Modelling of branching morphogenesis
Some organs, such as lungs and kidneys, for example, require a high surface-to-volume ratio for function, creating highly branched tubular structures during a developmental process called branching morphogenesis. The mechanisms, molecular signalling and cellular reorganisation necessary for creation of the organ structure remain fundamental open questions. The EU-funded Demos project will use theoretical methods to understand how stochastic rules lead to organ morphogenesis, including bidirectional coordination of the individual cells' fate. Researchers will apply their broad experience in modelling cytoskeletal interactions, stem cell dynamics and branching processes in general by combining systems biology and biophysical approaches at multiple scales.
Fields of science
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