Structure and Cellular Dynamics of the Sarcomere

Información del proyecto

StuDySARCOMERE

Identificador del acuerdo de subvención: 856118

DOI

10.3030/856118

Fecha de la firma de la CE 11 Diciembre 2019

Fecha de inicio 1 Febrero 2020

Fecha de finalización 31 Enero 2027

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 10 936 440,00

Aportación de la UE

€ 10 936 440,00

Coordinado por

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (29)

A nanobody toolbox to investigate localisation and dynamics of Drosophila titins and other key sarcomeric proteins

Autores: Vincent Loreau; Renate Rees; Eunice HoYee Chan; Waltraud Taxer; Kathrin Gregor; Bianka Mußil; Christophe Pitaval; Nuno Miguel Luis; Pierre Mangeol; Frank Schnorrer; Dirk Görlich
Publicado en: eLife, Edición 1, 2023, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.79343

Structures from intact myofibrils reveal mechanism of thin filament regulation through nebulin

Autores: Zhexin Wang, Michael Grange, Sabrina Pospich, Thorsten Wagner, Ay Lin Kho,Mathias Gautel, Stefan Raunser
Publicado en: Science, 2022, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.abn1934

Structure of the native myosin filament in the relaxed cardiac sarcomere

Autores: Tamborrini D, Wang Z, Wagner T, Tacke S, Stabrin M, Grange M, Kho AL, Rees M, Bennett P, Gautel M, Raunser S
Publicado en: Nature, 2023, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-023-06690-5

Nanobodies combined with DNA-PAINT super-resolution reveal a staggered titin nano-architecture in flight muscles

Autores: Pierre Mangeol; Florian Schueder; Eunice HoYee Chan; Renate Rees; Jürgen Schünemann; Ralf Jungmann; Dirk Görlich; Frank Schnorrer
Publicado en: eLife, Edición 2, 2023, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.1101/2022.04.14.488306

Multistate kinetics of the syringe-like injection mechanism of Tc toxins

Autores: Peter Njenga Ng’ang’a, Julian Folz, Svetlana Kucher, Daniel Roderer, Ying Xu, Oleg Sitsel, Alexander Belyy, Daniel Prumbaum, Ralf Kühnemuth, Tufa E. Assafa, Min Dong, Claus A. M. Seidel, Enrica Bordignon, Stefan Raunser
Publicado en: Science Advances, Edición 11, 2025, ISSN 2375-2548
Editor: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/sciadv.adr2019

Location-Dependent Differences in Cardiac and Skeletal Muscle Dysfunction Associated With Truncating Titin ( <i>ttn.2</i> ) Variants

Autores: Celine F. Santiago, Inken G. Huttner, Ailbhe K. O'Brien, Melissa A.B. Amerudin, Pauline M. Bennett, Jasmina Cvetkovska, Renee Chand, Mark Holt, Gunjan Trivedi, Louis W. Wang, Xiaoping Yang, Kelly A. Smith, Mathias Gautel, Diane Fatkin, Yaniv Hinits
Publicado en: Circulation Research, Edición 138, 2026, ISSN 0009-7330
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.124.325999

Microtubules coordinate mitochondria transport with myofibril morphogenesis during muscle development

Autores: Jerome Avellaneda, Duarte Candeias, Ana da Rosa Soares, Edgar R. Gomes, Nuno Miguel Luis, Frank Schnorrer
Publicado en: Developmental Cell, Edición 60, 2025, Página(s) 2962-2975.e5, ISSN 1534-5807
Editor: Cell Press
DOI: 10.1016/j.devcel.2025.06.033

Structural Biochemistry of Muscle Contraction

Autores: Wang Z, Raunser S
Publicado en: Ann. Rev. Biochem., 2023, ISSN 0066-4154
Editor: Annual Reviews, Inc.
DOI: 10.1146/annurev-biochem-052521-042909

Spatial transcriptomics in adult Drosophila reveals new cell types in the brain and identifies subcellular mRNA patterns in muscles

Autores: Jasper Janssens, Pierre Mangeol, Nikolai Hecker, Gabriele Partel, Katina Spanier, Joy Ismail, Gert Hulselmans, Stein Aerts, Frank Schnorrer
Publicado en: eLife, 2024, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.92618.1

