From iPSC-Macrophage Biology Towards Regenerative Therapies Targeting Respiratory Infections

Project Information

iPSC2Therapy

Grant agreement ID: 852178

DOI

10.3030/852178

Project closed

EC signature date 18 November 2019

Start date 1 January 2020

End date 30 November 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 499 100,00

EU contribution

€ 1 499 100,00

Coordinated by

MEDIZINISCHE HOCHSCHULE HANNOVER
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (25)

Tuberculosis in otherwise healthy adults with inherited TNF deficiency

Author(s): Andrés A. Arias, Anna-Lena Neehus, Masato Ogishi, Vincent Meynier, Adam Krebs, Tomi Lazarov, Angela M. Lee, Carlos A. Arango-Franco, Rui Yang, Julio Orrego, Melissa Corcini Berndt, Julian Rojas, Hailun Li, Darawan Rinchai, Lucia Erazo-Borrás, Ji Eun Han, Bethany Pillay, Khoren Ponsin, Matthieu Chaldebas, Quentin Philippot, Jonathan Bohlen, Jérémie Rosain, Tom Le Voyer, Till Janotte, Krishnajin
Published in: Nature, Issue 633, 2024, Page(s) 417-425, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-024-07866-3

In vitro systems to study inborn errors of immunity using human induced pluripotent stem cells

Author(s): Eirini Nikolouli, Janne Reichstein, Gesine Hansen, Nico Lachmann
Published in: Frontiers in Immunology, Issue 13, 2022, ISSN 1664-3224
Publisher: the International Union of Immunological Societies (IUIS)
DOI: 10.3389/fimmu.2022.1024935

Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria

Author(s): Jérémie Rosain, Anna-Lena Neehus, Jérémy Manry, Rui Yang, Jérémie Le Pen, Wassim Daher, Zhiyong Liu, Yi-Hao Chan, Natalia Tahuil, Özden Türel, Mathieu Bourgey, Masato Ogishi, Jean-Marc Doisne, Helena M. Izquierdo, Takayoshi Shirasaki, Tom Le Voyer, Antoine Guérin, Paul Bastard, Marcela Moncada-Vélez, Ji Eun Han, Taushif Khan, Franck Rapaport, Seon-Hui Hong, Andrew Cheung, Kathrin Haake,
Published in: Cell, Issue 186, 2023, Page(s) 621-645.e33, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2022.12.038

CARs and beyond: tailoring macrophage-based cell therapeutics to combat solid malignancies

Author(s): Shifaa M. Abdin, Daniela Paasch, Michael Morgan, Nico Lachmann
Published in: Journal for ImmunoTherapy of Cancer, Issue 9, 2021, Page(s) e002741, ISSN 2051-1426
Publisher: BMJ
DOI: 10.1136/jitc-2021-002741

Immune activation and response dynamics of human <scp>iPSC</scp> ‐derived macrophages in tuberculosis infection models

Author(s): Daniela Paasch, Hannah Schevel, Andrea Riehle, Bibiana Costa, Hassan Toufaili, Tabea Gehnen, Julia Dahlmann, Andreas Pavlou, Anna‐Lena Neehus, Ariane Hai Ha Nguyen, Erika Schiering, Theresa Buchegger, Jacinta Bustamante, Gesine Hansen, Ulrich Kalinke, Erich Gulbins, Heike Grassmé, Nico Lachmann
Published in: Clinical &amp; Translational Immunology, Issue 15, 2026, ISSN 2050-0068
Publisher: Wiley
DOI: 10.1002/cti2.70071

Macrophage-Mediated Control of Implant-Associated Biofilms in a Three-Dimensional Human Oral Mucosa Model

Author(s): Muhammad Imran Rahim, Shuli Chen, Carina Mikolai, Daniela Paasch, Andreas Winkel, Katharina Doll-Nikutta, Nico Lachmann, Henning Menzel, Dagmar Wirth, Hansjörg Hauser, Meike Stiesch
Published in: Acta Materialia, 2025, ISSN 1556-5068
Publisher: Elsevier
DOI: 10.2139/ssrn.5137948

Targeted Integration of Inducible Caspase-9 in Human iPSCs Allows Efficient in vitro Clearance of iPSCs and iPSC-Macrophages

Author(s): Alexandra Lipus, Ewa Janosz, Mania Ackermann, Miriam Hetzel, Julia Dahlke, Theresa Buchegger, Stephanie Wunderlich, Ulrich Martin, Toni Cathomen, Axel Schambach, Thomas Moritz, Nico Lachmann
Published in: International Journal of Molecular Sciences, Issue 21, 2024, Page(s) 2481, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21072481

Alveolar macrophages in tissue homeostasis, inflammation, and infection: evolving concepts of therapeutic targeting

Author(s): Christina Malainou, Shifaa M. Abdin, Nico Lachmann, Ulrich Matt, Susanne Herold
Published in: Journal of Clinical Investigation, Issue 133, 2023, ISSN 1558-8238
Publisher: the American Society for Clinical Investigation
DOI: 10.1172/jci170501

