Molecular origins of aneuploidies in healthy and diseased human tissues

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Deep-freezing and decontamination strategy for a large autologous bone graft with presentation of the osteogenic potential of resident osteoblasts

Author(s): Marija Zekušić, Marija Skoko, Kruno Vukušić, Maja Ledinski, Marina Bujić Mihica, Dejan Blažević, Zlata A. Sošić, Mario Đura, Jelena Martinčić, Ivana Vrgoč Zimić, Ivanka Batarilo, Denis Polančec, Lucija Zenić, Snježana Ramić, Patricija Sesar, Kristina Crkvenac Gornik, Slaven Babić, Jure Pavešić, Srećko Sabalić, Iva M. Tolić, Inga Urlić, Stanka Misir Šitum, Tiha Vučemilo,
Published in: Stem Cell Research & Therapy, Issue 17, 2026, ISSN 1757-6512
Publisher: BioMed Central
DOI: 10.1186/s13287-025-04839-9

Coordinated control of both microtubule ends regulates mitotic spindle length

Author(s): Shane A. Fiorenza, Sheba Cheeran, Elena Doria, Iva M. Tolić, Patrick Meraldi, Nenad Pavin
Published in: Nature Communications, 2026, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-026-78426-8

Augmin regulates kinetochore tension and spatial arrangement of spindle microtubules by nucleating bridging fibers

Author(s): Martina Manenica; Isabella Koprivec; Valentina Štimac; Juraj Simunić; Iva M. Tolić
Published in: eLife, Issue 11, 2022, Page(s) e83287, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.1101/2020.09.10.291740

Mechanobiology of the Mitotic Spindle

Author(s): Nenad Pavin, Iva M. Tolić
Published in: Developmental Cell, Issue 56/2, 2021, Page(s) 192-201, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2020.11.003

Length-dependent poleward flux of sister kinetochore fibers promotes chromosome alignment

Author(s): Patrik Risteski, Domagoj Božan, Mihaela Jagrić, Agneza Bosilj, Nenad Pavin, Iva M. Tolić
Published in: Cell Reports, Issue 40(5), 2022, Page(s) 111169, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2022.111169

Microtubule-sliding modules based on kinesins EG5 and PRC1-dependent KIF4A drive human spindle elongation

Author(s): Kruno Vukušić, Ivana Ponjavić, Renata Buđa, Patrik Risteski, Iva M. Tolić
Published in: Developmental Cell, Issue 56/9, 2021, Page(s) 1253-1267.e10, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2021.04.005

Polar Chromosomes - Challenges of a Risky Path

Author(s): Iva Tolić; Kruno Vukušić
Published in: Cells, Issue 11(9), 2022, Page(s) 1531, ISSN 2073-4409
Publisher: MDPI Journals
DOI: 10.3390/cells11091531

Mitotic spindle: lessons from theoretical modeling

Author(s): Iva M. Tolić, Nenad Pavin
Published in: Molecular Biology of the Cell, Issue 32/3, 2021, Page(s) 218-222, ISSN 1059-1524
Publisher: American Society for Cell Biology
DOI: 10.1091/mbc.e20-05-0335

Biomechanics of chromosome alignment at the spindle midplane

Author(s): Patrik Risteski, Mihaela Jagrić, Nenad Pavin, Iva M. Tolić
Published in: Current Biology, Issue 31/10, 2021, Page(s) R574-R585, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2021.03.082

Microtubule nucleation from the fibrous corona by LIC1-pericentrin promotes chromosome congression

Author(s): Jingchao Wu; Ainhoa Larreategui-Aparicio; Maaike L.A. Lambers; Dani L. Bodor; Sjoerd J. Klaasen; Eveline Tollenaar; Marta de Ruijter-Villani; Geert J.P.L. Kops
Published in: Current Biology, Issue 33, 2023, Page(s) 912–925, ISSN 2079-7737
Publisher: Cell Press
DOI: 10.1016/j.cub.2023.01.010

Oblique circle method for measuring the curvature and twist of mitotic spindle microtubule bundles

