Celluloepidemiology: a novel paradigm for modeling T-cell responses on a population level.

Información del proyecto

CELLULO-EPI

Identificador del acuerdo de subvención: 851752

DOI

10.3030/851752

Proyecto cerrado

Fecha de la firma de la CE 12 Febrero 2020

Fecha de inicio 1 Marzo 2020

Fecha de finalización 31 Agosto 2025

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 499 734,00

Aportación de la UE

€ 1 499 734,00

Coordinado por

UNIVERSITEIT ANTWERPEN
Belgium

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (11)

Modeling antibody dynamics following herpes zoster indicates that higher varicella-zoster virus viremia generates more VZV-specific antibodies

Autores: Hajar Besbassi, Irene Garcia-Fogeda, Mark Quinlivan, Judy Breuer, Steven Abrams, Niel Hens, Benson Ogunjimi, Philippe Beutels
Publicado en: Frontiers in Immunology, Edición 14, 2023, ISSN 1664-3224
Editor: Frontiers Media SA
DOI: 10.3389/fimmu.2023.1104605

Unravelling the immune signature of herpes zoster: Insights into pathophysiology and the HLA risk profile

Autores: R. Vandoren, M. Boeren, Jolien Schippers, E. Bartholomeus, K. Mullan, N. Michels, O. Aerts, J. Leysen, A. Bervoets, J. Lambert, E. Leuridan, J. Wens, Karin Peeters, MP. Emonds, H. Jansens, JL. Casanova, P. Bastard, A. Suls, V. Van Tendeloo, P. Ponsaerts, P. Delputte, Benson Ogunjimi, K. Laukens, Pieter Meysman
Publicado en: The Journal of Infectious Diseases, Edición 229(2), 2024, Página(s) 507-516, ISSN 0022-1899
Editor: University of Chicago Press
DOI: 10.1093/infdis/jiad609

Multi-view learning to unravel the different levels underlying hepatitis B vaccine response. Vaccines

Autores: Fabio Affaticati, E. Bartholomeus, K. Mullan, P. Van Damme, P. Beutels, Benson Ogunjimi, K. Laukens, Pieter Meysman
Publicado en: Vaccines, 2023, ISSN 2076-393X
Editor: Multidisciplinary Digital Publishing Institute (MDPI)

Lack of functional TCR-epitope interaction is associated with herpes zoster through reduced downstream T cell activation

Autores: Marlies Boeren, Nicky de Vrij, My K. Ha, Sebastiaan Valkiers, Aisha Souquette, Sofie Gielis, Maria Kuznetsova, Jolien Schippers, Esther Bartholomeus, Johan Van den Bergh, Nele Michels, Olivier Aerts, Julie Leysen, An Bervoets, Julien Lambert, Elke Leuridan, Johan Wens, Karin Peeters, Marie-Paule Emonds, George Elias, Niels Vandamme, Hilde Jansens, Wim Adriaensen, Arvid Suls, Stijn Vanhee, Niel Hen
Publicado en: Cell Reports, Edición 43, 2024, Página(s) 114062, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2024.114062

Within-host mathematical models to study antibody kinetics after the prophylactic Ebola vaccine in the Democratic Republic of the Congo

Autores: Irene Garcia-Fogeda, Steven Abrams, Stijn Vanhee, Maha Salloum, Benson Ogunjimi, Niel Hens
Publicado en: Vaccine, Edición 64, 2025, Página(s) 127707, ISSN 0264-410X
Editor: Elsevier BV
DOI: 10.1016/j.vaccine.2025.127707

Multi-view learning to unravel the different levels underlying hepatitis B vaccine response

Autores: Fabio Affaticati, Esther Bartholomeus, Kerry Mullan, Pierre Van Damme, Philippe Beutels, Benson Ogunjimi, Kris Laukens, Pieter Meysman
Publicado en: Vaccines, 2024, ISSN 2076-393X
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.1101/2023.02.23.529670

Modeling Antigen-Specific T Cell Dynamics Following Hepatitis B Vaccination indicates differences between conventional and regulatory T cell dynamics

Autores: Hajar Besbassi, George Elias, Pieter Meysman, Hilde Jansens, Kris Laukens, Pierre Van Damme, Niel Hens, Philippe Beutels, Benson Ogunjimi
Publicado en: Vaccine, 2023, ISSN 0264-410X
Editor: Elsevier BV
DOI: 10.1101/2023.05.27.542434

Celluloepidemiology—A paradigm for quantifying infectious disease dynamics on a population level

