Immune Safety Avatar: nonclinical mimicking of the immune system effects of immunomodulatory therapies

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Involvement of Regulatory Agencies
Summary of Patient Engagement

Summry of Patient Engagement

2nd iteration refined in vivo and in vitro model readouts IL-2 MoA

This will be the second iteration of improved model readouts that have been initially refined based upon the outcome of the imSAVAR workshop on IL-2 MoA. This will be a report that defines the refinements and describes and confirmatory work that has been done.

Preliminary irAOP - CPI Mo

Same as D2.1, but for Checkpoint inhibitors

1st iteration refined hepatoxicity in vivo models

This will be a set of models that have been initially refined based upon the outcome of the imSAVAR workshop on Checkpoint inhibitor MoA. This will be a report that defines the refinements and describes and confirmatory work that has been done.

CPI immune safety assessment research roadmap

Same as D23 but for Checkpoint inhibitors

Patient Engagement Update M60

Update of Patient Engagement M60

2nd iteration in vitro & MPS models

This is a second iteration of D2.5 which will include further refinements and possibly new models

1st iteration refined CRS in vivo models

This will be a set of models that have been initially refined based upon the outcome of the imSAVAR workshop on CAR-T/BiTE MoA. This will be a report that defines the refinements and describes and confirmatory work that has been done.

CAR-T & BITE immune safety assessment research roadmap

A document that is based upon the outcome of the imSAVAR workshops on CAR-T/BiTE immune safety assessment. It will contain a description of the highest priority irAOPs for CAR-T/BiTE MoAs, input from different stakeholders including regulators. This document will also highlight the most important areas where further research and development is needed with specific representation of what is planned for the effort in imSAVAR

1st iteration in vivo and in vitro models IL-2 Moa

This will be a set of refined in vivo models and in vitro that have been initially refined based upon the outcome of the imSAVAR workshop on IL2 MoA This will be a report that defines the refinements and describes and confirmatory work that has been done

Dissemination materials

A websiste, overview, slides, and a dynamic set of messages for use in describing and disseminating the outputs of imSAVAR and for building the stakeholder community.

TReg-IL2 immune safety assessment research roadmap

A document that is based upon the outcome of the imSAVAR workshop on TR-IL2 MoA. It will contain a description of the highest priority irAOPs for TR-IL2 MoA, and the input from different stakeholders including regulators. This document will also highlight the most important areas where further research and development is needed with specific representation of what is planned for the effort in imSAVAR

Preliminary irAOP - CAR-T & BiTE MoAs

In order to inform the attendees for the workshop and to form the basis for the assessment roadmap the preliminary irAOPs will be pathways of the most different adverse outcomes for CAR-T and BiTEs. These will be defined by the consortium members and supplemented by research and available data where possible.

Preliminary irAOP - IL2-TREG

In order to inform the attendees for the workshop and to from the basis for the assessment roadmap the preliminary irAOPs will be pathways of the most different adverse outcomes for IL2-TREG MoA. These will be define by the consortium members and supplemented by research and available data where possible.

1st iteration refined in vivo & in vitro model readouts IL-2 MoA

This will be a set of improved model readouts that have been initially refined based upon the outcome of the imSAVAR workshop on IL 2 MoA This will be a report that defines the refinements and describes and confirmatory work that has been done

3rd imSAVAR workshop

Same as 13 but for IL2 Treg MoA

1st imSAVAR workshop

This workshop will be multi-stakeholder, multi-disciplinary workshop to define irAOPs specific case study for CAR-T cells and CD3-targeted bispecific antibodies. Within this workshop the gaps for where models need to be refined or new models developed.

2nd iteration in vivo and in vitro models IL-2 Moa

This will be the second iteration of the refined in vivo and in vitro models.

1st iteration in vitro & MPS models

This will be a set of models that have been initially refined based upon the outcome of the imSAVAR workshops on the different in vitro MPSs models developed to address the gaps in the irAOPs This will be a report that defines the refinements and describes and confirmatory work that has been done

2nd iteration to characterize molecular mechanism leading to irAEs

2nd iteration of the characterizing molecular mechanisms of irAEs.

1st iteration to characterize molecular mechanism leading to irAEs

A data catalogue of analysed and interpreted high throughput molecular profiling datasets to reveal molecular mechanism leading to irAEs. The exact modelling methods will be based upon the type of profiling data generated in Task 4.2. and the criteria established in the analysis plans.

