Lipid droplet hypertrophy : the link between adipocyte dysfunction and cardiometabolic diseases

Project Information

SPHERES

Grant agreement ID: 856404

DOI 10.3030/856404

EC signature date 18 March 2020

Start date 1 September 2020

End date 31 August 2027

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 9 741 774,25

EU contribution € 9 741 774,00

Coordinated by

UNIVERSITE DE TOULOUSE
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (36)

Lipid exchange at ER–trans-Golgi contact sites governs polarized cargo sorting

Author(s): Dávid Kovács, Anne-Sophie Gay, Delphine Debayle, Sophie Abélanet, Amanda Patel, Bruno Mesmin, Frédéric Luton, Bruno Antonny
Published in: Journal of Cell Biology, Issue 223, 2023, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.202307051

3D Adipose Tissue Culture Links the Organotypic Microenvironment to Improved Adipogenesis

Author(s): Joanne X. Shen, Morgane Couchet, Jérémy Dufau, Thais de Castro Barbosa, Marie-Adeline Marques, Niklas Mejhert, Volker M. Lauschke
Published in: Advanced Science, Issue Vol. 8 Issue 16, 2021, ISSN 2198-3844
Publisher: John Wiley & Sons, Ltd
DOI: 10.1002/advs.202100106

Metabolic and cardiovascular adaptations to an 8-wk lifestyle weight loss intervention in younger and older obese men

Author(s): Julie Vion, Veronika Sramkova, Emilie Montastier, Marie-Adeline Marques, Sylvie Caspar-Bauguil, Thibaut Duparc, Laurent O Martinez , Virginie Bourlier, Isabelle Harant, Dominique Larrouy, Nabila Moussaoui, Sophie Bonnel, Cécile Vindis, Cédric Dray, Philippe Valet, Jean-Sébastien Saulnier-Blache, Joost P Schanstra, Claire Thalamas, Nathalie Viguerie, Cedric Moro, Dominique Lan
Published in: American journal of physiology. Endocrinology and metabolism., Issue 2021 Sep 1, 2021, ISSN 0193-1849
Publisher: American Physiological Society
DOI: 10.1152/ajpendo.00109.2021

Baseline gene expression in subcutaneous adipose tissue predicts diet-induced weight loss in individuals with obesity

Author(s): Oghabian, A., van der Kolk, B. W., Marttinen, P., Valsesia, A., Saris, W. H., Astrup, A., Blaak, E. E. & Pietilainen, K. H.
Published in: PeerJ - Life and Environment, 2023, ISSN 2167-8359
Publisher: PeerJ
DOI: 10.7717/peerj.15100

Glycogen metabolism links glucose homeostasis to thermogenesis in adipocytes

Author(s): Omer Keinan, Joseph M. Valentine, Haopeng Xiao, Sushil K. Mahata, Shannon M. Reilly, Mohammad Abu-Odeh, Julia H. Deluca, Benyamin Dadpey, Leslie Cho, Austin Pan, Ruth T. Yu, Yang Dai, Christopher Liddle, Michael Downes, Ronald M. Evans, Aldons J. Lusis, Markku Laakso, Edward T. Chouchani, Mikael Rydén, Alan R. Saltiel
Published in: Nature, Issue 599, 2022, Page(s) 296-301, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-021-04019-8

Cold-induced thermogenesis requires neutral-lipase-mediated intracellular lipolysis in brown adipocytes

Author(s): Etienne Mouisel, Anaïs Bodon, Christophe Noll, Stéphanie Cassant-Sourdy, Marie-Adeline Marques, Remy Flores-Flores, Elodie Riant, Camille Bergoglio, Pierre Vezin, Sylvie Caspar-Bauguil, Camille Fournes-Fraresso, Geneviève Tavernier, Khalil Acheikh Ibn Oumar, Pierre Gourdy, Denis P. Blondin, Pierre-Damien Denechaud, André C. Carpentier, Dominique Langin
Published in: Cell Metabolism, Issue 37, 2025, Page(s) 429-440.e5, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2024.10.018

Epigenetic suppression of creatine kinase B in adipocytes links endoplasmic reticulum stress to obesity-associated inflammation

Author(s): Gianluca Renzi, Ivan Vlassakev, Mattias Hansen, Romane Higos, Simon Lecoutre, Merve Elmastas, Ondrej Hodek, Thomas Moritz, Lynn M. Alaeddine, Scott Frendo–Cumbo, Ingrid Dahlman, Alastair Kerr, Salwan Maqdasy, Niklas Mejhert, Mikael Rydén
Published in: Molecular Metabolism, Issue 92, 2025, Page(s) 102082, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2024.102082

