CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.
Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .
Livrables
2nd iteration of the characterizing molecular mechanisms of irAEs.
1st iteration to characterize molecular mechanism leading to irAEsA data catalogue of analysed and interpreted high throughput molecular profiling datasets to reveal molecular mechanism leading to irAEs. The exact modelling methods will be based upon the type of profiling data generated in Task 4.2. and the criteria established in the analysis plans.
Same as D2.1, but for Checkpoint inhibitors
1st iteration refined hepatoxicity in vivo modelsThis will be a set of models that have been initially refined based upon the outcome of the imSAVAR workshop on Checkpoint inhibitor MoA. This will be a report that defines the refinements and describes and confirmatory work that has been done.
CPI immune safety assessment research roadmapSame as D23 but for Checkpoint inhibitors
2nd iteration in vitro & MPS modelsThis is a second iteration of D2.5 which will include further refinements and possibly new models
CAR-T & BITE immune safety assessment research roadmapA document that is based upon the outcome of the imSAVAR workshops on CAR-T/BiTE immune safety assessment. It will contain a description of the highest priority irAOPs for CAR-T/BiTE MoAs, input from different stakeholders including regulators. This document will also highlight the most important areas where further research and development is needed with specific representation of what is planned for the effort in imSAVAR
1st iteration in vivo and in vitro models IL-2 MoaThis will be a set of refined in vivo models and in vitro that have been initially refined based upon the outcome of the imSAVAR workshop on IL2 MoA This will be a report that defines the refinements and describes and confirmatory work that has been done
Dissemination materialsA websiste, overview, slides, and a dynamic set of messages for use in describing and disseminating the outputs of imSAVAR and for building the stakeholder community.
TReg-IL2 immune safety assessment research roadmapA document that is based upon the outcome of the imSAVAR workshop on TR-IL2 MoA. It will contain a description of the highest priority irAOPs for TR-IL2 MoA, and the input from different stakeholders including regulators. This document will also highlight the most important areas where further research and development is needed with specific representation of what is planned for the effort in imSAVAR
Preliminary irAOP - CAR-T & BiTE MoAsIn order to inform the attendees for the workshop and to form the basis for the assessment roadmap the preliminary irAOPs will be pathways of the most different adverse outcomes for CAR-T and BiTEs. These will be defined by the consortium members and supplemented by research and available data where possible.
Preliminary irAOP - IL2-TREGIn order to inform the attendees for the workshop and to from the basis for the assessment roadmap the preliminary irAOPs will be pathways of the most different adverse outcomes for IL2-TREG MoA. These will be define by the consortium members and supplemented by research and available data where possible.
1st iteration refined in vivo & in vitro model readouts IL-2 MoAThis will be a set of improved model readouts that have been initially refined based upon the outcome of the imSAVAR workshop on IL 2 MoA This will be a report that defines the refinements and describes and confirmatory work that has been done
3rd imSAVAR workshopSame as 13 but for IL2 Treg MoA
1st imSAVAR workshopThis workshop will be multi-stakeholder, multi-disciplinary workshop to define irAOPs specific case study for CAR-T cells and CD3-targeted bispecific antibodies. Within this workshop the gaps for where models need to be refined or new models developed.
1st iteration in vitro & MPS modelsThis will be a set of models that have been initially refined based upon the outcome of the imSAVAR workshops on the different in vitro MPSs models developed to address the gaps in the irAOPs This will be a report that defines the refinements and describes and confirmatory work that has been done
A system the process of know which types of samples are available where and support the process of accessing them.
Network of disease domain providers for providing samplesA defined network of centres and defined processes for accessing samples taking into consideration ethics and data privacy concerns. The report on this deliverable will include a description of how this network was used in during the implementation of imSAVAR
1st iteration of advanced immune cell profilingA dataset of high throughput molecular profiling datasets. The exact molecular profiling techniques will be based upon the outcomes of the workshops, the progress in model, development, and the criteria established in the analysis plans. This will have undergone initial bioinformatic processings to produce a dataset that is useful for identifying biomarkers as well as mechanistic insights from the models being refined and developed in imSAVAR.
2nd iteration of advanced immune cell profiling2nd iteration of the molecular profiling datasets.