Autores: My K. Ha, Anna Postovskaya, Maria Kuznetsova, Pieter Meysman, Vincent Van Deuren, Sabrina Van Ierssel, Hans De Reu, Jolien Schippers, Karin Peeters, Hajar Besbassi, Leo Heyndrickx, Betty Willems, Joachim Mariën, Esther Bartholomeus, Koen Vercauteren, Philippe Beutels, Pierre Van Damme, Eva Lion, Erika Vlieghe, Kris Laukens, Samuel Coenen, Reinout Naesens, Kevin K. Ariën, Benson Ogunjimi
Publicado en: Science Advances, Edición 11, 2025, ISSN 2375-2548
Editor: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/sciadv.adt2926

Modeling antibody dynamics following herpes zoster indicates that higher varicella-zoster virus (VZV) viremia generates more VZV-specific antibodies

Autores: Hajar Besbassi, Irene Garcia-Fogeda, Mark Quinlivan, Judy Breuer, Stevens Abrams, Niel Hens*, Benson Ogunjimi* & Philippe Beutels*.*equal contribution
Publicado en: Frontiers in Immunology, 2023, ISSN 1664-3224
Editor: Frontiers

"Modeling antigen-specific <mml:math xmlns:mml=""http://www.w3.org/1998/Math/MathML"" altimg=""si66.svg"" display=""inline"" id=""d1e1296""><mml:mi>T</mml:mi></mml:math> cell dynamics following Hepatitis B Vaccination indicates differences between conventional and regulatory <mml:math xmlns:mml=""http://www.w3.org/1998/Math/MathML"" altimg=""si66.svg"" display=""inline"" id=""d1e1301""><mml:mi>T</mml:mi></mml:math"

Autores: Hajar Besbassi, George Elias, Pieter Meysman, Hilde Jansens, Kris Laukens, Pierre Van Damme, Niel Hens, Philippe Beutels, Benson Ogunjimi
Publicado en: Vaccine, Edición 42, 2024, Página(s) 126148, ISSN 0264-410X
Editor: Elsevier BV
DOI: 10.1016/j.vaccine.2024.07.049

Within-host modeling to measure dynamics of antibody responses after natural infection or vaccination: A systematic review.

Autores: Irene Garcia-Fogeda, Hajar Besbassi, Ynke Lariviere, Benson Ogunjimi, Steven Abrams & Niel Hens
Publicado en: Vaccine, 2023, ISSN 0264-410X
Editor: Elsevier BV
DOI: 10.1016/j.vaccine.2023.04.030

Other (4)

Linking myelin and Epstein-Barr virus specific immune responses in multiple sclerosis: insights from integrated public T cell receptor repertoires

Autores: Sebastiaan Valkiers, Amber Dams, Maria Kuznetsova, My Ha, Ibo Janssens, Barbara Willekens, Kris Laukens, Benson Ogunjimi, Nathalie Cools, Pieter Meysman
Publicado en: biorxiv, 2024
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.10.23.619834

Bridging immunotypes and enterotypes using a systems immunology approach

Autores: Fabio Affaticati, My K. Ha, Thies Gehrmann, Ilke De Boeck, Maria Kuznetsova, Romi Vandoren, Vincent Van Deuren, Hilde Jansens, Hans De Reu, Jolien Schippers, Karin Peeters, Esther Bartholomeus, Sabrina Van Ierssel, Samuel Coenen, Reinout Naesens, Kevin K. Ariën, Koen Vercauteren, Erika Vlieghe, Philippe Beutels, Pierre Van Damme, Herman Goossens, Eva Lion, Arvid Suls, Sarah Lebeer, Kris Laukens,
Publicado en: biorxiv, 2024
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.11.29.625344

Generation of a T cell receptor, cytokine and cell repertoire synovial fluid atlas to define commonalities and dissimilarities between arthritic diseases through systems immunology approaches

Autores: My K. Ha, Vincent Van Deuren, Carlos Alberto de Carvalho Fraga, An Hotterbeekx, Joke Dehoorne, Thomas Renson, Elke Geens, Nicolaas Aerts, Christiaan Heusdens, Maria Kuznetsova, Margot Van Mechelen, Michaël Vanden Bulcke, Ilse Hoffman, Ruth Wittoek, Eva De Wachter, Aurelie Andrzejewski, Esther Bartholomeus, Nick de Vrij, Arvid Suls, Eva Lion, Stijn Vanhee, Wim Adriaensen, Kerry Mullan, Helder Naka
Publicado en: biorxiv, 2025
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.01.10.632345

T cell-microbiome associations captured through T cell receptor convergence analysis

Autores: Romi Vandoren, My Ha, Vincent Van Deuren, Naomi De Roeck, Ting Pu, Eelco C. Brand, Maria Kuznetsova, Hajar Besbassi, Esther Bartholomeus, Fabio Affaticati, Ilke De Boeck, Thies Gehrmann, Sarah Lebeer, Bas Oldenburg, Femke van Wijk, Peter Delputte, Sara Verbandt, Sabine Tejpar, Kris Laukens, Benson Ogunjimi, Pieter Meysman
Publicado en: biorxiv, 2025
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.09.30.679432