Myofibril and mitochondria morphogenesis are coordinated by a mechanical feedback mechanism in muscle

Autores: Jerome Avellaneda, Clement Rodier, Fabrice Daian, Nicolas Brouilly, Thomas Rival, Nuno Miguel Luis, Frank Schnorrer
Publicado en: Nature Communications, Edición 12/1, 2021, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-22058-7

The molecular basis for sarcomere organization in vertebrate skeletal muscle

Autores: Zhexin Wang, Michael Grange, Thorsten Wagner, Ay Lin Kho, Mathias Gautel, Stefan Raunser
Publicado en: Cell, Edición 184/8, 2021, Página(s) 2135-2150.e13, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2021.02.047

Phalloidin and DNase I-bound F-actin pointed end structures reveal principles of filament stabilization and disassembly

Autores: Micaela Boiero Sanders, Wout Oosterheert, Oliver Hofnagel, Peter Bieling, Stefan Raunser
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-52251-3

Molecular mechanisms of inorganic-phosphate release from the core and barbed end of actin filaments

Autores: Oosterheert W, Blanc FEC, Roy A, Belyy A, Sanders MB, Hofnagel O, Hummer G, Bieling P, Raunser S
Publicado en: Nat Struct Mol Biol, 2023, ISSN 1545-9993
Editor: Nature Publishing Group
DOI: 10.1038/s41594-023-01101-9

Mechanoresponsive regulation of myogenesis by the force-sensing transcriptional regulator Tono

Autores: Xu Zhang, Jerome Avellaneda, Maria L. Spletter, Sandra B. Lemke, Pierre Mangeol, Bianca H. Habermann, Frank Schnorrer
Publicado en: Current Biology, 2024, ISSN 0960-9822
Editor: Cell Press
DOI: 10.1016/j.cub.2024.07.079

Mechanisms of Sarcomere Assembly in Muscle Cells Inferred from Sequential Ordering of Myofibril Components

Autores: Francine Kolley, Clara Sidor, Benoit Dehapiot, Frank Schnorrer, Benjamin M. Friedrich
Publicado en: PRX Life, Edición 2, 2024, ISSN 2835-8279
Editor: American Physical Society, College Park
DOI: 10.1103/prxlife.2.013002

High-resolution structures of the actomyosin-V complex in three nucleotide states provide insights into the force generation mechanism.

Autores: Sabrina Pospich; H. Lee Sweeney; Anne Houdusse; Stefan Raunser
Publicado en: eLife, Edición 1, 2021, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.73724

Titin-dependent biomechanical feedback tailors sarcomeres to specialized muscle functions in insects

Autores: Vincent Loreau, Wouter H. Koolhaas, Eunice HoYee Chan, Paul De Boissier, Nicolas Brouilly, Sabina Avosani, Aditya Sane, Christophe Pitaval, Stefanie Reiter, Nuno Miguel Luis, Pierre Mangeol, Anne C. von Philipsborn, Jean-François Rupprecht, Dirk Görlich, Bianca H. Habermann, Frank Schnorrer
Publicado en: Science Advances, Edición 11, 2025, ISSN 2375-2548
Editor: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/sciadv.ads8716

The physical basis of sarcomere self-assembly

Autores: Francine Kolley-Köchel, Frank Schnorrer, Benjamin M. Friedrich
Publicado en: Biophysics Reviews, Edición 6, 2025, ISSN 2688-4089
Editor: AIP Publishing
DOI: 10.1063/5.0281811

Spatial transcriptomics in the adult Drosophila brain and body

Autores: Jasper Janssens, Pierre Mangeol, Nikolai Hecker, Gabriele Partel, Katina I Spanier, Joy N Ismail, Gert J Hulselmans, Stein Aerts, Frank Schnorrer
Publicado en: eLife, Edición 13, 2025, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.92618.3

Mechanobiology of muscle and myofibril morphogenesis.

