Structure and Cellular Dynamics of the Sarcomere

Informazioni relative al progetto

StuDySARCOMERE

ID dell’accordo di sovvenzione: 856118

DOI

10.3030/856118

Data della firma CE 11 Dicembre 2019

Data di avvio 1 Febbraio 2020

Data di completamento 31 Gennaio 2027

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 10 936 440,00

Contributo UE

€ 10 936 440,00

Coordinato da

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (22)

A nanobody toolbox to investigate localisation and dynamics of Drosophila titins and other key sarcomeric proteins

Autori: Vincent Loreau; Renate Rees; Eunice HoYee Chan; Waltraud Taxer; Kathrin Gregor; Bianka Mußil; Christophe Pitaval; Nuno Miguel Luis; Pierre Mangeol; Frank Schnorrer; Dirk Görlich
Pubblicato in: eLife, Numero 1, 2023, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.79343

Structures from intact myofibrils reveal mechanism of thin filament regulation through nebulin

Autori: Zhexin Wang, Michael Grange, Sabrina Pospich, Thorsten Wagner, Ay Lin Kho,Mathias Gautel, Stefan Raunser
Pubblicato in: Science, 2022, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.abn1934

Structure of the native myosin filament in the relaxed cardiac sarcomere

Autori: Tamborrini D, Wang Z, Wagner T, Tacke S, Stabrin M, Grange M, Kho AL, Rees M, Bennett P, Gautel M, Raunser S
Pubblicato in: Nature, 2023, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-023-06690-5

Nanobodies combined with DNA-PAINT super-resolution reveal a staggered titin nano-architecture in flight muscles

Autori: Pierre Mangeol; Florian Schueder; Eunice HoYee Chan; Renate Rees; Jürgen Schünemann; Ralf Jungmann; Dirk Görlich; Frank Schnorrer
Pubblicato in: eLife, Numero 2, 2023, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.1101/2022.04.14.488306

Multistate kinetics of the syringe-like injection mechanism of Tc toxins

Autori: Peter Njenga Ng’ang’a, Julian Folz, Svetlana Kucher, Daniel Roderer, Ying Xu, Oleg Sitsel, Alexander Belyy, Daniel Prumbaum, Ralf Kühnemuth, Tufa E. Assafa, Min Dong, Claus A. M. Seidel, Enrica Bordignon, Stefan Raunser
Pubblicato in: Science Advances, Numero 11, 2025, ISSN 2375-2548
Editore: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/sciadv.adr2019

Structural Biochemistry of Muscle Contraction

Autori: Wang Z, Raunser S
Pubblicato in: Ann. Rev. Biochem., 2023, ISSN 0066-4154
Editore: Annual Reviews, Inc.
DOI: 10.1146/annurev-biochem-052521-042909

Spatial transcriptomics in adult Drosophila reveals new cell types in the brain and identifies subcellular mRNA patterns in muscles

Autori: Jasper Janssens, Pierre Mangeol, Nikolai Hecker, Gabriele Partel, Katina Spanier, Joy Ismail, Gert Hulselmans, Stein Aerts, Frank Schnorrer
Pubblicato in: eLife, 2024, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.92618.1

Myofibril and mitochondria morphogenesis are coordinated by a mechanical feedback mechanism in muscle

Autori: Jerome Avellaneda, Clement Rodier, Fabrice Daian, Nicolas Brouilly, Thomas Rival, Nuno Miguel Luis, Frank Schnorrer
Pubblicato in: Nature Communications, Numero 12/1, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-22058-7

The molecular basis for sarcomere organization in vertebrate skeletal muscle

Autori: Zhexin Wang, Michael Grange, Thorsten Wagner, Ay Lin Kho, Mathias Gautel, Stefan Raunser
Pubblicato in: Cell, Numero 184/8, 2021, Pagina/e 2135-2150.e13, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2021.02.047

Phalloidin and DNase I-bound F-actin pointed end structures reveal principles of filament stabilization and disassembly

Autori: Micaela Boiero Sanders, Wout Oosterheert, Oliver Hofnagel, Peter Bieling, Stefan Raunser
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-52251-3

Molecular mechanisms of inorganic-phosphate release from the core and barbed end of actin filaments

Autori: Oosterheert W, Blanc FEC, Roy A, Belyy A, Sanders MB, Hofnagel O, Hummer G, Bieling P, Raunser S
Pubblicato in: Nat Struct Mol Biol, 2023, ISSN 1545-9993
Editore: Nature Publishing Group
DOI: 10.1038/s41594-023-01101-9