Catalogue of datasets

This will be a catalogue of the description of different datasets within imSAVAR and external to imSAVAR that are relevant. This will support the cataloguing of datasets in relation to the immune safety roadmaps from WP 1.

Distributed network biobanking system

A system the process of know which types of samples are available where and support the process of accessing them.

Network of disease domain providers for providing samples

A defined network of centres and defined processes for accessing samples taking into consideration ethics and data privacy concerns. The report on this deliverable will include a description of how this network was used in during the implementation of imSAVAR

1st iteration of advanced immune cell profiling

A dataset of high throughput molecular profiling datasets. The exact molecular profiling techniques will be based upon the outcomes of the workshops, the progress in model, development, and the criteria established in the analysis plans. This will have undergone initial bioinformatic processings to produce a dataset that is useful for identifying biomarkers as well as mechanistic insights from the models being refined and developed in imSAVAR.

2nd iteration of advanced immune cell profiling

2nd iteration of the molecular profiling datasets.

Pubblicazioni

IL-2-mediated hepatotoxicity: knowledge gap identification based on the irAOP concept

Autori: Luise A. Roser, Christina Sakellariou, Malin Lindstedt, Vanessa Neuhaus, Susann Dehmel, Charline Sommer, Martin Raasch, Thierry Flandre, Sigrid Roesener, Philip Hewitt, Michael J. Parnham, Katherina S
Pubblicato in: Journal of Immunotoxicology, Numero 21, 2024, ISSN 1547-691X
Editore: Taylor and Francis
DOI: 10.1080/1547691x.2024.2332177

The role of antidrug antibodies in ustekinumab therapy and the impact of methotrexate

Autori: Sorwe Mojtahed Poor, Marina Henke, Thomas Ulshöfer, Michaela Köhm, Frank Behrens, Harald Burkhardt, Susanne Schiffmann
Pubblicato in: Rheumatology, Numero 62, 2023, Pagina/e 3993-3999, ISSN 1462-0324
Editore: Oxford University Press
DOI: 10.1093/rheumatology/kead177

Revival of recombinant IL-2 therapy – approaches from the past until today

Autori: Luise A. Roser, Charline Sommer, Samira Ortega Iannazzo, Christina Sakellariou, Zoe Waibler, Patricia Gogesch
Pubblicato in: Journal of Immunotoxicology, Numero 21, 2024, ISSN 1547-691X
Editore: Taylor and Francis
DOI: 10.1080/1547691x.2024.2335219

Bispecific Antibodies as Bridging to BCMA CAR-T Cell Therapy for Relapsed/Refractory Multiple Myeloma

Autori: David Fandrei, Sabine Seiffert, Michael Rade, Susanne Rieprecht, Nico Gagelmann, Patrick Born, Thomas Wiemers, Heike Weidner, Markus Kreuz, Tamara Schassberger, Jannik Koßmann, Marlene Mangold, Danie
Pubblicato in: Blood Cancer Discovery, Numero 6, 2025, Pagina/e 38-54, ISSN 2643-3230
Editore: American Association for Cancer Research (AACR)
DOI: 10.1158/2643-3230.bcd-24-0118

Identifying CD19-targeted CAR-T cell immune pathways in an in vitro human immune mimetic cytokine release assay

Autori: Thuvan Dinh-Le, John Escobar, Louis Poisson, Karissa Adkins, Maria Jornet Culubret, Lukas Scheller, Jan van den Brulle, Michael Hudecek, Donald R. Drake III, Miriam Alb, Ernesto Luna
Pubblicato in: Journal of Immunotoxicology, Numero 21, 2024, ISSN 1547-691X
Editore: Taylor and Francis
DOI: 10.1080/1547691x.2024.2378729

A time-resolved meta-analysis of consensus gene expression profiles during human T-cell activation

Autori: Michael Rade; Sebastian Böhlen; Vanessa Neuhaus; Dennis Löffler; Conny Blumert; Maximilian Merz; Ulrike Köhl; Susann Dehmel; Katherina Sewald; Kristin Reiche
Pubblicato in: Genome Biology, 2023, ISSN 1474-760X
Editore: Springer Nature
DOI: 10.1186/s13059-023-03120-7

CARAMBA: a first-in-human clinical trial with SLAMF7 CAR-T cells prepared by virus-free Sleeping Beauty gene transfer to treat multiple myeloma

