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Lipid droplet hypertrophy : the link between adipocyte dysfunction and cardiometabolic diseases

Project description

Multi-level dynamics of adipocyte hypertrophy

Adipocyte hypertrophy is a condition associated with larger than normal lipid droplets (LDs), the adipocyte organelles that store energy in the form of triglycerides. Adipocyte hypertrophy is irrespective of body fat and causes a wide range of pathological conditions including cardiometabolic diseases. The scope of the EU-funded SPHERES project is to investigate the hypothesis that disturbances in the interaction between LD proteins and LD lipid composition lead to adipocyte hypertrophy. Run by a multi-disciplinary network of experts, the project will develop beyond-state-of-the-art models and methods to study the formation and maintenance of large adipocyte LDs. The work will pave the way for a better understanding of the underlying mechanisms of adipocyte hypertrophy as well as the identification of therapeutic strategies targeting adipocytes.

Call for proposal

ERC-2019-SyG
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Host institution

UNIVERSITE PAUL SABATIER TOULOUSE III
Address
Route De Narbonne 118
31062 Toulouse Cedex 9
France
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 3 537 143

Beneficiaries (3)

UNIVERSITE PAUL SABATIER TOULOUSE III
France
EU contribution
€ 3 537 143
Address
Route De Narbonne 118
31062 Toulouse Cedex 9
Activity type
Higher or Secondary Education Establishments
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 3 004 881
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 3 199 750
Address
Rue Michel Ange 3
75794 Paris
Activity type
Other