Publications
Auteurs:
Michael Rade; Sebastian Böhlen; Vanessa Neuhaus; Dennis Löffler; Conny Blumert; Maximilian Merz; Ulrike Köhl; Susann Dehmel; Katherina Sewald; Kristin Reiche
Publié dans:
Genome Biology, 2023, ISSN 1474-760X
Éditeur:
Springer Nature
DOI:
10.1186/s13059-023-03120-7
Auteurs:
Maulana, Tengku Ibrahim; Kromidas, Elena; Wallstabe, Lars; Cipriano, Madalena; Alb, Miriam; Zaupa, Cécile; Hudecek, Michael; Fogal, Birgit; Loskill, Peter
Publié dans:
Advanced Drug Delivery Reviews, 2021, Page(s) 281-305, ISSN 0169-409X
Éditeur:
Elsevier BV
DOI:
10.1016/j.addr.2021.03.015
Auteurs:
Maria Schmidt; Susanna Avagyan; Kristin Reiche; Hans Binder; Henry Loeffler-Wirth
Publié dans:
Current Numéros in Molecular Biology, 2024, ISSN 1467-3037
Éditeur:
Caister Academic Press
DOI:
10.3390/cimb46050284
Auteurs:
Tengku Ibrahim Maulana; Claudia Teufel; Julia Roosz; Lisa Lazarevski; Francijna E. van den Hil; Lukas Scheller; Valeria Orlova; André Koch; Michael Hudecek; Miriam Alb; Peter Loskill
Publié dans:
Cell Stem Cell, Numéro Cell Press, 2024, ISSN 1934-5909
Éditeur:
Cell Press
DOI:
10.1016/j.stem.2024.04.018
Auteurs:
Luise A. Roser; Sonja Luckhardt; Nicole Ziegler; Dominique Thomas; Pia Viktoria Wagner; Georg Damm; Andrea Scheffschick; Philip Hewitt; Michael J. Parnham;Susanne Schiffmann
Publié dans:
Frontiers in Immunology, 2023, ISSN 1664-3224
Éditeur:
Frontiers Media SA
DOI:
10.3389/fimmu.2023.1275368
Auteurs:
Henry Loeffler-Wirth, Michael Rade, Arsen Arakelyan, Markus Kreuz, Markus Loeffler, Ulrike Koehl,
Kristin Reiche, and Hans Binder
Publié dans:
Frontiers in Immunology, 2022, ISSN 1664-3224
Éditeur:
Frontiers Media SA
DOI:
10.3389/fimmu.2022.994885
Auteurs:
Ziena Abdulrahman; Saskia J Santegoets; Gregor Sturm; Pornpimol Charoentong; Marieke E Ijsselsteijn; Antonios Somarakis; Thomas Höllt; Francesca Finotello; Zlatko Trajanoski; Sylvia L van Egmond; Dana A M Mustafa; Marij J P Welters; Noel F C C de Miranda; Sjoerd H van der Burg
Publié dans:
Journal for ImmunoTherapy of Cancer, 2022, ISSN 2051-1426
Éditeur:
Society for Immunotherapy of Cancer
DOI:
10.1136/jitc-2021-004346
Auteurs:
Xiang Zhou; Leo Rasche; K. Martin Kortüm; Sophia Danhof; Michael Hudecek; Hermann Einsele
Publié dans:
Frontiers in Immunology, 2020, ISSN 1664-3224
Éditeur:
Frontiers Media SA,Frontiers Media S.A.
DOI:
10.3389/fimmu.2020.620312
Auteurs:
Toralf Kirsten, Frank A. Meineke, Henry Loeffler-Wirth, Christoph Beger, Alexandr Uciteli, Sebastian Stäubert, Matthias Löbe, René Hänsel, Franziska G. Rauscher, Judith Schuster, Thomas Peschel, Heinrich Herre, Jonas Wagner, Silke Zachariae, Christoph Engel, Markus Scholz, Erhard Rahm, Hans Binder, Markus Loeffler
Publié dans:
Methods of Information in Medicine, 2022, ISSN 0026-1270
Éditeur:
Schattauer
DOI:
10.1055/a-1914-1985
Auteurs:
Zhi Zhao, Manuela Zucknick, Tero Aittokallio
Publié dans:
Bioinformatics Advances, 2022, ISSN 2635-0041
Éditeur:
Oxford University Press
DOI:
10.1093/bioadv/vbac073
Auteurs:
Charline Sommer; Jarish Cohen; Susann Dehmel; Vanessa Neuhaus; Dirk Schaudien, Armin Braun; Katherina Sewald; Michael Rosenblum
Publié dans:
European Journal of Immunology, 2024, ISSN 1521-4141
Éditeur:
Wiley-VCH GmbH
DOI:
10.1002/eji.202350580
Auteurs:
Hélène Lê; Charlotte Ponté; Jules Desforges; Guoqiang Hua; Ysia Idoux-Gillet; Véronique Lindner; Anne Olland; Pierre-Emanuel Falcoz; Cécile Zaupa; Eric Quéméneur; Jean-Marc Balloul; Nadia Jessel
Publié dans:
iScience, 2023, ISSN 2589-0042
Éditeur:
Elsevier
DOI:
10.21203/rs.3.rs-2560741/v1
Auteurs:
Charline Sommer, Sophie Jacob, Tonia Bargmann, Muhammad Shoaib, Basel Alshaikhdeeb,
Venkata P. Satagopam, Susann Dehmel, Vanessa Neuhaus, Armin Braun, Katherina Sewald
Publié dans:
Clinical Immunology, 2024, ISSN 1573-2592
Éditeur:
Springer Nature
DOI:
10.1016/j.clim.2024.110288
Auteurs:
Bettina Glatte; Kerstin Wenk; Anja Grahnert; Maik Friedrich; Maximilian Merz; Vladan Vucinic; Luise Fischer; Kristin Reiche; Miriam Alb; Michael Hudecek; Paul Franz; Stephan Fricke; Uwe Platzbecker; Ulrike Koehl; Ulrich Sack; Andreas Boldt; Sunna Hauschildt; Ronald Weiss
Publié dans:
Blood Advances, 2023, ISSN 2473-9529
Éditeur:
American Society of Hematology
DOI:
10.1182/bloodadvances.2023009714
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