Autori: Sabrina Prommersberger, Michael Reiser, Julia Beckmann, Sophia Danhof, Maximilian Amberger, Patricia Quade-Lyssy, Hermann Einsele, Michael Hudecek, Halvard Bonig, Zoltán Ivics
Pubblicato in: Gene Therapy, Numero 28, 2021, Pagina/e 560-571, ISSN 0969-7128
Editore: Nature Publishing Group
DOI: 10.1038/s41434-021-00254-w

Immunocompetent cancer-on-chip models to assess immuno-oncology therapy

Autori: Maulana, Tengku Ibrahim; Kromidas, Elena; Wallstabe, Lars; Cipriano, Madalena; Alb, Miriam; Zaupa, Cécile; Hudecek, Michael; Fogal, Birgit; Loskill, Peter
Pubblicato in: Advanced Drug Delivery Reviews, 2021, Pagina/e 281-305, ISSN 0169-409X
Editore: Elsevier BV
DOI: 10.1016/j.addr.2021.03.015

Blood-perfused Vessels-on-Chips stimulated with patient plasma recapitulate endothelial activation and microthrombosis in COVID-19

Autori: Huub J. Weener, Thijs F. van Haaps, Ruben W. J. van Helden, Hugo J. Albers, Rozemarijn Haverkate, Heleen H. T. Middelkamp, Milan L. Ridderikhof, Thijs E. van Mens, Albert van den Berg, Christine L. Mu
Pubblicato in: Lab on a Chip, Numero 25, 2025, Pagina/e 1787-1800, ISSN 1473-0197
Editore: Royal Society of Chemistry
DOI: 10.1039/d4lc00848k

Accelerating CAR-T Cell Therapies with Small-Molecule Inhibitors

Autori: Katrin Mestermann, Andoni Garitano-Trojaola, Michael Hudecek
Pubblicato in: BioDrugs, Numero 39, 2025, Pagina/e 33-51, ISSN 1173-8804
Editore: Adis International Ltd.
DOI: 10.1007/s40259-024-00688-9

Patient-derived tumoroids and proteomic signatures: tools for early drug discovery

Autori: Hélène Lê, Jules Deforges, Pasquale Cutolo, Anissa Lamarque, Guoqiang Hua, Véronique Lindner, Shreyansh Jain, Jean-Marc Balloul, Nadia Benkirane-Jessel, Eric Quéméneur
Pubblicato in: Frontiers in Immunology, Numero 15, 2024, ISSN 1664-3224
Editore: frontiers
DOI: 10.3389/fimmu.2024.1379613

A Spatial Transcriptomics Browser for Discovering Gene Expression Landscapes across Microscopic Tissue Sections

Autori: Maria Schmidt; Susanna Avagyan; Kristin Reiche; Hans Binder; Henry Loeffler-Wirth
Pubblicato in: Current Numeros in Molecular Biology, 2024, ISSN 1467-3037
Editore: Caister Academic Press
DOI: 10.3390/cimb46050284

Immune cells play a critical role in cytokine- and endotoxin-mediated endothelial permeability

Autori: Patricia Gogesch, Samira Ortega Iannazzo, Nicole Rupp, Joachim Rom, Markus Kreuz, Kristin Reiche, Martina Anzaghe, Zoe Waibler, null null
Pubblicato in: PLOS One, Numero 20, 2025, Pagina/e e0329700, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0329700

Breast cancer-on-chip for patient-specific efficacy and safety testing of CAR-T cells

Autori: Tengku Ibrahim Maulana; Claudia Teufel; Julia Roosz; Lisa Lazarevski; Francijna E. van den Hil; Lukas Scheller; Valeria Orlova; André Koch; Michael Hudecek; Miriam Alb; Peter Loskill
Pubblicato in: Cell Stem Cell, Numero Cell Press, 2024, ISSN 1934-5909
Editore: Cell Press
DOI: 10.1016/j.stem.2024.04.018

Cellular Therapies for Multiple Myeloma: Engineering Hope

Autori: Sarah Vera-Cruz, Maria Jornet Culubret, Verena Konetzki, Miriam Alb, Sabrina R. Friedel, Michael Hudecek, Hermann Einsele, Sophia Danhof, Lukas Scheller
Pubblicato in: Cancers, Numero 16, 2025, Pagina/e 3867, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers16223867

