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Optical interrogation of the claustrum from synapses to behavior

Descrizione del progetto

Definire il ruolo del claustro nella funzione cerebrale

Il claustro è una delle strutture meno studiate ed enigmatiche del cervello, ma recenti rapporti suggeriscono che potrebbe essere una delle più importanti. Il claustro è una sottile struttura laminare irregolare che si trova sotto la superficie interna della neocorteccia. Ha pochissimi tipi di cellule e nessuna stratificazione. Degno di nota è che tale struttura riceve e invia propaggini in quasi tutte le regioni della corteccia. Ciò lo colloca in una posizione unica per integrare le informazioni sensorimotorie multimodali associate all’esperienza cosciente. Il progetto CLAUSTRUM, finanziato dall’UE, intende fare progressi significativi nella definizione del ruolo del claustro nella funzione cerebrale attraverso lo sviluppo e l’applicazione di nuove tecniche per monitorarlo e manipolarlo.

Obiettivo

How does the brain integrate inputs from the environment to generate perception and drive decisions? An enigmatic brain region called the claustrum has been suggested to play a role by integrating inputs from multiple brain regions. There is strong interconnectivity between claustrum and nearly every neocortical brain region, indicating that it exerts widespread influence on brain function. However, approaches to specifically record from or manipulate activity in the claustrum have been hindered by the inability to target it selectively. This has been difficult due to the anatomy of the claustrum: it is a long, thin bilateral nucleus buried between the neocortex and the striatum. This proposal aims to understand the role of the claustrum in multisensory integration and behaviour by developing new approaches for monitoring and manipulating the activity of the claustrum. We will harness recent advances in electrophysiological, genetic, optical, and behavioural tools to probe its connectivity, activity, and function in a precise manner. Understanding the role of the claustrum in brain function will provide fundamental insight into information processing in the neocortex, which is a major goal in neuroscience. The claustrum is unique because of its dense reciprocal connectivity with neocortex but nearly complete lack of direct subcortical sensory input. This particular anatomical structure indicates the possibility of a unique function, but none has been observed yet. This proposal will rectify the paucity of data on this distinctive structure by applying a battery of modern tools to address the function of the claustrum. Experiments will address the following key questions:

1. How are claustrocortical inputs integrated and what is the effect of corticoclaustral feedback?

2. What is the activity of claustral neurons during sensory stimulation and motor output?

3. What are the causal relationships between claustrum activity and animal behaviour?

Meccanismo di finanziamento

ERC-STG - Starting Grant

Istituzione ospitante

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Contribution nette de l'UE
€ 1 500 000,00
Indirizzo
WELLINGTON SQUARE UNIVERSITY OFFICES
OX1 2JD Oxford
Regno Unito

Mostra sulla mappa

Regione
South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire
Tipo di attività
Higher or Secondary Education Establishments
Collegamenti
Costo totale
€ 1 500 000,00

Beneficiari (1)