From iPSC-Macrophage Biology Towards Regenerative Therapies Targeting Respiratory Infections

Información del proyecto

iPSC2Therapy

Identificador del acuerdo de subvención: 852178

DOI

10.3030/852178

Fecha de la firma de la CE 18 Noviembre 2019

Fecha de inicio 1 Enero 2020

Fecha de finalización 30 Noviembre 2025

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 499 100,00

Aportación de la UE

€ 1 499 100,00

Coordinado por

MEDIZINISCHE HOCHSCHULE HANNOVER
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (19)

In vitro systems to study inborn errors of immunity using human induced pluripotent stem cells

Autores: Eirini Nikolouli, Janne Reichstein, Gesine Hansen, Nico Lachmann
Publicado en: Frontiers in Immunology, Edición 13, 2022, ISSN 1664-3224
Editor: the International Union of Immunological Societies (IUIS)
DOI: 10.3389/fimmu.2022.1024935

Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria

Autores: Jérémie Rosain, Anna-Lena Neehus, Jérémy Manry, Rui Yang, Jérémie Le Pen, Wassim Daher, Zhiyong Liu, Yi-Hao Chan, Natalia Tahuil, Özden Türel, Mathieu Bourgey, Masato Ogishi, Jean-Marc Doisne, Helena M. Izquierdo, Takayoshi Shirasaki, Tom Le Voyer, Antoine Guérin, Paul Bastard, Marcela Moncada-Vélez, Ji Eun Han, Taushif Khan, Franck Rapaport, Seon-Hui Hong, Andrew Cheung, Kathrin Haake,
Publicado en: Cell, Edición 186, 2023, Página(s) 621-645.e33, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2022.12.038

CARs and beyond: tailoring macrophage-based cell therapeutics to combat solid malignancies

Autores: Shifaa M. Abdin, Daniela Paasch, Michael Morgan, Nico Lachmann
Publicado en: Journal for ImmunoTherapy of Cancer, Edición 9, 2021, Página(s) e002741, ISSN 2051-1426
Editor: BMJ
DOI: 10.1136/jitc-2021-002741

Targeted Integration of Inducible Caspase-9 in Human iPSCs Allows Efficient in vitro Clearance of iPSCs and iPSC-Macrophages

Autores: Alexandra Lipus, Ewa Janosz, Mania Ackermann, Miriam Hetzel, Julia Dahlke, Theresa Buchegger, Stephanie Wunderlich, Ulrich Martin, Toni Cathomen, Axel Schambach, Thomas Moritz, Nico Lachmann
Publicado en: International Journal of Molecular Sciences, Edición 21, 2024, Página(s) 2481, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21072481

Alveolar macrophages in tissue homeostasis, inflammation, and infection: evolving concepts of therapeutic targeting

Autores: Christina Malainou, Shifaa M. Abdin, Nico Lachmann, Ulrich Matt, Susanne Herold
Publicado en: Journal of Clinical Investigation, Edición 133, 2023, ISSN 1558-8238
Editor: the American Society for Clinical Investigation
DOI: 10.1172/jci170501

CAR macrophages on a fast track to solid tumor therapy

Autores: Shifaa M. Abdin, Daniela Paasch, Nico Lachmann
Publicado en: Nature Immunology, Edición 25, 2024, Página(s) 11-12, ISSN 1529-2908
Editor: Nature Publishing Group
DOI: 10.1038/s41590-023-01696-7

The Immune-Modulatory Properties of iPSC-Derived Antigen-Presenting Cells

Autores: Mania Ackermann, Anna Christina Dragon, Nico Lachmann
Publicado en: Transfusion Medicine and Hemotherapy, Edición 47, 2024, Página(s) 444-453, ISSN 1660-3796
Editor: S. Karger AG
DOI: 10.1159/000512721

Standardized generation of human iPSC-derived hematopoietic organoids and macrophages utilizing a benchtop bioreactor platform under fully defined conditions

Autores: Mania Ackermann, Fawaz Saleh, Shifaa M. Abdin, Anna Rafiei Hashtchin, Ingrid Gensch, Julia Golgath, Marco Carvalho Oliveira, Ariane H. H. Nguyen, Svenja Gaedcke, Arno Fenske, Mi-Sun Jang, Adan C. Jirmo, Markus Abeln, Gesine Hansen, Nico Lachmann
Publicado en: Stem Cell Research & Therapy, Edición 15, 2024, ISSN 1757-6512
Editor: BioMed Central
DOI: 10.1186/s13287-024-03785-2

Scalable generation of functional human iPSC-derived CAR-macrophages that efficiently eradicate CD19-positive leukemia

Autores: Shifaa M. Abdin, Daniela Paasch, Arnold Kloos, Marco Carvalho Oliveira, Mi-Sun Jang, Mania Ackermann, Andriana Stamopoulou, Philipp J Mroch, Christine S Falk, Constantin S von Kaisenberg, Axel Schambach, Michael Heuser, Thomas Moritz, Gesine Hansen, Michael Morgan, Nico Lachmann
Publicado en: Journal for ImmunoTherapy of Cancer, Edición 11, 2023, Página(s) e007705, ISSN 2051-1426
Editor: BMJ
DOI: 10.1136/jitc-2023-007705

A 3D iPSC-differentiation model identifies interleukin-3 as a regulator of early human hematopoietic specification