Current Non-Viral-Based Strategies to Manufacture CAR-T Cells

Autori: Leon Gehrke, Vasco Dos Reis Gonçalves, Dominik Andrae, Tamas Rasko, Patrick Ho, Hermann Einsele, Michael Hudecek, Sabrina R. Friedel
Pubblicato in: International Journal of Molecular Sciences, Numero 25, 2025, Pagina/e 13685, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms252413685

Novel strategies to assess cytokine release mediated by chimeric antigen receptor T cells based on the adverse outcome pathway concept

Autori: Miriam Alb, Kristin Reiche, Michael Rade, Katherina Sewald, Peter Loskill, Madalena Cipriano, Tengku Ibrahim Maulana, Andries D. van der Meer, Huub J. Weener, Laure-Alix Clerbaux, Birgit Fogal, Nirav
Pubblicato in: Journal of Immunotoxicology, Numero 21, 2024, ISSN 1547-691X
Editore: Taylor and Francis
DOI: 10.1080/1547691x.2024.2345158

Immuno-inflammatory in vitro hepatotoxicity models to assess side effects of biologicals exemplified by aldesleukin

Autori: Luise A. Roser; Sonja Luckhardt; Nicole Ziegler; Dominique Thomas; Pia Viktoria Wagner; Georg Damm; Andrea Scheffschick; Philip Hewitt; Michael J. Parnham;Susanne Schiffmann
Pubblicato in: Frontiers in Immunology, 2023, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.3389/fimmu.2023.1275368

Immune digital twins for complex human pathologies: applications, limitations, and challenges

Autori: Anna Niarakis, Reinhard Laubenbacher, Gary An, Yaron Ilan, Jasmin Fisher, Åsmund Flobak, Kristin Reiche, María Rodríguez Martínez, Liesbet Geris, Luiz Ladeira, Lorenzo Veschini, Michael L. Blinov,
Pubblicato in: npj Systems Biology and Applications, Numero 10, 2024, ISSN 2056-7189
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s41540-024-00450-5

Tutorial on survival modeling with applications to omics data

Autori: Zhi Zhao, John Zobolas, Manuela Zucknick, Tero Aittokallio
Pubblicato in: Bioinformatics, Numero 40, 2024, ISSN 1367-4811
Editore: Oxford University Press
DOI: 10.1093/bioinformatics/btae132

Functional and spatial proteomics profiling reveals intra- and intercellular signaling crosstalk in colorectal cancer

Autori: Christina Plattner, Giorgia Lamberti, Peter Blattmann, Alexander Kirchmair, Dietmar Rieder, Zuzana Loncova, Gregor Sturm, Stefan Scheidl, Marieke Ijsselsteijn, Georgios Fotakis, Asma Noureen, Rebecca Lisandrelli, Nina Böck, Niloofar Nemati, Anne Krogsdam, Sophia Daum, Francesca Finotello, Antonios Somarakis, Alexander Schäfer, Doris Wilflingseder, Miguel Gonzalez Acera, Dietmar Öfner, Lukas A.
Pubblicato in: iScience, Numero 26, 2024, Pagina/e 108399, ISSN 2589-0042
Editore: Elsevier, Cell Press (iScience)
DOI: 10.1016/j.isci.2023.108399

Transcriptional states of CAR-T infusion relate to neurotoxicity – lessons from high-resolution single-cell SOM expression portraying

Autori: Henry Loeffler-Wirth, Michael Rade, Arsen Arakelyan, Markus Kreuz, Markus Loeffler, Ulrike Koehl, Kristin Reiche, and Hans Binder
Pubblicato in: Frontiers in Immunology, 2022, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.3389/fimmu.2022.994885

In vitro vascularized immunocompetent patient-derived model to test cancer therapies

Autori: Hélène Lê, Jules Deforges, Guoqiang Hua, Ysia Idoux-Gillet, Charlotte Ponté, Véronique Lindner, Anne Olland, Pierre-Emanuel Falcoz, Cécile Zaupa, Shreyansh Jain, Eric Quéméneur, Nadia Benkirane-Jessel, Jean-Marc Balloul
Pubblicato in: iScience, Numero 26, 2024, Pagina/e 108094, ISSN 2589-0042
Editore: Elsevier, Cell Press (iScience)
DOI: 10.1016/j.isci.2023.108094

