CORDIS - Risultati della ricerca dell’UE
CORDIS

RAtional design of canceR ImmunoTherapY: one size does not fit all

Risultati finali

Data Management Plan

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Pubblicazioni

Visual cohort comparison for spatial single-cell omics-data

Autori: Antonios Somarakis, Marieke E. Ijsselsteijn, Sietse J. Luk, Boyd Kenkhuis, Noel F.C.C. de Miranda, Boudewijn P.F. Lelieveldt, Thomas Hollt
Pubblicato in: IEEE Transactions on Visualization and Computer Graphics, Numero 27/2, 2021, Pagina/e 733-743, ISSN 1077-2626
Editore: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tvcg.2020.3030336

Immune-based biomarker accurately predicts response to imiquimod immunotherapy in cervical high-grade squamous intraepithelial lesions

Autori: Ziena Abdulrahman; Natasja Hendriks; Arnold J Kruse; Antonios Somarakis; Anna J M van de Sande; Heleen J van Beekhuizen; Jurgen M J Piek; Noel F C C de Miranda; Loes F S Kooreman; Brigitte F M Slangen; Sjoerd H van der Burg; Peggy J de Vos van Steenwijk; Edith M G van Esch
Pubblicato in: Journal for ImmunoTherapy of Cancer, 10(11):e005288. BioMed Central Ltd., Numero 2, 2022, ISSN 2051-1426
Editore: BMJ
DOI: 10.1136/jitc-2022-005288

Semi‐automated background removal limits data loss and normalizes imaging mass cytometry data

Autori: Marieke E. Ijsselsteijn, Antonios Somarakis, Boudewijn P. F. Lelieveldt, Thomas Höllt, Noel F. C. C. Miranda
Pubblicato in: Cytometry Part A, 2021, ISSN 1552-4922
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/cyto.a.24480

Transcriptomic and immunophenotypic profiling reveals molecular and immunological hallmarks of colorectal cancer tumourigenesis

Autori: Jessica Roelands; Manon van der Ploeg; Marieke E Ijsselsteijn; Hao Dang; Jurjen J Boonstra; James C H Hardwick; Lukas J A C Hawinkels; Hans Morreau; Noel F C C de Miranda
Pubblicato in: Gut, Numero 1, 2022, ISSN 1468-3288
Editore: BMJ
DOI: 10.1136/gutjnl-2022-327608

Local and systemic immune profiles of human pancreatic ductal adenocarcinoma revealed by single-cell mass cytometry

Autori: Brouwer TP, de Vries NL, Abdelaal T, Krog RT, Li Z, Ruano D, Fariña A, Lelieveldt BPF, Morreau H, Bonsing BA, Vahrmeijer AL, Koning F, de Miranda NFCC
Pubblicato in: J Immunother Cancer, 2022, ISSN 2051-1426
Editore: BMJ
DOI: 10.1136/jitc-2022-004638

Tumor-specific T cells support chemokine-driven spatial organization of intratumoral immune microaggregates needed for long survival

Autori: Ziena Abdulrahman; Saskia J Santegoets; Gregor Sturm; Pornpimol Charoentong; Marieke E Ijsselsteijn; Antonios Somarakis; Thomas Höllt; Francesca Finotello; Zlatko Trajanoski; Sylvia L van Egmond; Dana A M Mustafa; Marij J P Welters; Noel F C C de Miranda; Sjoerd H van der Burg
Pubblicato in: J Immunother Cancer, Numero 2, 2022, ISSN 1756-1833
Editore: BMJ
DOI: 10.1136/jitc-2021-004346

Immunophenotype of Gastric Tumors Unveils a Pleiotropic Role of Regulatory T Cells in Tumor Development

Autori: Sara Rocha; Afonso P Basto; Marieke E. Ijsselsteijn; Sara Pinto Teles; Maria M. Azevedo; Gilza Gonçalves; Irene Gullo; Gabriela M. Almeida; Joaquín J Maqueda; Marta I. Oliveira; Fátima Carneiro; João T. Barata; Luis Graca; Noel F C C de Miranda; Joana Carvalho; Carla Oliveira
Pubblicato in: Cancers, Numero 4, 2021, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)

