RAtional design of canceR ImmunoTherapY: one size does not fit all

Informazioni relative al progetto

RARITY

ID dell’accordo di sovvenzione: 852832

DOI

10.3030/852832

Progetto chiuso

Data della firma CE 27 Novembre 2019

Data di avvio 1 Dicembre 2019

Data di completamento 30 Novembre 2024

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 499 795,00

Contributo UE

€ 1 499 795,00

Coordinato da

ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Open Research Data Pilot (1)

Data Management Plan

The participant will submit a plan describing how to deal with the research data generated in the current project

Pubblicazioni

Peer reviewed articles (22)

Visual cohort comparison for spatial single-cell omics-data

Autori: Antonios Somarakis, Marieke E. Ijsselsteijn, Sietse J. Luk, Boyd Kenkhuis, Noel F.C.C. de Miranda, Boudewijn P.F. Lelieveldt, Thomas Hollt
Pubblicato in: IEEE Transactions on Visualization and Computer Graphics, Numero 27/2, 2021, Pagina/e 733-743, ISSN 1077-2626
Editore: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tvcg.2020.3030336

Semi‐automated background removal limits data loss and normalizes imaging mass cytometry data

Autori: Marieke E. Ijsselsteijn, Antonios Somarakis, Boudewijn P. F. Lelieveldt, Thomas Höllt, Noel F. C. C. Miranda
Pubblicato in: Cytometry Part A, 2021, ISSN 1552-4922
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/cyto.a.24480

PENGUIN: A rapid and efficient image preprocessing tool for multiplexed spatial proteomics

Autori: A.M. Sequeira, M.E. Ijsselsteijn, M. Rocha, Noel F.C.C. de Miranda
Pubblicato in: Computational and Structural Biotechnology Journal, Numero 23, 2025, Pagina/e 3920-3928, ISSN 2001-0370
Editore: Elsevier BV
DOI: 10.1016/j.csbj.2024.10.048

Cancer-Associated Fibroblasts Are Key Determinants of Cancer Cell Invasion in the Earliest Stage of Colorectal Cancer

Autori: Hao Dang, Tom J. Harryvan, Chen-Yi Liao, Erik H.J. Danen, Vienna N.L.N. Spalburg, Szymon M. Kielbasa, Hailiang Mei, Jelle J. Goeman, Eveline S. de Jonge-Muller, Stefanus G.T. Janson, Johan J. van der Reijden, Stijn Crobach, James C.H. Hardwick, Jurjen J. Boonstra, Noel F.C.C. de Miranda, Lukas J.A.C. Hawinkels
Pubblicato in: Cellular and Molecular Gastroenterology and Hepatology, Numero 16, 2024, Pagina/e 107-131, ISSN 2352-345X
Editore: Elsevier Inc.
DOI: 10.1016/j.jcmgh.2023.04.004

Integration of mass cytometry and mass spectrometry imaging for spatially resolved single-cell metabolic profiling

Autori: Joana B. Nunes, Marieke E. Ijsselsteijn, Tamim Abdelaal, Rick Ursem, Manon van der Ploeg, Martin Giera, Bart Everts, Ahmed Mahfouz, Bram Heijs, Noel F. C. C. de Miranda
Pubblicato in: Nature Methods, Numero 21, 2024, Pagina/e 1796-1800, ISSN 1548-7091
Editore: Nature Publishing Group
DOI: 10.1038/s41592-024-02392-6

CD103 and CD39 coexpression identifies neoantigen-specific cytotoxic T cells in colorectal cancers with low mutation burden

Autori: Jitske van den Bulk, Manon van der Ploeg, Marieke E Ijsselsteijn, Dina Ruano, Ruud van der Breggen, Rebekka Duhen, Koen C M J Peeters, Arantza Fariña-Sarasqueta, Els M E Verdegaal, Sjoerd H van der Burg, Thomas Duhen, Noel F C C de Miranda
Pubblicato in: Journal for ImmunoTherapy of Cancer, Numero 11, 2024, Pagina/e e005887, ISSN 2051-1426
Editore: SITC
DOI: 10.1136/jitc-2022-005887

Transcriptomic and immunophenotypic profiling reveals molecular and immunological hallmarks of colorectal cancer tumourigenesis

