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Design Principles of Branching Morphogenesis

Project description

Modelling of branching morphogenesis

Some organs, such as lungs and kidneys, for example, require a high surface-to-volume ratio for function, creating highly branched tubular structures during a developmental process called branching morphogenesis. The mechanisms, molecular signalling and cellular reorganisation necessary for creation of the organ structure remain fundamental open questions. The EU-funded Demos project will use theoretical methods to understand how stochastic rules lead to organ morphogenesis, including bidirectional coordination of the individual cells' fate. Researchers will apply their broad experience in modelling cytoskeletal interactions, stem cell dynamics and branching processes in general by combining systems biology and biophysical approaches at multiple scales.

Call for proposal

ERC-2019-STG
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Host institution

INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA
Address
Am Campus 1
3400 Klosterneuburg
Austria
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 452 604

Beneficiaries (1)

INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA
Austria
EU contribution
€ 1 452 604
Address
Am Campus 1
3400 Klosterneuburg
Activity type
Higher or Secondary Education Establishments