Immunotherapy for pancreatic cancer: chasing the light at the end of the tunnel

Autori: Thomas P. Brouwer, Alexander L. Vahrmeijer, Noel F. C. C. de Miranda
Pubblicato in: Cellular Oncology, Numero 44/2, 2021, Pagina/e 261-278, ISSN 2211-3428
Editore: Springer Verlag
DOI: 10.1007/s13402-021-00587-z

Revising the Role of Integrin Subunit β4 Expression in Colon Cancer Progression and Survival

Autori: Eva Rademaker; Esther Bastiaannet; Jan Oosting; Neeltje G. Dekker-Ensink; Peter J. K. Kuppen; Noel F. C. C. de Miranda; Gerrit J. Liefers
Pubblicato in: Journal of Gastrointestinal Cancer, 2022, ISSN 1941-6636
Editore: Springer
DOI: 10.1007/s12029-021-00787-8

Linking Immunity with Genomics in Sarcomas: Is Genomic Complexity an Immunogenic Trigger?

Autori: Siddh van Oost, Debora M. Meijer, Marieke L. Kuijjer, Judith V. M. G. Bovée, and Noel F. C. C. de Miranda
Pubblicato in: Biomedicines, 2021, ISSN 2078-2489
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biomedicines9081048

Unraveling the Complexity of the Cancer Microenvironment With Multidimensional Genomic and Cytometric Technologies

Autori: Natasja L. de Vries, Ahmed Mahfouz, Frits Koning, Noel F. C. C. de Miranda
Pubblicato in: Frontiers in Oncology, Numero 10, 2020, ISSN 2234-943X
Editore: Frontiers Media S. A.
DOI: 10.3389/fonc.2020.01254

Therapeutic targeting of TGF-β in cancer: hacking a master switch of immune suppression

Autori: Jitske van den Bulk, Noel F.C.C. de Miranda, Peter ten Dijke
Pubblicato in: Clinical Science, Numero 135/1, 2021, Pagina/e 35-52, ISSN 0143-5221
Editore: Portland Press, Ltd.
DOI: 10.1042/cs20201236

Discordant prognosis of mismatch repair deficiency in colorectal and endometrial cancer reflects variation in antitumour immune response and immune escape

Autori: Mark A Glaire; Neil AJ Ryan; Marieke E Ijsselsteijn; Katarzyna Kedzierska; Sofia Obolenski; Reem Ali; Emma J Crosbie; Tjalling Bosse; Noel FCC Miranda; David N Church
Pubblicato in: Journal of Pathology, Numero 2, 2022, ISSN 1096-9896
Editore: Pathological Society of Great Britain and Ireland
DOI: 10.1002/path.5894

Targeting pancreatic cancer by TAK-981: a SUMOylation inhibitor that activates the immune system and blocks cancer cell cycle progression in a preclinical model

Autori: Sumit Kumar, Mark J A Schoonderwoerd, Jessie S Kroonen, Ilona J de Graaf, Marjolein Sluijter, Dina Ruano, Román González-Prieto, Matty Verlaan-de Vries, Jasper Rip, Ramon Arens, Noel F C C de Miranda, Lukas J A C Hawinkels, Thorbald van Hall, Alfred C O Vertegaal
Pubblicato in: Gut, 2022, ISSN 1752-069X
Editore: BMJ
DOI: 10.1136/gutjnl-2021-324834

γδ T cells are effectors of immune checkpoint blockade in mismatch repair-deficient colon cancers with antigen presentation defects

Autori: de Vries NL, van de Haar J, Veninga V, Chalabi M, Ijsselsteijn ME, van der Ploeg M, van den Bulk J, Ruano D, Haanen JB, Schumacher TN, Wessels LFA, Koning F, de Miranda NF, Voest E
Pubblicato in: bioRxiv, 2021
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2021.10.14.464229

Revisiting colorectal cancer tumorigenesis with spatially-resolved gene expression profiling

Autori: Roelands J, van der Ploeg M, Dang H, Boonstra JJ, Hardwick JCH, Hawinkels LJAC, Morreau H, de Miranda NF
Pubblicato in: bioRxiv, 2021
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2021.09.30.462502

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