Age-dependent mechanisms of sporadic Alzheimer’s Disease in patient-derived neurons

Informazioni relative al progetto

AGEMEC

ID dell’accordo di sovvenzione: 852086

DOI 10.3030/852086

Progetto concluso il 1 Marzo 2023

Data della firma CE 14 Gennaio 2020

Data di avvio 1 Febbraio 2020

Data di completamento 31 Gennaio 2025

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 499 565,00

Contributo UE € 1 499 565,00

Coordinato da

UNIVERSITAET INNSBRUCK
Austria

Pubblicazioni

Peer reviewed articles (6)

Chemical Replacement of Noggin with Dorsomorphin Homolog 1 for Cost-Effective Direct Neuronal Conversion

Autori: Lena Böhnke, Lucia Zhou-Yang, Silvia Pelucchi, Flora Kogler, Daniela Frantal, Florian Schön, Stina Lagerström, Oliver Borgogno, Jennifer Baltazar, Joseph R Herdy, Sarah Kittel-Schneider, Michaela Defrancesco, Jerome Mertens
Pubblicato in: Cellular Reprogramming, 2022, ISSN 2152-4971
Editore: Mary Ann Liebert Inc.
DOI: 10.1089/cell.2021.0200

Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer’s disease

Autori: Larissa Traxler, Joseph R Herdy, Davide Stefanoni, Sophie Eichhorner, Silvia Pelucchi, Attila Szücs, Alice Santagostino, Yongsung Kim, Ravi K Agarwal, Johannes C M Schlachetzki, Christopher K Glass, Jessica Lagerwall, Douglas Galasko, Fred H Gage, Angelo D'Alessandro, Jerome Mertens
Pubblicato in: Cell Metabolism, 2022, ISSN 1550-4131
Editore: Cell Press
DOI: 10.1016/j.cmet.2022.07.014

Improved Method for Efficient Generation of Functional Neurons from Murine Neural Progenitor Cells

Autori: Abhinav Soni, Diana Klütsch, Xin Hu, Judith Houtman, Nicole Rund, Asako McCloskey, Jerome Mertens, Simon T. Schafer, Hayder Amin, Tomohisa Toda
Pubblicato in: Cells, Numero 10/8, 2021, Pagina/e 1894, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells10081894

When function follows form: Nuclear compartment structure and the epigenetic landscape of the aging neuron

Autori: Johannes C.M. Schlachetzki, Tomohisa Toda, Jerome Mertens
Pubblicato in: Experimental Gerontology, Numero 133, 2020, Pagina/e 110876, ISSN 0531-5565
Editore: Elsevier BV
DOI: 10.1016/j.exger.2020.110876

Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients

Autori: Jerome Mertens, Joseph R. Herdy, Larissa Traxler, Simon T. Schafer, Johannes C.M. Schlachetzki, Lena Böhnke, Dylan A. Reid, Hyungjun Lee, Dina Zangwill, Diana P. Fernandes, Ravi K. Agarwal, Raffaella Lucciola, Lucia Zhou-Yang, Lukas Karbacher, Frank Edenhofer, Shani Stern, Steve Horvath, Apua C.M. Paquola, Christopher K. Glass, Shauna H. Yuan, Manching Ku, Attila Szücs, Lawrence S.B. Goldstein,
Pubblicato in: Cell Stem Cell, Numero 28/9, 2021, Pagina/e 1533-1548.e6, ISSN 1934-5909
Editore: Cell Press
DOI: 10.1016/j.stem.2021.04.004

Metabolism navigates neural cell fate in development, aging and neurodegeneration

Autori: Larissa Traxler, Jessica Lagerwall, Sophie Eichhorner, Davide Stefanoni, Angelo D'Alessandro, Jerome Mertens
Pubblicato in: Disease Models & Mechanisms, Numero 14/8, 2021, ISSN 1754-8403
Editore: The Company of Biologists Ltd.
DOI: 10.1242/dmm.048993