RAtional design of canceR ImmunoTherapY: one size does not fit all

Livrables

The participant will submit a plan describing how to deal with the research data generated in the current project

Publications

Visual cohort comparison for spatial single-cell omics-data

Auteurs: Antonios Somarakis, Marieke E. Ijsselsteijn, Sietse J. Luk, Boyd Kenkhuis, Noel F.C.C. de Miranda, Boudewijn P.F. Lelieveldt, Thomas Hollt
Publié dans: IEEE Transactions on Visualization and Computer Graphics, Numéro 27/2, 2021, Page(s) 733-743, ISSN 1077-2626
Éditeur: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tvcg.2020.3030336

Immune-based biomarker accurately predicts response to imiquimod immunotherapy in cervical high-grade squamous intraepithelial lesions

Auteurs: Ziena Abdulrahman; Natasja Hendriks; Arnold J Kruse; Antonios Somarakis; Anna J M van de Sande; Heleen J van Beekhuizen; Jurgen M J Piek; Noel F C C de Miranda; Loes F S Kooreman; Brigitte F M Slangen; Sjoerd H van der Burg; Peggy J de Vos van Steenwijk; Edith M G van Esch
Publié dans: Journal for ImmunoTherapy of Cancer, 10(11):e005288. BioMed Central Ltd., Numéro 2, 2022, ISSN 2051-1426
Éditeur: BMJ
DOI: 10.1136/jitc-2022-005288

Semi‐automated background removal limits data loss and normalizes imaging mass cytometry data

Auteurs: Marieke E. Ijsselsteijn, Antonios Somarakis, Boudewijn P. F. Lelieveldt, Thomas Höllt, Noel F. C. C. Miranda
Publié dans: Cytometry Part A, 2021, ISSN 1552-4922
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/cyto.a.24480

Transcriptomic and immunophenotypic profiling reveals molecular and immunological hallmarks of colorectal cancer tumourigenesis

Auteurs: Jessica Roelands; Manon van der Ploeg; Marieke E Ijsselsteijn; Hao Dang; Jurjen J Boonstra; James C H Hardwick; Lukas J A C Hawinkels; Hans Morreau; Noel F C C de Miranda
Publié dans: Gut, Numéro 1, 2022, ISSN 1468-3288
Éditeur: BMJ
DOI: 10.1136/gutjnl-2022-327608

Local and systemic immune profiles of human pancreatic ductal adenocarcinoma revealed by single-cell mass cytometry

Auteurs: Brouwer TP, de Vries NL, Abdelaal T, Krog RT, Li Z, Ruano D, Fariña A, Lelieveldt BPF, Morreau H, Bonsing BA, Vahrmeijer AL, Koning F, de Miranda NFCC
Publié dans: J Immunother Cancer, 2022, ISSN 2051-1426
Éditeur: BMJ
DOI: 10.1136/jitc-2022-004638

Tumor-specific T cells support chemokine-driven spatial organization of intratumoral immune microaggregates needed for long survival

Auteurs: Ziena Abdulrahman; Saskia J Santegoets; Gregor Sturm; Pornpimol Charoentong; Marieke E Ijsselsteijn; Antonios Somarakis; Thomas Höllt; Francesca Finotello; Zlatko Trajanoski; Sylvia L van Egmond; Dana A M Mustafa; Marij J P Welters; Noel F C C de Miranda; Sjoerd H van der Burg
Publié dans: J Immunother Cancer, Numéro 2, 2022, ISSN 1756-1833
Éditeur: BMJ
DOI: 10.1136/jitc-2021-004346

Immunophenotype of Gastric Tumors Unveils a Pleiotropic Role of Regulatory T Cells in Tumor Development

Auteurs: Sara Rocha; Afonso P Basto; Marieke E. Ijsselsteijn; Sara Pinto Teles; Maria M. Azevedo; Gilza Gonçalves; Irene Gullo; Gabriela M. Almeida; Joaquín J Maqueda; Marta I. Oliveira; Fátima Carneiro; João T. Barata; Luis Graca; Noel F C C de Miranda; Joana Carvalho; Carla Oliveira
Publié dans: Cancers, Numéro 4, 2021, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)