Autores: Nuno Miguel Luis, Frank Schnorrer
Publicado en: Cells & development., Edición 2021 Dec:168:203760, 2021, ISSN 2667-2901
Editor: [Amsterdam] : Elsevier B.V., [2021]-
DOI: 10.1016/j.cdev.2021.203760

PatternJ: an ImageJ toolset for the automated and quantitative analysis of regular spatial patterns found in sarcomeres, axons, somites, and more

Autores: Mélina Baheux Blin, Vincent Loreau, Frank Schnorrer, Pierre Mangeol
Publicado en: Biology Open, Edición 13, 2024, ISSN 2046-6390
Editor: Biol Open
DOI: 10.1242/bio.060548

Structural insights into actin filament turnover

Autores: Wout Oosterheert, Micaela Boiero Sanders, Peter Bieling, Stefan Raunser
Publicado en: Trends in Cell Biology, Edición 35, 2025, Página(s) 893-906, ISSN 0962-8924
Editor: Elsevier BV
DOI: 10.1016/j.tcb.2024.12.009

Choreography of rapid actin filament disassembly by coronin, cofilin, and AIP1

Autores: Wout Oosterheert, Micaela Boiero Sanders, Oliver Hofnagel, Peter Bieling, Stefan Raunser
Publicado en: Cell, Edición 188, 2025, Página(s) 6845-6860.e27, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2025.09.016

Tension-driven multi-scale self-organisation in human iPSC-derived muscle fibers

Autores: Achyuth Acharya; Qiyan Mao; Alejandra Rodríguez-delaRosa; Fabio Marchiano; Benoit Dehapiot; Ziad Al Tanoury; Jyoti Rao; Margarete Díaz-Cuadros; Arian Mansur; Erica Wagner; Claire Chardes; Vandana Gupta; Pierre-François Lenne; Bianca H Habermann; Olivier Theodoly; Olivier Pourquié; Frank Schnorrer
Publicado en: eLife, Edición 1, 2022, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.76649

A comprehensive framework for the interpretation of TTN missense variants

Autores: Maria Francesca Di Feo, Martin Rees, Victoria Lillback, Ay Lin Kho, Angelina Meybatova, Mark Holt, Heinz Jungbluth, Francesco Muntoni, Giovanni Baranello, Anna Sarkozy, Chiara Fiorillo, Serena Baratto, Claudio Bruno, Monica Traverso, Michele Iacomino, Marina Pedemonte, Noemi Brolatti, Francesca Faravelli, Federico Zara, G. M. Luana Mandarà, Alan H. Beggs, Casie A. Genetti, Pamela Barraza-Flores,
Publicado en: Genome Medicine, 2026, ISSN 1756-994X
Editor: BioMed Central
DOI: 10.1186/s13073-026-01605-1

TITINdb2—expanding annotation and structural information for protein variants in the giant sarcomeric protein titin

Autores: Timir Weston, Joseph Ng, Oriol Gracia Carmona, Mathias Gautel, Franca Fraternali
Publicado en: Bioinformatics Advances, Edición 5, 2025, ISSN 2635-0041
Editor: Oxford University Press (OUP)
DOI: 10.1093/bioadv/vbaf062

Molecular mechanism of actin filament elongation by formins

Autores: Wout Oosterheert, Micaela Boiero Sanders, Johanna Funk, Daniel Prumbaum, Stefan Raunser, Peter Bieling
Publicado en: Science, Edición 384, 2024, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.adn9560

Structural Basis of actin filament assembly and aging

Autores: Wout Oosterheert, Björn U. Klink, Alexander Belyy, Sabrina Pospich,Stefan Raunser
Publicado en: Nature, 2022, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-022-05241-8

Muscle growth by sarcomere divisions

Autores: Clement Rodier, Ian D. Estabrook, Eunice HoYee Chan, Gavin Rice, Vincent Loreau, Stefan Raunser, Dirk Görlich, Benjamin M. Friedrich, Frank Schnorrer
Publicado en: Science Advances, Edición 11, 2025, ISSN 2375-2548
Editor: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/sciadv.adw9445

Non-peer reviewed articles (1)

Nucleoporin-binding nanobodies that either track or inhibit nuclear pore complex assembly

Autores: Mireia Solà Colom, Zhenglin Fu, Thomas Güttler, Sergei Trakhanov, Vasundara Srinivasan, Kathrin Gregor, Tino Pleiner & Dirk Görlich
Publicado en: bioRxiv, 2023, ISSN 2692-8205
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.09.12.557426