Transcriptional determinants of lipid mobilization in human adipocytes

Author(s): Alison C. Ludzki, Mattias Hansen, Danae Zareifi, Jutta Jalkanen, Zhiqiang Huang, Muhmmad Omar-Hmeadi, Gianluca Renzi, Felix Klingelhuber, Sebastian Boland, Yohannes A. Ambaw, Na Wang, Anastasios Damdimopoulos, Jianping Liu, Tomas Jernberg, Paul Petrus, Peter Arner, Natalie Krahmer, Rongrong Fan, Eckardt Treuter, Hui Gao, Mikael Rydén, Niklas Mejhert
Published in: Science Advances, Issue 10, 2024, ISSN 2375-2548
Publisher: American Association for the Advancement of Science's
DOI: 10.1126/sciadv.adi2689

In vitro and ex vivo models of adipocytes

Author(s): Jérémy Dufau, Joanne X. Shen, Morgane Couchet, Thais De Castro Barbosa, Niklas Mejhert, Lucas Massier, Elena Griseti, Etienne Mouisel, Ez-Zoubir Amri, Volker M. Lauschke, Mikael Rydén, and Dominique Langin
Published in: Cell Physiology, Issue Vol. 320 Issue 5, 2021, ISSN 0363-6143
Publisher: American Physiological Society
DOI: 10.1152/ajpcell.00519.2020

Beyond Fluidity: The Role of Lipid Unsaturation in Membrane Function

Author(s): Harayama, T.
Published in: Cold Spring Harbor Perspectives in Biology, 2023, ISSN 1943-0264
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/cshperspect.a041409

Spatial mapping reveals human adipocyte subpopulations with distinct sensitivities to insulin

Author(s): Jesper Bäckdahl, Lovisa Franzén, Lucas Massier, Qian Li, Jutta Jalkanen, Hui Gao, Alma Andersson, Nayanika Bhalla, Anders Thorell, Mikael Rydén, Patrik L. Ståhl, Niklas Mejhert
Published in: Cell Metabolism, Issue Volume 33, Issue 9, 2021, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2021.07.018

ChREBPβ is dispensable for the control of glucose homeostasis and energy balance

Author(s): Emeline Recazens, Geneviève Tavernier, Jérémy Dufau, Camille Bergoglio, Fadila Benhamed, Stéphanie Cassant-Sourdy, Marie-Adeline Marques, Sylvie Caspar-Bauguil, Alice Brion, Laurent Monbrun, Renaud Dentin, Clara Ferrier, Mélanie Leroux, Pierre-Damien Denechaud, Cedric Moro, Jean-Paul Concordet, Catherine Postic, Etienne Mouisel, Dominique Langin
Published in: JCI Insight, Issue Vol. 7, Issue 4, 2022, ISSN 2379-3708
Publisher: The American Society for Clinical Investigation
DOI: 10.1172/jci.insight.153431

Adipocyte heterogeneity revealed by spatial transcriptomics of human adipose tissue: Painting and more

Author(s): Dominique Langin
Published in: Cell Metabolism, Issue Vol 33 Issue 9, 2021, Page(s) 1869-1882, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2021.08.011

Age-Induced Reduction in Human Lipolysis: A Potential Role for Adipocyte Noradrenaline Degradation

Author(s): Hui Gao, Peter Arner, Gallic Beauchef, Christelle Guéré, Katell Vie, Ingrid Dahlman, Niklas Mejhert, Mikael Rydén
Published in: Cell Metabolism, Issue 32, 2022, Page(s) 1-3, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2020.06.007

New insights into the OSBP‒VAP cycle

Author(s): Subra M., Mesmin, B.
Published in: Current Opinion in Cell Biology, 2023, ISSN 0955-0674
Publisher: Elsevier BV
DOI: 10.1016/j.ceb.2023.102172

Adipogenic characterization of immortalized CD55 ⁺ progenitor cells from human white adipose tissue

Author(s): Morgane Couchet, Hui Gao, Felix Klingelhuber, Jutta Jalkanen, Thais De Castro Barbosa, Muhmmad Omar-Hmeadi, Lucas Massier, Natalie Krahmer, Niklas Mejhert, Mikael Rydén
Published in: Adipocyte, 2024, ISSN 2162-3945
Publisher: Taylor & Francis Online
DOI: 10.1080/21623945.2023.2283213

Hepatic miR-144 Drives Fumarase Activity Preventing NRF2 Activation During Obesity

Author(s): Valerio Azzimato, Ping Chen, Emelie Barreby, Cecilia Morgantini, Laura Levi, Ana Vankova, Jennifer Jager, André Sulen, Marina Diotallevi, Joanne X. Shen, Anne Miller, Ewa Ellis, Mikael Rydén, Erik Näslund, Anders Thorell, Volker M. Lauschke, Keith M. Channon, Mark J. Crabtree, Arvand Haschemi, Siobhan M. Craige, Mattia Mori, Francesco Spallotta, and Myriam Aouadi
Published in: Gastroenterology, Issue Volume 161, Issue 6, 2021, ISSN 0016-5085
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2021.08.030

