Age-dependent mechanisms of sporadic Alzheimer’s Disease in patient-derived neurons

Project Information

AGEMEC

Grant agreement ID: 852086

DOI 10.3030/852086

Project terminated on 1 March 2023

EC signature date 14 January 2020

Start date 1 February 2020

End date 31 January 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 499 565,00

EU contribution € 1 499 565,00

Coordinated by

UNIVERSITAET INNSBRUCK
Austria

Publications

Peer reviewed articles (6)

Chemical Replacement of Noggin with Dorsomorphin Homolog 1 for Cost-Effective Direct Neuronal Conversion

Author(s): Lena Böhnke, Lucia Zhou-Yang, Silvia Pelucchi, Flora Kogler, Daniela Frantal, Florian Schön, Stina Lagerström, Oliver Borgogno, Jennifer Baltazar, Joseph R Herdy, Sarah Kittel-Schneider, Michaela Defrancesco, Jerome Mertens
Published in: Cellular Reprogramming, 2022, ISSN 2152-4971
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/cell.2021.0200

Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer’s disease

Author(s): Larissa Traxler, Joseph R Herdy, Davide Stefanoni, Sophie Eichhorner, Silvia Pelucchi, Attila Szücs, Alice Santagostino, Yongsung Kim, Ravi K Agarwal, Johannes C M Schlachetzki, Christopher K Glass, Jessica Lagerwall, Douglas Galasko, Fred H Gage, Angelo D'Alessandro, Jerome Mertens
Published in: Cell Metabolism, 2022, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2022.07.014

Improved Method for Efficient Generation of Functional Neurons from Murine Neural Progenitor Cells

Author(s): Abhinav Soni, Diana Klütsch, Xin Hu, Judith Houtman, Nicole Rund, Asako McCloskey, Jerome Mertens, Simon T. Schafer, Hayder Amin, Tomohisa Toda
Published in: Cells, Issue 10/8, 2021, Page(s) 1894, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10081894

When function follows form: Nuclear compartment structure and the epigenetic landscape of the aging neuron

Author(s): Johannes C.M. Schlachetzki, Tomohisa Toda, Jerome Mertens
Published in: Experimental Gerontology, Issue 133, 2020, Page(s) 110876, ISSN 0531-5565
Publisher: Elsevier BV
DOI: 10.1016/j.exger.2020.110876

Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients

Author(s): Jerome Mertens, Joseph R. Herdy, Larissa Traxler, Simon T. Schafer, Johannes C.M. Schlachetzki, Lena Böhnke, Dylan A. Reid, Hyungjun Lee, Dina Zangwill, Diana P. Fernandes, Ravi K. Agarwal, Raffaella Lucciola, Lucia Zhou-Yang, Lukas Karbacher, Frank Edenhofer, Shani Stern, Steve Horvath, Apua C.M. Paquola, Christopher K. Glass, Shauna H. Yuan, Manching Ku, Attila Szücs, Lawrence S.B. Goldstein,
Published in: Cell Stem Cell, Issue 28/9, 2021, Page(s) 1533-1548.e6, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2021.04.004

Metabolism navigates neural cell fate in development, aging and neurodegeneration

Author(s): Larissa Traxler, Jessica Lagerwall, Sophie Eichhorner, Davide Stefanoni, Angelo D'Alessandro, Jerome Mertens
Published in: Disease Models & Mechanisms, Issue 14/8, 2021, ISSN 1754-8403
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dmm.048993