From iPSC-Macrophage Biology Towards Regenerative Therapies Targeting Respiratory Infections

Informazioni relative al progetto

iPSC2Therapy

ID dell’accordo di sovvenzione: 852178

DOI

10.3030/852178

Data della firma CE 18 Novembre 2019

Data di avvio 1 Gennaio 2020

Data di completamento 30 Novembre 2025

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 499 100,00

Contributo UE

€ 1 499 100,00

Coordinato da

MEDIZINISCHE HOCHSCHULE HANNOVER
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (19)

In vitro systems to study inborn errors of immunity using human induced pluripotent stem cells

Autori: Eirini Nikolouli, Janne Reichstein, Gesine Hansen, Nico Lachmann
Pubblicato in: Frontiers in Immunology, Numero 13, 2022, ISSN 1664-3224
Editore: the International Union of Immunological Societies (IUIS)
DOI: 10.3389/fimmu.2022.1024935

Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria

Autori: Jérémie Rosain, Anna-Lena Neehus, Jérémy Manry, Rui Yang, Jérémie Le Pen, Wassim Daher, Zhiyong Liu, Yi-Hao Chan, Natalia Tahuil, Özden Türel, Mathieu Bourgey, Masato Ogishi, Jean-Marc Doisne, Helena M. Izquierdo, Takayoshi Shirasaki, Tom Le Voyer, Antoine Guérin, Paul Bastard, Marcela Moncada-Vélez, Ji Eun Han, Taushif Khan, Franck Rapaport, Seon-Hui Hong, Andrew Cheung, Kathrin Haake,
Pubblicato in: Cell, Numero 186, 2023, Pagina/e 621-645.e33, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2022.12.038

CARs and beyond: tailoring macrophage-based cell therapeutics to combat solid malignancies

Autori: Shifaa M. Abdin, Daniela Paasch, Michael Morgan, Nico Lachmann
Pubblicato in: Journal for ImmunoTherapy of Cancer, Numero 9, 2021, Pagina/e e002741, ISSN 2051-1426
Editore: BMJ
DOI: 10.1136/jitc-2021-002741

Targeted Integration of Inducible Caspase-9 in Human iPSCs Allows Efficient in vitro Clearance of iPSCs and iPSC-Macrophages

Autori: Alexandra Lipus, Ewa Janosz, Mania Ackermann, Miriam Hetzel, Julia Dahlke, Theresa Buchegger, Stephanie Wunderlich, Ulrich Martin, Toni Cathomen, Axel Schambach, Thomas Moritz, Nico Lachmann
Pubblicato in: International Journal of Molecular Sciences, Numero 21, 2024, Pagina/e 2481, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21072481

Alveolar macrophages in tissue homeostasis, inflammation, and infection: evolving concepts of therapeutic targeting

Autori: Christina Malainou, Shifaa M. Abdin, Nico Lachmann, Ulrich Matt, Susanne Herold
Pubblicato in: Journal of Clinical Investigation, Numero 133, 2023, ISSN 1558-8238
Editore: the American Society for Clinical Investigation
DOI: 10.1172/jci170501

CAR macrophages on a fast track to solid tumor therapy

Autori: Shifaa M. Abdin, Daniela Paasch, Nico Lachmann
Pubblicato in: Nature Immunology, Numero 25, 2024, Pagina/e 11-12, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/s41590-023-01696-7

The Immune-Modulatory Properties of iPSC-Derived Antigen-Presenting Cells

Autori: Mania Ackermann, Anna Christina Dragon, Nico Lachmann
Pubblicato in: Transfusion Medicine and Hemotherapy, Numero 47, 2024, Pagina/e 444-453, ISSN 1660-3796
Editore: S. Karger AG
DOI: 10.1159/000512721

Standardized generation of human iPSC-derived hematopoietic organoids and macrophages utilizing a benchtop bioreactor platform under fully defined conditions

Autori: Mania Ackermann, Fawaz Saleh, Shifaa M. Abdin, Anna Rafiei Hashtchin, Ingrid Gensch, Julia Golgath, Marco Carvalho Oliveira, Ariane H. H. Nguyen, Svenja Gaedcke, Arno Fenske, Mi-Sun Jang, Adan C. Jirmo, Markus Abeln, Gesine Hansen, Nico Lachmann
Pubblicato in: Stem Cell Research & Therapy, Numero 15, 2024, ISSN 1757-6512
Editore: BioMed Central
DOI: 10.1186/s13287-024-03785-2

Scalable generation of functional human iPSC-derived CAR-macrophages that efficiently eradicate CD19-positive leukemia

Autori: Shifaa M. Abdin, Daniela Paasch, Arnold Kloos, Marco Carvalho Oliveira, Mi-Sun Jang, Mania Ackermann, Andriana Stamopoulou, Philipp J Mroch, Christine S Falk, Constantin S von Kaisenberg, Axel Schambach, Michael Heuser, Thomas Moritz, Gesine Hansen, Michael Morgan, Nico Lachmann
Pubblicato in: Journal for ImmunoTherapy of Cancer, Numero 11, 2023, Pagina/e e007705, ISSN 2051-1426
Editore: BMJ
DOI: 10.1136/jitc-2023-007705

A 3D iPSC-differentiation model identifies interleukin-3 as a regulator of early human hematopoietic specification

