Project description
Super-resolution ultrasound imaging of erythrocytes
The goal of the EU-funded SURE project is to develop and research a super-resolution 3D ultrasound imaging method capable of visualising capillary flow in the human body. The approach will track the motion of the individual erythrocytes for the full visualisation of anatomy, flow and perfusion. The 3D super-resolution imaging is performed without any contrast agents and is 2 600 times faster than current methods. The method will achieve an isotropic resolution of 50 micrometers in all directions, and the volumetric resolution will be 100–400 times better than current state-of-the-art 3D ultrasound imaging. The research will be concluded by the clinical trials conducted on rodents and human subjects to study the changes in perfusion for diabetes and cancer.
Objective
"The SURE project: ""Super resolution Ultrasound Real time imaging of Erythrocytes"" will develop and research a new super resolution ultrasound imaging method capable of resolving capillary flow in the human body. The approach tracks the motion of the individual red blood cells (erythrocytes) in a three-dimensional volume for a full visualization of anatomy, flow, and perfusion in a volume down to 13 cm at 20 volumes per second. The super resolution imaging is performed without using contrast agents and is thereby 2600 times faster than current methods. The method has an isotropic resolution of 50 micrometer in all directions, and the volumetric resolution is thereby 100-400 times better than current state-of-the-art 3-D ultrasound imaging. These highly ambitious goals are attained in a synergistic research effort combing four research groups. The scientific project includes breakthroughs in silicon row-column probes with 1 million elements, advanced synthetic aperture ultrafast coded imaging, deep learning for detecting and tracking of cells, pressure gradient estimation, and visualization and quantification of several hundreds of Gbytes volumetric data. The research finally leads to clinical trials conducted on rodents and humans for studying the changes in perfusion for diabetes and cancer. The SURE imaging approach can yield a paradigm shift in the scientific study, diagnoses, and treatment of cancer, diabetes, and vascular disease at the capillary level, as it enables the possibility of volumetric visualizing capillary perfusion in real-time at frame rates above 20 Hz without injection of contrast agents. Imaging is performed using ultrasound at normal diagnostic levels with no known adverse effects and can, thus, be used on a wide range of the population from newborns to the elderly for both diagnosis and repeated screening."
Fields of science (EuroSciVoc)
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CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-SyG - Synergy grant
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2019-SyG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
2800 Kongens Lyngby
Denmark
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