Description du projet
Une échographie à super-résolution des érythrocytes
L’objectif du projet SURE, financé par l’UE, consiste à mettre au point et faire des recherches sur une méthode d’échographie 3D à super-résolution capable de mettre en évidence le flux capillaire de l’organisme humain. Cette approche suivra le mouvement de chaque érythrocyte, afin d’obtenir une image complète de l’anatomie, du flux et de la perfusion. Cette technique d’imagerie 3D à super-résolution est effectuée sans aucun produit de contraste et est 2 600 fois plus rapide que les méthodes actuelles. Cette méthode atteindra une résolution isotrope de 50 micromètres dans toutes les directions, et la résolution volumétrique sera 100 à 400 fois supérieure à celle des échographies 3D de pointe d’aujourd’hui. Les recherches seront achevées par des essais cliniques menés chez des rongeurs et des sujets humains en vue d’étudier les changements liés à la perfusion dans le diabète et le cancer.
Objectif
"The SURE project: ""Super resolution Ultrasound Real time imaging of Erythrocytes"" will develop and research a new super resolution ultrasound imaging method capable of resolving capillary flow in the human body. The approach tracks the motion of the individual red blood cells (erythrocytes) in a three-dimensional volume for a full visualization of anatomy, flow, and perfusion in a volume down to 13 cm at 20 volumes per second. The super resolution imaging is performed without using contrast agents and is thereby 2600 times faster than current methods. The method has an isotropic resolution of 50 micrometer in all directions, and the volumetric resolution is thereby 100-400 times better than current state-of-the-art 3-D ultrasound imaging. These highly ambitious goals are attained in a synergistic research effort combing four research groups. The scientific project includes breakthroughs in silicon row-column probes with 1 million elements, advanced synthetic aperture ultrafast coded imaging, deep learning for detecting and tracking of cells, pressure gradient estimation, and visualization and quantification of several hundreds of Gbytes volumetric data. The research finally leads to clinical trials conducted on rodents and humans for studying the changes in perfusion for diabetes and cancer. The SURE imaging approach can yield a paradigm shift in the scientific study, diagnoses, and treatment of cancer, diabetes, and vascular disease at the capillary level, as it enables the possibility of volumetric visualizing capillary perfusion in real-time at frame rates above 20 Hz without injection of contrast agents. Imaging is performed using ultrasound at normal diagnostic levels with no known adverse effects and can, thus, be used on a wide range of the population from newborns to the elderly for both diagnosis and repeated screening."
Champ scientifique
- medical and health sciencesbasic medicineanatomy and morphology
- medical and health sciencesclinical medicineangiologyvascular diseases
- medical and health sciencesclinical medicineendocrinologydiabetes
- medical and health sciencesclinical medicineoncology
- natural sciencesphysical sciencesacousticsultrasound
Mots‑clés
Programme(s)
Thème(s)
Régime de financement
ERC-SyG - Synergy grantInstitution d’accueil
2800 Kongens Lyngby
Danemark