RAtional design of canceR ImmunoTherapY: one size does not fit all

Project Information

RARITY

Grant agreement ID: 852832

DOI

10.3030/852832

Project closed

EC signature date 27 November 2019

Start date 1 December 2019

End date 30 November 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 499 795,00

EU contribution

€ 1 499 795,00

Coordinated by

ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data Management Plan

The participant will submit a plan describing how to deal with the research data generated in the current project

Publications

Peer reviewed articles (22)

Visual cohort comparison for spatial single-cell omics-data

Author(s): Antonios Somarakis, Marieke E. Ijsselsteijn, Sietse J. Luk, Boyd Kenkhuis, Noel F.C.C. de Miranda, Boudewijn P.F. Lelieveldt, Thomas Hollt
Published in: IEEE Transactions on Visualization and Computer Graphics, Issue 27/2, 2021, Page(s) 733-743, ISSN 1077-2626
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tvcg.2020.3030336

Semi‐automated background removal limits data loss and normalizes imaging mass cytometry data

Author(s): Marieke E. Ijsselsteijn, Antonios Somarakis, Boudewijn P. F. Lelieveldt, Thomas Höllt, Noel F. C. C. Miranda
Published in: Cytometry Part A, 2021, ISSN 1552-4922
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cyto.a.24480

PENGUIN: A rapid and efficient image preprocessing tool for multiplexed spatial proteomics

Author(s): A.M. Sequeira, M.E. Ijsselsteijn, M. Rocha, Noel F.C.C. de Miranda
Published in: Computational and Structural Biotechnology Journal, Issue 23, 2025, Page(s) 3920-3928, ISSN 2001-0370
Publisher: Elsevier BV
DOI: 10.1016/j.csbj.2024.10.048

Cancer-Associated Fibroblasts Are Key Determinants of Cancer Cell Invasion in the Earliest Stage of Colorectal Cancer

Author(s): Hao Dang, Tom J. Harryvan, Chen-Yi Liao, Erik H.J. Danen, Vienna N.L.N. Spalburg, Szymon M. Kielbasa, Hailiang Mei, Jelle J. Goeman, Eveline S. de Jonge-Muller, Stefanus G.T. Janson, Johan J. van der Reijden, Stijn Crobach, James C.H. Hardwick, Jurjen J. Boonstra, Noel F.C.C. de Miranda, Lukas J.A.C. Hawinkels
Published in: Cellular and Molecular Gastroenterology and Hepatology, Issue 16, 2024, Page(s) 107-131, ISSN 2352-345X
Publisher: Elsevier Inc.
DOI: 10.1016/j.jcmgh.2023.04.004

Integration of mass cytometry and mass spectrometry imaging for spatially resolved single-cell metabolic profiling

Author(s): Joana B. Nunes, Marieke E. Ijsselsteijn, Tamim Abdelaal, Rick Ursem, Manon van der Ploeg, Martin Giera, Bart Everts, Ahmed Mahfouz, Bram Heijs, Noel F. C. C. de Miranda
Published in: Nature Methods, Issue 21, 2024, Page(s) 1796-1800, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1038/s41592-024-02392-6

CD103 and CD39 coexpression identifies neoantigen-specific cytotoxic T cells in colorectal cancers with low mutation burden

Author(s): Jitske van den Bulk, Manon van der Ploeg, Marieke E Ijsselsteijn, Dina Ruano, Ruud van der Breggen, Rebekka Duhen, Koen C M J Peeters, Arantza Fariña-Sarasqueta, Els M E Verdegaal, Sjoerd H van der Burg, Thomas Duhen, Noel F C C de Miranda
Published in: Journal for ImmunoTherapy of Cancer, Issue 11, 2024, Page(s) e005887, ISSN 2051-1426
Publisher: SITC
DOI: 10.1136/jitc-2022-005887

Transcriptomic and immunophenotypic profiling reveals molecular and immunological hallmarks of colorectal cancer tumourigenesis

Author(s): Jessica Roelands; Manon van der Ploeg; Marieke E Ijsselsteijn; Hao Dang; Jurjen J Boonstra; James C H Hardwick; Lukas J A C Hawinkels; Hans Morreau; Noel F C C de Miranda
Published in: Gut, Issue 1, 2022, ISSN 1468-3288
Publisher: BMJ
DOI: 10.1136/gutjnl-2022-327608