Autores: Mania Ackermann, Kathrin Haake, Henning Kempf, Paul Kaschutnig, Anna-Carina Weiss, Ariane H.H. Nguyen, Markus Abeln, Sylvia Merkert, Mark Phillip Kühnel, Dorothee Hartmann, Danny Jonigk, Thomas Thum, Andreas Kispert, Michael D. Milsom, Nico Lachmann
Publicado en: Haematologica, 2021, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2019.228064

Pulmonary Alveolar Proteinosis and new therapeutic concepts

Autores: Claudio Rodriguez Gonzalez, Hannah Schevel, Gesine Hansen, Nicolaus Schwerk, Nico Lachmann
Publicado en: Klinische Pädiatrie, Edición 236, 2024, Página(s) 73-79, ISSN 0300-8630
Editor: Georg Thieme Verlag
DOI: 10.1055/a-2233-1243

Sensor macrophages derived from human induced pluripotent stem cells to assess pyrogenic contaminations in parenteral drugs

Autores: Shifaa M Abdin, Friederike Mansel, Anna Rafiei Hashtchin, Mania Ackermann, Gesine Hansen, Björn Becker, Benjamin Kick, Nhi Pham, Hendrik Dietz, Christoph Schaniel, Ulrich Martin, Ingo Spreitzer, Nico Lachmann
Publicado en: Biofabrication, Edición 16, 2024, Página(s) 035017, ISSN 1758-5082
Editor: IOS Press
DOI: 10.1088/1758-5090/ad4744

Continuous human iPSC-macrophage mass production by suspension culture in stirred tank bioreactors

Autores: Mania Ackermann, Anna Rafiei Hashtchin , Felix Manstein, Marco Carvalho Oliveira, Henning Kempf, Robert Zweigerdt, Nico Lachmann
Publicado en: Nature Protocols, 2022, ISSN 1754-2189
Editor: Nature Publishing Group
DOI: 10.1038/s41596-021-00654-7

From macrophage biology to macrophage-based cellular immunotherapies

Autores: Elvira Mass, Nico Lachmann
Publicado en: Gene Therapy, Edición 28, 2023, Página(s) 473-476, ISSN 0969-7128
Editor: Nature Publishing Group
DOI: 10.1038/s41434-021-00221-5

Human iPSC-derived macrophages for efficient Staphylococcus aureus clearance in a murine pulmonary infection model

Autores: Anna Rafiei Hashtchin, Beate Fehlhaber, Miriam Hetzel, Felix Manstein, Jan Lennart Stall, Silke Glage, Markus Abeln, Robert Zweigerdt, Antje Munder, Dorothee Viemann, Mania Ackermann, Nico Lachmann
Publicado en: Blood Advances, 2021, ISSN 2473-9529
Editor: Elsevier BV
DOI: 10.1182/bloodadvances.2021004853

Genetic Correction of IL-10RB Deficiency Reconstitutes Anti-Inflammatory Regulation in iPSC-Derived Macrophages

Autores: Dirk Hoffmann, Johanna Sens, Sebastian Brennig, Daniel Brand, Friederike Philipp, Philippe Vollmer Barbosa, Johannes Kuehle, Doris Steinemann, Daniela Lenz, Theresa Buchegger, Michael Morgan, Christine S. Falk, Christoph Klein, Nico Lachmann, Axel Schambach
Publicado en: Journal of Personalized Medicine, Edición 11/3, 2021, Página(s) 221, ISSN 2075-4426
Editor: MDPI Multidisciplinary Digital Publishing Institute
DOI: 10.3390/jpm11030221

Beyond “Big Eaters”: The Versatile Role of Alveolar Macrophages in Health and Disease

Autores: Miriam Hetzel, Mania Ackermann, Nico Lachmann
Publicado en: International Journal of Molecular Sciences, Edición 22/7, 2021, Página(s) 3308, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22073308

Human Lentiviral Gene Therapy Restores the Cellular Phenotype of Autosomal Recessive Complete IFN-γR1 Deficiency

Autores: Katharina Hahn, Liart Pollmann, Juliette Nowak, Ariane Hai Ha Nguyen, Kathrin Haake, Anna-Lena Neehus, Syed F. Hassnain Waqas, Frank Pessler, Ulrich Baumann, Miriam Hetzel, Jean-Laurent Casanova, Ansgar Schulz, Jacinta Bustamante, Mania Ackermann, Nico Lachmann
Publicado en: Molecular Therapy - Methods & Clinical Development, Edición 17, 2020, Página(s) 785-795, ISSN 2329-0501
Editor: Cell Press
DOI: 10.1016/j.omtm.2020.04.002

Human inherited CCR2 deficiency underlies progressive polycystic lung disease

Autores: Anna-Lena Neehus, Brenna Carey, Marija Landekic, Patricia Panikulam, Gail Deutsch, Masato Ogishi, Carlos A. Arango-Franco, Quentin Philippot, Mohammadreza Modaresi, Iraj Mohammadzadeh, Melissa Corcini Berndt, Darawan Rinchai, Tom Le Voyer, Jérémie Rosain, Mana Momenilandi, Marta Martin-Fernandez, Taushif Khan, Jonathan Bohlen, Ji Eun Han, Alexandre Deslys, Mathilde Bernard, Tania Gajardo-Carrasc
Publicado en: Cell, Edición 187, 2024, Página(s) 390-408.e23, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2023.11.036