Author(s): Arian Ivec, Monika Trupinić, Iva M. Tolić, Nenad Pavin
Published in: Biophysical Journal, Issue 120/17, 2021, Page(s) 3641-3648, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2021.07.024

Vertebrate centromeres in mitosis are functionally bipartite structures stabilized by cohesin

Author(s): Sacristan, Carlos; Samejima, Kumiko; Andrade Ruiz, Lorena; Deb, Moonmoon; Lambers, Maaike L.A.; Buckle, Adam; Brackley, Chris A.; Robertson, Daniel; Hori, Tetsuya; Webb, Shaun; Kiewisz, Robert; Bepler
Published in: Cell, Issue 187, 2024, Page(s) 1–18, ISSN 1097-4172
Publisher: Elsevier Inc.
DOI: 10.1016/j.cell.2024.04.014

Maternal Genetic Variants in Kinesin Motor Domains Prematurely Increase Egg Aneuploidy

Author(s): Leelabati Biswas, Katarzyna M. Tyc, Mansour Aboelenaain, Siqi Sun, Iva Dundovic, Kruno Vukusic, Jason Liu, Vanessa Guo, Min Xu, Richard T. Scott, Xin Tao, Iva M. Tolic, Jinchuan Xing, Karen Schindler
Published in: Obstetrical & Gynecological Survey, Issue 80, 2025, Page(s) 642-643, ISSN 0029-7828
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/01.ogx.0001169636.66823.60

CENP-E initiates chromosome congression by opposing Aurora kinases to promote end-on attachments

Author(s): Kruno Vukušić, Iva M. Tolić
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-025-64148-w

Nuclear chromosome locations dictate segregation error frequencies

Author(s): Sjoerd J. Klaasen, My Anh Truong, Richard H. van Jaarsveld, Isabella Koprivec, Valentina Štimac, Sippe G. de Vries, Patrik Risteski, Snježana Kodba, Kruno Vukušić, Kim L. de Luca, Joana F. Marques, Elianne M. Gerrits, Bjorn Bakker, Floris Foijer, Jop Kind, Iva M. Tolić, Susanne M. A. Lens & Geert J. P. L. Kops
Published in: Nature, Issue 607, 2022, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-04938-0

Mechanisms of Chromosome Positioning During Mitosis

Author(s): Ivan Sigmund, Domagoj Božan, Ivana Šarić, Nenad Pavin
Published in: PRX Life, Issue 2, 2024, ISSN 2835-8279
Publisher: American Physical Society (APS)
DOI: 10.1103/prxlife.2.043017

Plasmodium ARK2 and EB1 drive unconventional spindle dynamics, during chromosome segregation in sexual transmission stages

Author(s): Mohammad Zeeshan, Edward Rea, Steven Abel, Kruno Vukušić, Robert Markus, Declan Brady, Antonius Eze, Ravish Rashpa, Aurelia C. Balestra, Andrew R. Bottrill, Mathieu Brochet, David S. Guttery, Iva M. Tolić, Anthony A. Holder, Karine G. Le Roch, Eelco C. Tromer, Rita Tewari
Published in: Nature Communications, Issue 14, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-41395-3

Kinetochore- and chromosome-driven transition of microtubules into bundles promotes spindle assembly

Author(s): Jurica Matković; Subhadip Ghosh; Mateja Ćosić; Marin Barisic; Nenad Pavin; Iva Tolić
Published in: Nature Communications, Issue 13:7307, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-34957-4

Non-cell-autonomous mechanisms of tumor initiation and relapse by chromosomal instability

Author(s): Simona J. A. Lafirenze, Bastiaan van Gerwen, Ajit I. Quirindongo, Natasja Costermans, Aniek Janssen, Banafsheh Etemad, Pim Toonen, Marco A. D. Louro, Wilma H. M. Hoevenaar, Sameh Youssef, Alain de Bruin, Lodewijk A. A. Brosens, Nannette Jelluma, Geert J. P. L. Kops
Published in: Proceedings of the National Academy of Sciences, Issue 123, 2026, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2531095123