Immunotherapy for pancreatic cancer: chasing the light at the end of the tunnel

Auteurs: Thomas P. Brouwer, Alexander L. Vahrmeijer, Noel F. C. C. de Miranda
Publié dans: Cellular Oncology, Numéro 44/2, 2021, Page(s) 261-278, ISSN 2211-3428
Éditeur: Springer Verlag
DOI: 10.1007/s13402-021-00587-z

Revising the Role of Integrin Subunit β4 Expression in Colon Cancer Progression and Survival

Auteurs: Eva Rademaker; Esther Bastiaannet; Jan Oosting; Neeltje G. Dekker-Ensink; Peter J. K. Kuppen; Noel F. C. C. de Miranda; Gerrit J. Liefers
Publié dans: Journal of Gastrointestinal Cancer, 2022, ISSN 1941-6636
Éditeur: Springer
DOI: 10.1007/s12029-021-00787-8

Linking Immunity with Genomics in Sarcomas: Is Genomic Complexity an Immunogenic Trigger?

Auteurs: Siddh van Oost, Debora M. Meijer, Marieke L. Kuijjer, Judith V. M. G. Bovée, and Noel F. C. C. de Miranda
Publié dans: Biomedicines, 2021, ISSN 2078-2489
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biomedicines9081048

Unraveling the Complexity of the Cancer Microenvironment With Multidimensional Genomic and Cytometric Technologies

Auteurs: Natasja L. de Vries, Ahmed Mahfouz, Frits Koning, Noel F. C. C. de Miranda
Publié dans: Frontiers in Oncology, Numéro 10, 2020, ISSN 2234-943X
Éditeur: Frontiers Media S. A.
DOI: 10.3389/fonc.2020.01254

Therapeutic targeting of TGF-β in cancer: hacking a master switch of immune suppression

Auteurs: Jitske van den Bulk, Noel F.C.C. de Miranda, Peter ten Dijke
Publié dans: Clinical Science, Numéro 135/1, 2021, Page(s) 35-52, ISSN 0143-5221
Éditeur: Portland Press, Ltd.
DOI: 10.1042/cs20201236

Discordant prognosis of mismatch repair deficiency in colorectal and endometrial cancer reflects variation in antitumour immune response and immune escape

Auteurs: Mark A Glaire; Neil AJ Ryan; Marieke E Ijsselsteijn; Katarzyna Kedzierska; Sofia Obolenski; Reem Ali; Emma J Crosbie; Tjalling Bosse; Noel FCC Miranda; David N Church
Publié dans: Journal of Pathology, Numéro 2, 2022, ISSN 1096-9896
Éditeur: Pathological Society of Great Britain and Ireland
DOI: 10.1002/path.5894

Targeting pancreatic cancer by TAK-981: a SUMOylation inhibitor that activates the immune system and blocks cancer cell cycle progression in a preclinical model

Auteurs: Sumit Kumar, Mark J A Schoonderwoerd, Jessie S Kroonen, Ilona J de Graaf, Marjolein Sluijter, Dina Ruano, Román González-Prieto, Matty Verlaan-de Vries, Jasper Rip, Ramon Arens, Noel F C C de Miranda, Lukas J A C Hawinkels, Thorbald van Hall, Alfred C O Vertegaal
Publié dans: Gut, 2022, ISSN 1752-069X
Éditeur: BMJ
DOI: 10.1136/gutjnl-2021-324834

γδ T cells are effectors of immune checkpoint blockade in mismatch repair-deficient colon cancers with antigen presentation defects

Auteurs: de Vries NL, van de Haar J, Veninga V, Chalabi M, Ijsselsteijn ME, van der Ploeg M, van den Bulk J, Ruano D, Haanen JB, Schumacher TN, Wessels LFA, Koning F, de Miranda NF, Voest E
Publié dans: bioRxiv, 2021
Éditeur: Cold Spring Harbor Laboratory
DOI: 10.1101/2021.10.14.464229

Revisiting colorectal cancer tumorigenesis with spatially-resolved gene expression profiling

Auteurs: Roelands J, van der Ploeg M, Dang H, Boonstra JJ, Hardwick JCH, Hawinkels LJAC, Morreau H, de Miranda NF
Publié dans: bioRxiv, 2021
Éditeur: Cold Spring Harbor Laboratory
DOI: 10.1101/2021.09.30.462502

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