Age-dependent mechanisms of sporadic Alzheimer’s Disease in patient-derived neurons

Publications

Chemical Replacement of Noggin with Dorsomorphin Homolog 1 for Cost-Effective Direct Neuronal Conversion

Auteurs: Lena Böhnke, Lucia Zhou-Yang, Silvia Pelucchi, Flora Kogler, Daniela Frantal, Florian Schön, Stina Lagerström, Oliver Borgogno, Jennifer Baltazar, Joseph R Herdy, Sarah Kittel-Schneider, Michaela Defrancesco, Jerome Mertens
Publié dans: Cellular Reprogramming, 2022, ISSN 2152-4971
Éditeur: Mary Ann Liebert Inc.
DOI: 10.1089/cell.2021.0200

Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer’s disease

Auteurs: Larissa Traxler, Joseph R Herdy, Davide Stefanoni, Sophie Eichhorner, Silvia Pelucchi, Attila Szücs, Alice Santagostino, Yongsung Kim, Ravi K Agarwal, Johannes C M Schlachetzki, Christopher K Glass, Jessica Lagerwall, Douglas Galasko, Fred H Gage, Angelo D'Alessandro, Jerome Mertens
Publié dans: Cell Metabolism, 2022, ISSN 1550-4131
Éditeur: Cell Press
DOI: 10.1016/j.cmet.2022.07.014

Improved Method for Efficient Generation of Functional Neurons from Murine Neural Progenitor Cells

Auteurs: Abhinav Soni, Diana Klütsch, Xin Hu, Judith Houtman, Nicole Rund, Asako McCloskey, Jerome Mertens, Simon T. Schafer, Hayder Amin, Tomohisa Toda
Publié dans: Cells, Numéro 10/8, 2021, Page(s) 1894, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells10081894

When function follows form: Nuclear compartment structure and the epigenetic landscape of the aging neuron

Auteurs: Johannes C.M. Schlachetzki, Tomohisa Toda, Jerome Mertens
Publié dans: Experimental Gerontology, Numéro 133, 2020, Page(s) 110876, ISSN 0531-5565
Éditeur: Elsevier BV
DOI: 10.1016/j.exger.2020.110876

Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients

Auteurs: Jerome Mertens, Joseph R. Herdy, Larissa Traxler, Simon T. Schafer, Johannes C.M. Schlachetzki, Lena Böhnke, Dylan A. Reid, Hyungjun Lee, Dina Zangwill, Diana P. Fernandes, Ravi K. Agarwal, Raffaella Lucciola, Lucia Zhou-Yang, Lukas Karbacher, Frank Edenhofer, Shani Stern, Steve Horvath, Apua C.M. Paquola, Christopher K. Glass, Shauna H. Yuan, Manching Ku, Attila Szücs, Lawrence S.B. Goldstein,
Publié dans: Cell Stem Cell, Numéro 28/9, 2021, Page(s) 1533-1548.e6, ISSN 1934-5909
Éditeur: Cell Press
DOI: 10.1016/j.stem.2021.04.004

Metabolism navigates neural cell fate in development, aging and neurodegeneration

Auteurs: Larissa Traxler, Jessica Lagerwall, Sophie Eichhorner, Davide Stefanoni, Angelo D'Alessandro, Jerome Mertens
Publié dans: Disease Models & Mechanisms, Numéro 14/8, 2021, ISSN 1754-8403
Éditeur: The Company of Biologists Ltd.
DOI: 10.1242/dmm.048993

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