Description du projet
Définir le rôle du claustrum dans la fonction cérébrale
Le claustrum est l’une des structures du cerveau les moins étudiées et les plus mystérieuses: des rapports récents suggèrent pourtant qu’il pourrait être l’une des plus importantes. Le claustrum est une structure mince et irrégulière en forme de feuille sous la surface intérieure du néocortex. Il a très peu de types de cellules et n’a aucune stratification. Ce qui est remarquable, c’est qu’il communique avec presque toutes les régions du cortex, leur envoyant et recevant des projections. Cela le place dans une position unique pour intégrer les informations sensorimotrices multimodales associées à l’expérience consciente. Le projet CLAUSTRUM, financé par l’UE, a l’intention de réaliser des progrès significatifs dans la définition du rôle du claustrum dans la fonction cérébrale grâce au développement et à l’application de nouvelles techniques pour le surveiller et le manipuler.
Objectif
How does the brain integrate inputs from the environment to generate perception and drive decisions? An enigmatic brain region called the claustrum has been suggested to play a role by integrating inputs from multiple brain regions. There is strong interconnectivity between claustrum and nearly every neocortical brain region, indicating that it exerts widespread influence on brain function. However, approaches to specifically record from or manipulate activity in the claustrum have been hindered by the inability to target it selectively. This has been difficult due to the anatomy of the claustrum: it is a long, thin bilateral nucleus buried between the neocortex and the striatum. This proposal aims to understand the role of the claustrum in multisensory integration and behaviour by developing new approaches for monitoring and manipulating the activity of the claustrum. We will harness recent advances in electrophysiological, genetic, optical, and behavioural tools to probe its connectivity, activity, and function in a precise manner. Understanding the role of the claustrum in brain function will provide fundamental insight into information processing in the neocortex, which is a major goal in neuroscience. The claustrum is unique because of its dense reciprocal connectivity with neocortex but nearly complete lack of direct subcortical sensory input. This particular anatomical structure indicates the possibility of a unique function, but none has been observed yet. This proposal will rectify the paucity of data on this distinctive structure by applying a battery of modern tools to address the function of the claustrum. Experiments will address the following key questions:
1. How are claustrocortical inputs integrated and what is the effect of corticoclaustral feedback?
2. What is the activity of claustral neurons during sensory stimulation and motor output?
3. What are the causal relationships between claustrum activity and animal behaviour?
Champ scientifique
Mots‑clés
Programme(s)
Thème(s)
Régime de financement
ERC-STG - Starting GrantInstitution d’accueil
OX1 2JD Oxford
Royaume-Uni