Synthetic Oligonucleotide Quality Control Software

Información del proyecto

SOLQC

Identificador del acuerdo de subvención: 851018

DOI

10.3030/851018

Proyecto cerrado

Fecha de la firma de la CE 6 Junio 2019

Fecha de inicio 1 Julio 2019

Fecha de finalización 30 Junio 2020

Financiado con arreglo a

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Coste total

€ 100 000,00

Aportación de la UE

€ 100 000,00

Coordinado por

TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
Israel

Periodic Reporting for period 1 - SOLQC (Synthetic Oligonucleotide Quality Control Software)

Período documentado: 2019-07-01 hasta 2020-06-30

Resumen del contexto y de los objetivos generales del proyecto

In this work we present SOLQC, a software tool that supports and potentially standardize the statistical analysis and quality control of OLs. The tool is designed to facilitate analysis by individual labs to obtain information about DNA libraries and to perform error analysis before or during experiments.
The aim of SOLQC was to develop a reliable quality control software for oligonucleotide libraries. Furthermore – we aimed to bring this software tool to a technical level that can position it to be possibly adapted by commercial partners/entities. The final result of this work is novel analysis tool, enabling fast and comprehensive quality analysis of synthetic oligo libraries, based on NGS data. SOLQC provides detailed statistics, information and insights about the state and quality of the library, to the user, and allows for more informed decisions on next stages of the OL experiment.

Trabajo realizado desde el comienzo del proyecto hasta el final del período abarcado por el informe y los principales resultados hasta la fecha

We demonstrate SOLQC by analyzing literature libraries. We also discuss the potential benefits and relevance of the different components of the analysis.
SOLQC now has a functioning website that allows for the complete analysis.
The tool is published as a paper in Bioinformatics, a leading journal in the field, read by academia and industry leaders (doi:10.1093/bioinformatics/btaa740).
SOLQC was presented in central venues of the DNA storage and synthetic biology communities. Initial contacts with a commercial partner were formed. Following the publication in Bionformatics we expect more interest in using SOLQC, from OL users in the industry, the healthcare sector and in academia.

Avances que van más allá del estado de la técnica e impacto potencial esperado (incluida la repercusión socioeconómica y las implicaciones sociales más amplias del proyecto hasta la fecha)

We expect increased interest from academia and the private sector in the coming year, as the usage of oligo-libraries become more wide-spread within the biological community.

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