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Molecular origins of aneuploidies in healthy and diseased human tissues

Publications

Augmin regulates kinetochore tension and spatial arrangement of spindle microtubules by nucleating bridging fibers

Auteurs: Martina Manenica; Isabella Koprivec; Valentina Štimac; Juraj Simunić; Iva M. Tolić
Publié dans: eLife, Issue 11, 2022, Page(s) e83287, ISSN 2050-084X
Éditeur: eLife Sciences Publications
DOI: 10.1101/2020.09.10.291740

Mechanobiology of the Mitotic Spindle

Auteurs: Nenad Pavin, Iva M. Tolić
Publié dans: Developmental Cell, Issue 56/2, 2021, Page(s) 192-201, ISSN 1534-5807
Éditeur: Cell Press
DOI: 10.1016/j.devcel.2020.11.003

Length-dependent poleward flux of sister kinetochore fibers promotes chromosome alignment

Auteurs: Patrik Risteski, Domagoj Božan, Mihaela Jagrić, Agneza Bosilj, Nenad Pavin, Iva M. Tolić
Publié dans: Cell Reports, Issue 40(5), 2022, Page(s) 111169, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2022.111169

Microtubule-sliding modules based on kinesins EG5 and PRC1-dependent KIF4A drive human spindle elongation

Auteurs: Kruno Vukušić, Ivana Ponjavić, Renata Buđa, Patrik Risteski, Iva M. Tolić
Publié dans: Developmental Cell, Issue 56/9, 2021, Page(s) 1253-1267.e10, ISSN 1534-5807
Éditeur: Cell Press
DOI: 10.1016/j.devcel.2021.04.005

Polar Chromosomes - Challenges of a Risky Path

Auteurs: Iva Tolić; Kruno Vukušić
Publié dans: Cells, Issue 11(9), 2022, Page(s) 1531, ISSN 2073-4409
Éditeur: MDPI Journals
DOI: 10.3390/cells11091531

Mitotic spindle: lessons from theoretical modeling

Auteurs: Iva M. Tolić, Nenad Pavin
Publié dans: Molecular Biology of the Cell, Issue 32/3, 2021, Page(s) 218-222, ISSN 1059-1524
Éditeur: American Society for Cell Biology
DOI: 10.1091/mbc.e20-05-0335

Biomechanics of chromosome alignment at the spindle midplane

Auteurs: Patrik Risteski, Mihaela Jagrić, Nenad Pavin, Iva M. Tolić
Publié dans: Current Biology, Issue 31/10, 2021, Page(s) R574-R585, ISSN 0960-9822
Éditeur: Cell Press
DOI: 10.1016/j.cub.2021.03.082

Microtubule nucleation from the fibrous corona by LIC1-pericentrin promotes chromosome congression

Auteurs: Jingchao Wu; Ainhoa Larreategui-Aparicio; Maaike L.A. Lambers; Dani L. Bodor; Sjoerd J. Klaasen; Eveline Tollenaar; Marta de Ruijter-Villani; Geert J.P.L. Kops
Publié dans: Current Biology, Issue 33, 2023, Page(s) 912–925, ISSN 2079-7737
Éditeur: Cell Press
DOI: 10.1016/j.cub.2023.01.010

Oblique circle method for measuring the curvature and twist of mitotic spindle microtubule bundles

Auteurs: Arian Ivec, Monika Trupinić, Iva M. Tolić, Nenad Pavin
Publié dans: Biophysical Journal, Issue 120/17, 2021, Page(s) 3641-3648, ISSN 0006-3495
Éditeur: Biophysical Society
DOI: 10.1016/j.bpj.2021.07.024

Nuclear chromosome locations dictate segregation error frequencies

Auteurs: Sjoerd J. Klaasen, My Anh Truong, Richard H. van Jaarsveld, Isabella Koprivec, Valentina Štimac, Sippe G. de Vries, Patrik Risteski, Snježana Kodba, Kruno Vukušić, Kim L. de Luca, Joana F. Marques, Elianne M. Gerrits, Bjorn Bakker, Floris Foijer, Jop Kind, Iva M. Tolić, Susanne M. A. Lens & Geert J. P. L. Kops
Publié dans: Nature, Issue 607, 2022, ISSN 0028-0836
Éditeur: Nature Publishing Group
DOI: 10.1038/s41586-022-04938-0