Separation of polar and neutral lipids from mammalian cell lines by high-performance thin-layer chromatography

Author(s): Ana Rita Dias Araújo, Océane Buvry, Bruno Antonny, Delphine Debayle
Published in: Journal of Chromatography A, Issue 1741, 2025, Page(s) 465610, ISSN 0021-9673
Publisher: Elsevier BV
DOI: 10.1016/j.chroma.2024.465610

Surface tension-driven sorting of human perilipins on lipid droplets

Author(s): Ana Rita Dias Araujo, Abdoul Akim Bello, Joëlle Bigay, Céline Franckhauser, Romain Gautier, Julie Cazareth, David Kovacs, Frédéric Brau, Nicolas Fuggetta, Alenka Copic, Bruno Antonny
Published in: bioRxiv, 2024, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1101/2024.02.12.579497

Molecular mechanisms of perilipin protein function in lipid droplet metabolism

Author(s): Elena Griseti, Abdoul Akim Bello, Eric Bieth, Bayane Sabbagh, Jason S. Iacovoni, Joëlle Bigay, Henrik Laurell, Alenka Čopič
Published in: FEBS Letters, Issue 598, 2024, Page(s) 1170-1198, ISSN 0014-5793
Publisher: Elsevier BV
DOI: 10.1002/1873-3468.14792

The long noncoding RNA ADIPINT regulates human adipocyte metabolism via pyruvate carboxylase

Author(s): Kerr, A. G., Wang, Z., Wang, N., Kwok, K. H. M., Jalkanen, J., Ludzki, A., Lecoutre, S., Bergo, M. O., Dahlman, I., Mim, C., Arner, P. & Gao, H.
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-30620-0

Human White Adipose Tissue Displays Selective Insulin Resistance in the Obese State

Author(s): Enrichetta Mileti, Kelvin H.M. Kwok, Daniel P. Andersson, Anthony Mathelier, Amitha Raman, Jesper Bäckdahl, Jutta Jalkanen, Lucas Massier, Anders Thorell, Hui Gao, Peter Arner, Niklas Mejhert, Carsten O. Daub, Mikael Ryden
Published in: diabetes, 2021, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db21-0001

Surface tension–driven sorting of human perilipins on lipid droplets

Author(s): Ana Rita Dias Araújo, Abdoul Akim Bello, Joëlle Bigay, Céline Franckhauser, Romain Gautier, Julie Cazareth, Dávid Kovács, Frédéric Brau, Nicolas Fuggetta, Alenka Čopič, Bruno Antonny
Published in: Journal of Cell Biology, Issue 223, 2024, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.202403064

ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity

Author(s): """Fougerat, A., Schoiswohl, G., Polizzi, A., Regnier, M., Wagner, C., Smati, S., Fougeray, T., Lippi, Y., Lasserre, F., Raho, I., Melin, V., Tramunt, B., Metivier, R., Sommer, C., Benhamed, F., Alkhoury, C., Greulich, F., Jouffe, C., Emile, A., Schupp, M., Gourdy, P., Dubot, P., Levade, T., Meynard, D., Ellero-Simatos, S., Gamet-Payrastre, L., Panasyuk, G., Uhlenhaut, H., Amri, E. Z., Cruciani-Gugl"
Published in: Cell Reports, Issue 22111247, 2022, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2022.110910

Impaired phosphocreatine metabolism in white adipocytes promotes inflammation

Author(s): Salwan Maqdasy, Simon Lecoutre, Gianluca Renzi, Scott Frendo-Cumbo, David Rizo-Roca, Thomas Moritz, Marta Juvany, Ondrej Hodek, Hui Gao, Morgane Couchet, Michael Witting, Alastair Kerr, Martin O Bergo, Robin P Choudhury, Myriam Aouadi, Juleen R Zierath, Anna Krook, Niklas Mejhert, Mikael Rydén
Published in: Nature metabolism, Issue Vol. 4 February 2022, 2022, ISSN 2522-5812
Publisher: Springer Nature
DOI: 10.1038/s42255-022-00525-9

VAP-A intrinsically disordered regions enable versatile tethering at membrane contact sites

Author(s): Subra M., Dezi M., Bigay J., Lacas-Gervais S., Di Cicco A., Araújo A.R.D., Abélanet S., Fleuriot L., Debayle D., Gautier R., Patel A., Roussi F., Lévy D., Mesmin B.
Published in: Developmental Cell, 2023, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2022.12.010

