Projektbeschreibung
Funktion des Claustrums im Hirn wird geklärt
Das Claustrum ist eine der am wenigsten erforschten und rätselhaftesten Strukturen im Gehirn. Neuere Arbeiten deuten jedoch darauf hin, dass es gleichermaßen eine der wichtigsten sein könnte. Es handelt sich um eine dünne, unregelmäßige, flächige Struktur unterhalb der inneren Oberfläche des Neokortex, die nur über sehr wenige Zelltypen und keine Schichtung verfügt. Das Bemerkenswerte am Claustrum ist, dass es aus fast allen Regionen des Kortex Signale empfängt und Projektionen in fast alle Regionen des Kortex weiterleitet. So kann es auf einzigartige Weise multimodale sensomotorische Informationen verknüpfen, die mit dem bewussten Erleben verbunden sind. Das EU-finanzierte Projekt CLAUSTRUM will mit der Entwicklung und Anwendung neuartiger Verfahren zur Überwachung und Manipulation des Claustrums bedeutende Fortschritte bei der Definition von dessen Rolle für die Gehirnfunktion erzielen.
Ziel
How does the brain integrate inputs from the environment to generate perception and drive decisions? An enigmatic brain region called the claustrum has been suggested to play a role by integrating inputs from multiple brain regions. There is strong interconnectivity between claustrum and nearly every neocortical brain region, indicating that it exerts widespread influence on brain function. However, approaches to specifically record from or manipulate activity in the claustrum have been hindered by the inability to target it selectively. This has been difficult due to the anatomy of the claustrum: it is a long, thin bilateral nucleus buried between the neocortex and the striatum. This proposal aims to understand the role of the claustrum in multisensory integration and behaviour by developing new approaches for monitoring and manipulating the activity of the claustrum. We will harness recent advances in electrophysiological, genetic, optical, and behavioural tools to probe its connectivity, activity, and function in a precise manner. Understanding the role of the claustrum in brain function will provide fundamental insight into information processing in the neocortex, which is a major goal in neuroscience. The claustrum is unique because of its dense reciprocal connectivity with neocortex but nearly complete lack of direct subcortical sensory input. This particular anatomical structure indicates the possibility of a unique function, but none has been observed yet. This proposal will rectify the paucity of data on this distinctive structure by applying a battery of modern tools to address the function of the claustrum. Experiments will address the following key questions:
1. How are claustrocortical inputs integrated and what is the effect of corticoclaustral feedback?
2. What is the activity of claustral neurons during sensory stimulation and motor output?
3. What are the causal relationships between claustrum activity and animal behaviour?
Wissenschaftliches Gebiet
Schlüsselbegriffe
Programm/Programme
Thema/Themen
Finanzierungsplan
ERC-STG - Starting GrantGastgebende Einrichtung
OX1 2JD Oxford
Vereinigtes Königreich