Pre-transplant Renal Ex vivo Imaging and Multi-omics for Advanced Graft Evaluation

Project description

Understanding the impact of ex vivo perfusion on organ physiology

Considering the shortage of donor kidneys, transplant centres are employing normothermic machine perfusion to better evaluate organs prior to transplantation. However, little is known about the molecular pathways that are active during perfusion. To address this problem, the EU-funded PRE-IMAGE project will undertake molecular and multi-omics analyses alongside the imaging of ex vivo perfused kidneys to identify biomarkers specifically associated with ex vivo physiology and transplantation outcome. The behaviour of ex vivo perfused kidneys will be compared to the organ's state in vivo, and personalised pre-transplant prediction models will be generated for improved post-transplant outcomes.

Programme(s)

• H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)

Topic(s)

• ERC-2019-STG - ERC Starting Grant

Call for proposal

ERC-2019-STG
See other projects for this call

Funding Scheme

ERC-STG - Starting Grant

Host institution

ACADEMISCH ZIEKENHUIS GRONINGEN

Address

Hanzeplein 1
9713 GZ Groningen
Netherlands

Activity type

Higher or Secondary Education Establishments

EU contribution

€ 1 499 961

Beneficiaries (1)

ACADEMISCH ZIEKENHUIS GRONINGEN

Netherlands

EU contribution

€ 1 499 961

Address

Hanzeplein 1
9713 GZ Groningen

Activity type

Higher or Secondary Education Establishments