Kinetochore-centrosome feedback linking CENP-E and Aurora kinases controls chromosome congression

Author(s): Kruno Vukušić, Iva M. Tolić
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-025-64804-1

The chirality of the mitotic spindle provides a mechanical response to forces and depends on microtubule motors and augmin

Author(s): Monika Trupinić, Barbara Kokanović, Ivana Ponjavić, Ivan Barišić, Siniša Šegvić, Arian Ivec, Iva M. Tol
Published in: Current Biology, Issue 32, 2022, Page(s) 1–14, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2022.04.035

Naegleria’s mitotic spindles are built from unique tubulins and highlight core spindle features

Author(s): Velle, Katrina B.; Kennard, Andrew S.; Trupinić, Monika; Ivec, Arian; Swafford, Andrew J.M.; Nolton, Emily; Rice, Luke; Tolić, Iva M.; Fritz-Laylin, Lillian K.; Wadsworth, Patricia.
Published in: Current Biology, Issue 32(6), 2022, Page(s) 1247–1261, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2022.01.034

Causes and Consequences of Non-Random Segregation Errors in Mitosis and Meiosis

Author(s): Sjoerd Klaasen; Geert Kops
Published in: Cells, Issue 11, 2022, Page(s) 3564, ISSN 2073-4409
Publisher: MDPI Journals
DOI: 10.3390/cells11223564

Life-cycle-coupled evolution of mitosis in close relatives of animals

Author(s): Hiral Shah, Marine Olivetta, Chandni Bhickta, Paolo Ronchi, Monika Trupinić, Eelco C. Tromer, Iva M. Tolić, Yannick Schwab, Omaya Dudin, Gautam Dey
Published in: Nature, Issue 630, 2024, Page(s) 116-122, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-024-07430-z

A farnesyl-dependent structural role for CENP-E in expansion of the fibrous corona

Author(s): Jingchao Wu, Maximilian W.D. Raas, Paula Sobrevals Alcaraz, Harmjan R. Vos, Eelco C. Tromer, Berend Snel, Geert J.P.L. Kops
Published in: Journal of Cell Biology, Issue 223, 2023, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.202303007

Vertebrate centromere architecture: from chromatin threads to functional structures

Author(s): Lorena Andrade Ruiz, Geert J. P. L. Kops, Carlos Sacristan
Published in: Chromosoma, Issue 133, 2024, Page(s) 169-181, ISSN 0009-5915
Publisher: Springer Verlag
DOI: 10.1007/s00412-024-00823-z

Proliferative advantage of specific aneuploid cells drives evolution of tumor karyotypes

Author(s): Ivana Ban, Lucija Tomašić, Marianna Trakala, Iva M. Tolić, Nenad Pavin
Published in: Biophysical Journal, Issue 122, 2023, Page(s) 632–645, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2023.01.017

Power-law scaling of mitotic spindles with genome sizes across eukaryotes is driven by chromosome crowding

Author(s): Lovro Gudlin, Kruno Vukušić, Maja Novak, Monika Trupinić, Matko Ljulj, Iva Dundović, Ana Petelinec, Loren Petrušić, Anna Hertel, Thomas van Ravesteyn, Marianna Trakala, Geert J. P. L. Kops, Zuzana Storchová, Josip Tambača, Nenad Pavin, Iva M. Tolić
Published in: Nature Cell Biology, Issue 28, 2026, Page(s) 1996-2007, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-026-02005-8

Single-cell DNA sequencing reveals a high incidence of chromosomal abnormalities in human blastocysts

Author(s): Effrosyni A. Chavli, Sjoerd J. Klaasen, Diane Van Opstal, Joop S.E. Laven, Geert J.P.L. Kops, Esther B. Baart
Published in: Journal of Clinical Investigation, Issue 134, 2024, ISSN 1558-8238
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci174483

Polar chromosomes are rescued from missegregation by spindle elongation-driven microtubule pivoting

