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Lipid droplet hypertrophy : the link between adipocyte dysfunction and cardiometabolic diseases


3D Adipose Tissue Culture Links the Organotypic Microenvironment to Improved Adipogenesis

Author(s): Joanne X. Shen, Morgane Couchet, Jérémy Dufau, Thais de Castro Barbosa, Marie-Adeline Marques, Niklas Mejhert, Volker M. Lauschke
Published in: Advanced Science, Vol. 8 Issue 16, 2021, ISSN 2198-3844
Publisher: John Wiley & Sons, Ltd
DOI: 10.1002/advs.202100106

Metabolic and cardiovascular adaptations to an 8-wk lifestyle weight loss intervention in younger and older obese men

Author(s): Julie Vion, Veronika Sramkova, Emilie Montastier, Marie-Adeline Marques, Sylvie Caspar-Bauguil, Thibaut Duparc, Laurent O Martinez , Virginie Bourlier, Isabelle Harant, Dominique Larrouy, Nabila Moussaoui, Sophie Bonnel, Cécile Vindis, Cédric Dray, Philippe Valet, Jean-Sébastien Saulnier-Blache, Joost P Schanstra, Claire Thalamas, Nathalie Viguerie, Cedric Moro, Dominique Lan
Published in: American journal of physiology. Endocrinology and metabolism., 2021 Sep 1, 2021, ISSN 0193-1849
Publisher: American Physiological Society
DOI: 10.1152/ajpendo.00109.2021

In vitro and ex vivo models of adipocytes

Author(s): Jérémy Dufau, Joanne X. Shen, Morgane Couchet, Thais De Castro Barbosa, Niklas Mejhert, Lucas Massier, Elena Griseti, Etienne Mouisel, Ez-Zoubir Amri, Volker M. Lauschke, Mikael Rydén, and Dominique Langin
Published in: Cell Physiology, Vol. 320 Issue 5, 2021, ISSN 0363-6143
Publisher: American Physiological Society
DOI: 10.1152/ajpcell.00519.2020

Spatial mapping reveals human adipocyte subpopulations with distinct sensitivities to insulin

Author(s): Jesper Bäckdahl, Lovisa Franzén, Lucas Massier, Qian Li, Jutta Jalkanen, Hui Gao, Alma Andersson, Nayanika Bhalla, Anders Thorell, Mikael Rydén, Patrik L. Ståhl, Niklas Mejhert
Published in: Cell Metabolism, Volume 33, Issue 9, 2021, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2021.07.018

ChREBPβ is dispensable for the control of glucose homeostasis and energy balance

Author(s): Emeline Recazens, Geneviève Tavernier, Jérémy Dufau, Camille Bergoglio, Fadila Benhamed, Stéphanie Cassant-Sourdy, Marie-Adeline Marques, Sylvie Caspar-Bauguil, Alice Brion, Laurent Monbrun, Renaud Dentin, Clara Ferrier, Mélanie Leroux, Pierre-Damien Denechaud, Cedric Moro, Jean-Paul Concordet, Catherine Postic, Etienne Mouisel, Dominique Langin
Published in: JCI Insight, Vol. 7, Issue 4, 2022, ISSN 2379-3708
Publisher: The American Society for Clinical Investigation
DOI: 10.1172/jci.insight.153431

Adipocyte heterogeneity revealed by spatial transcriptomics of human adipose tissue: Painting and more

Author(s): Dominique Langin
Published in: Cell Metabolism, Vol 33 Issue 9, 2021, Page(s) 1869-1882, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2021.08.011

Hepatic miR-144 Drives Fumarase Activity Preventing NRF2 Activation During Obesity

Author(s): Valerio Azzimato, Ping Chen, Emelie Barreby, Cecilia Morgantini, Laura Levi, Ana Vankova, Jennifer Jager, André Sulen, Marina Diotallevi, Joanne X. Shen, Anne Miller, Ewa Ellis, Mikael Rydén, Erik Näslund, Anders Thorell, Volker M. Lauschke, Keith M. Channon, Mark J. Crabtree, Arvand Haschemi, Siobhan M. Craige, Mattia Mori, Francesco Spallotta, and Myriam Aouadi
Published in: Gastroenterology, Volume 161, Issue 6, 2021, ISSN 0016-5085
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2021.08.030

