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Molecular origins of aneuploidies in healthy and diseased human tissues

Project description

The molecular origin of aneuploidy

Errors in chromosome segregation during cell division lead to an abnormal number of chromosomes, a condition known as aneuploidy. There is a lack of knowledge on the mechanisms underlying these mitotic errors and how they cause genomic instability. To uncover the molecular events that lead to genomic abnormalities, scientists of the EU-funded ANEUPLOIDY project will apply cell biology, molecular biology and biophysics methodologies in healthy and cancer organoids. They plan to complement the experimental strategy with a modelling approach to link the mechanisms of mitotic errors with chromosome segregation fidelity in cells. The results will shed light on how mitotic errors emerge and propagate, leading to malignant transformation.

Host institution

RUDER BOSKOVIC INSTITUTE
Net EU contribution
€ 3 833 375,00
Address
Bijenicka Cesta 54
10000 Zagreb
Croatia

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Region
Hrvatska Grad Zagreb Grad Zagreb
Activity type
Research Organisations
Non-EU contribution
€ 0,00

Beneficiaries (5)

RUDER BOSKOVIC INSTITUTE
Croatia
Net EU contribution
€ 3 833 375,00
Address
Bijenicka Cesta 54
10000 Zagreb

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Region
Hrvatska Grad Zagreb Grad Zagreb
Activity type
Research Organisations
Non-EU contribution
€ 0,00
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
Netherlands
Net EU contribution
€ 3 321 250,00
Address
Kloveniersburgwal 29 Het Trippenhuis
1011 JV Amsterdam

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Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Other
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
Net EU contribution
€ 168 000,00
Address
Heidelberglaan 100
3584 CX Utrecht

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Region
West-Nederland Utrecht Utrecht
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
United States
Net EU contribution
€ 1 177 500,00
Address
Massachusetts Avenue 77
02139 Cambridge

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
FACULTY OF SCIENCE UNIVERSITY OF ZAGREB
Croatia
Net EU contribution
€ 1 499 625,00
Address
Horvatovac 102/A
10000 Zagreb

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Region
Hrvatska Grad Zagreb Grad Zagreb
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00