The dark side of evolution: the deleterious mutational landscape of RNA viruses

Project Information

RNAVirFitness

Grant agreement ID: 852223

DOI

10.3030/852223

Project closed

EC signature date 10 February 2020

Start date 1 June 2020

End date 31 March 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 495 625,00

EU contribution

€ 1 495 625,00

Coordinated by

TEL AVIV UNIVERSITY
Israel

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (6)

Navigating a Fine Balance: Point-Mutant Cheater Viruses Disrupt the Viral Replication Cycle

Author(s): Moran Meir, Arielle Kahn, Carmel Farage, Yael Maoz, Noam Harel, Adi Ben Zvi, Shir Segev, Maria Volkov, Ravit Yahud, Uri Gophna, Adi Stern
Published in: Molecular Biology and Evolution, Issue 42, 2025, ISSN 0737-4038
Publisher: Oxford University Press
DOI: 10.1093/molbev/msae258

Mutation rate, selection, and epistasis inferred from RNA virus haplotypes via neural posterior estimation

Author(s): Itamar Caspi, Moran Meir, Nadav Ben Nun, Reem Abu Rass, Uri Yakhini, Adi Stern, Yoav Ram
Published in: Virus Evolution, 2023, ISSN 2057-1577
Publisher: Oxford university press
DOI: 10.1093/ve/vead033

Drivers of adaptive evolution during chronic SARS-CoV-2 infections

Author(s): Sheri Harari, Maayan Tahor, Natalie Rutsinsky, Suzy Meijer, Danielle Miller, Oryan Henig, Ora Halutz, Katia Levytskyi, Ronen Ben-Ami, Amos Adler, Yael Paran & Adi Stern
Published in: Nature Medicine, 2022, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-022-01882-4

Using big sequencing data to identify chronic SARS-Coronavirus-2 infections

Author(s): Sheri Harari, Danielle Miller, Shay Fleishon, David Burstein, Adi Stern
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-44803-4

Evidence for increased breakthrough rates of SARS-CoV-2 variants of concern in BNT162b2-mRNA-vaccinated individuals

Author(s): Talia Kustin, Noam Harel, Uriah Finkel, Shay Perchik, Sheri Harari, Maayan Tahor, Itamar Caspi, Rachel Levy, Michael Leshchinsky, Shifra Ken Dror, Galit Bergerzon, Hala Gadban, Faten Gadban, Eti Eliassian, Orit Shimron, Loulou Saleh, Haim Ben-Zvi, Elena Keren Taraday, Doron Amichay, Anat Ben-Dor, Dana Sagas, Merav Strauss, Yonat Shemer Avni, Amit Huppert, Eldad Kepten, Ran D. Balicer, Doron Netzer
Published in: Nature Medicine, Issue 27/8, 2021, Page(s) 1379-1384, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-021-01413-7

Diverse patterns of intra-host genetic diversity in chronically infected SARS-CoV-2 patients

Author(s): Natalie Rutsinsky, Adi Ben Zvi, Ido Fabian, Shir T. Segev, Bar Jacobi, Sheri Harari, Suzy Meijers, Yael Paran, Adi Stern
Published in: Virus Evolution, 2026, ISSN 2057-1577
Publisher: Oxford Academix Press
DOI: 10.1101/2024.11.23.624482