From iPSC-Macrophage Biology Towards Regenerative Therapies Targeting Respiratory Infections

Información del proyecto

iPSC2Therapy

Identificador del acuerdo de subvención: 852178

DOI 10.3030/852178

Fecha de la firma de la CE 18 Noviembre 2019

Fecha de inicio 1 Enero 2020

Fecha de finalización 31 Diciembre 2024

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total € 1 499 100,00

Aportación de la UE € 1 499 100,00

Coordinado por

MEDIZINISCHE HOCHSCHULE HANNOVER
Germany

Publicaciones

Peer reviewed articles (6)

A 3D iPSC-differentiation model identifies interleukin-3 as a regulator of early human hematopoietic specification

Autores: Mania Ackermann, Kathrin Haake, Henning Kempf, Paul Kaschutnig, Anna-Carina Weiss, Ariane H.H. Nguyen, Markus Abeln, Sylvia Merkert, Mark Phillip Kühnel, Dorothee Hartmann, Danny Jonigk, Thomas Thum, Andreas Kispert, Michael D. Milsom, Nico Lachmann
Publicado en: Haematologica, 2021, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2019.228064

Continuous human iPSC-macrophage mass production by suspension culture in stirred tank bioreactors

Autores: Mania Ackermann, Anna Rafiei Hashtchin , Felix Manstein, Marco Carvalho Oliveira, Henning Kempf, Robert Zweigerdt, Nico Lachmann
Publicado en: Nature Protocols, 2022, ISSN 1754-2189
Editor: Nature Publishing Group
DOI: 10.1038/s41596-021-00654-7

Human iPSC-derived macrophages for efficient Staphylococcus aureus clearance in a murine pulmonary infection model

Autores: Anna Rafiei Hashtchin, Beate Fehlhaber, Miriam Hetzel, Felix Manstein, Jan Lennart Stall, Silke Glage, Markus Abeln, Robert Zweigerdt, Antje Munder, Dorothee Viemann, Mania Ackermann, Nico Lachmann
Publicado en: Blood Advances, 2021, ISSN 2473-9529
Editor: Elsevier BV
DOI: 10.1182/bloodadvances.2021004853

Genetic Correction of IL-10RB Deficiency Reconstitutes Anti-Inflammatory Regulation in iPSC-Derived Macrophages

Autores: Dirk Hoffmann, Johanna Sens, Sebastian Brennig, Daniel Brand, Friederike Philipp, Philippe Vollmer Barbosa, Johannes Kuehle, Doris Steinemann, Daniela Lenz, Theresa Buchegger, Michael Morgan, Christine S. Falk, Christoph Klein, Nico Lachmann, Axel Schambach
Publicado en: Journal of Personalized Medicine, Edición 11/3, 2021, Página(s) 221, ISSN 2075-4426
Editor: MDPI Multidisciplinary Digital Publishing Institute
DOI: 10.3390/jpm11030221

Beyond “Big Eaters”: The Versatile Role of Alveolar Macrophages in Health and Disease

Autores: Miriam Hetzel, Mania Ackermann, Nico Lachmann
Publicado en: International Journal of Molecular Sciences, Edición 22/7, 2021, Página(s) 3308, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22073308

Human Lentiviral Gene Therapy Restores the Cellular Phenotype of Autosomal Recessive Complete IFN-γR1 Deficiency

Autores: Katharina Hahn, Liart Pollmann, Juliette Nowak, Ariane Hai Ha Nguyen, Kathrin Haake, Anna-Lena Neehus, Syed F. Hassnain Waqas, Frank Pessler, Ulrich Baumann, Miriam Hetzel, Jean-Laurent Casanova, Ansgar Schulz, Jacinta Bustamante, Mania Ackermann, Nico Lachmann
Publicado en: Molecular Therapy - Methods & Clinical Development, Edición 17, 2020, Página(s) 785-795, ISSN 2329-0501
Editor: Cell Press
DOI: 10.1016/j.omtm.2020.04.002