Molecular origins of aneuploidies in healthy and diseased human tissues

Project Information

ANEUPLOIDY

Grant agreement ID: 855158

DOI 10.3030/855158

EC signature date 20 March 2020

Start date 1 April 2020

End date 31 March 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 9 999 750,00

EU contribution € 9 999 750,00

Coordinated by

RUDER BOSKOVIC INSTITUTE
Croatia

Publications

Peer reviewed articles (21)

Augmin regulates kinetochore tension and spatial arrangement of spindle microtubules by nucleating bridging fibers

Author(s): Martina Manenica; Isabella Koprivec; Valentina Štimac; Juraj Simunić; Iva M. Tolić
Published in: eLife, Issue 11, 2022, Page(s) e83287, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.1101/2020.09.10.291740

Mechanobiology of the Mitotic Spindle

Author(s): Nenad Pavin, Iva M. Tolić
Published in: Developmental Cell, Issue 56/2, 2021, Page(s) 192-201, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2020.11.003

Length-dependent poleward flux of sister kinetochore fibers promotes chromosome alignment

Author(s): Patrik Risteski, Domagoj Božan, Mihaela Jagrić, Agneza Bosilj, Nenad Pavin, Iva M. Tolić
Published in: Cell Reports, Issue 40(5), 2022, Page(s) 111169, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2022.111169

Microtubule-sliding modules based on kinesins EG5 and PRC1-dependent KIF4A drive human spindle elongation

Author(s): Kruno Vukušić, Ivana Ponjavić, Renata Buđa, Patrik Risteski, Iva M. Tolić
Published in: Developmental Cell, Issue 56/9, 2021, Page(s) 1253-1267.e10, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2021.04.005

Polar Chromosomes - Challenges of a Risky Path

Author(s): Iva Tolić; Kruno Vukušić
Published in: Cells, Issue 11(9), 2022, Page(s) 1531, ISSN 2073-4409
Publisher: MDPI Journals
DOI: 10.3390/cells11091531

Mitotic spindle: lessons from theoretical modeling

Author(s): Iva M. Tolić, Nenad Pavin
Published in: Molecular Biology of the Cell, Issue 32/3, 2021, Page(s) 218-222, ISSN 1059-1524
Publisher: American Society for Cell Biology
DOI: 10.1091/mbc.e20-05-0335

Biomechanics of chromosome alignment at the spindle midplane

Author(s): Patrik Risteski, Mihaela Jagrić, Nenad Pavin, Iva M. Tolić
Published in: Current Biology, Issue 31/10, 2021, Page(s) R574-R585, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2021.03.082

Microtubule nucleation from the fibrous corona by LIC1-pericentrin promotes chromosome congression

Author(s): Jingchao Wu; Ainhoa Larreategui-Aparicio; Maaike L.A. Lambers; Dani L. Bodor; Sjoerd J. Klaasen; Eveline Tollenaar; Marta de Ruijter-Villani; Geert J.P.L. Kops
Published in: Current Biology, Issue 33, 2023, Page(s) 912–925, ISSN 2079-7737
Publisher: Cell Press
DOI: 10.1016/j.cub.2023.01.010

Oblique circle method for measuring the curvature and twist of mitotic spindle microtubule bundles

Author(s): Arian Ivec, Monika Trupinić, Iva M. Tolić, Nenad Pavin
Published in: Biophysical Journal, Issue 120/17, 2021, Page(s) 3641-3648, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2021.07.024

Vertebrate centromeres in mitosis are functionally bipartite structures stabilized by cohesin

Author(s): Sacristan, Carlos; Samejima, Kumiko; Andrade Ruiz, Lorena; Deb, Moonmoon; Lambers, Maaike L.A.; Buckle, Adam; Brackley, Chris A.; Robertson, Daniel; Hori, Tetsuya; Webb, Shaun; Kiewisz, Robert; Bepler, Tristan; van Kwawegen, Eloïse; Risteski, Patrik; Vukušić, Kruno; Tolić, Iva M.; Müller-Reichert, Thomas; Fukagawa, Tatsuo; Gilbert, Nick; Marenduzzo, Davide; Earnshaw, William C. and Kops, Geer
Published in: Cell, Issue 187, 2024, Page(s) 1–18, ISSN 1097-4172
Publisher: Elsevier Inc.
DOI: 10.1016/j.cell.2024.04.014