Autori: Jessica Roelands; Manon van der Ploeg; Marieke E Ijsselsteijn; Hao Dang; Jurjen J Boonstra; James C H Hardwick; Lukas J A C Hawinkels; Hans Morreau; Noel F C C de Miranda
Pubblicato in: Gut, Numero 1, 2022, ISSN 1468-3288
Editore: BMJ
DOI: 10.1136/gutjnl-2022-327608

Local and systemic immune profiles of human pancreatic ductal adenocarcinoma revealed by single-cell mass cytometry

Autori: Brouwer TP, de Vries NL, Abdelaal T, Krog RT, Li Z, Ruano D, Fariña A, Lelieveldt BPF, Morreau H, Bonsing BA, Vahrmeijer AL, Koning F, de Miranda NFCC
Pubblicato in: J Immunother Cancer, 2022, ISSN 2051-1426
Editore: BMJ
DOI: 10.1136/jitc-2022-004638

Enabling next-generation engineered TCR-T therapies based on high-throughput TCR discovery from diagnostic tumor biopsies

Autori: Thomas Kuilman, Deborah S. Schrikkema, Jules Gadiot, Raquel Gomez-Eerland, Laura Bies, Julia Walker, Robbert M. Spaapen, Hanna Kok, Demi Houg, Milena Viyacheva, Yvonne B. Claassen, Manuel Saornil, Oscar Krijgsman, Bas Stringer, Huiwen Ding, Anou Geleijnse, Anne C. Meinema, Bianca Weissbrich, Melissa Lancee, Carmen G. Engele, Marianna Sabatino, Pei-Ling Chen, Kenneth Y. Tsai, James J. Mulé, Vernon
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-55420-6

Neoantigen Targetability in Progressive Advanced Melanoma

Autori: Jitske van den Bulk, Els M.E. Verdegaal, Manon van der Ploeg, Marten Visser, Joana B. Nunes, Arnoud H. de Ru, Rayman T.N. Tjokrodirijo, Marieke E. Ijsselsteijn, Natasja I. Janssen, Ruud van der Breggen, Linda de Bruin, Pita de Kok, George M.C. Janssen, Dina Ruano, Ellen H.W. Kapiteijn, Peter A. van Veelen, Noel F.C.C. de Miranda, Sjoerd H. van der Burg
Pubblicato in: Clinical Cancer Research, Numero 29, 2023, Pagina/e 4278-4288, ISSN 1078-0432
Editore: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-23-1106

Tumor-specific T cells support chemokine-driven spatial organization of intratumoral immune microaggregates needed for long survival

Autori: Ziena Abdulrahman; Saskia J Santegoets; Gregor Sturm; Pornpimol Charoentong; Marieke E Ijsselsteijn; Antonios Somarakis; Thomas Höllt; Francesca Finotello; Zlatko Trajanoski; Sylvia L van Egmond; Dana A M Mustafa; Marij J P Welters; Noel F C C de Miranda; Sjoerd H van der Burg
Pubblicato in: J Immunother Cancer, Numero 2, 2022, ISSN 1756-1833
Editore: BMJ
DOI: 10.1136/jitc-2021-004346

Enhanced immune responses are accompanied by increased MAGEA expression in osteosarcoma metastases

Autori: Debora M Meijer, Siddh van Oost, Jessica P Roelands, Dina Ruano, I H Briaire-de Bruijn, B E van den Akker, A B Kruisselbrink, P M Wijers-Koster, Manon van der Ploeg, Marieke Ijsselsteijn, S W Lam, Arnoud H de Ru, R T N Tjokrodirijo, M A J van de Sande, Hans Gelderblom, Peter A Van Veelen, M L Kuijjer, Noel de Miranda, Judith V M G Bovee
Pubblicato in: BMJ Oncology, Numero 3, 2024, Pagina/e e000472, ISSN 2752-7948
Editore: BMJ Oncology
DOI: 10.1136/bmjonc-2024-000472

Autologous dendritic cells pulsed with allogeneic tumour cell lysate induce tumour-reactive T-cell responses in patients with pancreatic cancer: A phase I study

Autori: S.P. Lau, L. Klaase, M. Vink, J. Dumas, K. Bezemer, A. van Krimpen, R. van der Breggen, L.V. Wismans, M. Doukas, W. de Koning, A.P. Stubbs, D.A.M. Mustafa, H. Vroman, R. Stadhouders, J.B. Nunes, C. Stingl, N.F.C.C. de Miranda, T.M. Luider, S.H. van der Burg, J.G. Aerts, C.H.J. van Eijck
Pubblicato in: European Journal of Cancer, Numero 169, 2022, Pagina/e 20-31, ISSN 0959-8049
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.ejca.2022.03.015