The Lipid Droplet Knowledge Portal: A resource for systematic analyses of lipid droplet biology

Author(s): Niklas Mejhert, Katlyn R.Gabriel, Scott Frendo-Cumbo, Natalie Krahmer, Jiunn Song, Leena Kuruvilla, Chandramohan Chitraju, Sebastian Boland, Dong-Keun Jang, Marcin von Grotthuss, Maria C.Costanzo, Mikael Ryden, James A.Olzmann, Jason Flannick, Noël P.Burtt, Robert V. Farese Jr.,Tobias C. Walther
Published in: Developmental Cell, 2022, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2022.01.003

Exceptional stability of a perilipin on lipid droplets depends on its polar residues, suggesting multimeric assembly

Author(s): Manuel Giménez-Andrés, Tadej Emeršič, Sandra Antoine-Bally, Juan Martin D'Ambrosio, Bruno Antonny, Jure Derganc, Alenka Čopič
Published in: eLife, Issue 10, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.61401

Reduced adipocyte glutaminase activity promotes energy expenditure and metabolic health

Author(s): Simon Lecoutre, Salwan Maqdasy, David Rizo-Roca, Gianluca Renzi, Ivan Vlassakev, Lynn M. Alaeddine, Romane Higos, Jutta Jalkanen, Jiawei Zhong, Danae S. Zareifi, Scott Frendo-Cumbo, Lucas Massier, Ondrej Hodek, Marta Juvany, Thomas Moritz, Thais de Castro Barbosa, Muhmmad Omar-Hmeadi, Marta López-Yus, Fatiha Merabtene, Jimon Boniface Abatan, Geneviève Marcelin, Elie-Julien El Hachem, Christine R
Published in: Nature Metabolism, Issue 6, 2024, Page(s) 1329-1346, ISSN 2522-5812
Publisher: Nature Publishing Group
DOI: 10.1038/s42255-024-01083-y

Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics

Author(s): Pauline Morigny, Jeremie Boucher, Peter Arner, Dominique Langin
Published in: Nature reviews endocrinology, 2021, ISSN 1759-5029
Publisher: Nature Publishing Group
DOI: 10.1038/s41574-021-00471-8

Cellular senescence and its role in white adipose tissue

Author(s): Ulf Smith, Qian Li, Mikael Rydén, Kirsty L. Spalding
Published in: International Journal of Obesity, 2021, ISSN 0307-0565
Publisher: Nature Publishing Group
DOI: 10.1038/s41366-021-00757-x

Hormone-sensitive lipase: sixty years later

Author(s): Emeline Recazens, Etienne Mouisel, Dominique Langin
Published in: Progress in Lipid Research, Issue 82, 2021, ISSN 0163-7827
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.plipres.2020.101084

Effects of Fatty Acid Metabolites on Adipocytes Britening: Role of Thromboxane A2

Author(s): Colson, C., Batrow, P. L., Dieckmann, S., Contu, L., Roux, C. H., Balas, L., Vigor, C., Fourmaux, B., Gautier, N., Rochet, N., Bernoud-Hubac, N., Durand, T., Klingenspor, M. & Amri, E. Z.
Published in: Cells, 2023, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells12030446

An integrated single cell and spatial transcriptomic map of human white adipose tissue

Author(s): Massier L, Jalkanen J, Elmastas M, Zhong J, Wang T, Nono Nankam PA, Frendo-Cumbo S, Bäckdahl J, Subramanian N, Sekine T, Kerr AG, Tseng BTP, Laurencikiene J, Buggert M, Lourda M, Kublickiene K, Bhalla N, Andersson A, Valsesia A, Astrup A, Blaak EE, Ståhl PL, Viguerie N, Wolfrum C, Blüher M, Mejhert N.
Published in: Nature Publishing Group, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-36983-2

β3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity

Author(s): Hui Gao, Ruth T. Yu, Christopher Liddle, Michael Downes, Jin Zhang, Aldons J. Lusis, Alan D. Attie, Ronald M. Evans, Mikael Rydén, and Alan R. Saltiel
Published in: JCI The Journal of Clinical Investigation, 2021, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci153357

Adipose tissue retains an epigenetic memory of obesity after weight loss

Author(s): Laura C. Hinte, Daniel Castellano-Castillo, Adhideb Ghosh, Kate Melrose, Emanuel Gasser, Falko Noé, Lucas Massier, Hua Dong, Wenfei Sun, Anne Hoffmann, Christian Wolfrum, Mikael Rydén, Niklas Mejhert, Matthias Blüher, Ferdinand von Meyenn
Published in: Nature, Issue 636, 2024, Page(s) 457-465, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-024-08165-7