CAR macrophages on a fast track to solid tumor therapy

Author(s): Shifaa M. Abdin, Daniela Paasch, Nico Lachmann
Published in: Nature Immunology, Issue 25, 2024, Page(s) 11-12, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-023-01696-7

The Immune-Modulatory Properties of iPSC-Derived Antigen-Presenting Cells

Author(s): Mania Ackermann, Anna Christina Dragon, Nico Lachmann
Published in: Transfusion Medicine and Hemotherapy, Issue 47, 2024, Page(s) 444-453, ISSN 1660-3796
Publisher: S. Karger AG
DOI: 10.1159/000512721

Standardized generation of human iPSC-derived hematopoietic organoids and macrophages utilizing a benchtop bioreactor platform under fully defined conditions

Author(s): Mania Ackermann, Fawaz Saleh, Shifaa M. Abdin, Anna Rafiei Hashtchin, Ingrid Gensch, Julia Golgath, Marco Carvalho Oliveira, Ariane H. H. Nguyen, Svenja Gaedcke, Arno Fenske, Mi-Sun Jang, Adan C. Jirmo, Markus Abeln, Gesine Hansen, Nico Lachmann
Published in: Stem Cell Research &amp; Therapy, Issue 15, 2024, ISSN 1757-6512
Publisher: BioMed Central
DOI: 10.1186/s13287-024-03785-2

Scalable generation of functional human iPSC-derived CAR-macrophages that efficiently eradicate CD19-positive leukemia

Author(s): Shifaa M. Abdin, Daniela Paasch, Arnold Kloos, Marco Carvalho Oliveira, Mi-Sun Jang, Mania Ackermann, Andriana Stamopoulou, Philipp J Mroch, Christine S Falk, Constantin S von Kaisenberg, Axel Schambach, Michael Heuser, Thomas Moritz, Gesine Hansen, Michael Morgan, Nico Lachmann
Published in: Journal for ImmunoTherapy of Cancer, Issue 11, 2023, Page(s) e007705, ISSN 2051-1426
Publisher: BMJ
DOI: 10.1136/jitc-2023-007705

A 3D iPSC-differentiation model identifies interleukin-3 as a regulator of early human hematopoietic specification

Author(s): Mania Ackermann, Kathrin Haake, Henning Kempf, Paul Kaschutnig, Anna-Carina Weiss, Ariane H.H. Nguyen, Markus Abeln, Sylvia Merkert, Mark Phillip Kühnel, Dorothee Hartmann, Danny Jonigk, Thomas Thum, Andreas Kispert, Michael D. Milsom, Nico Lachmann
Published in: Haematologica, 2021, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2019.228064

Pulmonary Alveolar Proteinosis and new therapeutic concepts

Author(s): Claudio Rodriguez Gonzalez, Hannah Schevel, Gesine Hansen, Nicolaus Schwerk, Nico Lachmann
Published in: Klinische Pädiatrie, Issue 236, 2024, Page(s) 73-79, ISSN 0300-8630
Publisher: Georg Thieme Verlag
DOI: 10.1055/a-2233-1243

Sensor macrophages derived from human induced pluripotent stem cells to assess pyrogenic contaminations in parenteral drugs

Author(s): Shifaa M Abdin, Friederike Mansel, Anna Rafiei Hashtchin, Mania Ackermann, Gesine Hansen, Björn Becker, Benjamin Kick, Nhi Pham, Hendrik Dietz, Christoph Schaniel, Ulrich Martin, Ingo Spreitzer, Nico Lachmann
Published in: Biofabrication, Issue 16, 2024, Page(s) 035017, ISSN 1758-5082
Publisher: IOS Press
DOI: 10.1088/1758-5090/ad4744

Continuous human iPSC-macrophage mass production by suspension culture in stirred tank bioreactors

Author(s): Mania Ackermann, Anna Rafiei Hashtchin , Felix Manstein, Marco Carvalho Oliveira, Henning Kempf, Robert Zweigerdt, Nico Lachmann
Published in: Nature Protocols, 2022, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-021-00654-7

From macrophage biology to macrophage-based cellular immunotherapies

Author(s): Elvira Mass, Nico Lachmann
Published in: Gene Therapy, Issue 28, 2023, Page(s) 473-476, ISSN 0969-7128
Publisher: Nature Publishing Group
DOI: 10.1038/s41434-021-00221-5

Human iPSC-derived macrophages for efficient Staphylococcus aureus clearance in a murine pulmonary infection model

Author(s): Anna Rafiei Hashtchin, Beate Fehlhaber, Miriam Hetzel, Felix Manstein, Jan Lennart Stall, Silke Glage, Markus Abeln, Robert Zweigerdt, Antje Munder, Dorothee Viemann, Mania Ackermann, Nico Lachmann
Published in: Blood Advances, 2021, ISSN 2473-9529
Publisher: Elsevier BV
DOI: 10.1182/bloodadvances.2021004853