Multiomic profiling of T cell lymphoma after therapy with anti-BCMA CAR T cells and GPRC5D-directed bispecific antibody

Autori: Till Braun, Michael Rade, Maximilian Merz, Hanna Klepzig, Florian Große, David Fandrei, Nhu-Nguyen Pham, Markus Kreuz, Christina Katharina Kuhn, Florian Kuschel, Dennis Löffler, Jörn Meinel, Eva He
Pubblicato in: Nature Medicine, Numero 31, 2025, Pagina/e 1145-1153, ISSN 1078-8956
Editore: Nature Publishing Group
DOI: 10.1038/s41591-025-03499-9

Type 2 responses determine skin rash during recombinant interleukin-2 therapy

Autori: Charline Sommer, Vanessa Neuhaus, Patricia Gogesch, Thierry Flandre, Susann Dehmel, Katherina Sewald
Pubblicato in: Journal of Immunotoxicology, Numero 21, 2024, ISSN 1547-691X
Editore: Taylor and Francis
DOI: 10.1080/1547691x.2024.2343359

Effective use of anti-CD19 chimeric antigen receptor T cells in a case of treatment-resistant granulomatosis with polyangiitis

Autori: Luisa Uhlmann, Matthias Pierer, Marco Krasselt, Georg Franke, Robert Zeidler, Osama Sabri, Timm Denecke, Ulrich Sack, Ulrike Köhl, Andreas Boldt, Dominic Borie, Ulf Wagner, Uwe Platzbecker, Vladan Vu
Pubblicato in: Annals of the Rheumatic Diseases, Numero 84, 2025, Pagina/e 1280-1283, ISSN 0003-4967
Editore: BMJ Publishing Group
DOI: 10.1016/j.ard.2025.04.029

Tumor-specific T cells support chemokine-driven spatial organization of intratumoral immune microaggregates needed for long survival

Autori: Ziena Abdulrahman; Saskia J Santegoets; Gregor Sturm; Pornpimol Charoentong; Marieke E Ijsselsteijn; Antonios Somarakis; Thomas Höllt; Francesca Finotello; Zlatko Trajanoski; Sylvia L van Egmond; Dana A M Mustafa; Marij J P Welters; Noel F C C de Miranda; Sjoerd H van der Burg
Pubblicato in: Journal for ImmunoTherapy of Cancer, 2022, ISSN 2051-1426
Editore: Society for Immunotherapy of Cancer
DOI: 10.1136/jitc-2021-004346

Using interactive platforms to encode, manage and explore immune-related adverse outcome pathways

Autori: Alexander Mazein, Muhammad Shoaib, Miriam Alb, Christina Sakellariou, Charline Sommer, Katherina Sewald, Kristin Reiche, Patricia Gogesch, Luise A. Roser, Samira Ortega Iannazzo, Sapna Sheth, Susanne
Pubblicato in: Journal of Immunotoxicology, Numero 21, 2024, ISSN 1547-691X
Editore: Taylor and Francis
DOI: 10.1080/1547691x.2024.2345154

Toxicities of Chimeric Antigen Receptor T Cell Therapy in Multiple Myeloma: An Overview of Experience From Clinical Trials, Pathophysiology, and Management Strategies.

Autori: Xiang Zhou; Leo Rasche; K. Martin Kortüm; Sophia Danhof; Michael Hudecek; Hermann Einsele
Pubblicato in: Frontiers in Immunology, 2020, ISSN 1664-3224
Editore: Frontiers Media SA,Frontiers Media S.A.
DOI: 10.3389/fimmu.2020.620312

The Leipzig Health Atlas - An open platform to present, archive and share bio-medical data, analyses and models online

Autori: Toralf Kirsten, Frank A. Meineke, Henry Loeffler-Wirth, Christoph Beger, Alexandr Uciteli, Sebastian Stäubert, Matthias Löbe, René Hänsel, Franziska G. Rauscher, Judith Schuster, Thomas Peschel, Heinrich Herre, Jonas Wagner, Silke Zachariae, Christoph Engel, Markus Scholz, Erhard Rahm, Hans Binder, Markus Loeffler
Pubblicato in: Methods of Information in Medicine, 2022, ISSN 0026-1270
Editore: Schattauer
DOI: 10.1055/a-1914-1985

