Plasticity of tumour metabolism
Glycolysis and oxidative phosphorylation are the main energy-producing machineries in living cells. Cancer cells reprogramme their metabolism to fuel rapid growth and until recently it was explained though increase in glycolysis. However, recent advances in metabolism studies showed that tumours might have more heterogeneous energy production. The EU-funded ONco-Energetics_OFF project aims to uncover the molecular markers, mechanisms of regulation and implications of tumour metabolic plasticity. Previous studies of the project team demonstrated that cancer cells can be sorted into: bioenergetically committed to one of the two pathways, or bioenergetically plastic according to their ability to switch between pathways depending on metabolic challenges. This project will investigate plasticity mechanisms and the potential significance for new drugs targeting tumour energy production.
Fields of science
Call for proposalSee other projects for this call
Funding SchemeERC-STG - Starting Grant
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