Genetic Correction of IL-10RB Deficiency Reconstitutes Anti-Inflammatory Regulation in iPSC-Derived Macrophages

Author(s): Dirk Hoffmann, Johanna Sens, Sebastian Brennig, Daniel Brand, Friederike Philipp, Philippe Vollmer Barbosa, Johannes Kuehle, Doris Steinemann, Daniela Lenz, Theresa Buchegger, Michael Morgan, Christine S. Falk, Christoph Klein, Nico Lachmann, Axel Schambach
Published in: Journal of Personalized Medicine, Issue 11/3, 2021, Page(s) 221, ISSN 2075-4426
Publisher: MDPI Multidisciplinary Digital Publishing Institute
DOI: 10.3390/jpm11030221

Beyond “Big Eaters”: The Versatile Role of Alveolar Macrophages in Health and Disease

Author(s): Miriam Hetzel, Mania Ackermann, Nico Lachmann
Published in: International Journal of Molecular Sciences, Issue 22/7, 2021, Page(s) 3308, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22073308

Human Lentiviral Gene Therapy Restores the Cellular Phenotype of Autosomal Recessive Complete IFN-γR1 Deficiency

Author(s): Katharina Hahn, Liart Pollmann, Juliette Nowak, Ariane Hai Ha Nguyen, Kathrin Haake, Anna-Lena Neehus, Syed F. Hassnain Waqas, Frank Pessler, Ulrich Baumann, Miriam Hetzel, Jean-Laurent Casanova, Ansgar Schulz, Jacinta Bustamante, Mania Ackermann, Nico Lachmann
Published in: Molecular Therapy - Methods & Clinical Development, Issue 17, 2020, Page(s) 785-795, ISSN 2329-0501
Publisher: Cell Press
DOI: 10.1016/j.omtm.2020.04.002

iPSC-derived T cells and macrophages: Manufacturing and next-generation application approaches

Author(s): Débora Basílio-Queirós, Isabelle Rivière, Sjoukje J.C. van der Stegen, Nico Lachmann
Published in: Advanced Drug Delivery Reviews, Issue 227, 2026, Page(s) 115713, ISSN 0169-409X
Publisher: Elsevier BV
DOI: 10.1016/j.addr.2025.115713

Sensory neurons shape local macrophage identity via TGF-β signaling

Author(s): Julia Kolter, Clarissa-Laura Döring, Samah Sarout, Sebastian Baasch, Lloyd Steele, Reem Alsumati, Gabriel V. Lucena Silva, Conceição E. Aníbal Silva, Isadora Marques Paiva, Zohreh Mansoori Moghadam, Vitka Gres, Florens Lohrmann, Philipp Aktories, Theresa Buchegger, Mitchell Bijnen, Layal Doumard, Benjamin Voisin, Christelle Le Foll, Nico Lachmann, Melanie Greter, Katrin Kierdorf, Muzlifah Hani
Published in: Immunity, Issue 58, 2026, Page(s) 2556-2573.e8, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2025.08.004

Human inherited CCR2 deficiency underlies progressive polycystic lung disease

Author(s): Anna-Lena Neehus, Brenna Carey, Marija Landekic, Patricia Panikulam, Gail Deutsch, Masato Ogishi, Carlos A. Arango-Franco, Quentin Philippot, Mohammadreza Modaresi, Iraj Mohammadzadeh, Melissa Corcini Berndt, Darawan Rinchai, Tom Le Voyer, Jérémie Rosain, Mana Momenilandi, Marta Martin-Fernandez, Taushif Khan, Jonathan Bohlen, Ji Eun Han, Alexandre Deslys, Mathilde Bernard, Tania Gajardo-Carrasc
Published in: Cell, Issue 187, 2024, Page(s) 390-408.e23, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2023.11.036

Human CFTR deficient iPSC-macrophages reveal impaired functional and transcriptomic response upon Pseudomonas aeruginosa infection

Author(s): Claudio Rodriguez Gonzalez, Débora Basílio-Queirós, Anna-Lena Neehus, Sylvia Merkert, David Tschritter, Sinem Ünal, Jan Hegermann, Matthias Mörgelin, Jacinta Bustamante, Manuel Manfred Nietert, Ulrich Martin, Burkhard Tümmler, Antje Munder, Nico Lachmann
Published in: Frontiers in Immunology, Issue 15, 2024, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2024.1397886

Non-peer reviewed articles (1)

Commensal Microflora Coating Endows Implants with Biofilm-Repellent, Immunomodulatory and Osteogenic Properties

Author(s): Muhammad Imran Rahim, Shehneela Baseer, Daniela Paasch, Matthias Steglich, Syed Fakhar H. Waqas, Nico Lachmann, Christine S. Falk, Meike Stiesch
Published in: SSNR Electronic Journal, 2025, ISSN 1556-5068
Publisher: Elsevier
DOI: 10.2139/ssrn.5380435