Using irAOP for non-clinical safety evaluation of biotechnology-derived pharmaceuticals and ATMPs: a paradigm shift into a systematic and holistic framework

Autori: Armin Braun, Susann Dehmel
Pubblicato in: Journal of Immunotoxicology, Numero 21, 2024, ISSN 1547-691X
Editore: Taylor and Francis
DOI: 10.1080/1547691x.2024.2390920

An overview of immune safety avatar: mimicking the effects of immunomodulatory therapies on the immune system

Autori: Vanessa Neuhaus, Laure-Alix Clerbaux, Katherina Sewald
Pubblicato in: Journal of Immunotoxicology, Numero 21, 2024, ISSN 1547-691X
Editore: Taylor and Francis
DOI: 10.1080/1547691x.2024.2354213

An explorable model of an adverse outcome pathway of cytokine release syndrome related to the administration of immunomodulatory biotherapeutics and cellular therapies

Autori: Alexander Mazein, Oxana Lopata, Kristin Reiche, Katherina Sewald, Miriam Alb, Christina Sakellariou, Patricia Gogesch, Hannah Morgan, Vanessa Neuhaus, Nhu-Nguyen Pham, Charline Sommer, Ethan Perkins,
Pubblicato in: Frontiers in Immunology, Numero 16, 2025, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.3389/fimmu.2025.1601670

Evaluation of Anti-CAR Linker mAbs for CAR T Monitoring after BiTEs/bsAbs and CAR T-Cell Pretreatment

Autori: Anja Grahnert, Sabine Seiffert, Kerstin Wenk, Dominik Schmiedel, Andreas Boldt, Vladan Vucinic, Maximilian Merz, Uwe Platzbecker, Christian Klemann, Ulrike Koehl, Maik Friedrich
Pubblicato in: Biomedicines, Numero 12, 2025, Pagina/e 1641, ISSN 2227-9059
Editore: MDPI AG
DOI: 10.3390/biomedicines12081641

Fine tuning of the innate and adaptive immune responses by Interleukin-2

Autori: Christina Sakellariou, Luise A. Roser, Susanne Schiffmann, Malin Lindstedt
Pubblicato in: Journal of Immunotoxicology, Numero 21, 2024, ISSN 1547-691X
Editore: Taylor and Francis
DOI: 10.1080/1547691x.2024.2332175

Necessity for next-generation quality assessment of CAR T cell manufacturing and advancedtherapy guidance

Autori: Barbara Seliger, Kristin Reiche, Chiara Massa, Stephan Fricke, Gerno Schmiedeknecht, Friedemann Horn, Conny Blumert, Miriam Alb, Michael Hudecek, Ulrike Koehl
Pubblicato in: Cell & Gene Therapy Insights, 2020, ISSN 2059-7800
Editore: BioInsights Publishing
DOI: 10.18609/ioi.2020.019

EnrichIntersect: an R package for custom set enrichment analysis and interactive visualization of intersecting sets

Autori: Zhi Zhao, Manuela Zucknick, Tero Aittokallio
Pubblicato in: Bioinformatics Advances, 2022, ISSN 2635-0041
Editore: Oxford University Press
DOI: 10.1093/bioadv/vbac073

Next-generation T cell immunotherapies engineered with CRISPR base and prime editing: challenges and opportunities

Autori: Karl Petri, Elvira D’Ippolito, Annette Künkele, Ulrike Köhl, Dirk H. Busch, Hermann Einsele, Michael Hudecek
Pubblicato in: Nature Reviews Clinical Oncology, Numero 22, 2025, Pagina/e 902-923, ISSN 1759-4774
Editore: Nature Publishing Group
DOI: 10.1038/s41571-025-01072-4

Interleukin-2-induced skin inflammation

Autori: Charline Sommer; Jarish Cohen; Susann Dehmel; Vanessa Neuhaus; Dirk Schaudien, Armin Braun; Katherina Sewald; Michael Rosenblum
Pubblicato in: European Journal of Immunology, 2024, ISSN 1521-4141
Editore: Wiley-VCH GmbH
DOI: 10.1002/eji.202350580

Vascularized patient-derived tumoroids supplemented with immune cells to predict response towards treatment for lung cancer patients