Local and systemic immune profiles of human pancreatic ductal adenocarcinoma revealed by single-cell mass cytometry

Author(s): Brouwer TP, de Vries NL, Abdelaal T, Krog RT, Li Z, Ruano D, Fariña A, Lelieveldt BPF, Morreau H, Bonsing BA, Vahrmeijer AL, Koning F, de Miranda NFCC
Published in: J Immunother Cancer, 2022, ISSN 2051-1426
Publisher: BMJ
DOI: 10.1136/jitc-2022-004638

Enabling next-generation engineered TCR-T therapies based on high-throughput TCR discovery from diagnostic tumor biopsies

Author(s): Thomas Kuilman, Deborah S. Schrikkema, Jules Gadiot, Raquel Gomez-Eerland, Laura Bies, Julia Walker, Robbert M. Spaapen, Hanna Kok, Demi Houg, Milena Viyacheva, Yvonne B. Claassen, Manuel Saornil, Oscar Krijgsman, Bas Stringer, Huiwen Ding, Anou Geleijnse, Anne C. Meinema, Bianca Weissbrich, Melissa Lancee, Carmen G. Engele, Marianna Sabatino, Pei-Ling Chen, Kenneth Y. Tsai, James J. Mulé, Vernon
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-55420-6

Neoantigen Targetability in Progressive Advanced Melanoma

Author(s): Jitske van den Bulk, Els M.E. Verdegaal, Manon van der Ploeg, Marten Visser, Joana B. Nunes, Arnoud H. de Ru, Rayman T.N. Tjokrodirijo, Marieke E. Ijsselsteijn, Natasja I. Janssen, Ruud van der Breggen, Linda de Bruin, Pita de Kok, George M.C. Janssen, Dina Ruano, Ellen H.W. Kapiteijn, Peter A. van Veelen, Noel F.C.C. de Miranda, Sjoerd H. van der Burg
Published in: Clinical Cancer Research, Issue 29, 2023, Page(s) 4278-4288, ISSN 1078-0432
Publisher: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-23-1106

Tumor-specific T cells support chemokine-driven spatial organization of intratumoral immune microaggregates needed for long survival

Author(s): Ziena Abdulrahman; Saskia J Santegoets; Gregor Sturm; Pornpimol Charoentong; Marieke E Ijsselsteijn; Antonios Somarakis; Thomas Höllt; Francesca Finotello; Zlatko Trajanoski; Sylvia L van Egmond; Dana A M Mustafa; Marij J P Welters; Noel F C C de Miranda; Sjoerd H van der Burg
Published in: J Immunother Cancer, Issue 2, 2022, ISSN 1756-1833
Publisher: BMJ
DOI: 10.1136/jitc-2021-004346

Enhanced immune responses are accompanied by increased MAGEA expression in osteosarcoma metastases

Author(s): Debora M Meijer, Siddh van Oost, Jessica P Roelands, Dina Ruano, I H Briaire-de Bruijn, B E van den Akker, A B Kruisselbrink, P M Wijers-Koster, Manon van der Ploeg, Marieke Ijsselsteijn, S W Lam, Arnoud H de Ru, R T N Tjokrodirijo, M A J van de Sande, Hans Gelderblom, Peter A Van Veelen, M L Kuijjer, Noel de Miranda, Judith V M G Bovee
Published in: BMJ Oncology, Issue 3, 2024, Page(s) e000472, ISSN 2752-7948
Publisher: BMJ Oncology
DOI: 10.1136/bmjonc-2024-000472

Autologous dendritic cells pulsed with allogeneic tumour cell lysate induce tumour-reactive T-cell responses in patients with pancreatic cancer: A phase I study

Author(s): S.P. Lau, L. Klaase, M. Vink, J. Dumas, K. Bezemer, A. van Krimpen, R. van der Breggen, L.V. Wismans, M. Doukas, W. de Koning, A.P. Stubbs, D.A.M. Mustafa, H. Vroman, R. Stadhouders, J.B. Nunes, C. Stingl, N.F.C.C. de Miranda, T.M. Luider, S.H. van der Burg, J.G. Aerts, C.H.J. van Eijck
Published in: European Journal of Cancer, Issue 169, 2022, Page(s) 20-31, ISSN 0959-8049
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.ejca.2022.03.015

