Structure and Cellular Dynamics of the Sarcomere

Información del proyecto

StuDySARCOMERE

Identificador del acuerdo de subvención: 856118

DOI

10.3030/856118

Fecha de la firma de la CE 11 Diciembre 2019

Fecha de inicio 1 Febrero 2020

Fecha de finalización 31 Enero 2027

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 10 936 440,00

Aportación de la UE

€ 10 936 440,00

Coordinado por

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (18)

A nanobody toolbox to investigate localisation and dynamics of Drosophila titins and other key sarcomeric proteins

Autores: Vincent Loreau; Renate Rees; Eunice HoYee Chan; Waltraud Taxer; Kathrin Gregor; Bianka Mußil; Christophe Pitaval; Nuno Miguel Luis; Pierre Mangeol; Frank Schnorrer; Dirk Görlich
Publicado en: eLife, Edición 1, 2023, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.79343

Structures from intact myofibrils reveal mechanism of thin filament regulation through nebulin

Autores: Zhexin Wang, Michael Grange, Sabrina Pospich, Thorsten Wagner, Ay Lin Kho,Mathias Gautel, Stefan Raunser
Publicado en: Science, 2022, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.abn1934

Structure of the native myosin filament in the relaxed cardiac sarcomere

Autores: Tamborrini D, Wang Z, Wagner T, Tacke S, Stabrin M, Grange M, Kho AL, Rees M, Bennett P, Gautel M, Raunser S
Publicado en: Nature, 2023, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-023-06690-5

Nanobodies combined with DNA-PAINT super-resolution reveal a staggered titin nano-architecture in flight muscles

Autores: Pierre Mangeol; Florian Schueder; Eunice HoYee Chan; Renate Rees; Jürgen Schünemann; Ralf Jungmann; Dirk Görlich; Frank Schnorrer
Publicado en: eLife, Edición 2, 2023, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.1101/2022.04.14.488306

Structural Biochemistry of Muscle Contraction

Autores: Wang Z, Raunser S
Publicado en: Ann. Rev. Biochem., 2023, ISSN 0066-4154
Editor: Annual Reviews, Inc.
DOI: 10.1146/annurev-biochem-052521-042909

Spatial transcriptomics in adult Drosophila reveals new cell types in the brain and identifies subcellular mRNA patterns in muscles

Autores: Jasper Janssens, Pierre Mangeol, Nikolai Hecker, Gabriele Partel, Katina Spanier, Joy Ismail, Gert Hulselmans, Stein Aerts, Frank Schnorrer
Publicado en: eLife, 2024, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.92618.1

Myofibril and mitochondria morphogenesis are coordinated by a mechanical feedback mechanism in muscle

Autores: Jerome Avellaneda, Clement Rodier, Fabrice Daian, Nicolas Brouilly, Thomas Rival, Nuno Miguel Luis, Frank Schnorrer
Publicado en: Nature Communications, Edición 12/1, 2021, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-22058-7

The molecular basis for sarcomere organization in vertebrate skeletal muscle

Autores: Zhexin Wang, Michael Grange, Thorsten Wagner, Ay Lin Kho, Mathias Gautel, Stefan Raunser
Publicado en: Cell, Edición 184/8, 2021, Página(s) 2135-2150.e13, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2021.02.047

Phalloidin and DNase I-bound F-actin pointed end structures reveal principles of filament stabilization and disassembly

Autores: Micaela Boiero Sanders, Wout Oosterheert, Oliver Hofnagel, Peter Bieling, Stefan Raunser
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-52251-3

Molecular mechanisms of inorganic-phosphate release from the core and barbed end of actin filaments

Autores: Oosterheert W, Blanc FEC, Roy A, Belyy A, Sanders MB, Hofnagel O, Hummer G, Bieling P, Raunser S
Publicado en: Nat Struct Mol Biol, 2023, ISSN 1545-9993
Editor: Nature Publishing Group
DOI: 10.1038/s41594-023-01101-9

Mechanoresponsive regulation of myogenesis by the force-sensing transcriptional regulator Tono

Autores: Xu Zhang, Jerome Avellaneda, Maria L. Spletter, Sandra B. Lemke, Pierre Mangeol, Bianca H. Habermann, Frank Schnorrer
Publicado en: Current Biology, 2024, ISSN 0960-9822
Editor: Cell Press
DOI: 10.1016/j.cub.2024.07.079

Mechanisms of Sarcomere Assembly in Muscle Cells Inferred from Sequential Ordering of Myofibril Components

Autores: Francine Kolley, Clara Sidor, Benoit Dehapiot, Frank Schnorrer, Benjamin M. Friedrich
Publicado en: PRX Life, Edición 2, 2024, ISSN 2835-8279
Editor: American Physical Society, College Park
DOI: 10.1103/prxlife.2.013002

High-resolution structures of the actomyosin-V complex in three nucleotide states provide insights into the force generation mechanism.

Autores: Sabrina Pospich; H. Lee Sweeney; Anne Houdusse; Stefan Raunser
Publicado en: eLife, Edición 1, 2021, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.73724

Mechanobiology of muscle and myofibril morphogenesis.

Autores: Nuno Miguel Luis, Frank Schnorrer
Publicado en: Cells & development., Edición 2021 Dec:168:203760, 2021, ISSN 2667-2901
Editor: [Amsterdam] : Elsevier B.V., [2021]-
DOI: 10.1016/j.cdev.2021.203760

PatternJ: an ImageJ toolset for the automated and quantitative analysis of regular spatial patterns found in sarcomeres, axons, somites, and more

Autores: Mélina Baheux Blin, Vincent Loreau, Frank Schnorrer, Pierre Mangeol
Publicado en: Biology Open, Edición 13, 2024, ISSN 2046-6390
Editor: Biol Open
DOI: 10.1242/bio.060548

Tension-driven multi-scale self-organisation in human iPSC-derived muscle fibers

Autores: Achyuth Acharya; Qiyan Mao; Alejandra Rodríguez-delaRosa; Fabio Marchiano; Benoit Dehapiot; Ziad Al Tanoury; Jyoti Rao; Margarete Díaz-Cuadros; Arian Mansur; Erica Wagner; Claire Chardes; Vandana Gupta; Pierre-François Lenne; Bianca H Habermann; Olivier Theodoly; Olivier Pourquié; Frank Schnorrer
Publicado en: eLife, Edición 1, 2022, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.76649

Molecular mechanism of actin filament elongation by formins

Autores: Wout Oosterheert, Micaela Boiero Sanders, Johanna Funk, Daniel Prumbaum, Stefan Raunser, Peter Bieling
Publicado en: Science, Edición 384, 2024, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.adn9560

Structural Basis of actin filament assembly and aging

Autores: Wout Oosterheert, Björn U. Klink, Alexander Belyy, Sabrina Pospich,Stefan Raunser
Publicado en: Nature, 2022, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-022-05241-8

Non-peer reviewed articles (1)

Nucleoporin-binding nanobodies that either track or inhibit nuclear pore complex assembly

Autores: Mireia Solà Colom, Zhenglin Fu, Thomas Güttler, Sergei Trakhanov, Vasundara Srinivasan, Kathrin Gregor, Tino Pleiner & Dirk Görlich
Publicado en: bioRxiv, 2023, ISSN 2692-8205
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.09.12.557426