Immunotherapy for pancreatic cancer: chasing the light at the end of the tunnel

Autori: Thomas P. Brouwer, Alexander L. Vahrmeijer, Noel F. C. C. de Miranda
Pubblicato in: Cellular Oncology, Numero 44/2, 2021, Pagina/e 261-278, ISSN 2211-3428
Editore: Springer Verlag
DOI: 10.1007/s13402-021-00587-z

Fibroblasts in Orchestrating Colorectal Tumorigenesis and Progression

Autori: Subinuer Abudukelimu, Noel F.C.C. de Miranda, Lukas J.A.C. Hawinkels
Pubblicato in: Cellular and Molecular Gastroenterology and Hepatology, Numero 17, 2024, Pagina/e 821-826, ISSN 2352-345X
Editore: Elsevier Inc.
DOI: 10.1016/j.jcmgh.2024.01.013

Discordant prognosis of mismatch repair deficiency in colorectal and endometrial cancer reflects variation in antitumour immune response and immune escape

Autori: Mark A Glaire, Neil AJ Ryan, Marieke E Ijsselsteijn, Katarzyna Kedzierska, Sofia Obolenski, Reem Ali, Emma J Crosbie, Tjalling Bosse, Noel FCC de Miranda, David N Church
Pubblicato in: The Journal of Pathology, Numero 257, 2023, Pagina/e 340-351, ISSN 0022-3417
Editore: John Wiley & Sons Inc.
DOI: 10.1002/path.5894

Linking Immunity with Genomics in Sarcomas: Is Genomic Complexity an Immunogenic Trigger?

Autori: Siddh van Oost, Debora M. Meijer, Marieke L. Kuijjer, Judith V. M. G. Bovée, and Noel F. C. C. de Miranda
Pubblicato in: Biomedicines, 2021, ISSN 2078-2489
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biomedicines9081048

A Paradoxical Role for Regulatory T Cells in the Tumor Microenvironment of Pancreatic Cancer

Autori: Thomas Brouwer, Marieke Ijsselsteijn, Jan Oosting, Dina Ruano, Manon van der Ploeg, Frederike Dijk, Bert Bonsing, Arantza Fariña, Hans Morreau, Alexander Vahrmeijer, Noel de Miranda
Pubblicato in: Cancers, Numero 14, 2025, Pagina/e 3862, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14163862

γδ T cells are effectors of immunotherapy in cancers with HLA class I defects

Autori: Natasja L. de Vries, Joris van de Haar, Vivien Veninga, Myriam Chalabi, Marieke E. Ijsselsteijn, Manon van der Ploeg, Jitske van den Bulk, Dina Ruano, Jose G. van den Berg, John B. Haanen, Laurien J. Zeverijn, Birgit S. Geurts, Gijs F. de Wit, Thomas W. Battaglia, Hans Gelderblom, Henk M. W. Verheul, Ton N. Schumacher, Lodewyk F. A. Wessels, Frits Koning, Noel F. C. C. de Miranda, Emile E. Voest
Pubblicato in: Nature, Numero 613, 2023, Pagina/e 743-750, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-022-05593-1

Unraveling the Complexity of the Cancer Microenvironment With Multidimensional Genomic and Cytometric Technologies

Autori: Natasja L. de Vries, Ahmed Mahfouz, Frits Koning, Noel F. C. C. de Miranda
Pubblicato in: Frontiers in Oncology, Numero 10, 2020, ISSN 2234-943X
Editore: Frontiers Media S. A.
DOI: 10.3389/fonc.2020.01254

Therapeutic targeting of TGF-β in cancer: hacking a master switch of immune suppression

Autori: Jitske van den Bulk, Noel F.C.C. de Miranda, Peter ten Dijke
Pubblicato in: Clinical Science, Numero 135/1, 2021, Pagina/e 35-52, ISSN 0143-5221
Editore: Portland Press, Ltd.
DOI: 10.1042/cs20201236

Advancing multiplexed imaging for enhanced tissue complexity analysis

Autori: Marieke E. Ijsselsteijn, Noel F. C. C. de Miranda
Pubblicato in: Nature Methods, Numero 20, 2023, Pagina/e 1280-1281, ISSN 1548-7091
Editore: Nature Publishing Group
DOI: 10.1038/s41592-023-01935-7