Human White Adipose Tissue Displays Selective Insulin Resistance in the Obese State

Author(s): Enrichetta Mileti, Kelvin H.M. Kwok, Daniel P. Andersson, Anthony Mathelier, Amitha Raman, Jesper Bäckdahl, Jutta Jalkanen, Lucas Massier, Anders Thorell, Hui Gao, Peter Arner, Niklas Mejhert, Carsten O. Daub, Mikael Ryden
Published in: diabetes, 2021, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db21-0001

ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity

Author(s): """Fougerat, A., Schoiswohl, G., Polizzi, A., Regnier, M., Wagner, C., Smati, S., Fougeray, T., Lippi, Y., Lasserre, F., Raho, I., Melin, V., Tramunt, B., Metivier, R., Sommer, C., Benhamed, F., Alkhoury, C., Greulich, F., Jouffe, C., Emile, A., Schupp, M., Gourdy, P., Dubot, P., Levade, T., Meynard, D., Ellero-Simatos, S., Gamet-Payrastre, L., Panasyuk, G., Uhlenhaut, H., Amri, E. Z., Cruciani-Gugl"
Published in: Cell Reports, 22111247, 2022, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2022.110910

Impaired phosphocreatine metabolism in white adipocytes promotes inflammation

Author(s): Salwan Maqdasy, Simon Lecoutre, Gianluca Renzi, Scott Frendo-Cumbo, David Rizo-Roca, Thomas Moritz, Marta Juvany, Ondrej Hodek, Hui Gao, Morgane Couchet, Michael Witting, Alastair Kerr, Martin O Bergo, Robin P Choudhury, Myriam Aouadi, Juleen R Zierath, Anna Krook, Niklas Mejhert, Mikael Rydén
Published in: Nature metabolism, Vol. 4 February 2022, 2022, ISSN 2522-5812
Publisher: Springer Nature
DOI: 10.1038/s42255-022-00525-9

The Lipid Droplet Knowledge Portal: A resource for systematic analyses of lipid droplet biology

Author(s): Niklas Mejhert, Katlyn R.Gabriel, Scott Frendo-Cumbo, Natalie Krahmer, Jiunn Song, Leena Kuruvilla, Chandramohan Chitraju, Sebastian Boland, Dong-Keun Jang, Marcin von Grotthuss, Maria C.Costanzo, Mikael Ryden, James A.Olzmann, Jason Flannick, Noël P.Burtt, Robert V. Farese Jr.,Tobias C. Walther
Published in: Developmental Cell, 2022, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2022.01.003

Exceptional stability of a perilipin on lipid droplets depends on its polar residues, suggesting multimeric assembly

Author(s): Manuel Giménez-Andrés, Tadej Emeršič, Sandra Antoine-Bally, Juan Martin D'Ambrosio, Bruno Antonny, Jure Derganc, Alenka Čopič
Published in: eLife, 10, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.61401

Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics

Author(s): Pauline Morigny, Jeremie Boucher, Peter Arner, Dominique Langin
Published in: Nature reviews endocrinology, 2021, ISSN 1759-5029
Publisher: Nature Publishing Group
DOI: 10.1038/s41574-021-00471-8

Cellular senescence and its role in white adipose tissue

Author(s): Ulf Smith, Qian Li, Mikael Rydén, Kirsty L. Spalding
Published in: International Journal of Obesity, 2021, ISSN 0307-0565
Publisher: Nature Publishing Group
DOI: 10.1038/s41366-021-00757-x

Hormone-sensitive lipase: sixty years later

Author(s): Emeline Recazens, Etienne Mouisel, Dominique Langin
Published in: Progress in Lipid Research, 82, 2021, ISSN 0163-7827
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.plipres.2020.101084

β3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity

Author(s): Hui Gao, Ruth T. Yu, Christopher Liddle, Michael Downes, Jin Zhang, Aldons J. Lusis, Alan D. Attie, Ronald M. Evans, Mikael Rydén, and Alan R. Saltiel
Published in: JCI The Journal of Clinical Investigation, 2021, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci153357

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