Molecular origins of aneuploidies in healthy and diseased human tissues

Publicaciones

Augmin regulates kinetochore tension and spatial arrangement of spindle microtubules by nucleating bridging fibers

Autores: Martina Manenica; Isabella Koprivec; Valentina Štimac; Juraj Simunić; Iva M. Tolić
Publicado en: eLife, Edición 11, 2022, Página(s) e83287, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.1101/2020.09.10.291740

Mechanobiology of the Mitotic Spindle

Autores: Nenad Pavin, Iva M. Tolić
Publicado en: Developmental Cell, Edición 56/2, 2021, Página(s) 192-201, ISSN 1534-5807
Editor: Cell Press
DOI: 10.1016/j.devcel.2020.11.003

Length-dependent poleward flux of sister kinetochore fibers promotes chromosome alignment

Autores: Patrik Risteski, Domagoj Božan, Mihaela Jagrić, Agneza Bosilj, Nenad Pavin, Iva M. Tolić
Publicado en: Cell Reports, Edición 40(5), 2022, Página(s) 111169, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2022.111169

Microtubule-sliding modules based on kinesins EG5 and PRC1-dependent KIF4A drive human spindle elongation

Autores: Kruno Vukušić, Ivana Ponjavić, Renata Buđa, Patrik Risteski, Iva M. Tolić
Publicado en: Developmental Cell, Edición 56/9, 2021, Página(s) 1253-1267.e10, ISSN 1534-5807
Editor: Cell Press
DOI: 10.1016/j.devcel.2021.04.005

Polar Chromosomes - Challenges of a Risky Path

Autores: Iva Tolić; Kruno Vukušić
Publicado en: Cells, Edición 11(9), 2022, Página(s) 1531, ISSN 2073-4409
Editor: MDPI Journals
DOI: 10.3390/cells11091531

Mitotic spindle: lessons from theoretical modeling

Autores: Iva M. Tolić, Nenad Pavin
Publicado en: Molecular Biology of the Cell, Edición 32/3, 2021, Página(s) 218-222, ISSN 1059-1524
Editor: American Society for Cell Biology
DOI: 10.1091/mbc.e20-05-0335

Biomechanics of chromosome alignment at the spindle midplane

Autores: Patrik Risteski, Mihaela Jagrić, Nenad Pavin, Iva M. Tolić
Publicado en: Current Biology, Edición 31/10, 2021, Página(s) R574-R585, ISSN 0960-9822
Editor: Cell Press
DOI: 10.1016/j.cub.2021.03.082

Microtubule nucleation from the fibrous corona by LIC1-pericentrin promotes chromosome congression

Autores: Jingchao Wu; Ainhoa Larreategui-Aparicio; Maaike L.A. Lambers; Dani L. Bodor; Sjoerd J. Klaasen; Eveline Tollenaar; Marta de Ruijter-Villani; Geert J.P.L. Kops
Publicado en: Current Biology, Edición 33, 2023, Página(s) 912–925, ISSN 2079-7737
Editor: Cell Press
DOI: 10.1016/j.cub.2023.01.010

Oblique circle method for measuring the curvature and twist of mitotic spindle microtubule bundles

Autores: Arian Ivec, Monika Trupinić, Iva M. Tolić, Nenad Pavin
Publicado en: Biophysical Journal, Edición 120/17, 2021, Página(s) 3641-3648, ISSN 0006-3495
Editor: Biophysical Society
DOI: 10.1016/j.bpj.2021.07.024

Vertebrate centromeres in mitosis are functionally bipartite structures stabilized by cohesin

Autores: Sacristan, Carlos; Samejima, Kumiko; Andrade Ruiz, Lorena; Deb, Moonmoon; Lambers, Maaike L.A.; Buckle, Adam; Brackley, Chris A.; Robertson, Daniel; Hori, Tetsuya; Webb, Shaun; Kiewisz, Robert; Bepler, Tristan; van Kwawegen, Eloïse; Risteski, Patrik; Vukušić, Kruno; Tolić, Iva M.; Müller-Reichert, Thomas; Fukagawa, Tatsuo; Gilbert, Nick; Marenduzzo, Davide; Earnshaw, William C. and Kops, Geer
Publicado en: Cell, Edición 187, 2024, Página(s) 1–18, ISSN 1097-4172
Editor: Elsevier Inc.
DOI: 10.1016/j.cell.2024.04.014

Nuclear chromosome locations dictate segregation error frequencies

Autores: Sjoerd J. Klaasen, My Anh Truong, Richard H. van Jaarsveld, Isabella Koprivec, Valentina Štimac, Sippe G. de Vries, Patrik Risteski, Snježana Kodba, Kruno Vukušić, Kim L. de Luca, Joana F. Marques, Elianne M. Gerrits, Bjorn Bakker, Floris Foijer, Jop Kind, Iva M. Tolić, Susanne M. A. Lens & Geert J. P. L. Kops
Publicado en: Nature, Edición 607, 2022, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-022-04938-0

Kinetochore- and chromosome-driven transition of microtubules into bundles promotes spindle assembly