Mechanoresponsive regulation of myogenesis by the force-sensing transcriptional regulator Tono

Autori: Xu Zhang, Jerome Avellaneda, Maria L. Spletter, Sandra B. Lemke, Pierre Mangeol, Bianca H. Habermann, Frank Schnorrer
Pubblicato in: Current Biology, 2024, ISSN 0960-9822
Editore: Cell Press
DOI: 10.1016/j.cub.2024.07.079

Mechanisms of Sarcomere Assembly in Muscle Cells Inferred from Sequential Ordering of Myofibril Components

Autori: Francine Kolley, Clara Sidor, Benoit Dehapiot, Frank Schnorrer, Benjamin M. Friedrich
Pubblicato in: PRX Life, Numero 2, 2024, ISSN 2835-8279
Editore: American Physical Society, College Park
DOI: 10.1103/prxlife.2.013002

High-resolution structures of the actomyosin-V complex in three nucleotide states provide insights into the force generation mechanism.

Autori: Sabrina Pospich; H. Lee Sweeney; Anne Houdusse; Stefan Raunser
Pubblicato in: eLife, Numero 1, 2021, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.73724

Mechanobiology of muscle and myofibril morphogenesis.

Autori: Nuno Miguel Luis, Frank Schnorrer
Pubblicato in: Cells & development., Numero 2021 Dec:168:203760, 2021, ISSN 2667-2901
Editore: [Amsterdam] : Elsevier B.V., [2021]-
DOI: 10.1016/j.cdev.2021.203760

PatternJ: an ImageJ toolset for the automated and quantitative analysis of regular spatial patterns found in sarcomeres, axons, somites, and more

Autori: Mélina Baheux Blin, Vincent Loreau, Frank Schnorrer, Pierre Mangeol
Pubblicato in: Biology Open, Numero 13, 2024, ISSN 2046-6390
Editore: Biol Open
DOI: 10.1242/bio.060548

Structural insights into actin filament turnover

Autori: Wout Oosterheert, Micaela Boiero Sanders, Peter Bieling, Stefan Raunser
Pubblicato in: Trends in Cell Biology, Numero 35, 2025, Pagina/e 893-906, ISSN 0962-8924
Editore: Elsevier BV
DOI: 10.1016/j.tcb.2024.12.009

Choreography of rapid actin filament disassembly by coronin, cofilin, and AIP1

Autori: Wout Oosterheert, Micaela Boiero Sanders, Oliver Hofnagel, Peter Bieling, Stefan Raunser
Pubblicato in: Cell, Numero 188, 2025, Pagina/e 6845-6860.e27, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2025.09.016

Tension-driven multi-scale self-organisation in human iPSC-derived muscle fibers

Autori: Achyuth Acharya; Qiyan Mao; Alejandra Rodríguez-delaRosa; Fabio Marchiano; Benoit Dehapiot; Ziad Al Tanoury; Jyoti Rao; Margarete Díaz-Cuadros; Arian Mansur; Erica Wagner; Claire Chardes; Vandana Gupta; Pierre-François Lenne; Bianca H Habermann; Olivier Theodoly; Olivier Pourquié; Frank Schnorrer
Pubblicato in: eLife, Numero 1, 2022, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.76649

Molecular mechanism of actin filament elongation by formins

Autori: Wout Oosterheert, Micaela Boiero Sanders, Johanna Funk, Daniel Prumbaum, Stefan Raunser, Peter Bieling
Pubblicato in: Science, Numero 384, 2024, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.adn9560

Structural Basis of actin filament assembly and aging

Autori: Wout Oosterheert, Björn U. Klink, Alexander Belyy, Sabrina Pospich,Stefan Raunser
Pubblicato in: Nature, 2022, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-022-05241-8

Muscle growth by sarcomere divisions

Autori: Clement Rodier, Ian D. Estabrook, Eunice HoYee Chan, Gavin Rice, Vincent Loreau, Stefan Raunser, Dirk Görlich, Benjamin M. Friedrich, Frank Schnorrer
Pubblicato in: Science Advances, Numero 11, 2025, ISSN 2375-2548
Editore: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/sciadv.adw9445

Non-peer reviewed articles (1)

Nucleoporin-binding nanobodies that either track or inhibit nuclear pore complex assembly

Autori: Mireia Solà Colom, Zhenglin Fu, Thomas Güttler, Sergei Trakhanov, Vasundara Srinivasan, Kathrin Gregor, Tino Pleiner & Dirk Görlich
Pubblicato in: bioRxiv, 2023, ISSN 2692-8205
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.09.12.557426