Autori: Hélène Lê; Charlotte Ponté; Jules Desforges; Guoqiang Hua; Ysia Idoux-Gillet; Véronique Lindner; Anne Olland; Pierre-Emanuel Falcoz; Cécile Zaupa; Eric Quéméneur; Jean-Marc Balloul; Nadia Jessel
Pubblicato in: iScience, 2023, ISSN 2589-0042
Editore: Elsevier
DOI: 10.21203/rs.3.rs-2560741/v1

Bridging therapy-induced phenotypes and genetic immune dysregulation to study interleukin-2-induced immunotoxicology

Autori: Charline Sommer, Sophie Jacob, Tonia Bargmann, Muhammad Shoaib, Basel Alshaikhdeeb, Venkata P. Satagopam, Susann Dehmel, Vanessa Neuhaus, Armin Braun, Katherina Sewald
Pubblicato in: Clinical Immunology, 2024, ISSN 1573-2592
Editore: Springer Nature
DOI: 10.1016/j.clim.2024.110288

Analyzing IL-2-induced vascular leakage with an irAOP as tool

Autori: Patricia Gogesch, Samira Ortega Iannazzo, Tamara Zimmermann, Remi Villenave, Katherina Sewald, Zoe Waibler, null null
Pubblicato in: Journal of Immunotoxicology, Numero 21, 2024, ISSN 1547-691X
Editore: Taylor and Francis
DOI: 10.1080/1547691x.2024.2369123

Emerging T-cell lymphomas after CAR T-cell therapy

Autori: Till Braun, Florian Kuschel, Kristin Reiche, Maximilian Merz, Marco Herling
Pubblicato in: Leukemia, Numero 39, 2025, Pagina/e 1337-1341, ISSN 0887-6924
Editore: Nature Publishing Group
DOI: 10.1038/s41375-025-02574-x

Tissue-specific identification of multi-omics features for pan-cancer drug response prediction

Autori: Zhi Zhao, Shixiong Wang, Manuela Zucknick, Tero Aittokallio
Pubblicato in: iScience, Numero 25, 2024, Pagina/e 104767, ISSN 2589-0042
Editore: Elsevier
DOI: 10.1016/j.isci.2022.104767

Multiplexed Organ-on-Chips with integrated macro valves for automated cell culture

Autori: Bossink, Elsbeth G.B.M.; Vollertsen, Anke Ricarda; Hagen, Lieke P.; van der Meer, A.; Segerink, Loes; Odijk, Mathieu
Pubblicato in: Numero 4, 2021
Editore: µTAS 2021

Automated medium recirculation using macro valves for high flow rates in an endothelial cell culture chip

Autori: Bossink, Elsbeth G.B.M.; Vollertsen, Anke Ricarda; Segerink, Loes; van der Meer, A.; Odijk, Mathieu
Pubblicato in: Numero 13, 2021
Editore: µTAS 2021

Teclistamab impairs detection of BCMA CAR-T cells

Autori: Bettina Glatte; Kerstin Wenk; Anja Grahnert; Maik Friedrich; Maximilian Merz; Vladan Vucinic; Luise Fischer; Kristin Reiche; Miriam Alb; Michael Hudecek; Paul Franz; Stephan Fricke; Uwe Platzbecker; Ulrike Koehl; Ulrich Sack; Andreas Boldt; Sunna Hauschildt; Ronald Weiss
Pubblicato in: Blood Advances, 2023, ISSN 2473-9529
Editore: American Society of Hematology
DOI: 10.1182/bloodadvances.2023009714

Solid tumor-on-chip model for efficacy and safety assessment of CAR-T cell therapy

Autori: Tengku Ibrahim Maulana, Claudia Teufel, Madalena Cipriano, Lisa Lazarevski, Francijna E. van den Hil, Valeria Orlova, André Koch, Miriam Alb, Michael Hudecek, Peter Loskill
Pubblicato in: 2023
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.07.13.548856

Using interactive platforms to encode, manage and explore immune-related adverse outcome pathways

Autori: Alexander Mazein, Muhammad Shoaib, Miriam Alb, Christina Sakellariou, Charline Sommer, Katherina Sewald, Kristin Reiche, Patricia Gogesch, Luise A Roser, Samira Ortega Iannazzo, Sapna Sheth, Susanne Schiffmann, Zoe Waibler, Vanessa Neuhaus, Susann Dehmel, Venkata Satagopam, Reinhard Schneider, Marek Ostaszewski, Wei Gu
Pubblicato in: 2023
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.03.21.533620

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