Kinetochore- and chromosome-driven transition of microtubules into bundles promotes spindle assembly

Auteurs: Jurica Matković; Subhadip Ghosh; Mateja Ćosić; Marin Barisic; Nenad Pavin; Iva Tolić
Publié dans: Nature Communications, Issue 13:7307, 2022, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1101/2022.02.25.481924

The chirality of the mitotic spindle provides a mechanical response to forces and depends on microtubule motors and augmin

Auteurs: Monika Trupinić, Barbara Kokanović, Ivana Ponjavić, Ivan Barišić, Siniša Šegvić, Arian Ivec, Iva M. Tol
Publié dans: Current Biology, Issue 32, 2022, Page(s) 1–14, ISSN 0960-9822
Éditeur: Cell Press
DOI: 10.1016/j.cub.2022.04.035

Naegleria’s mitotic spindles are built from unique tubulins and highlight core spindle features

Auteurs: Velle, Katrina B.; Kennard, Andrew S.; Trupinić, Monika; Ivec, Arian; Swafford, Andrew J.M.; Nolton, Emily; Rice, Luke; Tolić, Iva M.; Fritz-Laylin, Lillian K.; Wadsworth, Patricia.
Publié dans: Current Biology, 2022, ISSN 0960-9822
Éditeur: Cell Press
DOI: 10.1016/j.cub.2022.01.034

Causes and Consequences of Non-Random Segregation Errors in Mitosis and Meiosis

Auteurs: Sjoerd Klaasen; Geert Kops
Publié dans: Cells, Issue 11, 2022, Page(s) 3564, ISSN 2073-4409
Éditeur: MDPI Journals
DOI: 10.3390/cells11223564

Proliferative advantage of specific aneuploid cells drives evolution of tumor karyotypes

Auteurs: Ivana Ban, Lucija Tomašić, Marianna Trakala, Iva M. Tolić, Nenad Pavin
Publié dans: Biophysical Journal, Issue 122, 2023, Page(s) 632–645, ISSN 0006-3495
Éditeur: Biophysical Society
DOI: 10.1016/j.bpj.2023.01.017

Anaphase B: Long-standing models meet new concepts

Auteurs: Kruno Vukušić, Iva M. Tolić
Publié dans: Seminars in Cell & Developmental Biology, Issue 117, 2021, Page(s) 127-139, ISSN 1084-9521
Éditeur: Academic Press
DOI: 10.1016/j.semcdb.2021.03.023

Clonal selection of stable aneuploidies in progenitor cells drives high-prevalence tumorigenesis

Auteurs: Marianna Trakala, Muskaan Aggarwal, Courtney Sniffen, Lauren Zasadil, Allison Carroll, Duanduan Ma, Xiaofeng A. Su, Darawalee Wangsa, Ashleigh Meyer, Cynthia J. Sieben, Jian Zhong, Pei-hsin Hsu, Glenn Paradis, Thomas Ried, Andrew Holland, Jan Van Deursen, Angelika Amon
Publié dans: Genes & Development, Issue 35/15-16, 2021, Page(s) 1079-1092, ISSN 0890-9369
Éditeur: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.348341.121

Optogenetic control of PRC1 reveals its role in chromosome alignment on the spindle by overlap length-dependent forces

Auteurs: Mihaela Jagrić, Patrik Risteski, Jelena Martinčić, Ana Milas, Iva M Tolić
Publié dans: eLife, Issue 10, 2021, ISSN 2050-084X
Éditeur: eLife Sciences Publications
DOI: 10.7554/elife.61170

Expansion microscopy of the mitotic spindle

Auteurs: Ivana Ponjavić, Kruno Vukušić, Iva M. Tolić
Publié dans: Expansion Microscopy for Cell Biology, Issue 161, 2021, Page(s) 247-274, ISBN 9780128208076
Éditeur: Elsevier
DOI: 10.1016/bs.mcb.2020.04.014

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