Autores: Jurica Matković; Subhadip Ghosh; Mateja Ćosić; Marin Barisic; Nenad Pavin; Iva Tolić
Publicado en: Nature Communications, Edición 13:7307, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1101/2022.02.25.481924

The chirality of the mitotic spindle provides a mechanical response to forces and depends on microtubule motors and augmin

Autores: Monika Trupinić, Barbara Kokanović, Ivana Ponjavić, Ivan Barišić, Siniša Šegvić, Arian Ivec, Iva M. Tol
Publicado en: Current Biology, Edición 32, 2022, Página(s) 1–14, ISSN 0960-9822
Editor: Cell Press
DOI: 10.1016/j.cub.2022.04.035

Naegleria’s mitotic spindles are built from unique tubulins and highlight core spindle features

Autores: Velle, Katrina B.; Kennard, Andrew S.; Trupinić, Monika; Ivec, Arian; Swafford, Andrew J.M.; Nolton, Emily; Rice, Luke; Tolić, Iva M.; Fritz-Laylin, Lillian K.; Wadsworth, Patricia.
Publicado en: Current Biology, 2022, ISSN 0960-9822
Editor: Cell Press
DOI: 10.1016/j.cub.2022.01.034

Causes and Consequences of Non-Random Segregation Errors in Mitosis and Meiosis

Autores: Sjoerd Klaasen; Geert Kops
Publicado en: Cells, Edición 11, 2022, Página(s) 3564, ISSN 2073-4409
Editor: MDPI Journals
DOI: 10.3390/cells11223564

A farnesyl-dependent structural role for CENP-E in expansion of the fibrous corona

Autores: Jingchao Wu, Maximilian W.D. Raas, Paula Sobrevals Alcaraz, Harmjan R. Vos, Eelco C. Tromer, Berend Snel, Geert J.P.L. Kops
Publicado en: Journal of Cell Biology, Edición 223, 2023, ISSN 0021-9525
Editor: Rockefeller University Press
DOI: 10.1083/jcb.202303007

Vertebrate centromere architecture: from chromatin threads to functional structures

Autores: Lorena Andrade Ruiz, Geert J. P. L. Kops, Carlos Sacristan
Publicado en: Chromosoma, Edición 133, 2024, Página(s) 169-181, ISSN 0009-5915
Editor: Springer Verlag
DOI: 10.1007/s00412-024-00823-z

Proliferative advantage of specific aneuploid cells drives evolution of tumor karyotypes

Autores: Ivana Ban, Lucija Tomašić, Marianna Trakala, Iva M. Tolić, Nenad Pavin
Publicado en: Biophysical Journal, Edición 122, 2023, Página(s) 632–645, ISSN 0006-3495
Editor: Biophysical Society
DOI: 10.1016/j.bpj.2023.01.017

Single-cell DNA sequencing reveals a high incidence of chromosomal abnormalities in human blastocysts

Autores: Effrosyni A. Chavli, Sjoerd J. Klaasen, Diane Van Opstal, Joop S.E. Laven, Geert J.P.L. Kops, Esther B. Baart
Publicado en: Journal of Clinical Investigation, Edición 134, 2024, ISSN 1558-8238
Editor: American Society for Clinical Investigation
DOI: 10.1172/jci174483

Anaphase B: Long-standing models meet new concepts

Autores: Kruno Vukušić, Iva M. Tolić
Publicado en: Seminars in Cell & Developmental Biology, Edición 117, 2021, Página(s) 127-139, ISSN 1084-9521
Editor: Academic Press
DOI: 10.1016/j.semcdb.2021.03.023

Clonal selection of stable aneuploidies in progenitor cells drives high-prevalence tumorigenesis

Autores: Marianna Trakala, Muskaan Aggarwal, Courtney Sniffen, Lauren Zasadil, Allison Carroll, Duanduan Ma, Xiaofeng A. Su, Darawalee Wangsa, Ashleigh Meyer, Cynthia J. Sieben, Jian Zhong, Pei-hsin Hsu, Glenn Paradis, Thomas Ried, Andrew Holland, Jan Van Deursen, Angelika Amon
Publicado en: Genes & Development, Edición 35/15-16, 2021, Página(s) 1079-1092, ISSN 0890-9369
Editor: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.348341.121

Optogenetic control of PRC1 reveals its role in chromosome alignment on the spindle by overlap length-dependent forces

Autores: Mihaela Jagrić, Patrik Risteski, Jelena Martinčić, Ana Milas, Iva M Tolić
Publicado en: eLife, Edición 10, 2021, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.61170

The TRIM69-MST2 signaling axis regulates centrosome dynamics and chromosome segregation

Autores: Yilin Wang, Patrik Risteski, Yang Yang, Huan Chen, Gaith Droby, Andrea Walens, Deepika Jayaprakash, Melissa Troester, Laura Herring, Jonathan Chernoff, Iva M Tolić, Jessica Bowser, Cyrus Vaziri
Publicado en: Nucleic Acids Research, Edición 51(19), 2023, Página(s) 10568–10589, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkad766

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