Project description
The molecular origin of aneuploidy
Errors in chromosome segregation during cell division lead to an abnormal number of chromosomes, a condition known as aneuploidy. There is a lack of knowledge on the mechanisms underlying these mitotic errors and how they cause genomic instability. To uncover the molecular events that lead to genomic abnormalities, scientists of the EU-funded ANEUPLOIDY project will apply cell biology, molecular biology and biophysics methodologies in healthy and cancer organoids. They plan to complement the experimental strategy with a modelling approach to link the mechanisms of mitotic errors with chromosome segregation fidelity in cells. The results will shed light on how mitotic errors emerge and propagate, leading to malignant transformation.
Fields of science
Programme(s)
Topic(s)
Funding Scheme
ERC-SyG - Synergy grant
Host institution
10000 Zagreb
Croatia
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Beneficiaries (5)
10000 Zagreb
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1011 JV Amsterdam
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
3584 CX Utrecht
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02139 Cambridge
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10000 Zagreb
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