Nuclear chromosome locations dictate segregation error frequencies

Author(s): Sjoerd J. Klaasen, My Anh Truong, Richard H. van Jaarsveld, Isabella Koprivec, Valentina Štimac, Sippe G. de Vries, Patrik Risteski, Snježana Kodba, Kruno Vukušić, Kim L. de Luca, Joana F. Marques, Elianne M. Gerrits, Bjorn Bakker, Floris Foijer, Jop Kind, Iva M. Tolić, Susanne M. A. Lens & Geert J. P. L. Kops
Published in: Nature, Issue 607, 2022, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-04938-0

Kinetochore- and chromosome-driven transition of microtubules into bundles promotes spindle assembly

Author(s): Jurica Matković; Subhadip Ghosh; Mateja Ćosić; Marin Barisic; Nenad Pavin; Iva Tolić
Published in: Nature Communications, Issue 13:7307, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1101/2022.02.25.481924

The chirality of the mitotic spindle provides a mechanical response to forces and depends on microtubule motors and augmin

Author(s): Monika Trupinić, Barbara Kokanović, Ivana Ponjavić, Ivan Barišić, Siniša Šegvić, Arian Ivec, Iva M. Tol
Published in: Current Biology, Issue 32, 2022, Page(s) 1–14, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2022.04.035

Plasmodium ARK2 and EB1 drive unconventional spindle dynamics, during chromosome segregation in sexual transmission stages

Author(s): Mohammad Zeeshan, Edward Rea, Steven Abel, Kruno Vukušić, Robert Markus, Declan Brady, Antonius Eze, Ravish Rashpa, Aurelia C. Balestra, Andrew R. Bottrill, Mathieu Brochet, David S. Guttery, Iva M. Tolić, Anthony A. Holder, Karine G. Le Roch, Eelco C. Tromer & Rita Tewari
Published in: Nature Communications, Issue 14, 2023, Page(s) 5652, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-41395-3

Naegleria’s mitotic spindles are built from unique tubulins and highlight core spindle features

Author(s): Velle, Katrina B.; Kennard, Andrew S.; Trupinić, Monika; Ivec, Arian; Swafford, Andrew J.M.; Nolton, Emily; Rice, Luke; Tolić, Iva M.; Fritz-Laylin, Lillian K.; Wadsworth, Patricia.
Published in: Current Biology, 2022, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2022.01.034

Causes and Consequences of Non-Random Segregation Errors in Mitosis and Meiosis

Author(s): Sjoerd Klaasen; Geert Kops
Published in: Cells, Issue 11, 2022, Page(s) 3564, ISSN 2073-4409
Publisher: MDPI Journals
DOI: 10.3390/cells11223564

Proliferative advantage of specific aneuploid cells drives evolution of tumor karyotypes

Author(s): Ivana Ban, Lucija Tomašić, Marianna Trakala, Iva M. Tolić, Nenad Pavin
Published in: Biophysical Journal, Issue 122, 2023, Page(s) 632–645, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2023.01.017

Anaphase B: Long-standing models meet new concepts

Author(s): Kruno Vukušić, Iva M. Tolić
Published in: Seminars in Cell & Developmental Biology, Issue 117, 2021, Page(s) 127-139, ISSN 1084-9521
Publisher: Academic Press
DOI: 10.1016/j.semcdb.2021.03.023

Clonal selection of stable aneuploidies in progenitor cells drives high-prevalence tumorigenesis

Author(s): Marianna Trakala, Muskaan Aggarwal, Courtney Sniffen, Lauren Zasadil, Allison Carroll, Duanduan Ma, Xiaofeng A. Su, Darawalee Wangsa, Ashleigh Meyer, Cynthia J. Sieben, Jian Zhong, Pei-hsin Hsu, Glenn Paradis, Thomas Ried, Andrew Holland, Jan Van Deursen, Angelika Amon
Published in: Genes & Development, Issue 35/15-16, 2021, Page(s) 1079-1092, ISSN 0890-9369
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.348341.121

Optogenetic control of PRC1 reveals its role in chromosome alignment on the spindle by overlap length-dependent forces

Author(s): Mihaela Jagrić, Patrik Risteski, Jelena Martinčić, Ana Milas, Iva M Tolić
Published in: eLife, Issue 10, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.61170

The TRIM69-MST2 signaling axis regulates centrosome dynamics and chromosome segregation

Author(s): Yilin Wang, Patrik Risteski, Yang Yang, Huan Chen, Gaith Droby, Andrea Walens, Deepika Jayaprakash, Melissa Troester, Laura Herring, Jonathan Chernoff, Iva M Tolić, Jessica Bowser, Cyrus Vaziri
Published in: Nucleic Acids Research, Issue 51(19), 2023, Page(s) 10568–10589, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkad766