestrial venomous animals, the envenomings they cause, and treatment perspectives in the Middle East and North Africa.

Author(s): Timothy P. Jenkins; Shirin Ahmadi; Mátyás A. Bittenbinder; Mátyás A. Bittenbinder; Trenton K Stewart; Dilber E Akgun; Melissa Hale; Nafiseh Nasri Nasrabadi; Nafiseh Nasri Nasrabadi; Darian S Wolff; Freek J. Vonk; Freek J. Vonk; Jeroen Kool; Andreas Hougaard Laustsen
Published in: PLOS Neglected Tropical Diseases, 2021, ISSN 1935-2727
Publisher: Public Library of Science
DOI: 10.1371/journal.pntd.0009880