From iPSC-Macrophage Biology Towards Regenerative Therapies Targeting Respiratory Infections

Informazioni relative al progetto

iPSC2Therapy

ID dell’accordo di sovvenzione: 852178

DOI 10.3030/852178

Data della firma CE 18 Novembre 2019

Data di avvio 1 Gennaio 2020

Data di completamento 31 Dicembre 2024

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 499 100,00

Contributo UE € 1 499 100,00

Coordinato da

MEDIZINISCHE HOCHSCHULE HANNOVER
Germany

Pubblicazioni

Peer reviewed articles (6)

A 3D iPSC-differentiation model identifies interleukin-3 as a regulator of early human hematopoietic specification

Autori: Mania Ackermann, Kathrin Haake, Henning Kempf, Paul Kaschutnig, Anna-Carina Weiss, Ariane H.H. Nguyen, Markus Abeln, Sylvia Merkert, Mark Phillip Kühnel, Dorothee Hartmann, Danny Jonigk, Thomas Thum, Andreas Kispert, Michael D. Milsom, Nico Lachmann
Pubblicato in: Haematologica, 2021, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2019.228064

Continuous human iPSC-macrophage mass production by suspension culture in stirred tank bioreactors

Autori: Mania Ackermann, Anna Rafiei Hashtchin , Felix Manstein, Marco Carvalho Oliveira, Henning Kempf, Robert Zweigerdt, Nico Lachmann
Pubblicato in: Nature Protocols, 2022, ISSN 1754-2189
Editore: Nature Publishing Group
DOI: 10.1038/s41596-021-00654-7

Human iPSC-derived macrophages for efficient Staphylococcus aureus clearance in a murine pulmonary infection model

Autori: Anna Rafiei Hashtchin, Beate Fehlhaber, Miriam Hetzel, Felix Manstein, Jan Lennart Stall, Silke Glage, Markus Abeln, Robert Zweigerdt, Antje Munder, Dorothee Viemann, Mania Ackermann, Nico Lachmann
Pubblicato in: Blood Advances, 2021, ISSN 2473-9529
Editore: Elsevier BV
DOI: 10.1182/bloodadvances.2021004853

Genetic Correction of IL-10RB Deficiency Reconstitutes Anti-Inflammatory Regulation in iPSC-Derived Macrophages

Autori: Dirk Hoffmann, Johanna Sens, Sebastian Brennig, Daniel Brand, Friederike Philipp, Philippe Vollmer Barbosa, Johannes Kuehle, Doris Steinemann, Daniela Lenz, Theresa Buchegger, Michael Morgan, Christine S. Falk, Christoph Klein, Nico Lachmann, Axel Schambach
Pubblicato in: Journal of Personalized Medicine, Numero 11/3, 2021, Pagina/e 221, ISSN 2075-4426
Editore: MDPI Multidisciplinary Digital Publishing Institute
DOI: 10.3390/jpm11030221

Beyond “Big Eaters”: The Versatile Role of Alveolar Macrophages in Health and Disease

Autori: Miriam Hetzel, Mania Ackermann, Nico Lachmann
Pubblicato in: International Journal of Molecular Sciences, Numero 22/7, 2021, Pagina/e 3308, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22073308

Human Lentiviral Gene Therapy Restores the Cellular Phenotype of Autosomal Recessive Complete IFN-γR1 Deficiency

Autori: Katharina Hahn, Liart Pollmann, Juliette Nowak, Ariane Hai Ha Nguyen, Kathrin Haake, Anna-Lena Neehus, Syed F. Hassnain Waqas, Frank Pessler, Ulrich Baumann, Miriam Hetzel, Jean-Laurent Casanova, Ansgar Schulz, Jacinta Bustamante, Mania Ackermann, Nico Lachmann
Pubblicato in: Molecular Therapy - Methods & Clinical Development, Numero 17, 2020, Pagina/e 785-795, ISSN 2329-0501
Editore: Cell Press
DOI: 10.1016/j.omtm.2020.04.002