Immunotherapy for pancreatic cancer: chasing the light at the end of the tunnel

Author(s): Thomas P. Brouwer, Alexander L. Vahrmeijer, Noel F. C. C. de Miranda
Published in: Cellular Oncology, Issue 44/2, 2021, Page(s) 261-278, ISSN 2211-3428
Publisher: Springer Verlag
DOI: 10.1007/s13402-021-00587-z

Fibroblasts in Orchestrating Colorectal Tumorigenesis and Progression

Author(s): Subinuer Abudukelimu, Noel F.C.C. de Miranda, Lukas J.A.C. Hawinkels
Published in: Cellular and Molecular Gastroenterology and Hepatology, Issue 17, 2024, Page(s) 821-826, ISSN 2352-345X
Publisher: Elsevier Inc.
DOI: 10.1016/j.jcmgh.2024.01.013

Discordant prognosis of mismatch repair deficiency in colorectal and endometrial cancer reflects variation in antitumour immune response and immune escape

Author(s): Mark A Glaire, Neil AJ Ryan, Marieke E Ijsselsteijn, Katarzyna Kedzierska, Sofia Obolenski, Reem Ali, Emma J Crosbie, Tjalling Bosse, Noel FCC de Miranda, David N Church
Published in: The Journal of Pathology, Issue 257, 2023, Page(s) 340-351, ISSN 0022-3417
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/path.5894

Linking Immunity with Genomics in Sarcomas: Is Genomic Complexity an Immunogenic Trigger?

Author(s): Siddh van Oost, Debora M. Meijer, Marieke L. Kuijjer, Judith V. M. G. Bovée, and Noel F. C. C. de Miranda
Published in: Biomedicines, 2021, ISSN 2078-2489
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biomedicines9081048

A Paradoxical Role for Regulatory T Cells in the Tumor Microenvironment of Pancreatic Cancer

Author(s): Thomas Brouwer, Marieke Ijsselsteijn, Jan Oosting, Dina Ruano, Manon van der Ploeg, Frederike Dijk, Bert Bonsing, Arantza Fariña, Hans Morreau, Alexander Vahrmeijer, Noel de Miranda
Published in: Cancers, Issue 14, 2025, Page(s) 3862, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14163862

γδ T cells are effectors of immunotherapy in cancers with HLA class I defects

Author(s): Natasja L. de Vries, Joris van de Haar, Vivien Veninga, Myriam Chalabi, Marieke E. Ijsselsteijn, Manon van der Ploeg, Jitske van den Bulk, Dina Ruano, Jose G. van den Berg, John B. Haanen, Laurien J. Zeverijn, Birgit S. Geurts, Gijs F. de Wit, Thomas W. Battaglia, Hans Gelderblom, Henk M. W. Verheul, Ton N. Schumacher, Lodewyk F. A. Wessels, Frits Koning, Noel F. C. C. de Miranda, Emile E. Voest
Published in: Nature, Issue 613, 2023, Page(s) 743-750, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-05593-1

Unraveling the Complexity of the Cancer Microenvironment With Multidimensional Genomic and Cytometric Technologies

Author(s): Natasja L. de Vries, Ahmed Mahfouz, Frits Koning, Noel F. C. C. de Miranda
Published in: Frontiers in Oncology, Issue 10, 2020, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2020.01254

Therapeutic targeting of TGF-β in cancer: hacking a master switch of immune suppression

Author(s): Jitske van den Bulk, Noel F.C.C. de Miranda, Peter ten Dijke
Published in: Clinical Science, Issue 135/1, 2021, Page(s) 35-52, ISSN 0143-5221
Publisher: Portland Press, Ltd.
DOI: 10.1042/cs20201236

Advancing multiplexed imaging for enhanced tissue complexity analysis

Author(s): Marieke E. Ijsselsteijn, Noel F. C. C. de Miranda
Published in: Nature Methods, Issue 20, 2023, Page(s) 1280-1281, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1038/s41592-023-01935-7