Author(s): Isabella Koprivec, Valentina Štimac, Mario Đura, Kruno Vukušić, Petra Mikec, Iva M. Tolić
Published in: Nature Communications, Issue 17, 2026, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-026-69830-1

Microtubule poleward flux as a target for modifying chromosome segregation errors

Author(s): Patrik Risteski, Jelena Martinčić, Mihaela Jagrić, Erna Tintor, Ana Petelinec, Iva M. Tolić
Published in: Proceedings of the National Academy of Sciences, Issue 121, 2024, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2405015121

Mitotic BLM functions are required to maintain genomic stability

Author(s): Tamara Eleanore Hamann, Angela Wieland, Farbod Mohseni, Kruno Vukušić, Andrea Tirincsi, Rene Wardenaar, Marialucrezia Losito, Iris Harmsen, Ipek Ilgin Gönenc, Bernd Wollnik, Floris Foijer, Iva M Tolić, Zuzana Storchová, Markus Räschle
Published in: Nucleic Acids Research, Issue 54, 2026, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkag199

Single-cell DNA sequencing reveals a high incidence of chromosomal abnormalities in human blastocysts

Author(s): Chavli,Effrosyni A.; Klaasen,Sjoerd J.; Van Opstal,Diane; Laven,Joop S.E.; Kops, Geert J.P.L.; Baart,Esther B.; Cancer; CMM; Hubrecht Institute with UMC
Published in: The Journal of Clinical Investigation, Issue 8, 2024, ISSN 0021-9738
Publisher: American Society for Clinical Investigation

Anaphase B: Long-standing models meet new concepts

Author(s): Kruno Vukušić, Iva M. Tolić
Published in: Seminars in Cell & Developmental Biology, Issue 117, 2021, Page(s) 127-139, ISSN 1084-9521
Publisher: Academic Press
DOI: 10.1016/j.semcdb.2021.03.023

Clonal selection of stable aneuploidies in progenitor cells drives high-prevalence tumorigenesis

Author(s): Marianna Trakala, Muskaan Aggarwal, Courtney Sniffen, Lauren Zasadil, Allison Carroll, Duanduan Ma, Xiaofeng A. Su, Darawalee Wangsa, Ashleigh Meyer, Cynthia J. Sieben, Jian Zhong, Pei-hsin Hsu, Glenn Paradis, Thomas Ried, Andrew Holland, Jan Van Deursen, Angelika Amon
Published in: Genes & Development, Issue 35/15-16, 2021, Page(s) 1079-1092, ISSN 0890-9369
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.348341.121

Optogenetic control of PRC1 reveals its role in chromosome alignment on the spindle by overlap length-dependent forces

Author(s): Mihaela Jagrić, Patrik Risteski, Jelena Martinčić, Ana Milas, Iva M Tolić
Published in: eLife, Issue 10, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.61170

An evolutionary perspective on the relationship between kinetochore size and CENP-E dependence for chromosome alignment

Author(s): Ana C. Almeida, Helder Rocha, Maximilian W. D. Raas, Hanh Witte, Ralf J. Sommer, Berend Snel, Geert J. P. L. Kops, Reto Gassmann, Helder Maiato
Published in: Journal of Cell Science, Issue 137, 2024, ISSN 0021-9533
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/jcs.263466

The TRIM69-MST2 signaling axis regulates centrosome dynamics and chromosome segregation

Author(s): Yilin Wang, Patrik Risteski, Yang Yang, Huan Chen, Gaith Droby, Andrea Walens, Deepika Jayaprakash, Melissa Troester, Laura Herring, Jonathan Chernoff, Iva M Tolić, Jessica Bowser, Cyrus Vaziri
Published in: Nucleic Acids Research, Issue 51(19), 2023, Page(s) 10568–10589, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkad766

Super-Resolution Imaging of Mitotic Spindle Microtubules Using STED Microscopy

Author(s): Isabella Koprivec, Valentina Štimac, Iva M. Tolić
Published in: Methods in Molecular Biology, The Mitotic Spindle, 2025, Page(s) 3-19
Publisher: Springer US
DOI: 10.1007/978-1-0716-4224-5_1

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