Autori: Mania Ackermann, Kathrin Haake, Henning Kempf, Paul Kaschutnig, Anna-Carina Weiss, Ariane H.H. Nguyen, Markus Abeln, Sylvia Merkert, Mark Phillip Kühnel, Dorothee Hartmann, Danny Jonigk, Thomas Thum, Andreas Kispert, Michael D. Milsom, Nico Lachmann
Pubblicato in: Haematologica, 2021, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2019.228064

Pulmonary Alveolar Proteinosis and new therapeutic concepts

Autori: Claudio Rodriguez Gonzalez, Hannah Schevel, Gesine Hansen, Nicolaus Schwerk, Nico Lachmann
Pubblicato in: Klinische Pädiatrie, Numero 236, 2024, Pagina/e 73-79, ISSN 0300-8630
Editore: Georg Thieme Verlag
DOI: 10.1055/a-2233-1243

Sensor macrophages derived from human induced pluripotent stem cells to assess pyrogenic contaminations in parenteral drugs

Autori: Shifaa M Abdin, Friederike Mansel, Anna Rafiei Hashtchin, Mania Ackermann, Gesine Hansen, Björn Becker, Benjamin Kick, Nhi Pham, Hendrik Dietz, Christoph Schaniel, Ulrich Martin, Ingo Spreitzer, Nico Lachmann
Pubblicato in: Biofabrication, Numero 16, 2024, Pagina/e 035017, ISSN 1758-5082
Editore: IOS Press
DOI: 10.1088/1758-5090/ad4744

Continuous human iPSC-macrophage mass production by suspension culture in stirred tank bioreactors

Autori: Mania Ackermann, Anna Rafiei Hashtchin , Felix Manstein, Marco Carvalho Oliveira, Henning Kempf, Robert Zweigerdt, Nico Lachmann
Pubblicato in: Nature Protocols, 2022, ISSN 1754-2189
Editore: Nature Publishing Group
DOI: 10.1038/s41596-021-00654-7

From macrophage biology to macrophage-based cellular immunotherapies

Autori: Elvira Mass, Nico Lachmann
Pubblicato in: Gene Therapy, Numero 28, 2023, Pagina/e 473-476, ISSN 0969-7128
Editore: Nature Publishing Group
DOI: 10.1038/s41434-021-00221-5

Human iPSC-derived macrophages for efficient Staphylococcus aureus clearance in a murine pulmonary infection model

Autori: Anna Rafiei Hashtchin, Beate Fehlhaber, Miriam Hetzel, Felix Manstein, Jan Lennart Stall, Silke Glage, Markus Abeln, Robert Zweigerdt, Antje Munder, Dorothee Viemann, Mania Ackermann, Nico Lachmann
Pubblicato in: Blood Advances, 2021, ISSN 2473-9529
Editore: Elsevier BV
DOI: 10.1182/bloodadvances.2021004853

Genetic Correction of IL-10RB Deficiency Reconstitutes Anti-Inflammatory Regulation in iPSC-Derived Macrophages

Autori: Dirk Hoffmann, Johanna Sens, Sebastian Brennig, Daniel Brand, Friederike Philipp, Philippe Vollmer Barbosa, Johannes Kuehle, Doris Steinemann, Daniela Lenz, Theresa Buchegger, Michael Morgan, Christine S. Falk, Christoph Klein, Nico Lachmann, Axel Schambach
Pubblicato in: Journal of Personalized Medicine, Numero 11/3, 2021, Pagina/e 221, ISSN 2075-4426
Editore: MDPI Multidisciplinary Digital Publishing Institute
DOI: 10.3390/jpm11030221

Beyond “Big Eaters”: The Versatile Role of Alveolar Macrophages in Health and Disease

Autori: Miriam Hetzel, Mania Ackermann, Nico Lachmann
Pubblicato in: International Journal of Molecular Sciences, Numero 22/7, 2021, Pagina/e 3308, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22073308

Human Lentiviral Gene Therapy Restores the Cellular Phenotype of Autosomal Recessive Complete IFN-γR1 Deficiency

Autori: Katharina Hahn, Liart Pollmann, Juliette Nowak, Ariane Hai Ha Nguyen, Kathrin Haake, Anna-Lena Neehus, Syed F. Hassnain Waqas, Frank Pessler, Ulrich Baumann, Miriam Hetzel, Jean-Laurent Casanova, Ansgar Schulz, Jacinta Bustamante, Mania Ackermann, Nico Lachmann
Pubblicato in: Molecular Therapy - Methods & Clinical Development, Numero 17, 2020, Pagina/e 785-795, ISSN 2329-0501
Editore: Cell Press
DOI: 10.1016/j.omtm.2020.04.002

Human inherited CCR2 deficiency underlies progressive polycystic lung disease

Autori: Anna-Lena Neehus, Brenna Carey, Marija Landekic, Patricia Panikulam, Gail Deutsch, Masato Ogishi, Carlos A. Arango-Franco, Quentin Philippot, Mohammadreza Modaresi, Iraj Mohammadzadeh, Melissa Corcini Berndt, Darawan Rinchai, Tom Le Voyer, Jérémie Rosain, Mana Momenilandi, Marta Martin-Fernandez, Taushif Khan, Jonathan Bohlen, Ji Eun Han, Alexandre Deslys, Mathilde Bernard, Tania Gajardo-Carrasc
Pubblicato in: Cell, Numero 187, 2024, Pagina/e 390-408.e23, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2023.11.036