Structure and Cellular Dynamics of the Sarcomere

Project Information

StuDySARCOMERE

Grant agreement ID: 856118

DOI 10.3030/856118

EC signature date 11 December 2019

Start date 1 February 2020

End date 31 January 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 10 936 440,00

EU contribution € 10 936 440,00

Coordinated by

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany

Publications

Peer reviewed articles (10)

A nanobody toolbox to investigate localisation and dynamics of Drosophila titins and other key sarcomeric proteins

Author(s): Vincent Loreau; Renate Rees; Eunice HoYee Chan; Waltraud Taxer; Kathrin Gregor; Bianka Mußil; Christophe Pitaval; Nuno Miguel Luis; Pierre Mangeol; Frank Schnorrer; Dirk Görlich
Published in: eLife, Issue 1, 2023, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.79343

Structures from intact myofibrils reveal mechanism of thin filament regulation through nebulin

Author(s): Zhexin Wang, Michael Grange, Sabrina Pospich, Thorsten Wagner, Ay Lin Kho,Mathias Gautel, Stefan Raunser
Published in: Science, 2022, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abn1934

Nanobodies combined with DNA-PAINT super-resolution reveal a staggered titin nano-architecture in flight muscles

Author(s): Pierre Mangeol; Florian Schueder; Eunice HoYee Chan; Renate Rees; Jürgen Schünemann; Ralf Jungmann; Dirk Görlich; Frank Schnorrer
Published in: eLife, Issue 2, 2023, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.1101/2022.04.14.488306

Structural Biochemistry of Muscle Contraction

Author(s): Wang Z, Raunser S
Published in: Ann. Rev. Biochem., 2023, ISSN 0066-4154
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-biochem-052521-042909

Myofibril and mitochondria morphogenesis are coordinated by a mechanical feedback mechanism in muscle

Author(s): Jerome Avellaneda, Clement Rodier, Fabrice Daian, Nicolas Brouilly, Thomas Rival, Nuno Miguel Luis, Frank Schnorrer
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-22058-7

The molecular basis for sarcomere organization in vertebrate skeletal muscle

Author(s): Zhexin Wang, Michael Grange, Thorsten Wagner, Ay Lin Kho, Mathias Gautel, Stefan Raunser
Published in: Cell, Issue 184/8, 2021, Page(s) 2135-2150.e13, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2021.02.047

High-resolution structures of the actomyosin-V complex in three nucleotide states provide insights into the force generation mechanism.

Author(s): Sabrina Pospich; H. Lee Sweeney; Anne Houdusse; Stefan Raunser
Published in: eLife, Issue 1, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.73724

Mechanobiology of muscle and myofibril morphogenesis.

Author(s): Nuno Miguel Luis, Frank Schnorrer
Published in: Cells & development., Issue 2021 Dec:168:203760, 2021, ISSN 2667-2901
Publisher: [Amsterdam] : Elsevier B.V., [2021]-
DOI: 10.1016/j.cdev.2021.203760

Tension-driven multi-scale self-organisation in human iPSC-derived muscle fibers

Author(s): Achyuth Acharya; Qiyan Mao; Alejandra Rodríguez-delaRosa; Fabio Marchiano; Benoit Dehapiot; Ziad Al Tanoury; Jyoti Rao; Margarete Díaz-Cuadros; Arian Mansur; Erica Wagner; Claire Chardes; Vandana Gupta; Pierre-François Lenne; Bianca H Habermann; Olivier Theodoly; Olivier Pourquié; Frank Schnorrer
Published in: eLife, Issue 1, 2022, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.76649

Structural Basis of actin filament assembly and aging

Author(s): Wout Oosterheert, Björn U. Klink, Alexander Belyy, Sabrina Pospich,Stefan Raunser
Published in: Nature, 2022, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-05241-8